Category: 638-45-9

Schaefer, Bernhard published the artcileDitopic Hexadentate Ligands with a Central Dihydrobenzo-diimidazole Unit Forming a [2×2] Zn₄ Grid Complex, Formula: C6H13I, the publication is European Journal of Organic Chemistry (2021), 2021(16), 2301-2310, database is CAplus.

A family of ditopic hexadentate ligands based on the parent compound 2,6-bis(6-(pyrazol-1-yl)pyridin-2-yl)-1,5-dihydrobenzo[1,2-d:4,5-d’]diimidazole (L) was developed and synthesized by using a straightforward condensation reaction, which forms the interlinking central benzo[1,2-d:4,5-d’]diimidazole bridge in the ligand backbone. The two secondary amine groups of the benzodiimidazole unit tautomerize and allow the formation of two tauto-conformers, which upon treatment with metal salts forms different isomeric coordination complexes. Here authors report six new derivatives (1–6) that can tautomerize (varying the pyrazolylpyridine part) and 14 derivatives (7–13) with different alkyl and benzyl substitution on secondary amino groups (of L) that prevent the tautomerization. This way, it is possible to study the properties of isomeric coordination complexes and their intrinsic cooperativity by the example of [2×2] grid complexes in the future. A [2×2] Zn₄ complex of the ligand L was synthesized and structurally characterized.

European Journal of Organic Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Guobing published the artcileSmall molecules based on strongly electron-deficient aza-isatinylidene malononitrile for solution-processed n-type field-effect transistors, Recommanded Product: 1-Iodohexane, the publication is Synthetic Metals (2022), 117071, database is CAplus.

In this paper, three donor-acceptor (D/A) small mols. (M1, M2, and M3) based on aza-isatinylidene malononitrile (AIMN) and diketopyrrolopyrrole (DPP) containing different N-alkyl chains in AIMN unit were synthesized and characterized for application in solution-processable organic field-effect transistors (OFETs). The D/A small mols. with strongly electron-withdrawing AIMN and DPP units exhibited broad absorption spectra, low bandgaps, and deep LUMO energy levels (< – 4.0 eV). Consequently, OFET devices displayed unipolar electron transport characteristics with the highest electron mobilities of 0.26, 0.22, and 0.0079 cm2V-1s-1 for M1, M2, and M3, resp. The small mols. with linear side chains showed much higher field-effect performances than that of branched side chains- based small mol., due to the strong π-π stacking and appropriate morphol. This work indicated that the strongly electron-deficient AIMN should be a potential unit for constructing the n-type solution-processable small mol. semiconductors.

Synthetic Metals published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H7F3O3, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Mingxiang published the artcileSmall molecule semiconductors based on hemi-isoindigo and diketopyrrolopyrrole for solution-processed organic field-effect transistors, Product Details of C6H13I, the publication is Synthetic Metals (2021), 116833, database is CAplus.

Two small semiconductor mols. based on diketopyrrolopyrrole (DPP) and hemi-isoindigo units with and without fluorination were designed and synthesized for investigating the solution-processed organic field-effect transistors (OFETs). Bottom-gate/top-contact (BG/TC) OFETs were fabricated to explore carrier transport characteristics. The combination of d. functional theory (DFT) calculation, grazing incidence X-ray diffraction (GIXD), and at. force microscopy (AFM) allowed us to understand the relationship between structures and properties. The results revealed the small mol. with fluorination (DPP-T-FMI) exhibited better field-effect performance owing to the improved crystal packing and morphol. of thin-films.

Synthetic Metals published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H8O4, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ling, Mingjian published the artcileNIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics, Related Products of iodides-buliding-blocks, the publication is Nano Research (2022), 15(7), 6288-6296, database is CAplus.

Oral cancer is a common malignant tumor of the head and neck, and surgery combined with radiotherapy and chemotherapy is the primary treatment modality. However, a pos. resection margin that may lead to recurrence after surgery has always been a critical issue to address. Furthermore, radiotherapy and chemotherapy also have shortcomings such as resistance to chemotherapy and radiation, lack of targeting, and severe side effects. Therefore, exploring new methods of tumor surgical navigation and tumor treatment is of great significance for oral cancer. Although, the emerging near-IR II (NIR-II, 1,000-1,700 nm) region fluorescent imaging has revolutionized surgical navigation, a high tumor-targeting fluorescent probe remains lacking. Furthermore, while emerging photothermal therapy (PTT) can overcome chemoradiotherapy’s shortcomings and achieve precise treatment of tumors, its clin. application is still limited by the lack of high photothermal conversion efficiency, high photothermal stability, and highly penetrating materials. Herein, a NIR-II dye SQ890 is developed for tumor imaging and PTT of oral cancer. By assembling into nanoparticles (NPs) and being modified with epithelial growth factor receptor (EGFR)-targeting peptides GE11, SQ890 NPs-Pep can specifically accumulate in tumor sites via active targeting, and realize photoacoustic/NIR-II fluorescence dual-modality imaging-guided PTT of oral cancer.

Nano Research published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tian, Minggang published the artcileDual-Emissive Probe for Reversible Visualization of ΔΨ_m Revealing Voltage Heterogeneity in a Single Mitochondrion, Synthetic Route of 638-45-9, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(7), 3493-3501, database is CAplus and MEDLINE.

Mitochondrial membrane potential (ΔΨ_m) is a fundamentally important parameter in eukaryotic cells playing central roles in various vital biol. processes. Precise visualization of ΔΨ_m depends on the robust ratiometric fluorescent probes. In this work, a new dual-emissive fluorescent probe has been fabricated for ratiometric visualization of ΔΨ_m. The unique probe can form near-IR emissive aggregates (~670 nm) in mitochondria with high ΔΨ_m, which turned to green-emitting monomers (530 nm) with loss of ΔΨ_m. The reversible changes of ΔΨ_m can be clearly observed, and the ultralarge emission shift (~140 nm) is greatly favorable for the clear observation of voltage distribution under a super-resolution microscope. With the robust probe, the heterogenous voltage distribution in a single mitochondrion has been revealed for the first time, which can facilitate the in-depth understanding of fine structures in mitochondria. The cell damages induced by various reagents were successfully visualized using the innovative probe, demonstrating its pronounced potential for biol. research.

Analytical Chemistry (Washington, DC, United States) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C10H9IO4, Synthetic Route of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zubenko, Alexander A. published the artcileSystems with annulated thioxo azepinone moiety: an access through heterocyclic carbodithioate ring expansion, Application of 1-Iodohexane, the publication is Mendeleev Communications (2021), 31(4), 545-547, database is CAplus.

New 1-oxo-2-thioxo-1,2,4,5-tetrahydrobenz[d]azepines I [R¹ = H, MeO; R² = H, OH, OMe; R³ = Me, Et, n-Bu, n-hexyl, PhO(CH₂)₂] and 1-oxo-2-thioxo-1,2,4,5-tetrahydroazepino[4,5-b]indole were conveniently obtained by the novel recyclization reaction of (methylthio)carbonothioylsubstituted heterocyclic quaternary salts with expansion of the dihydropyridine ring.

Mendeleev Communications published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H10O4, Application of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manhas, Neha published the artcileCytotoxicity and Antibacterial Evaluation of O-Alkylated/Acylated Quinazolin-4-one Schiff Bases, Application of 1-Iodohexane, the publication is Chemistry & Biodiversity (2021), 18(5), e2100096, database is CAplus and MEDLINE.

A series of quinazolin-4-one Schiff bases were synthesized and tested in vitro for their cytotoxicity against two cancerous cell lines (MCF-7, Caco-2) and a human embryonic cell line (HEK-293) including their antibacterial evaluation against two Gram-pos. and four Gram-neg. bacterial strains. Most of the quinazoline-Schiff bases exhibited potent cytotoxicity against Caco-2. 3-[(Z)-({4-[(But-2-yn-1-yl)oxy]phenyl}methylidene)amino]-2-methylquinazolin-4(3H)-one (6f) with the O-butyne functional group displayed three-fold higher cytotoxic activity (IC50=376.8μM) as compared to 5-fluorouracil (5-FU; IC50=1086.1μM). However, all compounds were found to be toxic to HEK-293, except for 3-[(Z)-({4-[(2,4-difluorophenyl)methoxy]phenyl}methylidene)amino]-2-methylquinazolin-4(3H)-one (6h) that showed ∼three-fold lower toxicity and higher selectivity index than 5-FU. Structure-activity relationship (SAR) anal. revealed that O-alkylation generally increased the anticancer activity and selectivity of quinazoline-4-one Schiff bases toward Caco-2 cells. The fluorinated Schiff-base generally exhibited even more significant cytotoxic activity compared to their chlorine analogs. Surprisingly, none of the quinazoline-4-one Schiff bases displayed encouraging antibacterial activity against the bacterial strains investigated. Most of the compounds were predicted to show compliance with the Lipinski parameters and ADMET profiles, indicating their drug-like properties.

Chemistry & Biodiversity published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bombaca, Ana Cristina S. published the artcileNovel N,N-di-alkylnaphthoimidazolium derivative of β-lapachone impaired Trypanosoma cruzi mitochondrial electron transport system, Name: 1-Iodohexane, the publication is Biomedicine & Pharmacotherapy (2021), 111186, database is CAplus and MEDLINE.

The current treatments are based on benznidazole and nifurtimox; however, these drugs have important limitations and limited efficacy during the chronic phase, reinforcing the necessity of an alternative chemotherapy. Here, we show the synthesis of a novel β-lapachone-derived naphthoimidazolium named N4 and assess its activity on T. cruzi stages and the mechanism of action. The new compound was very active on all parasite stages (IC50/24 h in the range of 0.8-7.9 μM) and had a selectivity index of 5.4. Mechanistic analyses reveal that mitochondrial ROS production begins after short treatment starts and primarily affects the activity of complexes II-III. After 24 h treatment, a partial restoration of mitochondrial physiol. (normal complexes II-III and IV activities and controlled H2O2 release) was observed; however, an extensive injury in its morphol. was still detected. During treatment with N4, we also observed that trypanothione reductase activity increased in a time-dependent manner and concomitant with increased oxidative stress. Mol. docking calculations indicated the ubiquinone binding site of succinate dehydrogenase as an important interaction point with N4, as with the FMN binding site of dihydroorotate dehydrogenase. The results presented here may be a good starting point for the development of alternative treatments for Chagas disease and for understanding the mechanism of naphthoimidazoles in T. cruzi.

Biomedicine & Pharmacotherapy published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Milzarek, Tobias M. published the artcileEvaluation of the Substrate Promiscuity of SorbC for the Chemo-Enzymatic Total Synthesis of Structurally Diverse Sorbicillinoids, Safety of 1-Iodohexane, the publication is ACS Catalysis (2022), 12(3), 1898-1904, database is CAplus.

In the present work, the effects of structural changes to the natural substrate sorbicillin was systematically screened by HPLC-based anal. and comparative determination of key kinetic parameters. This not only provided important insight into substrate promiscuity of SorbC but also facilitated the efficient chemo-enzymic preparation of unnatural dimeric sorbicillinoids possessing modified backbones or hydroxylated sorbyl side chains. In addition, the total syntheses of the natural saturnispol C, saturnispol D, and trichosorbicillin A, as well as of demethyltrichosorbicillin A and dihydroxybisorbicillinol, both not yet known in nature, were reported.

ACS Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tong, Xiaoyu published the artcileCatalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl Electrophiles, Formula: C6H13I, the publication is Journal of the American Chemical Society (2022), 144(32), 14856-14863, database is CAplus and MEDLINE.

Herein the achievement of this objective, demonstrating that a nickel catalyst could accomplish enantioselective intermol. alkylations of racemic Reformatsky reagents with unactivated electrophiles; the resulting α-alkylated carbonyl compounds could be converted in one addnl. step into a diverse array of ubiquitous families of chiral mols was described. Applying a broad spectrum of mechanistic tools, have gained insight into key intermediates (including the alkylnickel(II) resting state) and elementary steps of the catalytic cycle.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C21H33BN2O6S, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com