Category: 63262-06-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, A new synthetic method of this compound is introduced below., Product Details of 63262-06-6

According to the above reaction formula, under nitrogen protection, the purchased 1,4-dibromo-2,5-diiodobenzene (1.00g/2.05mmol),Carbazole (514.29mg, 3.08mmol), potassium hydroxide (230.1mg, 4.10mmol 2,2,6,6-Tetramethyl-3,5-heptanedione (37.80mg, 0.205mmol) and cuprous oxide (29mg, 0.205mmol) were added to 10mL DMF,After heating to 110C for 124 hours, the reaction was extracted three times with 50 ml of saturated brine and 15 ml of dichloromethane.The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by column chromatography using petroleum etherdichloromethane=3:1 (VV) as eluent.1.02 g of white solid product was obtained with a yield of 87.8%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; South China University of Technology; Ying Lei; Zhong Zhiming; Li Yuanfeng; Guo Ting; Peng Junbiao; Cao Yong; (11 pag.)CN111116455; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,4-Dibromo-2,5-diiodobenzene

Add to a 300mL Schlenk tube with argon replacement equipped with a stir bar1,4-dibromo-2,5-diiodobenzene (25.0g, 51mmol), phenylboronic acid (13.1g, 107mmol), tetrakis(triphenylphosphine) palladium (8.95g, 7.7mmol), toluene (200mL) ,Water (80mL) and potassium carbonate (35.7g, 258mmol), after sealing,Stir at 100C for 16 hours. Then, the reaction vessel was allowed to cool for 4 hours to near room temperature, and the precipitate was collected by filtration. Then, wash with water and methanol,Thus, the target compound (A1) is obtained(The yield is 15.6 g, the yield is 78.4%).

The synthetic route of 63262-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guandong Chemical Co., Ltd.; Xi Weitaiyi; Ji Guangdayou; Zuo Tenghuixing; Yan Jingxin; Xin Neicongchang; (45 pag.)CN111253264; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 63262-06-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 2-(tributylstannyl)thiophene (20.7 g, 55.3 mmol) and1,4-dibromo-2,5-diiodobenzene (13.5 g, 27.7 mmol) in dry DMF (100 mL) was addedPd(PPh3)2Cl2 (0.78 g, 1.12 mmol). The mixture was stirred for 40 h at 80 C. Aftercooling to room temperature, the reaction mixture was poured into water and thenextracted with toluene. The combined organic layers were washed with water and driedover anhydrous Na2SO4. After filtration and evaporation, the crude product wasrecrystallized from methanol to provide 8 as a white solid (yield = 10.3 g, 93%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-diiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Komiyama, Hideaki; Adachi, Chihaya; Yasuda, Takuma; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1459 – 1466;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H2Br2I2

Under nitrogen atmosphere, 1,4-dibromo-2,5-diiodobenzene (3.0 g, 6.2 mmol) was dissolved in diisopropylamine (45 ml) and anhydrous benzene (45 ml), followed by stirring for 30 minutes. Copper iodide (235 mg, 0.12 mmol), PdCl2(PPh3)2 (430 mg, 0.61 mmol), and 1-dodecene (1.9 ml, 12.9 mmol) were added to the mixture, followed by stirring at room temperature for 14 hours. The reaction liquid was poured into water and extracted with chloroform, and the obtained organic layer was washed with 200 ml of water three times. The resulting organic layer was dried over anhydrous sodium sulfate and purified by a column chromatography (silica gel and methylene chloride:hexane = 1:3), followed by recrystallization in ethanol, thereby colorless powdery 1,4-dibromo-2,5-bis(octyne-1-yl)benzene was obtained (1.56 g, yield: 56%). 1H-NMR (400 MHz, CDCL3) delta7.59 (s, 2H) 2.45 (t, J=7.2 Hz, 4H) 1.65-1.23 (m, 32H) 0.88 (t, J=6.4 Hz, 6H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 63262-06-6.

Reference:
Patent; Nippon Kayaku Kabushiki Kaisha; Hiroshima University; EP2147923; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 63262-06-6,Some common heterocyclic compound, 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, molecular formula is C6H2Br2I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, dibromodiiodobenzene (2.5 g, 5.1 mmol), Intermediate 3 (4.97 g, 15.4 mmol), and Pd(PPh3)4 (237 mg, 0.205 mmol) were dissolved in toluene (250 mE) and dimethylsulfoxide (DMSO, 50 mE), 2 MNa2CO3 aqueous solution (13 mE) was added thereto, and the mixture was stirred with heating at 90 C. for 24 hours. Afier completion of the reaction, toluene was removed under reduced pressure, and the precipitated solid was filtered off. This solid was washed with methanol and ethyl acetate,whereby obtaining a white solid (2.5 g, yield: 75%). The obtained solid was Intermediate 4, which is an intended product, and by mass spectrum analysis, it was confirmed that it had an mle value of 626 with respect to a molecular weight of 626.

The synthetic route of 63262-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; Takahashi, Ryota; Ikeda, Hidetsugu; Seda, Keita; Nakano, Yuki; (152 pag.)US10249832; (2019); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 63262-06-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63262-06-6 as follows.

Under a nitrogen atmosphere,4.00 g (33.2 mmol) of 2,2,6,6-tetramethylpiperidine (Wako Pure Chemical Industries) and 12 ml of THF (dehydrated grade) were added to a 300 ml Schlenk reaction vessel.At 0 C.,Isopropyl magnesium chloride33.0 ml (42.9 mmol) of lithium chloride (Sigma-Aldrich, 1.3 M) in THF solution was added,And the mixture was stirred at room temperature for 2 days.The resulting magnesium chloride 2,2,6,6-tetramethylpiperidide5.18 g (45.3 mmol) of 3-methoxythiophene (Wako Pure Chemical Industries) was added dropwise to the lithium chloride solution,And aged at room temperature for 8 hours.20 ml of THF (dehydration grade) was added,It was cooled to -60 C.Here,A solution consisting of 6.13 g (45.0 mmol) of zinc chloride (Wako Pure Chemical Industries) and 40 ml of THF (dehydration grade) was charged using a Teflon cannula.Further washing was carried out using 10 ml of THF (dewatering grade).After gradually raising the temperature to room temperature,To the obtained white slurry liquid (3-methoxythienyl-2-zinc chloride)7.01 g (14.4 mmol) of 1,4-dibromo-2,5-diiodobenzene (Tokyo Chemical Industry Co., Ltd.)244 mg (0.214 mmol, 1.49 mol% based on 1,4-dibromo-2,5-diiodobenzene) of tetrakis (triphenylphosphine) palladium (Tokyo Chemical Industry)The obtained mixture was reacted at 50 C. for 8 hours.After cooling to room temperature,The whole was concentrated under reduced pressure.To the resulting residue were added 100 ml of water and 100 ml of hexane and filtered.The solid obtained by filtration was purified by silica gel column chromatography (hexane / toluene = 2/1 to 0/1) and recrystallized from toluene to give 1,4-di (3-methoxythienyl) -2, 4.19 g of 5-dibromobenzene as a pale yellow solid (yield 63%).

According to the analysis of related databases, 63262-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOSOH CORPORATION; WATANABE, MAKOTO; UENO, WATARU; UEDA, SAORI; HACHIYA, HITOSHI; (12 pag.)JP2017/31098; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1,4-Dibromo-2,5-diiodobenzene

100 ml to double-mouth bottle 1,4-dibromo -2,5- phenyl-diiodide 974.5 mg (2mmol), phenylboronic acid 609.5 mg (5mmol), four (triphenylphosphine) palladium 115.6 mg (0.1mmol), vacuum heat nitrogen three times post-injection by adding oxygen-free tetrahydrofuran 20 ml aqueous solution of potassium carbonate and the 10 ml (2mol/L), in 74 C lower reflux 8h, DCM extraction for reaction is ended, and salt water washing three phase after drying with anhydrous sodium sulfate, after filtration turns on lathe does, with pure petroleum ether column separation and purification, to obtain white powder 2,5-dibromo -1,4- diphenyl benzene, the yield is 63.7%, that is, the intermediate product 1. Product characterization data are as follows

The synthetic route of 63262-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University; Li, Lingzhi; Qin, Anjun; Tang, Benzhong; Sun, Jingzhi; (15 pag.)CN104844475; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 63262-06-6

Under a nitrogen atmosphere, to a 50mL three-necked flask 1,4-dibromo-2,5-di-iodobenzene 219 mg (0.45 mmol) and diethyl ether (5 ml) was added and cooled to -78 C..Thereafter, it was added dropwise n- butyllithium 0.54ml at the same temperature (1.66 M hexane solution, 0.90 mmol), and stirred for 1 hour.At Thereafter the same temperature, it was added dropwise synthesized bis previous step was dissolved in diethyl ether (1ml) (2-n- hexyl-4-thienyl) disulfide 359 mg (0.90 mmol), and stirred at room temperature for 12 hours.The reaction by the addition of water was stopped, after extraction with diethyl ether, and the organic layer was dried over anhydrous sodium sulfate.And concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (hexane), 1,4-bis [(2-n-hexyl-4-thienyl) sulfanyl] of 2,5-dibromobenzene yellow solid 228mg was obtained (80% yield).

The synthetic route of 63262-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOSOH CORPORATION; HACHIYA, HITOSHI; WATANABE, MAKOTO; UEDA, SAORI; (16 pag.)JP2015/227297; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, molecular formula is C6H2Br2I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H2Br2I2

Under the protection of nitrogen, 4.85 g of compound II, 2.50 g of trimethylsilylacetylene, 50 ml of triethylamine, 100 mg of cuprous iodide and 150 mg of dichlorobis(triphenylphosphine)palladium were added.Block the reaction system, stir at room temperature overnight, gas phase detectionReaction process, after the reaction is over,The triethylamine was distilled off under reduced pressure, and the column was eluted with a solvent of n-hexane to afford a crude product.White solid 3.2 g, yield 80%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63262-06-6, its application will become more common.

Reference:
Patent; Henan Academy Of Sciences Chemical Institute Co., Ltd.; Zhou Yang; Zhao Yongde; Dai Bencai; Liu Changchun; Wang Lantian; Zhang Yuli; Chai Cuncai; Chen Jieying; (11 pag.)CN108558948; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 63262-06-6, A common heterocyclic compound, 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, molecular formula is C6H2Br2I2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A nitrogen gas atmosphere was prepared in a reaction vessel equipped with a stirrer, then, a compound 1 (22.0 g), 2-bromophenylboronic acid (19.1 g), tetrakis(triphenylphosphine)palladium(0) (2.43 g) and tetrahydrofuran (440 mL) were added, and the mixture was heated at 45 C. Thereafier, to this was added silver carbonate (47.2 g), and the mixture was refluxed for 3 hours. The resultant reaction liquid was cooled down to room temperature, then, water and toluene were added, and the mixture was stirred at room temperature. Thereafter, the aqueous layer was separated, and the organic layer was washed with a saturated sodium chloride aqueous solution. To the resultant organic layer was added sodium sulfate, then, the layer was filtrated, and concentrated to obtain a coarse product. Thereafier, to this were added toluene and activated carbon, and the mixture was stirred at 70 C. for 1 hour. Thereafter, the mixture was filtrated through a filter pre-coated with Celite. The resultant residue was washed with toluene several times. The resultant washing liquid was concentrated, then, recrystallized using toluene, thereby obtaining 17.9 g of a compound 2 (yield:74%, purity: 98.9%) as a white solid. ?H-NMR (DMSO-d5, 300 MHz): oe (ppm)7.43 (4H, t), 7.49 (2H, t), 7.71 (2H, d), 7.76 (2H, d).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Chemical Company, Limited; USUI, Motoaki; FUKUSHIMA, Daisuke; TANAKA, Shin-ya; (58 pag.)US2017/137566; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com