Category: 63131-30-6

Wang, Heng-Yen published the artcileRegioselective synthesis of 2,3,4- or 2,3,5-trisubstituted pyrroles via [3,3] or [1,3] rearrangements of O-vinyl oximes, Application In Synthesis of 63131-30-6, the main research area is pyrrole derivative regioselective synthesis; vinyl oxime isomerization sigmatropic rearrangement Ir catalyst.

The regioselective synthesis of 2,3,4- or 2,3,5-trisubstituted pyrroles e. g., I has been achieved via [3,3] and [1,3] sigmatropic rearrangements of O-vinyl oximes, resp. Iridium-catalyzed isomerization of easily prepared O-allyl oximes enables rapid access to O-vinyl oximes. Optimization and scope of the O-allyl oxime isomerization and subsequent pyrrole formation are discussed and mechanistic pathways are proposed. The regioselectivity of pyrrole formation can be controlled by either the identity of the α-substituent or through the addition of an amine base. When enolization is favored, a [3,3] rearrangement followed by a Paal-Knorr cyclization provides a 2,3,4-trisubstituted pyrrole; when enolization is disfavored, a [1,3] rearrangement occurs prior to enolization to produce a 2,3,5-trisubstituted pyrrole after cyclization. Conditions are provided for selecting either the [3,3] rearrangement or the [1,3] rearrangement product with β-ester O-allyl oxime substrates.

Journal of Organic Chemistry published new progress about Isomerization. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Application In Synthesis of 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 63131-30-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63131-30-6 as follows.

10 ml test tube reaction of adding 0.2mmol2 – (4-methoxyphenylamino) methyl acetate and 0.01mmol trifluoro methane sulfonic acid copper, in order to 3 ml acetonitrile as the reaction solvent, added under stirring 0.1mmol4-iodophenylamino Carbamoyl ethyl acetate, the (green) LED illumination the reaction solution 1h rear, turns on lathe does reaction solvent, after column separation, the obtained product is nuclear magnetism hydrogen spectrum carbon spectrum and mass spectrum is identified as 1-ethyl 4-methyl 2 – (4-iodo benzoyl) – 3 – ((4-methoxylphenyl) amino) succinate

According to the analysis of related databases, 63131-30-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences; WU, LIZHU; GAO, XUEWANG; MENG, QINGYUAN; LEI, TAO; ZHONG, JIANJI; XIANG, MING; TONG, ZHENHE; (21 pag.)CN104230734; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 63131-30-6, A common heterocyclic compound, 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, molecular formula is C11H11IO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of ethyl 3-oxo-3-(p-tolyl)propanoate (320 mg, 1.552 mmol) in dry DMF (3.1 mL) was added K2CO3 (236 mg, 1.707 mmol) followed by a solution of propargyl bromide in PhMe (9.2 M, 0.202 mL, 1.862 mmol). The reaction mixture was allowed to stir at ambient room temperature for 12 h. The reaction was transferred to a separatory funnel and diluted with deionized water (20 mL) and the aqueous layer was extracted with ethyl acetate (3 * 20 mL). The combined organic layers were sequentially washed with deionized water (20 mL) and brine (20 mL). The organic layer was dried over sodium sulfate then concentrated in vacuo. The crude material was then purified by flash column chromotography (3% EtOAc/Hexanes) to provide 10 (313 mg, 82%) as a yellow oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Golonka, Alexander N.; Schindler, Corinna S.; Tetrahedron; vol. 73; 29; (2017); p. 4109 – 4114;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate

The reaction flask was charged sequentially with Cu (OAc) 2.H2O (0.15 mmol, 30 mg), Mg (OTf) 2 (0.2 mmol, 64 mg)DABCO (5 mmol, 560 mg), compound 1h(2 mmol, 634 mg), compound 2a (3 mmol, 342 mg), tBuONO (3 mmol, 309 mg), cyclohexane (10.0 mL).The system is then heated in the air at 80 C for about 12 hours,Extracted with ethyl acetate (40 mL x 3)The product was obtained by simple column chromatography for 3 h with a yield of 81%.The main test data obtained by the product are as follows, by analysis,The actual synthesis product is consistent with the theoretical analysis.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 63131-30-6.

Reference:
Patent; Soochow University (Suzhou); Wan Xiaobing; Chen Rongxiang; Chen Jijun; Fang Shangwen; Long Wenhao; (22 pag.)CN107445912; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 63131-30-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

10 ml test tube reaction of adding 0.2mmol2 – (4-methoxyanilino) ethyl acetate and 0.01mmol trifluoro methane sulfonic acid copper, in order to 3 ml acetonitrile as the reaction solvent, added under stirring 0.1mmol4-iodophenylamino Carbamoyl ethyl acetate, the (green) LED illumination the reaction solution 1h rear, turns on lathe does reaction solvent, after column separation, the obtained product is nuclear magnetism hydrogen spectrum carbon spectrum and mass spectrum is identified as b ethyl 2 – (4-iodo benzoyl) – 3 – ((4-methoxylphenyl) amino) succinate

The synthetic route of Ethyl 3-(4-iodophenyl)-3-oxopropanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences; WU, LIZHU; GAO, XUEWANG; MENG, QINGYUAN; LEI, TAO; ZHONG, JIANJI; XIANG, MING; TONG, ZHENHE; (21 pag.)CN104230734; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 63131-30-6

General procedure: To a degassed mixture of PhI=NTs (0.6 mmol, 224 mg) and powdered 4 A molecular sieves (240 mg)was added dichloromethane (1 mL). The reaction was then cooled to 0 oC and solution oftrifluoroacetic acid (0.05 mmol, 3.83 muL) in dichloromethane (1 mL) was added. Successively, 1,3-dicarbonyl compounds (0.5 mmol) was added and the reactions was monitored by TLC. Uponcompletion, the reaction was filtered, washed with EtOAc and concentrated under reduced pressure toafford the crude mixture. The latter was then purified by flash chromatography (1:4 EtOAc/n-Hex aseluent) to furnish the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 63131-30-6.

Reference:
Article; Tejo, Ciputra; Yeo, Hui Quan; Chan, Philip Wai Hong; Synlett; vol. 25; 2; (2014); p. 201 – 204;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 63131-30-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63131-30-6 as follows.

10 ml test tube reaction of adding 0.2mmol2 – (4-methoxyphenylamino) methyl acetate and 0.01mmol trifluoro methane sulfonic acid copper, in order to 3 ml acetonitrile as the reaction solvent, added under stirring 0.1mmol4-iodophenylamino Carbamoyl ethyl acetate, the (green) LED illumination the reaction solution 1h rear, turns on lathe does reaction solvent, after column separation, the obtained product is nuclear magnetism hydrogen spectrum carbon spectrum and mass spectrum is identified as 1-ethyl 4-methyl 2 – (4-iodo benzoyl) – 3 – ((4-methoxylphenyl) amino) succinate

According to the analysis of related databases, 63131-30-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences; WU, LIZHU; GAO, XUEWANG; MENG, QINGYUAN; LEI, TAO; ZHONG, JIANJI; XIANG, MING; TONG, ZHENHE; (21 pag.)CN104230734; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 63131-30-6, The chemical industry reduces the impact on the environment during synthesis 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, I believe this compound will play a more active role in future production and life.

To a solution of compound 56A (31.5 g, 99.02 mmol) in EtOH (300 mL) was added NH4OAc (20 g, 259.46 mmol), then the mixture was stirred at 85 C for 18h. The reaction mixture was concentrated to remove solvent, then diluted with water (150 mL) and extracted with EA (100 mL x 3), the organic layers were washed with saturated NaHCCL (100 mL x 2), dried over Na2S04, filtered and concentrated to give a residue. The residue was purified by flash silica gel chromatography (ISCO; 220 g SepaFlash Silica Flash Column, Eluent of 0-10% Ethyl acetate/Petroleum ethergradient 100 mL/min). Compound 56B (26 g, yield: 71.5%) as light yellow solid was obtained. 1H NMR (400MHz, DMSO-d6) d 7.86 – 7.75 (m, 2H), 7.44 – 7.34 (m, 2H), 4.77 (s, 1H), 4.05 (q, / = 7.1 Hz, 2H), 1.19 (t, / = 7.2 Hz, 3H). MS (ESI) m/z (M+H)+3l7.9.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(4-iodophenyl)-3-oxopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BLADE THERAPEUTICS, INC.; LIM, Sharlene; IBRAHIM, Prabha; FUENTES, Maria; (0 pag.)WO2020/6294; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 63131-30-6

General procedure: A mixture of 1H-benzo[d]imidazol-2-amine (1.5 mmol), ethyl 3-oxo-3-phenylpropanoate (0.5 mmol) and CBr4 (1 mmol) in CH3CN (2 mmol) was stirred in 80 C in a tube under air atmosphere. TLCmonitored the end of the reaction. Then the mixture was cooled toroom temperature and saturated brine (100 mL) was poured intothe solution. The mixture was extracted with EtOAc (3 50 mL).The organic phase was combined and dried by anhydrous Na2SO4.Finally, the product was separated by flash chromatography onsilica gel (petroleum ether/EtOAc 3: 1) and obtained aftervacuum-rotary evaporation.

The synthetic route of 63131-30-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Songhua; Li, Yunyi; Ma, Chen; Xie, Caixia; Tetrahedron; vol. 76; 9; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 63131-30-6

To a solution of compound 56A (3 1.5 g, 99.02 mmol) in EtOH (300 mL)was added NH40Ac (20 g, 259.46 mmol), then the mixture was stirred at 85 oc for 18h. Thereaction mixture was concentrated to remove solvent, then diluted with water (150 mL) andextracted with EA (100 mL x 3), the organic layers were washed with saturated NaHC03(100 mL x 2), dried over Na2S04, filtered and concentrated to give a residue. The residuewas purified by ±lash silica gel chromatography (lSCO.); 220 g SepaFlasM<) Silica FlashColumn, Eluent ofO~lO% Ethyl acetate/Petroleum ethergradient 100 mL/min). Compound56B (26 g, yield: 71.5%) as light yellow solid was obtained. 1H NMR (400MHz, DMSO-d6)8 7.86-7.75 (m, 2H), 7.44- 7.34 (m, 2H), 4.77 (s, lH), 4.05 (q, J= 7.1 Hz, 2H), 1.19 (t, J=7.2 Hz, 3H). MS (ESI) m/z (M--I-i)+317.9. The synthetic route of Ethyl 3-(4-iodophenyl)-3-oxopropanoate has been constantly updated, and we look forward to future research findings. Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad Owen; YUAN, Shendong; EMAYAN, Kumaraswamy; ADLER, Marc; IBRAHIM, Prabha; (247 pag.)WO2019/190885; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com