Category: 63069-48-7

《Pd/Cu-Catalyzed Enantioselective Sequential Heck/Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers》 was written by Bai, Xingfeng; Wu, Caizhi; Ge, Shaozhong; Lu, Yixin. Recommanded Product: 4-Chloro-2-iodoaniline And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

An asym. palladium and copper co-catalyzed Heck/Sonogashira reaction between o-iodoacrylanilides and terminal alkynes to synthesize chiral oxindoles was developed. In particular, a wide range of CF3-substituted o-iodoacrylanilides reacted with terminal alkynes, affording the corresponding chiral oxindoles containing trifluoromethylated quaternary stereogenic centers in high yields with excellent enantioselectivities (94-98% ee). This asym. Heck/Sonogashira reaction provides a general approach to access oxindole derivatives containing quaternary stereogenic centers including CF3-substituted ones. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Recommanded Product: 4-Chloro-2-iodoaniline) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Recommanded Product: 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Appa, Rama Moorthy; Ramesh Naidu, Bandameeda; Venkateswarlu, Derangula; Hanafiah, Marlia M.; Lakkaboyana, Sivarama Krishna; Lakshmidevi, Jangam; Venkateswarlu, Katta published their research in Green Chemistry Letters and Reviews in 2021. The article was titled 《Water extract of pomegranate ash-I2 as sustainable system for external oxidant/metal/catalyst-free oxidative iodination of (hetero)arenes》.HPLC of Formula: 63069-48-7 The article contains the following contents:

An added oxidant/metal/catalyst/additive and problematic solvent-free versatile and straightforward protocol was reported for the synthesis of aryl iodides (AIs) using mol. iodine (I2) in water extract of pomegranate ash (WEPA). These transformations were performed at room temperature (rt) and the reactions took place in 5-20 min to give 83-99% yields of aryl iodides. WEPA was characterized by using XPS, EDX, XRF, XRD and FTIR anal. and a plausible mechanism had been established based on these anal. along with some control experiments Further, the products were purified by recrystallization technique. This work with intrinsic sustainability, high substrate feasibility, utilization of biorenewable catalystytic media, ease of execution and separation of products, and added oxidant/catalyst/metal and additive-free conditions might became one among the forefront sustainable procedures in making aryl iodides. The use of waste-derived WEPA as catalystytic media for this iodination was the novelty of this method and might be used these aryl iodides for further in-process transformations (e.g. cross-couplings, nucleophilic reactions, etc.) to access fine chems. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Punjajom, Kunlayanee; Tummatorn, Jumreang; Ruchirawat, Somsak; Thongsornkleeb, Charnsak published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《PdCl2-Catalyzed Oxidative Cyclization of N-(2′-Alkynylaryl)-1,3-ketoamides: Synthesis of 3,4-Diacyl-2-Quinolones》.Computed Properties of C6H5ClIN The article contains the following contents:

3,4-Diacyl-2-quinolone derivatives were prepared in a rapid manner starting from N-(2′-alkynylaryl)-1,3-ketoamide substrates. The reaction showcased a mild radical process mediated by ceric ammonium nitrate (CAN) in the presence of 5 mol% PdCl2 under basic conditions and was applicable to a wide range of substrates, giving 3,4-diacyl-2-quinolone products in up to 91% yield in over 40 examples. The reaction proceeded via the generation of a radical intermediate which could be trapped as a TEMPO-adduct that was isolated and fully characterized. The reported method provided a practical and scalable synthetic access to densely functionalized 3,4-diacyl-2-quinolone derivatives which would be suitable for further applications including medicinal and bioactivity evaluations as well as synthetic transformations. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3》 was written by Phetcharawetch, Jongkonporn; Betterley, Nolan M.; Reutrakul, Vichai; Soorukram, Darunee; Leowanawat, Pawaret; Kuhakarn, Chutima. Application of 63069-48-7This research focused ontrifluoromethylthio indole preparation; alkynyl azidoarene silver trifluoromethanethiolate trifluoromethylthiolation. The article conveys some information:

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes 2-CCR-4-R1-5-R2C6H2N3 (R = n-Bu, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R1 = H, Me, Cl, CF3, etc.; R2 = H, Cl) with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles I. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rodriguez, Jose F.; Zhang, Anji; Bajohr, Jonathan; Whyte, Andrew; Mirabi, Bijan; Lautens, Mark published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Cycloisomerization of Carbamoyl Chlorides in Hexafluorisopropanol: Stereoselective Synthesis of Chlorinated Methylene Oxindoles and Quinolinones》.Safety of 4-Chloro-2-iodoaniline The article contains the following contents:

Hexafluorisopropanol (HFIP) was employed as an additive for the generation of 3-(chloromethylene)oxindoles I [R = n-Bu, (CH2)3CN, Ph, etc.; R1 = Me, cyclohexylmethyl, Bn, etc.; R2 = H, 5-Me, 5-F, etc.] via the chloroacylation of alkyne-tethered carbamoyl chlorides. This reaction avoided the use of a metal catalyst and accessed products in high yields and stereoselectivities. Addnl., this reaction was scalable and proved amenable to a series of product derivatizations, including the synthesis of nintedanib. The reactivity of alkene-tethered carbamoyl chlorides with hexafluorisopropanol (HFIP) was harnessed towards the synthesis of 2-quinolinones II [R3 = H, Me; R4 = Me, i-Pr, Ph; R5 = Me, CH2CH=CH2]. In the experimental materials used by the author, we found 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C6H5ClINIn 2022 ,《Nitrative bicyclization of 1,7-diynes for accessing skeletally diverse tricyclic pyrroles》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Wang, Lu; Zhang, Yin; Miao, An-Qi; Zhang, Tian-Shu; Wang, Xiang; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo. The article conveys some information:

A novel metal-free nitrative bicyclization of 1,7-diynes with tBuONO in the presence of H2O is reported, producing three types of skeletally diverse tricyclic pyrroles, namely pyrrolo[3,4-c]quinolines, chromeno[3,4-c]pyrroles and benzo[e]isoindoles, with moderate to good yields by simply tuning the linkers of the 1,7-diynes. This domino protocol demonstrates remarkable compatibility regarding 1,7-diynes with different linkers, such as nitrogen and oxygen atoms and a hydroxymethyl group, and tBuONO plays dual roles as a nitro precursor as well as a nitrogen atom source. In the experimental materials used by the author, we found 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Computed Properties of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides》 was written by Yao, Tuanli; Wang, Bo; Ren, Beige; Qin, Xiangyang; Li, Tao. Recommanded Product: 4-Chloro-2-iodoaniline And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021. The article conveys some information:

The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl anthranilamides I (R = t-Bu, cyclohexyl, 2,6-dimethylphenyl, etc.; R1 = H, OMe, Cl, F, etc.; R2 = H, Cl, C(O)OMe; R3 = H, F, Cl; R4 = Me, Ph, thiophen-3-yl, etc.) from isocyanides RNC, 2-iodoanilines 2-I-4-R1-5-R2-6-R3C6HNH2 and carboxylic acids R4C(O)OH has been developed. This method provides expeditious and highly efficient access to structurally diverse N-acyl anthranilamides I from readily available starting materials with good functional group compatibility. The utility of this method has been demonstrated by the late stage functionalization of two com. drugs: Flurbiprofen and Loxoprofen. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Recommanded Product: 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kittikhunnatham, Preecha; Leith, Gabrielle A.; Mathur, Abhijai; Naglic, Jennifer K.; Martin, Corey R.; Park, Kyoung Chul; McCullough, Katherine; Jayaweera, H. D. A. Chathumal; Corkill, Ryan E.; Lauterbach, Jochen; Karakalos, Stavros G.; Smith, Mark D.; Garashchuk, Sophya; Chen, Donna A.; Shustova, Natalia B. published an article in Angewandte Chemie, International Edition. The title of the article was 《A Metal-Organic Framework (MOF)-Based Multifunctional Cargo Vehicle for Reactive-Gas Delivery and Catalysis》.Category: iodides-buliding-blocks The author mentioned the following in the article:

The efficient delivery of reactive and toxic gaseous reagents to organic reactions was studied using metal-organic frameworks (MOFs). The simultaneous cargo vehicle and catalytic capabilities of several MOFs were probed for the first time using the examples of aromatization, aminocarbonylation and carbonylative Suzuki-Miyaura coupling reactions. These reactions highlight that MOFs served a dual role as a gas cargo vehicle and a catalyst, led to product formation with yields similar to reactions employing pure gases. Furthermore, the MOFs was recycled without sacrificing product yield, while simultaneously maintaining crystallinity. The reported findings were supported crystallog. and spectroscopically (e.g., diffuse reflectance IR Fourier transform spectroscopy), foreshadowing a pathway for the development of multifunctional MOF-based reagent-catalyst cargo vessels for reactive gas reagents as an attractive alternative to the use of toxic pure gases or gas generators. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Category: iodides-buliding-blocks)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of C6H5ClINIn 2022 ,《Photocatalytic Markovnikov-type addition and cyclization of terminal alkynes leading to 4-sulfonyl quinoline-2(1H)-ones》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Zhai, Yu-Lin; Zhou, Hui; Liu, Qing-Quan; Leng, Bo-Rong; Zhang, Zixian; Li, Jia-Zhuo; Wang, De-Cai; Zhu, Yi-Long. The article contains the following contents:

A new and expedient photocatalytic protocol for the construction of quinolin-2(1H)-ones I [R1 = H, 6-Me, 7-Cl, etc.; R2 = Me, cyclohexyl, Bn, etc.; Ar = Ph, 4-MeC6H4, 2-thienyl, etc.] via Markovnikov-type sulfonylation/6-endo-trig cyclization/selective C(O)-CF3 bond cleavage starting from N-alkyl-N-(2-ethynylphenyl)-2,2,2-trifluoroacetamides and sulfinic acids had been developed. It was as an unprecedented protocol for the preparation of 4-sulfonylquinoline-2(1H)-ones with high efficiency, mild reaction conditions, acceptable yields and a wide range of substrates. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Electric Literature of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Electric Literature of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com