Category: 63069-48-7

Wang, Jian-Shu; Na, Yi; Ying, Jun; Wu, Xiao-Feng published an article in 2021. The article was titled 《Palladium-catalyzed 1,2-amino carbonylation of 1,3-dienes with (N-SO2Py)-2-iodoanilines: 2,3-dihydroquinolin-4(1H)-ones synthesis》, and you may find the article in Organic Chemistry Frontiers.HPLC of Formula: 63069-48-7 The information in the text is summarized as follows:

A palladium-catalyzed 1,2-amino carbonylation of 1,3-dienes with (N-SO2Py)-2-iodoanilines was developed for the construction of 2,3-dihydroquinolin-4(1H)-one scaffolds. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source under the assistance of the N-SO2Py directing group, the reaction proceeded well to afford various 2,3-dihydroquinolin-4(1H)-ones in good yields (up to 88%). The effect of the directing groups was investigated and control experiments were performed to have a better understanding of the reaction pathway. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fang, Mao-Ying; Chen, Li-Ping; Huang, Lin; Fang, Dong-Mei; Chen, Xiao-Zhen; Wang, Bi-Qin; Feng, Chun; Xiang, Shi-Kai published an article in 2021. The article was titled 《Synthesis of Tribenzo[b,d,f]azepines via Palladium-Catalyzed Annulation Reaction of 2-Iodobiphenyls with 2-Halogenoanilines》, and you may find the article in Journal of Organic Chemistry.Product Details of 63069-48-7 The information in the text is summarized as follows:

A palladium-catalyzed annulation reaction of 2-iodobiphenyls with 2-halogenoanilines has been developed. A variety of 2-iodobiphenyls and 2-halogenoanilines can undergo this transformation. Diversified tribenzo[b,d,f]azepine derivatives can be synthesized in moderate to excellent yields according to this method.4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kajol, Km; Kumar, Sujeet; Kumar, Amit; Kant, Ruchir; Ramesh, Chintakunta published an article in Asian Journal of Organic Chemistry. The title of the article was 《Palladium-Catalyzed Intramolecular C-H Heteroarylation to Access Fused Tricyclic Oxazolo[4,5-c]Quinolines》.Synthetic Route of C6H5ClIN The author mentioned the following in the article:

Synthesis of fused tricyclic oxazolo[4,5-c]quinolines I (R = 3-Me, 2,5-difluorophenyl, thiophen-2-yl, etc. ; R1 = H, Me, Et, n-Bu, i-Pr, Cl, F; R2 = H, Me) from 2-iodo-N-((2-phenyloxazol-4-yl)methyl)anilines via intramol. C-H heteroarylation in the presence of palladium catalyst under ligand free conditions has been disclosed. Various substituted 2-iodo-N-((2-phenyloxazol-4-yl)methyl)anilines are well tolerated and furnished the products in good yields. The synthetic utility of the resulting mols. has been demonstrated. This method features broad substrate scope, mild reaction conditions, good functional group tolerance, and scalability. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rakshit, Amitava; Dhara, Hirendra Nath; Alam, Tipu; Dahiya, Anjali; Patel, Bhisma K. published an article in 2021. The article was titled 《Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles》, and you may find the article in Journal of Organic Chemistry.Product Details of 63069-48-7 The information in the text is summarized as follows:

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. Authors also demonstrated a few postsynthetic modifications. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Product Details of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Debrauwer, Vincent; Leito, Ivo; Lokov, Mart; Tshepelevitsh, Sofja; Parmentier, Michael; Blanchard, Nicolas; Bizet, Vincent published an article in 2021. The article was titled 《Synthesis and Physico-Chemical Properties of 2-SF5-(Aza)Indoles, A New Family of SF5-Heterocycles》, and you may find the article in ACS Organic & Inorganic Au.Product Details of 63069-48-7 The information in the text is summarized as follows:

Herein was described a strategy to access (pentafluoro-sulfanyl)indoles I [R = H, 5-Me, 5-OCF3, etc.; R1 = H, Ts] for the first time. The sequence relied on the radical addition of SF5Cl to the alkynyl π-system of 2-ethynyl anilines followed by a cyclization reaction. A telescoped sequence was proposed making this strategy very appealing and reproducible on gram scale. Downstream functionalizations were also demonstrated, allowing an easy diversification of N- and C3-positions. Ames test, pKa, logP and DSC measurements of several fluorinated 2-Rf-indoles were also disclosed. These studies highlighted the strategic advantages that a C2-pentafluorosulfanylated motif impart to a privileged scaffold such as indole. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Product Details of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C6H5ClINIn 2021 ,《Palladium-Catalyzed Carbonylative Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds》 appeared in Advanced Synthesis & Catalysis. The author of the article were Wang, Le-Cheng; Zhang, Yu; Chen, Zhengkai; Wu, Xiao-Feng. The article conveys some information:

A procedure on palladium-catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Formula: C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lauta, Nicholas R.; Williams, Ryan E.; Smith, David T.; Kumirov, Vlad K.; Njardarson, Jon T. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of o-Allenyl Anilines》.Synthetic Route of C6H5ClIN The article contains the following contents:

A new intramol. oxidative amino-hydroxylation of o-allenyl anilines was reported. Treatment of carbamate-protected anilines with lead(IV) carboxylates in dichloromethane at room temperature resulted in facile tandem C-N (allene cyclization) and C-O bond formation (carboxylate trapping) to form indole products I [R1 = H, Br, MeO, etc.; R2 = Me, H2CCCl3, t-Bu, Bn; R3 = Me, Ph, 4-FC6H4, 4-F3CC6H4, 4-MeOC6H4, HC=CHPh; R4 = H, Me; R5 = H, Me] . Detailed reaction scope, mechanistic and kinetic studies suggested a reaction pathway involving an initial Wessely dearomatization step followed by cyclization and rearomatization. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khandelia, Tamanna; Ghosh, Subhendu; Panigrahi, Pritishree; Shome, Rajib; Ghosh, Siddhartha Sankar; Patel, Bhisma K. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Copper(I)-Mediated Cascade Annulation via Dual C-H/C-H Activation: Access to Benzo[a]carbazolic AEEgens》.SDS of cas: 63069-48-7 The article contains the following contents:

A Cu(I)-mediated cascade cyclization/annulation of unprotected o-alkynylanilines 2-RNH-R1C6H3CCC6H4R2 (R = H, Me; R1 = H, 4-CF3, 4-Me, 5-Cl, etc.; R2 = H, 4-tert-Bu, 3-fluoro, 4-Me, etc.), 2-[2-(thiophen-2-yl)ethynyl]aniline with maleimides I (R3 = H, Et, benzyl, cyclohexyl, etc.) in one pot is developed. The protocol offers sequential formation of one C-N and two C-C bonds to deliver fused benzo[a]carbazoles II (R4 = H, 11-CF3, 11-Me, 10-Cl, etc.; R5 = H, 5-tert-Bu, 6-fluoro, 5-Me, etc.), 5-ethylpyrrolo[3,4-c]thieno[2,3-a]carbazole-4,6(5H,11H)-dione having free NH skeletons. The annulated products display fluorescence emission in the range of 485-502 nm with a large Stokes shift and fluorescence lifetime of ~17 ns. The annulated II (R = R4 = R5 = H, R3 = Et) displays AEE behavior in the ethanol/hexane system and possesses marigold-flower-like morphol. at the aggregated state. Cell viability assays enumerate biocompatible AEEgens, while their high intracellular fluorescence depicts cell imaging applicability. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Greiner, Luca C.; Inuki, Shinsuke; Arichi, Norihito; Oishi, Shinya; Suzuki, Rikito; Iwai, Tomohiro; Sawamura, Masaya; Hashmi, A. Stephen K.; Ohno, Hiroaki published their research in Chemistry – A European Journal in 2021. The article was titled 《Access to Indole-Fused Benzannulated Medium-Sized Rings through a Gold(I)-Catalyzed Cascade Cyclization of Azido-Alkynes》.Category: iodides-buliding-blocks The article contains the following contents:

Because benzannulated and indole-fused medium-sized rings are found in many bioactive compounds, combining these fragments might lead to unexplored areas of biol. relevant and uncovered chem. space. Herein is shown that α-imino gold carbene chem. can play an important role in solving the difficulty in the formation of medium-sized rings. Namely, phenylene-tethered azido-alkynes undergo arylative cyclization through the formation of a gold carbene intermediate to afford benzannulated indole-fused medium-sized tetracycles. The reactions allow a range of different aryl substitution patterns and efficient access to these otherwise difficult-to-obtain medium-sized rings. This study also demonstrates the feasibility of the semihollow-shaped C-dtbm ligand for the construction of a nine-membered ring. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Category: iodides-buliding-blocks) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Uppalabat, Thikhamporn; Tapdara, Anyawan; Khaikate, Onnicha; Worakul, Thanapat; Surawatanawong, Panida; Leowanawat, Pawaret; Soorukram, Darunee; Reutrakul, Vichai; Meesin, Jatuporn; Kuhakarn, Chutima published an article in New Journal of Chemistry. The title of the article was 《Synthesis of indolo- and benzothieno[3,2-c]quinolines via POCl3 mediated tandem cyclization of o-alkynylisocyanobenzenes derived from o-alkynyl-N-phenylformamides》.Name: 4-Chloro-2-iodoaniline The author mentioned the following in the article:

A synthesis of indolo[3,2-c]quinolines and benzothieno[3,2-c]quinolines has been developed employing o-alkynyl-N-phenylformamide derivatives as the substrates. The reaction proceeded via a tandem process involving POCl3-assisted intramol. cyclization of the firstly formed o-alkynylisocyanobenzenes, leading to the desired products in moderate to high yields. Furthermore, the reaction is efficient on a gram-scale and the products were structurally modified by amination, Suzuki-Miyaura reaction and Heck cross-coupling. Photophys. properties of several selected indolo[3,2-c]quinolines were studied by UV-Visible and fluorescence spectroscopy and rationalized using time-dependent DFT calculations The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Name: 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Name: 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com