Category: 63069-48-7

Shamsa, Farzaneh; Motavalizadehkakhky, Alireza; Zhiani, Rahele; Mehrzad, Jamshid; Hosseiny, Malihe Sadat published their research in RSC Advances in 2021. The article was titled 《ZnO nanoparticles supported on dendritic fibrous nanosilica as efficient catalysts for the one-pot synthesis of quinazoline-2,4(1H,3H)-diones》.HPLC of Formula: 63069-48-7 The article contains the following contents:

The transmutation of waste into valuable materials has a special place in green chem. Herein, we report the preparation of quinazoline-2,4(1H,3H)-diones from 2-iodoaniline, isocyanides, and carbon dioxide in the presence of ZnO NPs stably placed on the surface of dendritic fibrous nanosilica by cellulose (DFNS/cellulose-ZnO) as a catalyst. This is a great economic strategy to create three bonds in a one-pot multicomponent reaction step employing functional groups. To prepare the catalyst, the dendritic fibrous nanosilica surface was first activated using cellulose as a substrate to support ZnO NPs. Cellulose acts as a stabilizing and reducing agent for the ZnO nanocatalyst and eliminates the need for a reducing agent. The structure of the prepared DFNS/cellulose-ZnO was examined by various methods, including thermogravimetric anal. (TGA), X-ray diffraction (XRD), SEM, transmission electron microscopy (TEM), XPS, and inductively coupled plasma (ICP). The largest amount of quinazoline-2,4(1H,3H)-diones was obtained under ideal situations in the presence of 5 mg of DFNS/cellulose-ZnO under carbon dioxide (1 atm) utilizing a balloon set at 70°C for 3 h. The substance was reused for ten consecutive runs and the quinazoline-2,4(1H,3H)-dione content was more than 92% each time. This indicates the potential for application in the green and economic production of quinazoline-2,4(1H,3H)-diones, especially from low-cost feedstocks. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Leifert, Dirk; Weidlich, Frauke; Adler, Florin; Daniliuc, Constantin G.; Alasmary, Fatmah A.; Studer, Armido published an article in Organic Letters. The title of the article was 《2,3-Difunctionalized Indoles via Radical Acylation or Trifluoromethylation of ortho-Alkynylphenyl Isonitriles》.SDS of cas: 63069-48-7 The author mentioned the following in the article:

A radical cascade to 2,3-disubstituted indoles proceeding via acylation or trifluoromethylation of ortho-alkynylphenyl isonitriles was presented. In these cascades, two C-C bonds and one C-O bond was formed using an inexpensive oxidant and a catalytic copper or iron salt. The starting isonitriles were easily accessible, and com. available aldehydes and fluoromethylation reagents served as reaction partners. Functional group tolerance was high, as documented by the successful preparation of a series of 2,3-disubstituted indoles.4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tang, Jiaying; Ren, Linlin; Li, Jianwei; Wang, Yonggong; Hu, Dongyan; Tong, Xiaogang; Xia, Chengfeng published an article in 2022. The article was titled 《Photochemical Synthesis of Indolocarbazoles through Tandem Indolization/Dimerization/Mannich Cyclization from Allenes》, and you may find the article in Organic Letters.Category: iodides-buliding-blocks The information in the text is summarized as follows:

Disclosed herein was the photochem. synthesis of the indolocarbazole ring system from N-allenyl-2-iodoanilines. The tandem protocol included visible-light-mediated 5-exo-trig radical cyclization and subsequent radical dimerization, followed by acid-promoted deprotection and intramol. Mannich cyclization. This strategy showed exceptional functional group tolerance and was successfully applied in the concise synthesis of natural products tjipanazoles B and D. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Category: iodides-buliding-blocks)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xu, Jia-Cheng; Yin, Yi-Zhuo; Han, Zhi-Yong published their research in Organic Letters in 2021. The article was titled 《Asymmetric Counteranion Directed Catalytic Heck/Tsuji-Trost Annulation of Aryl Iodides and 1,3-Dienes》.COA of Formula: C6H5ClIN The article contains the following contents:

A chiral anion-mediated asym. Heck/Tsuji-Trost reaction of aryl iodides and 1,3-dienes was presented. Chiral indoline derivatives I [R1 = H, 5-OMe, 6-Me, etc.; R2 = Ms, Ts, Ns; R3 = Me, Ph, 2-naphthyl, etc.] could be afforded with remarkably higher yields and enantioselectivities than our previous chiral ligand-based method. Silver carbonate was employed as both base and halide scavenger to ensure fast and recyclable exchange of the catalytic amount of chiral anions. Fast salt metathesis, as well as the acceleration effect of the chiral anion, could both benefit the stereocontrol of the reaction. In the experimental materials used by the author, we found 4-Chloro-2-iodoaniline(cas: 63069-48-7COA of Formula: C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Bai, Xingfeng; Zheng, Wenrui; Ge, Shaozhong; Lu, Yixin published an article in Organic Letters. The title of the article was 《Enantioselective Palladium-Catalyzed Arylborylation/Cyclization of Alkenes to Access Boryl-Functionalized Heterocyclic Compounds Containing Quaternary Stereogenic Centers》.Computed Properties of C6H5ClIN The author mentioned the following in the article:

Asym. Pd-catalyzed arylboration/cyclization of both nonactivated and activated alkenes with B2pin2 was developed. A wide range of N-allyl-o-iodobenzamides and o-iodoacryanilides reacted with B2pin2 to afford borylated 3,4-dihydroisoquinolinones and oxindoles, resp., in high yields with high enantioselectivities. The synthetic utility of this enantioselective protocol was highlighted by synthesizing various chiral 3,4-dihydroisoquinolinone and oxindole derivatives containing quaternary stereogenic C centers, including enantioenriched Roche anticancer agent (S)-RO4999200 (no study). In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Minghao; Deng, Wenbo; Sun, Mingjie; Zhou, Liwei; Deng, Guobo; Liang, Yun; Yang, Yuan published their research in Organic Letters in 2021. The article was titled 《α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes》.Safety of 4-Chloro-2-iodoaniline The article contains the following contents:

Herein α-bromoacrylic acids had been employed as C1 insertion units to achieve the palladium-catalyzed [4+1] annulation of 2-iodobiphenyls, which provided an efficient platform for the construction of diverse dibenzofulvenes such as I [R1 = H, Me, Ph, etc.; R2 = H, n-Pr, 3-MeC6H4, etc.; R1R2 = (CH2)4, (CH2)6, (CH2)11, etc.; R3 = H; R4 = H, OMe, CHO, etc.; R5 = H, Me, Cl, CF3; R6 = H; R7 = H, Me, F, CF3, Cl; R8 = H, Me, F, Cl; R3R4 = CH=CH-CH=CH; R4R5 = CH=CH-CH=CH; R5R6 = CH=CH-CH=CH]. This protocol enabled the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It was particularly noteworthy that the method featured a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, could be successfully incorporated into the products. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Safety of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Tianze; Yu, Min; Huang, Hanmin published an article in 2021. The article was titled 《Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer》, and you may find the article in Chemical Science.Formula: C6H5ClIN The information in the text is summarized as follows:

An efficient Fe-catalyzed intramol. isonitrile-olefin coupling reaction delivering 3-substituted indoles, in which isonitrile was firstly applied as the hydrogen atom acceptor in the radical generation step by MHAT were reported. The protocol features low catalyst loading, mild reaction conditions and excellent functional group tolerance. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Formula: C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 63069-48-7In 2021 ,《Quasi-homogeneous catalytic conversion of CO2 into quinazolinones inside a metal-organic framework microreactor》 appeared in Green Chemistry. The author of the article were Zhou, Zhenzhen; Ma, Jian-Gong; Gao, Jianbo; Cheng, Peng. The article conveys some information:

Management of CO2 has been attracting great attention in this century. Reaction of CO2 with 2-haloanilines and isocyanides is an attractive way for both converting CO2 and producing quinazolinones, which are key intermediates for the synthesis of various biol. active products. However, the heterogeneous and relatively inert nature of CO2 with 2-haloaniline and isocyanide reactants limits the types of suitable catalysts. Herein, we use metal-organic frameworks (MOFs) as a “”microreactor””, in which Pd(PPh3)2Cl2 is well-dispersed as a single-mol. catalyst, and the reactants react in the mol. level through a “”quasi-homogeneous”” way to convert CO2 into quinazolinones under mild conditions with both promising yields over homogeneous catalysts and good recyclability as a heterogeneous reaction. The MOF-assisted single-mol. catalysis strategy should contribute to CO2 conversion, production of quinazolinone-type bioactive intermediates, and the epochal development of “”homo-and-heterogeneous”” catalysis. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Misal, Balu; Palav, Amey; Ganwir, Prerna; Chaturbhuj, Ganesh published their research in Tetrahedron Letters in 2021. The article was titled 《Sulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes》.Reference of 4-Chloro-2-iodoaniline The article contains the following contents:

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogeneous conditions, iodination protocol of arenes was developed, which can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activated N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tuned sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chems., API and natural products. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Reference of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Danilkina, Natalia A.; Andrievskaya, Ekaterina V.; Vasileva, Anna V.; Lyapunova, Anna G.; Rumyantsev, Andrey M.; Kuzmin, Andrey A.; Bessonova, Elena A.; Balova, Irina A. published their research in Molecules in 2021. The article was titled 《4-Azidocinnoline-Cinnoline-4-amine Pair as a New Fluorogenic and Fluorochromic Environment-Sensitive Probe》.Formula: C6H5ClIN The article contains the following contents:

A new type of fluorogenic and fluorochromic probe based on the reduction of weakly fluorescent 4-azido-6-(4-cyanophenyl)cinnoline to the corresponding fluorescent cinnoline-4-amine was developed. It was found that the fluorescence of 6-(4-cyanophenyl)cinnoline-4-amine was strongly affected by the nature of the solvent. The fluorogenic effect for the amine was detected in polar solvents with the strongest fluorescence increase in water. The environment-sensitive fluorogenic properties of cinnoline-4-amine in water were explained as a combination of two types of fluorescence mechanisms: aggregation-induced emission (AIE) and excited state intermol. proton transfer (ESPT). The suitability of an azide-amine pair as a fluorogenic probe was tested using a HepG2 hepatic cancer cell line with detection by fluorescent microscopy, flow cytometry, and HPLC anal. of cells lysates. The results obtained confirm the possibility of the transformation of the azide to amine in cells and the potential applicability of the discovered fluorogenic and fluorochromic probe for different anal. and biol. applications in aqueous medium.4-Chloro-2-iodoaniline(cas: 63069-48-7Formula: C6H5ClIN) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Formula: C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com