Category: 63069-48-7

In 2022,Bae, Jinsu; Kim, Yeo-Ok; Han, Xuehao; Yoon, Myung-Ha; Kim, Woong-Mo; Kim, Yong-Chul published an article in Molecules. The title of the article was 《Synthesis and Structure-Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents》.Application In Synthesis of 4-Chloro-2-iodoaniline The author mentioned the following in the article:

P2X3 receptors (P2X3R) are ATP-gated ion channels predominantly expressed in C- and Aδ-fiber primary afferent neurons and have been introduced as a novel therapeutic target for neurol. disorders, including neuropathic pain and chronic cough. Because of its localized distribution, antagonism of P2X3R has been thoroughly considered, and the avoidance of issues related to CNS side effects has been proven in clin. trials. In this article, benzimidazole-4,7-dione-based derivatives were introduced as a new chem. entity for the development of P2X3R antagonists. Starting from the discovery of a hit compound from the screening of 8364 random library compounds in the Korea Chem. Bank, which had an IC50 value of 1030 nM, studies of structure-activity and structure-property relationships enabled further optimization toward improving the antagonistic activities as well as the drug′s physicochem. properties, including metabolic stability. As for the results, the final optimized compound 14h was developed with an IC50 value of 375 nM at P2X3R with more than 23-fold selectivity vs. P2X2/3R, along with properties of metabolic stability and improved solubility In neuropathic pain animal models evoked by either nerve ligation or chemotherapeutics in male Sprague-Dawley rats, compound 14h showed anti-nociceptive effects through an increase in the mech. withdrawal threshold as measured by von Frey filament following i.v. administration. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Application In Synthesis of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Recyclable Heterogeneous Palladium-Catalyzed Carbonylative Cyclization of 2-Iodoanilines with Aryl Iodides Leading to 2-Arylbenzoxazinones》 was published in Synthesis in 2020. These research results belong to Xu, Zhaotao; Huang, Bin; Zhou, Zebiao; Cai, Mingzhong. Synthetic Route of C6H5ClIN The article mentions the following:

A highly efficient and practical heterogeneous palladium-catalyzed carbonylative coupling of 2-iodoanilines R-2-IC6H3NH2 (R = H, 4-Me, 5-Cl, 4-CN, etc.) with aryl iodides ArI (Ar = Ph, naphthalen-1-yl, thiophen-3-yl, etc.) has been developed. The reaction occurs smoothly in toluene at 110°C with N,N-diisopropylethylamine as base under carbon monoxide (5 bar) and offers a general and powerful tool for the construction of various valuable 2-arylbenzoxazinones I (R1 = H, 6-Me, 7-Cl, 6-CN, etc.) with excellent atom-economy, high functional group tolerance, good to high yields, and easy recyclability of the palladium catalyst. The reaction is the first example of heterogeneous palladium-catalyzed carbonylative coupling for the preparation of diverse 2-arylbenzoxazinones I from com. easily available 2-iodoanilines and aryl iodides. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《CuBr-Catalyzed One-Pot Three-Component Synthesis of Novel 2-(Carbazolyl)benzothiazoles》 was published in Synlett in 2020. These research results belong to Meesala, Ramu; Lee, Yean Kee; Arshad, Ahmad Saifuddin Mohamad; Abdullah, Iskandar; Mordi, Mohd Nizam; Abd Rahman, Noorsaadah. Product Details of 63069-48-7 The article mentions the following:

A facile synthesis of various 2-(carbazolyl)benzothiazoles were synthesized by one-pot CuBr-catalyzed three-component reactions of 2-iodoanilines, aryl aldehydes and elemental sulfur. Reaction exhibited a good functional group tolerance to produce the corresponding 2-(carbazolyl)benzothiazoles in good yields in the absence of any additive. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C6H5ClINIn 2022 ,《Recyclable Palladium-Catalyzed Carbonylative Coupling of 2-Iodoanilines, Trimethyl Orthoformate, and Amines: A Practical Synthesis of Quinazolin-4(3H)-ones》 appeared in Synthesis. The author of the article were Li, Jianying; Zhou, Zebiao; Xie, Gang; Cai, Mingzhong. The article conveys some information:

An efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-iodoanilines, tri-Me orthoformate, and amines has been developed. The reaction proceeds smoothly in toluene at 110°C using N,N-diisopropylethylamine (DiPEA) as base and 2 mol% of MCM-41-anchored bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)2] as catalyst under 10 bar of carbon monoxide and provides a general and practical method for the construction of a wide variety of quinazolin-4(3H)-ones in good to excellent yields from com. easily available starting materials. This heterogenized palladium catalyst can be easily recovered via a simple centrifugation process and reused more than nine times with almost consistent catalytic efficiency. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Li, Lin; Liu, Xin-Lian; Qi, Zhuang; Yang, Ai-Hua; Ma, Ai-Jun; Peng, Jin-Bao published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed Carbonylative Sonogashira/Annulation Reaction: Synthesis of Indolo[1,2-b]isoquinolines》.Related Products of 63069-48-7 The author mentioned the following in the article:

A palladium-catalyzed carbonylative Sonogashira/annulation reaction for the synthesis of indolo[1,2-b]isoquinolines I [Ar = Ph, 4-MeC6H4, 3,4-di-MeOC6H3, etc.; R1 = H, 3-F, 2-F, 2-Cl, 3-Cl, 3-Me; R2 = H, 8-F, 9-Me ] was developed. Tetracyclic 6/5/6/6 indoline skeletons I were synthesized in moderate to good yields from easily available 2-bromo-N-(2-iodophenyl)benzamides and terminal alkynes. Notably, this efficient methodol. established three C-C bonds and a C-N bond through a one-step transformation and provided a new method for the synthesis of indolo[1,2-b]isoquinoline derivatives I. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Related Products of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Lu; Xu, Ting; Rao, Qian; Zhang, Tian-Shu; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published an article in 2021. The article was titled 《Photocatalytic Biheterocyclization of 1,7-Diynes for Accessing Skeletally Diverse Tricyclic 2-Pyranones》, and you may find the article in Organic Letters.Synthetic Route of C6H5ClIN The information in the text is summarized as follows:

A new and green route to skeletally diverse oxo-heterocyclic architectures such as pyrano[3,4-c]chromen-2-ones and pyrano[3,4-c]quinolin-2-ones was reported via an unprecedented photocatalytic Kharasch-type cyclization/1,5-(SN”)-substitution/elimination/6π-electrocyclization/double nucleophilic substitution cascade starting from easily available heteroatom-linked 1,7-diynes and low-cost CBrCl3. During this reaction process, the full scission of carbon-halogen bonds of BrCCl3 was realized to directly build two new rings, including a lactone scaffold, using H2O as the oxygen source of the ester group. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Copper-catalyzed cascade bicyclization of o-alkenylphenyl isothiocyanates with sodium azide leading to 5H-benzo[d]tetrazolo[5,1-b][1,3]thiazines》 was published in Youji Huaxue in 2020. These research results belong to Zhang, Yahui; Liu, Yang; Miao, Jiankang; Hao, Wenyan. Electric Literature of C6H5ClIN The article mentions the following:

A simple and efficient method for the preparation of 5H-benzo[d]tetrazolo[5,1-b][1,3]thiazines has been developed. The transformation involved the copper (I)-catalyzed cascade bicyclization of o-alkenylphenyl isothiocyanates with sodium azide to afford corresponding products in moderate to good yields. This present strategy provides an effective way to construct small mol. N-, and S-heterocycles. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Electric Literature of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C6H5ClINIn 2022 ,《Spirocyclizative remote arylcarboxylation of nonactivated arenes with CO2 via visible-light-induced reductive dearomatization》 was published in CCS Chemistry. The article was written by Gao, Yuzhen; Wang, Hao; Chi, Zhuomin; Yang, Lei; Zhou, Chunlin; Li, Gang. The article contains the following contents:

Herein, a novel strategy to achieve a visible-light-induced spirocyclizative remote arylcarboxylation of nonactivated arenes including naphthalenyl- and phenyl-bearing aromatics with CO2 under mild conditions through a radical-polar crossover cascade (RPCC) was described. This reductive dearomatization protocol rapidly delivered a broad range of spirocyclic and valuable carboxylic acid derivatives e.g., I from readily accessible aromatic precursors with generally good regioselectivity and chemoselectivity. In the experimental materials used by the author, we found 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Qian; Lu, Maojian; Deng, Yinglan; Jian, Jing-Xin; Tong, Qing-Xiao; Zhong, Jian-Ji published their research in Organic Letters in 2021. The article was titled 《Photoinduced Radical Cascade Cyclization: A Metal-Free Approach to Access Difluoroalkylated Dioxodibenzothiazepines》.Reference of 4-Chloro-2-iodoaniline The article contains the following contents:

A simple and mild photoredox catalytic approach to access difluoroalkylated dioxodibenzothiazepines I [R1 = Me, Bz, cyclohexyl, etc.; R2 = CO2Et, C(O)NEt2, P(O)(OEt)2, etc.; R3 = H, Me, Ph, etc.; R4 = H, F, Cl, Br; R5 = H, Me, F, Cl, Br; R6 = H, Me, Cl, etc.] in high regioselectivity via radical cascade cyclization was described. In contrast to previous methods, this strategy did not involved the use of transition-metal catalysts and avoided the potential disadvantages of inevitable toxicity and the tedious removal process of metal catalysts. The com. available and inexpensive CF2 precursors, wide substrate scope and mild reaction conditions demonstrated the practicability of this approach. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Reference of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Reference of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liang, Hao; Zhu, Guoxun; Pu, Xiaoyun; Qiu, Liqin published their research in Organic Letters in 2021. The article was titled 《Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents》.Application In Synthesis of 4-Chloro-2-iodoaniline The article contains the following contents:

The copper-catalyzed enantioselective C-H arylation between 2-arylindoles I [R1 = naphthalen-1-yl, thiophen-2-yl, 4-chlorophenyl, etc.; R2 = H, 5-Cl, 6-Br, 5-(4-(trifluoromethoxy)phenyl)] and hypervalent iodine reagents II (R3 = 5-Me, 5-Cl, 3-Cl-5-Me, 5-OMe) has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole derivatives with a 2-aryl structures III (up to 99% ee). D. functional theory calculations and wave function anal. show that the key “”sandwich”” intermediate leads to high enantioselectivity of the reaction.4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application In Synthesis of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com