Category: 628-77-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-77-3, name is 1,5-Diiodopentane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: iodides-buliding-blocks

Diiodopentane (1.07 mL, 7.2 mmol, 5 eq) and potassium carbonate (200 mg, 1.44 mmol, 1 eq) were added to a solution of phenol 40 (800 mg, 1 .44 mmol) in acetone (8 mL, dried over molecular sieves). The reaction mixture was then warmed to 60C and stirred for 6 hours. Acetone was removed by rotary evaporation under reduced pressure. The resulting residue was subjected to flash column chromatography (silica gel; 50/50, v/v, hexane/ethyl acetate,). Pure fractions were collected and combined and excess eluent was removed to provide 41 (800 mg, 74%). LC/MS, method 2, 4.00 min (ES+) m/z (relative intensity) 750.66 ([M+H]+, 100).

The synthetic route of 628-77-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SPIROGEN SARL; HOWARD, Philip Wilson; TIBERGHIEN, Arnaud; WO2013/53872; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-77-3 as follows. Formula: C5H10I2

A solution of tert-butyl (11S,11aS)-8-hydroxy-7-methoxy-2-methylene-5-oxo-11-((tetrahydro-2H-pyran-2-yl)oxy)-2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate 46 (200 mg, 0.43 mmol) in DMF (5.0 mL) was added K2CO3 (60 mg, 0.43 mmol) and 1,5-diiodopentane (703 mg, 2.17 mmol). The reaction mixture was stirred at 90 C. for 12 h. The reaction mixture was concentrated and purified by silica chromatography (0-50% EtOAc in petroleum ether) to give tert-butyl (11S,11aS)-8-((5-iodopentyl)oxy)-7-methoxy-2-methylene-5-oxo-11-((tetrahydro-2H-pyran-2-yl)oxy)-2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10(5H)-carboxylate 47 (129 mg, 0.191 mmol, 43.9% yield) as a yellow oil. LCMS (5-95AB/1.5 min): RT=0.907 min, [M+H]+ 657.1

According to the analysis of related databases, 628-77-3, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-77-3, name is 1,5-Diiodopentane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1,5-Diiodopentane

Example 19. (1 laS, 1 ia?S)-8,8-(pentane- 1 ,5-diylbis(oxy))bis(7-methoxy-2-methylene-23-dihydro- 1H-benzo[e]pyrrolo[ 1 ,2-aj [1 ,4jdiazepin-5( 11 aH)-one) (97) To a stirred suspended solution of Cs2CO3 (0.761 g, 2.33 mmol) in butanone (8 ml) were added (S)-8-hydroxy-7-methoxy-2-methyiene-2,3-dihydro- 1 H-benzo[e]pyrroio[ 1,2- aj[1,4jdiazepin-5(1 laH)-one (401 mg, 1.55 mmol) and 1,5-diiodopentane (240 mg, 0.740mmol). The mixture was stirred at RT overnight, concentrated, and purified on Si02 chromatography eluted with EtOAc/CH2C12 (1:10) to afford 337 rng (78% yield) of the title producL ElMS mlz 607.2 ([Mj+Na).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 628-77-3.

Application of 628-77-3, These common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The [Reaction Scheme 1-5 obtained [Intermediate 1-e] 9.7 g in the reactor 300 mL (21 mmol), into a tetrahydrofuran 77 mL, was cooled to 0 . In potassium-tert-butoxide 7.1 g (63 mmol) slowly and stir. 10 minutes later, it was added dropwise a solution of 1,5-diiodopentane 10.3 g (32 mmol) in 10 mL tetrahydrofuran at 0 , and the temperature was raised to room temperature and stirred for 24 hours. Into water, then the organic layer was extracted and then concentrated under reduced pressure, the resulting solid was purified by recrystallization to obtain the compound [formula 2] 4.7 g (yield: 42.2%)

The synthetic route of 628-77-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 628-77-3,Some common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, molecular formula is C5H10I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium hydride (9.73 mg, 0.243 mmol, 60%> suspension in mineral oil) was added to a solution of l ,3-difluoro-2-(((l ,l ,l ,3,3,3-hexafluoro-2-(4-(((4- fluorophenyl)sulfonyl)methyl)phenyl)propan-2-yl)oxy)methyl)benzene (13.2 mg, 0.024 mmol) and 1 ,5-diiodopentane (31.5 mg, 0.097 mmol) in Nu,Nu-dimethylformamide (1 mL). After 1 h at room temperature, LCMS analysis showed that the reaction was complete. The mixture was quenched with water (1 mL), diluted with ether (10 mL), washed with water (2×10 mL), brine (5 mL), dried (magnesium sulfate), filtered and concentrated under reduced pressure. The crude material was purified via preparative LC/MS with the following conditions: Column: Waters XBridge C18, 19 x 150 mm, 5-muiotaeta particles; Guard Column: Waters XBridge C I 8, 19 x 10 mm, 5-muiotaeta particles; Mobile Phase A: 5 :95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95 :5 acetonitrile: water with 10-mM ammonium acetate; Gradient: 60-100% B over 15 minutes, then a 5-minute hold at 100% B; Flow: 20 mL/min. Fractions containing the desired product were combined and dried via centrifugal evaporation to give Example 1 (9.0 mg, 57% yield). LC/MS (M+18): 628.1 ; LC retention time: 3.130 min (analytical HPLC Method C); 1H NMR (500 MHz, 1 : 1 mixture of CDC13-CD30D) delta ppm 7.66 – 7.58 (m, 2H), 7.49 – 7.38 (m, 3H), 7.30 – 7.21 (m, 2H), 7.08 – 6.95 (m, 4H), 4.73 (s, 2H), 2.66 (d, J=12.9 Hz, 2H), 2.26 (td, J=13.3, 3.2 Hz, 2H), 1.83 (d, J=13.4 Hz, 2H), 1.67 (d, J=12.4 Hz, 1H), 1.47 – 1.34 (m, 1H), 1.28 (q, J=13.0 Hz, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Diiodopentane, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-77-3, name is 1,5-Diiodopentane, A new synthetic method of this compound is introduced below., COA of Formula: C5H10I2

Step 1: preparation of tert-butyl (trans-4-(piperidin-1-yl)cyclohexyl)carbamate Tert-butyl (trans-4-aminocyclohexyl)carbamate (214 mg, 1 mmol) and 1,5-diiodopentane (324 mg, 1 mmol) were dissolved in acetonitrile (5 mL). The reaction liquid was added with potassium carbonate (414 mg, 3 mmol), and reacted at 70 C for 2 hours. The reaction liquid was concentrated to dryness, dissolved in ethyl acetate (10 mL), washed with saturated brine, and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 250 mg of a pale yellow solid. Yield: 88.6%. MS (ESI, m/z): [M+H]+: 283.3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 628-77-3, name is 1,5-Diiodopentane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-77-3, Application In Synthesis of 1,5-Diiodopentane

Synthesis of Compound 59.1 [0424] To a solution of tert-butyl 2-(hydroxymethyl)pyrrolidine-l -carboxylate (1.0 g, 4.9 mmol, 1.0 eq) in MeCN (50 mL) were added NaOH (0.39 g, 9.8 mmol, 2.0 eq) and 1, 5- diiodopentane (3.2 g, 9.9 mmol, 2.0 eq). The reaction mixture was stirred at room temperature for 48 h and concentrated under reduced pressure. The residue was diluted with ethyl acetate (100 mL), washed with H20 (100 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column (PE : EA = 5 : 1) to give 59.1 (0.7 g, Y: 36%) as a yellow oil. 1H NMR (400 MHz, CDC13) delta: 3.96-3.92 (m, 1H), 3.54-3.51 (m, 1H), 3.48-3.39 (m, 2H), 3.33-3.32 (m, 3H), 3.19 (t, J = 6.8 Hz, 2H), 2.31-2.19 (m, 1H), 1.95-1.76 (m, 6H), 1.60-1.50 (m, 3H), 1.46 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Diiodopentane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIOGEN IDEC MA INC.; JENKINS, Tracy; VESSELS, Jeffery; WO2014/143672; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 628-77-3

EXAMPLE 1 N, N’-Pentane-1, 5-diyl-bis-pyridinium Diiodide (bPPeI).; 1,5-Diiodopentane (mmol) was added to a solution (30 mL) of dry pyridine, and the solution heated for 24 hours at 65C. The resulting precipitate was filtered, and the product washed five times with dry diethyl ether. The resulting yellow solid was isolated in a 90% yield. ‘H NMR (300 MHz, DMSO-D6) 8 9.14 (2H, d, C2&C6-H), 8.62 (1H, t, C4-H), 8.19 (2H, t, C3&C5-H), 4.62 (2H, t, C’1-CH2), 1.92 (2H, m, C’2-CH2), 1.25 (1H, m, C’3-CH2).

The synthetic route of 1,5-Diiodopentane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WO2005/66129; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 628-77-3, name is 1,5-Diiodopentane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-77-3, Product Details of 628-77-3

Diiodopentane (0.63 niL, 4.21 mmol, 5 eq) and potassium carbonate (116 mg, 0.84 mmol, 1 eq) were added to a solution of phenol 54 (400 mg, 0.84 mmol) in acetone (4 mL, dried over molecular sieves). The reaction mixture was then warmed to 60C and stirred for 6 hours. Acetone was removed by rotary evaporation under reduced pressure. The resulting residue was subjected to flash column chromatography (silica gel; 50/50, v/v, hexane/ethyl acetate,). Pure fractions were collected and combined and excess eluent was removed to provide 55 in 90% yield. LC/MS, 3.90 min (ES+) m/z (relative intensity) 670.91 ([M]+, 100). 1H NMR (400 MHz, CDC13) delta 7.23 (s, 1H), 6.69 (s, 1H), 6.60 (s, 1H), 5.87 (d, / = 8.8 Hz, 1H), 5.83 – 5.68 (m, J = 5.6 Hz, 1H), 5.15 – 5.01 (m, 2H), 4.67 – 4.58 (m, 1H), 4.45 – 4.35 (m, 1H), 4.04 – 3.93 (m, 2H), 3.91 (s, 3H), 3.73 (td, / = 10.0, 3.8 Hz, 1H), 3.25 – 3.14 (m, / = 8.5, 7.0 Hz, 2H), 2.92 (dd, J = 16.8, 10.3 Hz, 1H), 2.38 (d, / = 16.8 Hz, 1H), 1.95 – 1.81 (m, 4H), 1.77 (s, 3H), 1.64 – 1.49 (m, 2H), 0.88 (s, 9H), 0.25 (s, 3H), 0.23 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Diiodopentane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEDIMMUNE LIMITED; LLOYD, Christopher O.; MARWOOD, Rose; HOWARD, Philip; HARPER, III, John W.; HOLLINGSWORTH, Robert; KAMAL, Adeela; DIMASI, Nazzareno; GAO, Changshou; TOADER, Dorin; WANG, Fengjiang; GINGIPALLI, Lakshmaiah; WO2015/155345; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-77-3, name is 1,5-Diiodopentane, A new synthetic method of this compound is introduced below., Safety of 1,5-Diiodopentane

Diiodopentane (0.63 mL, 4.21 mmol, 5 eq) and potassium carbonate (116 mg, 0.84mmol, 1 eq) were added to a solution of phenol 54 (400 mg, 0.84 mmol) in acetone (4 mL,dried over molecular sieves). The reaction mixture was then warmed to 60C and stirred for 6 hours. Acetone was removed by rotary evaporation under reduced pressure. The resulting residue was subjected to flash column chromatography (silica gel; 50/50, v/v, hexane/ethyl acetate,). Pure fractions were collected and combined and excess eluent wasremoved to provide 55 in 90% yield. LC/MS, 3.90 mm (ES+) m/z (relative intensity)670.91 ([M], 100). ?H NMR (400 MHz, CDC13) oe 7.23 (s, 1H), 6.69 (s, 1H), 6.60 (s, 1H),5.87 (d, J= 8.8 Hz, 1H), 5.83 – 5.68 (m, J= 5.6 Hz, 1H), 5.15 – 5.01 (m, 2H), 4.67 -4.58(m, 1H), 4.45 -4.35 (m, 1H), 4.04 – 3.93 (m, 2H), 3.91 (s, 3H), 3.73 (td, J 10.0, 3.8 Hz,1H), 3.25 -3.14 (m, J= 8.5, 7.0 Hz, 2H), 2.92 (dd, J 16.8, 10.3 Hz, 1H), 2.38 (d, J16.8 Hz, 1H), 1.95 – 1.81 (m, 4H), 1.77 (s, 3H), 1.64 – 1.49 (m, 2H), 0.88 (s, 9H), 0.25 (s,3H), 0.23 (s, 3H).

The synthetic route of 628-77-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; STEM CENTRX, INC.; SPIROGEN SARL; TORGOV, Michael; HOWARD, Philip Wilson; WO2014/130879; (2014); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com