627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-Iodo-1-propanol
To a solution of 5-bromo-1, 2-dihydropyridin-2-one (1 g, 5.75 nMol, 1 equiv) and 3-iodopropan-1-ol (2.1 g, 11.49 nMol, 2 equiv) in DMF (15 mL) was added K 2CO 3 (1.6 g, 11.49 nMol, 2 equiv) at room temperature. The mixture was stirred for 4 hours at 80 under air atmosphere. The resulted mixture was concentrated under reduced pressure. The residue was purified by Prep-TLC (CHCl 3 /MeOH 20: 1) to afford 5-bromo-1- (3-hydroxypropyl) -1, 2-dihydropyridin-2-one (300 mg, 22.49%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 232.1, 234.1. 1H NMR: (300 MHz, DMSO-d 6) delta 1.12 (q, 2H) , 2.79 (m, 2H) , 3.27 (t, 2H) , 4.03 (s, 1H) , 5.69 (d, 1H) , 6.78 (dd, 1H) , 7.09 (d, 1H) .
The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; QI, Changhe; TSUI, Honchung; ZENG, Qingbei; YANG, Zhenfan; ZHANG, Xiaolin; (399 pag.)WO2020/35052; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com