September 18, 2021 News New downstream synthetic route of 627-32-7

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-Iodo-1-propanol

To a solution of 5-bromo-1, 2-dihydropyridin-2-one (1 g, 5.75 nMol, 1 equiv) and 3-iodopropan-1-ol (2.1 g, 11.49 nMol, 2 equiv) in DMF (15 mL) was added K 2CO 3 (1.6 g, 11.49 nMol, 2 equiv) at room temperature. The mixture was stirred for 4 hours at 80 under air atmosphere. The resulted mixture was concentrated under reduced pressure. The residue was purified by Prep-TLC (CHCl 3 /MeOH 20: 1) to afford 5-bromo-1- (3-hydroxypropyl) -1, 2-dihydropyridin-2-one (300 mg, 22.49%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 232.1, 234.1. 1H NMR: (300 MHz, DMSO-d 6) delta 1.12 (q, 2H) , 2.79 (m, 2H) , 3.27 (t, 2H) , 4.03 (s, 1H) , 5.69 (d, 1H) , 6.78 (dd, 1H) , 7.09 (d, 1H) .

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.; QI, Changhe; TSUI, Honchung; ZENG, Qingbei; YANG, Zhenfan; ZHANG, Xiaolin; (399 pag.)WO2020/35052; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

9/17/2021 News New downstream synthetic route of 627-32-7

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C3H7IO

The reaction of phenoxazine (500 mg, 2.729 mmol) and NaH (60% dispersion in mineral oil, 136.8 mg, 4.094 mmol) in distilled DMF (10 mL) with 3-bromo-1-propanol (621 mg, 4.094 mmol) ), as described above, gave compound 14 (480.7 mg, 1.992 mmol, 73 %) as dark navy oil.: Rf = 0.33 (n-hexane/EtOAc = 1:1); IR (neat, cm-1) 3365, 3065, 2947, 1592, 1487, 1380, 1272, 1130, 1044; 1H NMR (400 MHz, CD3OD) delta 6.72~6.76 (m, 2H), 6.51~6.61 (m, 6H), 3.66 (t, 2H, J = 5.6 Hz), 3.60 (t, 2H, J = 7.6 Hz), 1.80 (m, 2H); 13C NMR (100 MHz, CD3OD) delta 145.0, 133.4, 123.7, 120.6, 115.0, 111.6, 59.2, 40.5, 27.7; MS (FAB) m/z 241.1 (M+).

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gim, Hyo Jin; Li, Hua; Lee, Eun; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry Letters; vol. 23; 2; (2013); p. 513 – 517;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

September 7,2021 News The origin of a common compound about 627-32-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-32-7, Recommanded Product: 3-Iodo-1-propanol

K2CO3 (118mg, 0.86mmol), NaHCO3 (115mg, 1.36mmol) and, 3-iodo-1-propanol (0.06mL, 0.59mmol) were added to a solution of amine 19 (75mg, 0.39mmol) in acetone (4mL). The reaction mixture was heated to reflux. After 6h, the reaction was cooled to room temperature and the solvent was removed in vacuo. The reaction mixture was purified by chromatography (silica gel, gradient from CH2Cl2 to 95:5 CH2Cl2/MeOH) to afford compound 21 (66mg, 67%) as a brown solid; mp 85-87C; 1H NMR (400MHz, CDCl3) delta 3.77 (m, 2H), 3.13-3.00 (m, 2H), 2.66 (d, J=16.5Hz, 1H), 2.49 (dd, J=17.1, J=6.6Hz, 1H), 2.30-2.07 (m, 6H), 1.92 (m, 1H), 1.79 (m, 1H), 1.73-1.58 (m, 5H), 1.57-1.47 (m, 3H), 1.47-1.29 (m, 2H); 13C NMR (100MHz, CDCl3) delta 212.6, 64.5, 59.5, 48.5, 46.9, 44.3, 42.2, 39.0, 38.1, 35.8, 32.9, 27.8, 26.1, 25.6, 19.6; HRMS (ESI): m/z calcd for C15H26NO2 [M+H]+: 252.1958, found: 252.1962; FTIR (neat) numax: 3384, 2931, 2874, 1703, 1468, 1443, 1416, 1336, 1253, 1231, 1172, 1125, 1111, 1067, 733cm-1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; de Miguel, Irene; Velado, Marina; Herradon, Bernardo; Mann, Enrique; Tetrahedron; vol. 72; 31; (2016); p. 4617 – 4625;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

9/7/21 News Share a compound : 627-32-7

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Application of 627-32-7,Some common heterocyclic compound, 627-32-7, name is 3-Iodo-1-propanol, molecular formula is C3H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3. Preparation of 7-(2′-Trimethylsilanyl)ethyl-10-(3′-hydroxypropoxy) camptothecin (Compound 3) To a solution of 7-(2′-trimethylsilanyl)ethyl-10-hydroxy camptothecin (31 mg, 0.067 mmol) and potassium carbonate (15 mg, 0.11 mmol) in N,N-dimethylformamide (2 mL) was added 3-iodopropanol (0.1 ml) at -78 C. The resultant solution was stirred at room temperature for 16 hours. N,N-Dimethylformamide was removed by evaporation under reduced pressure. The residue was filtrated through silica gel with methanol/dichloromethane (10/90) and concentrated by rotary evaporation. Purification by radial preparative-layer chromatography (ethyl acetate/hexanes 50/50 to methanol/chloroform 2/98) provided 15 mg of 7-(2′-trimethylsilanyl)ethyl-10-(3′-hydroxypropoxy) camptothecin (Compound 3) as a yellow solid. 1H NMR (300 MHz, CDCl3) delta 8.02 (d, 1 H, J=9.3 Hz), 7.52 (s, 1 H), 7.34 (dd, 1 H, J1=9.3 Hz, J2=2.7 Hz), 7.14 (d, 1 H, J=2.7 Hz), 5.67 (d, 1 H, J=16.5 Hz), 5.22(d, 1 H, J=16.5 Hz), 5.09 (s, 2 H), 4.24-4.17 (m, 2 H), 3.90-3.85(m, 2 H), 3.00-2.88 (m, 2 H), 2.12-2.06 (m, 2 H), 1.90-1.76 (m, 2 H), 0.97(t, 3 H, J=7.3 Hz), 0.86-0.80 (m, 2H), 0.11 (s, 9 H). MS (m/z, M+1) 523.6

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BioNumerik Pharmaceuticals, Inc.; US2009/99166; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1-Sep-2021 News Discovery of 627-32-7

The chemical industry reduces the impact on the environment during synthesis 3-Iodo-1-propanol. I believe this compound will play a more active role in future production and life.

Application of 627-32-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-32-7, name is 3-Iodo-1-propanol, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 4; N’-(4-(3-Hydroxypropoxy)-3-methoxybenzylidene)-3-(3-methyl-lH-indol-1 -yl)propanehydrazide; [0496] (a) 4-(3-Hydroxypropoxy)-3-methoxybenzaldehyde: To a stirred solution of vanillin (304 mg, 2 mmol) in DMF (4 rnL) at room temperature was added 3-iodo-l-propanol (0.29 mL, 3 mmol) and K2CO3 (553 mg, 4 mmol). The reaction mixture was stirred at room temperature for 7 hours followed by quenching with aq. NH4Cl. The product was extracted three times into EtOAc and the combined organic layers were dried (Na2SO4). The material was purified on silica gel using EtOAc-hexanes (0 to 70%) and to give 392 mg (93%) of the product as an off-white waxy solid.

The chemical industry reduces the impact on the environment during synthesis 3-Iodo-1-propanol. I believe this compound will play a more active role in future production and life.

Reference:
Patent; STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O’GRADY, Harold; WO2010/132615; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extracurricular laboratory: Synthetic route of 627-32-7

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3-Iodo-1-propanol

D: 3-(4-Bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol3-Iodopropanol (11.23 g) was added to a mixture of 4-bromo-2-(trifluoromethyl)-phenol (15 g) and potassium carbonate (172 g) in acetonitrile (150 ml). The above mixture was refluxed for 4 hours then diluted with ethyl acetate (500 ml) and water (300 ml). Organic layer was seperated, dried over magnesium sulphate, solvent removed under reduced pressure to give expected product clean enough for use at the next step (18.6 g). 1H NMR (CDCl3) delta: 7.67 (d, 1H), 7.58 (dd, 1H), 6.90 (dd, 1H), 4.18 (t, 2H), 3.87 (q, 2H), 2.07 (tt, 2H).

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; N.V. Organon; US2010/184761; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Brief introduction of C3H7IO

The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.

Electric Literature of 627-32-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixture of emodin (10 mmol) in dry DMF (50 mL) were added Cs2CO3 (12 mmol) and hydroxybromides or iodides (30 mmol) at room temperature. After stirring for 36 h at 60 C, the resulting mixture was evaporated under reduced pressure and then mixed with water (100 mL). The pH value of aqueous phase was adjusted to around 5 with 10% hydrochloric acid solution, extracted with dichloromethane (2 100 mL). The combined organic layer was washed with brine (200 mL), dried over anhydrous sodium sulfate and evaporated to dryness. The crude product was purified by silica gel column chromatography with 1%-10% ethyl acetate in petroleum to afford compounds 6a-6f. 1,8-Dihydroxy-3-(3-hydroxypropsoxy)-6-methylanthracene-9,10-dione (6a). According to the generalprocedure C, emodin was treated with 3-iodopropan-1-ol and then purified by silica gel columnchromatography to give compound 6a: Brown solid; yield, 55%; 1H-NMR delta 12.14 (s, 1H), 11.96 (s, 1H),7.51 (s, 1H), 7.21-7.13 (m, 2H), 6.85 (d, J = 2.5 Hz, 1H), 4.62 (t, J = 5.2 Hz, 1H), 4.23 (t, J = 6.3 Hz, 2H),3.58 (q, J = 5.9 Hz, 2H), 2.43 (s, 3H), 1.95-1.87 (m, 2H); 13C-NMR delta 189.78, 180.98, 165.53, 164.32, 161.42,148.44, 134.66, 132.69, 124.13, 120.51, 113.30, 109.60, 107.84, 106.83, 65.99, 57.00, 31.71, 21.49; ESI, m/z:329.1 [M + H]+.

The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Kun; Jin, Ming-Ji; Quan, Zhe-Shan; Piao, Hu-Ri; Molecules; vol. 24; 5; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Brief introduction of C3H7IO

According to the analysis of related databases, 627-32-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 627-32-7 as follows. Recommanded Product: 3-Iodo-1-propanol

3-lodopropanol (11.23g) was added to a mixture of 4-bromo-2- (trifluoromethyl)-phenol (15g) and potassium carbonate (17.2g) in acetonitrile (150ml). The above mixture was refluxed for 4 hours then diluted with ethyl acetate (500ml) and water (300ml). Organic layer was seperated, dried over magnesium sulphate, solvent removed under reduced pressure to give expected product clean enough for use at the next step (18.6g). 1H NMR (CDCI3)delta: 7.67 (d, 1 H), 7.58 (dd, 1 H), 6.90 (dd, 1 H), 4.18 (t, 2H), 3.87 (q, 2H), 2.07 (tt, 2H).

According to the analysis of related databases, 627-32-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; N.V. ORGANON; CAI, Jiaqiang; BENNETT, David, Jonathan; ROBINSON, John, Stephen; JONES, Philip, Stephen; WO2010/81859; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple exploration of C3H7IO

The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 627-32-7, name is 3-Iodo-1-propanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-Iodo-1-propanol

The 1900g (10.22 muM) 3 – iodo propanol, 20g sulfuric acid are added to a reaction container, access oxirane 200g (4.50 muM), to maintain the reaction temperature 25 C the left and the right, reaction finishes rectification, to obtain the colorless liquid 1 – glycol ether propyl iodide 721g, the purity is greater than 95%, yield 69%, the structure of the characterization as shown in the following data.

The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Henan Longdou Petrochemical Co., Ltd.; Xu Bo; Zhuang Guanghai; Feng Wei; Zhuang Guoyin; Dong Xuekun; Guo Libing; (5 pag.)CN106554261; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New downstream synthetic route of C3H7IO

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C3H7IO

The reaction of phenoxazine (500 mg, 2.729 mmol) and NaH (60% dispersion in mineral oil, 136.8 mg, 4.094 mmol) in distilled DMF (10 mL) with 3-bromo-1-propanol (621 mg, 4.094 mmol) ), as described above, gave compound 14 (480.7 mg, 1.992 mmol, 73 %) as dark navy oil.: Rf = 0.33 (n-hexane/EtOAc = 1:1); IR (neat, cm-1) 3365, 3065, 2947, 1592, 1487, 1380, 1272, 1130, 1044; 1H NMR (400 MHz, CD3OD) delta 6.72~6.76 (m, 2H), 6.51~6.61 (m, 6H), 3.66 (t, 2H, J = 5.6 Hz), 3.60 (t, 2H, J = 7.6 Hz), 1.80 (m, 2H); 13C NMR (100 MHz, CD3OD) delta 145.0, 133.4, 123.7, 120.6, 115.0, 111.6, 59.2, 40.5, 27.7; MS (FAB) m/z 241.1 (M+).

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gim, Hyo Jin; Li, Hua; Lee, Eun; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry Letters; vol. 23; 2; (2013); p. 513 – 517;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com