Category: 626-02-8

In 2022,Bouzriba, Chahrazed; Chavez Alvarez, Atziri Corin; Gagne-Boulet, Mathieu; Ouellette, Vincent; Lacroix, Jacques; Cote, Marie-France; C.-Gaudreault, Rene; Fortin, Sebastien published an article in European Journal of Medicinal Chemistry. The title of the article was 《Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation》.Safety of 3-Iodophenol The author mentioned the following in the article:

We recently discovered a new family of prodrugs deriving from Ph 4-(2-oxo-3-imidazolidin-1-yl)benzenesulfonates (PIB-SOs) bioactivatable by cytochrome P 450 1A1 (CYP1A1) into potent antimitotics referred to as Ph 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs). PAIB-SOs display significant selectivity toward human breast cancer cells based on the N-dealkylation of PAIB-SOs into their corresponding PIB-SOs by CYP1A1. In this study, we have evaluated the mol. mechanism of the bioactivation of PAIB-SOs into PIB-SOs by branching the linear alkyl chain on the imidazolidin-2-one (IMZ) moiety of PAIB-SOs by branched alkyl groups such as iso-Pr, iso-Bu and sec-Bu. Our results show that PAIB-SOs bearing an iso-Bu group on the IMZ moiety and either a methoxy, a chloro or a bromo group at positions 3, 3,5 or 3,4,5 on the aromatic ring B exhibit antiproliferative activity ranging from 0.13 to 6.9 μM and selectivity toward MCF7 and MDA-MB-468 mammary cancer cells comparatively to other cell lines tested. Moreover, the most potent and selective PAIB-SOs bearing an iso-Bu group and either a 3,5-Cl (44), 3,5-Br (45) or a 3,4,5-OMe (46) on the IMZ moiety exhibit antiproliferative activity in the sub-micromolar range and high selectivity ratios toward mammary cancer cells. They stop the cell cycle of MCF7 cells in the G2/M phase and disrupt their cytoskeleton. Furthermore, our studies evidenced that PAIB-SOs bearing either an iso-Pr, a sec-Bu or an iso-Bu group are hydroxylated on the carbon atom adjacent to the IMZ (Cα-OH) but only PAIB-SOs bearing an iso-Bu group are bioactivated into PIB-SOs. Finally, PAIB-SOs 45 and 46 exhibit low toxicity toward normal cells and chick embryos and are thus promising antimitotic prodrugs highly selective toward CYP1A1-expressing breast cancer cells. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Gold (I/III)-Catalyzed Trifluoromethylthiolation and Trifluoromethylselenolation of Organohalides》 was written by Mudshinge, Sagar R.; Yang, Yuhao; Xu, Bo; Hammond, Gerald B.; Lu, Zhichao. Product Details of 626-02-8This research focused ontrifluoromethyl thioether preparation; silver trifluoromethanethiolate organohalide trifluoromethylthiolation gold redox catalyst; selenoether trifluoromethyl preparation; tetramethylammonium trifluoromethylselenate organohalide trifluoromethylselenolation gold redox catalyst; Cross-Coupling; Gold Catalysis; Organohalides; Trifluoromethylselenolation; Trifluoromethylthiolation. The article conveys some information:

The first C-SCF3/SeCF3 cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF3 or Me4NSeCF3, and organohalides ArI (Ar = Ph, 4-bromophenyl, 2,6-dimethoxypyridin-3-yl, ec.), (E/Z)-RCH=CHI (R = C(O)OMe, Ph, naphthalen-1-yl, etc.) and R1CCBr (R1 = Ph, 4-fluorophenyl, 4-nitrophenyl, etc.) as substrates are reported. The new methodol. enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers ArSCF3, (E/Z)-RCH=CHSCF3, R1CCSCF3, and RSeCF3 with a broad substrate scope (>60 examples with up to 97% isolated yield). The method is scalable, and its robustness is evidenced by the late-stage functionalization of various bioactive mols., which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio- and selenoethers for pharmaceutical and agrochem. research and development. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Product Details of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Product Details of 626-02-8 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Satrialdi; Munechika, Reina; Biju, Vasudevanpillai; Takano, Yuta; Harashima, Hideyoshi; Yamada, Yuma. Computed Properties of C6H5IO The article mentions the following:

The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Computed Properties of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Computed Properties of C6H5IO In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fanourakis, Alexander; Williams, Benjamin D.; Paterson, Kieran J.; Phipps, Robert J. published an article in 2021. The article was titled 《Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation》, and you may find the article in Journal of the American Chemical Society.Formula: C6H5IO The information in the text is summarized as follows:

A family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which the chiral cations are associated And derived from quaternized cinchona alkaloids, has been described. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates R(CH2)4OH (R = Ph, 1-naphthyl, 3-methylthiophen-2-yl, etc.) bearing pentyl hydroxyl groups. Addnl., the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of products RCH(NHS(O)2OCH2R1)(CH2)3OH (R1 = (CF2)2CF3) vs. Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Formula: C6H5IO) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C6H5IO Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Teixeira Campos, Patrick; Karkow Bones, Mariana; Siqueira da Silva, Rubia Mara published an article in European Journal of Organic Chemistry. The title of the article was 《Energetic and Topological Supramolecular Study and Nucleation Mechanism Proposal of Halogenated Phenols》.HPLC of Formula: 626-02-8 The author mentioned the following in the article:

In this work, an energetic and topol. supramol. study of 10 different halogenated phenols, X-C6H4-OH (X=F, Cl, Br and I) in the ortho, meta, and para positions was carried out, except for X=Br, in ortho- and meta-X-phenols. Most compounds have a mol. coordination number (MCN) of fourteen. All intermol. interactions were classified, and the robustness was evaluated. Strong intermol. interactions such as O-H···O and π···π contributed half the energy of the cluster, although interactions considered weak as C-H···X and C-H···π reached 40% in energetic contribution, as they revealed a greater number of occurrences. Addnl., these theor. data of energy were correlated with exptl. data of m.p. and packing d. revealing a notable trend. In almost all cases evaluating the same position, the higher the d., the higher the m.p. and the higher the stabilizing energy. Finally, nucleation proposals were suggested for all compounds and revealed that six compounds needed three stages, while four compounds needed only two stages to promote the growth of the supramol. structure in three directions. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8HPLC of Formula: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.HPLC of Formula: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach》 was published in Journal of Chemical Information and Modeling in 2020. These research results belong to de Souza, Mariana L.; de Oliveira Rezende, Celso Junior; Ferreira, Rafaela S.; Espinoza Chavez, Rocio Marisol; Ferreira, Leonardo L. G.; Slafer, Brian W.; Magalhaes, Luma G.; Krogh, Renata; Oliva, Glaucius; Cruz, Fabio Cardoso; Dias, Luiz Carlos; Andricopulo, Adriano D.. Related Products of 626-02-8 The article mentions the following:

A virtual screening conducted with nearly 4,000,000 compounds from lead-like and fragment-like subsets enabled the identification of a small-mol. inhibitor I of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. Subsequent comprehensive structure-based drug design and structure-activity relationship studies led to the discovery of carbamoyl imidazoles as potent, reversible, and competitive cruzain inhibitors. The most potent carbamoyl imidazole inhibitor II exhibited high affinity with a Ki value of 20 nM, presenting both in vitro and in vivo activity against T. cruzi. Furthermore, the most promising compounds reduced parasite burden in vivo and showed no toxicity at a dose of 100 mg/kg. These carbamoyl imidazoles are structurally attractive, nonpeptidic, and easy to prepare and synthetically modify. Finally, these results further advance our understanding of the noncovalent mode of inhibition of this pharmaceutically relevant enzyme, building strong foundations for drug discovery efforts. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Related Products of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Related Products of 626-02-8 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 3-IodophenolIn 2022 ,《Molecular engineering by σ-linkers enables delayed fluorescence emitters for high-efficiency sky-blue solution-processed OLEDs》 was published in Chemical Engineering Journal (Amsterdam, Netherlands). The article was written by Chen, Yanying; Li, Nengquan; Huang, Zhongyan; Xie, Guohua; Yang, Chuluo. The article contains the following contents:

Two novel thermally activated delayed fluorescence (TADF) emitters, Me2AcBO and F2AcBO, based on the 9,9-dimethylacridine donor and a rigid O-bridged cyclized B acceptor, were designed and synthesized for highly efficient blue solution-processed organic light-emitting diodes (OLEDs). Me2AcBO and F2AcBO feature a twin structure derived by coupling 2 individual TADF monomers through nonconjugated linkers. The 2 new emitters exhibit 3D mol. structures, excellent thermal/morphol. properties, high luminescence quantum yields >97%, and high reverse intersystem crossing rates ∼106 s-1, which greatly benefit the high device efficiency. Solution-processed sky-blue TADF OLEDs based on Me2AcBO and F2AcBO achieved the maximum external quantum efficiency of 11.0 and 10.9%, resp., with Commission Internationale de L’Eclairage (CIE) coordinates of (0.14, 0.25). Relatively low efficiency roll-offs of 33 and 34% at the luminance of 1000 cd/m2 were demonstrated for Me2AcBO and F2AcBO based devices, resp. This study presents a novel strategy to realize highly efficient sky-blue TADF emitters for solution-processed OLEDs. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Quality Control of 3-Iodophenol Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis and characterization of novel soluble poly(arylene ether amide triphenylphosphine oxide)s by heterogeneous palladium-catalyzed carbonylation polymerization》 was written by Li, Jianying; Huang, Bin; Tang, Huali; Cai, Mingzhong. Reference of 3-Iodophenol And the article was included in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. The article conveys some information:

A new aromatic diiodide monomer, bis(4-(3-iodophenoxy)phenyl)phenylphosphine oxide (BIPPO), was prepared by condensation of bis(4-fluorophenyl)phenylphosphine oxide with 3-iodophenol. A series of poly(arylene ether amide triphenylphosphine oxide)s were synthesized via heterogeneous palladium-catalyzed carbonylative polycondensation of BIPPO, aromatic diamines, and carbon monoxide. Polymerization reaction proceeded smoothly in N,N-dimethylacetamide (DMAc) at 120°C with 1,8-diazabicyclo[5,4,0]-7-undecene (DBU) as the base by using the bidentate phosphino-modified magnetic nanoparticles-anchored palladium complex [2P-Fe3O4@SiO2-PdCl2] as a recyclable catalyst under 1 bar of CO, producing new poly(arylene ether amide triphenylphosphine oxide)s with inherent viscosities ranging from 0.69 to 0.76 dL/g. All the polymers obtained were easily soluble in strong polar aprotic organic solvents and even in less polar pyridine at room temperature, and provided transparent, flexible and tough films by casting from their DMAc solutions These polymers displayed good thermal stability with the glass transition temperatures ranging from 196 to 249°C, the temperatures at 5% weight loss ranging from 441 to 490°C in nitrogen. All the polymers were amorphous and their films showed good mech. behavior with tensile strengths of 78.5-91.6 MPa, tensile moduli of 2.15-2.69 GPa, and elongations at break of 9.8-14.6%. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Reference of 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Reference of 3-IodophenolHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Serpell, Christopher J.; Park, Ah Young; Robinson, Carol V.; Beer, Paul D. published an article in 2021. The article was titled 《Imidazolium-based catenane host for bromide recognition in aqueous media》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Name: 3-Iodophenol The information in the text is summarized as follows:

The synthesis of a novel catenated system which is dense in cationic hydrogen bonding imidazolium units is described. The interlocked host system displays a preference for binding of bromide over other halides, overcoming basicity and Hofmeister trends, under aqueous conditions. This is the first example of an imidazolium-based catenane acting as an anion host through C-H hydrogen bonding. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8Name: 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Name: 3-IodophenolHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com