Category: 626-02-8

《Liquid crystalline behaviors of three series of hockey stick-like compounds》 was written by Jin, Gege; Guo, Yongmin; Wu, Limin; Li, Yi; Li, Baozong; Yang, Yonggang. SDS of cas: 626-02-8 And the article was included in Molecular Crystals and Liquid Crystals in 2020. The article conveys some information:

Three series of meta-perfluoroalkylphenol esters are synthesized. Both SmA and SmC phases are identified. Their clearing points increase with increasing the perfluorocarbon chain length, while decrease with increasing the alkoxy chain length. Comparison of the 3-tridecafluorohexylbenzoates and 3-tridecafluorohexylphenol esters, the 3-tridecafluorohexylbenzoates show higher clearing points, indicating that the direction of the ester bond plays an important role in the thermostability of the liquid crystalline phases. Moreover, it was proposed that the compounds with short and long alkoxy chains packed into different structures.3-Iodophenol(cas: 626-02-8SDS of cas: 626-02-8) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. SDS of cas: 626-02-8 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tague, Andrew J.; Putsathit, Papanin; Riley, Thomas V.; Keller, Paul A.; Pyne, Stephen G. published their research in ACS Medicinal Chemistry Letters in 2021. The article was titled 《Positional Isomers of Biphenyl Antimicrobial Peptidomimetic Amphiphiles》.Quality Control of 3-Iodophenol The article contains the following contents:

Small-mol. antimicrobial peptidomimetic amphiphiles represent a promising class of novel antimicrobials with the potential for widespread therapeutic application. To investigate the role of spatial positioning for key hydrophobic and hydrophilic groups on the antimicrobial efficacy and selectivity, positional isomers of the lead biphenyl antimicrobial peptidomimetic compound 1 were synthesized and subjected to microbial growth inhibition and mammalian toxicity assays. Positional isomer 4 exhibited 4-8x increased efficacy against the pathogenic Gram-neg. bacteria Pseudomonas aeruginosa and Escherichia coli (MIC = 2 μg/mL), while isomers 2, 3, and 7 exhibited a 4x increase in activity against Acinetobacter baumannii (MIC = 4 μg/mL). Changes in mol. shape had a significant impact on Gram-neg. antibacterial efficacy and the resultant spectrum of activity, whereas all structural isomers exhibited significant efficacy (MIC = 0.25-8 μg/mL) against Gram-pos. bacterial pathogens (e.g., methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis). In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Quality Control of 3-Iodophenol Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A Combination of Biocompatible Room Temperature Ionic Liquid and Palladium Catalyst for Base- and Ligand-free Suzuki Coupling Reactions》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Joo, Seong-Ryu; Kwon, Gyu-Tae; Kim, Seung-Hoi. HPLC of Formula: 626-02-8 The article mentions the following:

A system with mild and versatile reaction conditions for a carbon-carbon bond-forming reaction using arylboronic acids RB(OH)2 (R = Ph, 3,4-dimethoxyphenyl, pyridin-3-yl, etc.) and aryl halides R1X (R1 = 4-methylphenyl, 3-iodophenyl, thiophen-2-yl, etc.; X = I, F, Cl, Br) was developed. A readily available and biodegradable room-temperature ionic liquid, choline hydroxide (ChOH), was combined with a ligand-free Pd(OAc)2-catalyst, providing the corresponding sym. and/or unsym. biaryl products RR1 in satisfactory yields under aerobic conditions. No external base or ligand was required for completion of the cross-coupling reactions. More significantly, the reaction medium showed good recyclability, which is an important characteristic from the viewpoint of sustainable chem. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8HPLC of Formula: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.HPLC of Formula: 626-02-8Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Novel preparation of poly(arylene ether sulfone amide)s via supported palladium-catalyzed carbonylative polymerization》 was published in Polymer Bulletin (Heidelberg, Germany) in 2020. These research results belong to Liu, Limin; Li, Jianying; Yan, Tao; Cai, Mingzhong. SDS of cas: 626-02-8 The article mentions the following:

Two new aromatic diiodides with ether-sulfone linkages were synthesized via a 1-step procedure. Poly(arylene ether sulfone amide)s were synthesized by a supported Pd-catalyzed polycondensation of aromatic diiodides having ether-sulfone linkages, aromatic diamines, and CO. Polycondensation reactions were conducted in N,N-dimethylacetamide using a magnetic nanoparticles-bound Pd(II) complex [Fe3O4@SiO2-2P-PdCl2] as the catalyst and 1,8-diazabicycle[5,4,0]-7-undecene as the base at 120°, yielding poly(arylene ether sulfone amide)s having inherent viscosities of 0.43-0.77 dL/g. The resulting polymers were soluble in polar aprotic solvents and showed glass transition temperatures in the 204-265° range, with 10% weight losses occurring at temperatures >456° in N. Most of the polymers afforded transparent and tough films by solution-casting with tensile strengths of 71.8-82.2 MPa, Young’s moduli of 1.77-2.35 GPa, and elongations at break of 9.3-13.4%. More importantly, this supported Pd catalyst can facilely be separated from the product by simply using an external magnetic field and reused at least 7 times with almost consistent activity. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8SDS of cas: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. SDS of cas: 626-02-8 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sen, Anirban; Kumar, Rohit; Pandey, Swechchha; Vipin Raj, K.; Kumar, Pawan; Vanka, Kumar; Chikkali, Samir H. published an article in European Journal of Organic Chemistry. The title of the article was 《Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation》.Recommanded Product: 626-02-8 The author mentioned the following in the article:

Although hybrid bidentate ligands are known to yield highly enantioselective products in asym. hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile vs. C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72%). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H2 pressure, at room temperature The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson’s disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 3-IodophenolIn 2021 ,《Magnetic covalently immobilized nickel complex: A new and efficient method for the Suzuki cross-coupling reaction》 appeared in Applied Organometallic Chemistry. The author of the article were Keyhaniyan, Mahdi; Khojastehnezhad, Amir; Eshghi, Hossein; Shiri, Ali. The article conveys some information:

An efficient procedure is reported to prepare Fe3O4@SiO2 magnetic nanoparticles (MNPs) with immobilized nickel NPs. In order to increase the activity of this catalyst, creatine as a ligand with high content of nitrogen atoms was linked onto the magnetic core-shell structure. Then, Ni(II) ions were coordinated on the surface of the silica-coated MNPs and reduced to Ni(0) NPs to obtain the final catalyst. The catalytic activity of the prepared catalyst was studied for the synthesis of biaryl derivatives via the Suzuki-Miyaura cross-coupling reaction in high yields. The catalyst could also be recovered and reused with no loss of activity over five successful runs. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Safety of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guadalupe, Albarran; Rosalba, Ramos-Morales; Edith, Mendoza published an article in 2021. The article was titled 《Oxidation of halobenzenes by OH radical produced radiolytically in aqueous solution》, and you may find the article in Radiation Physics and Chemistry.Recommanded Product: 626-02-8 The information in the text is summarized as follows:

The radiolytic oxidation of aromatic compounds in dilute aqueous solution is due to the electrophilic strength of the •OH that results from the radiolysis of water. This radical is preferentially added to the electron-rich centers in aromatic rings. Therefore, studies of the charge distribution of the hydroxycyclohexadienyl radicals produced by the addition of the •OH to the aromatics can provide information about their charge distribution. In the present work, the radiolytic oxidation reaction of fluorobenzene, chlorobenzene, bromobenzene, and iodobenzene with the •OH in diluted aqueous solutions was studied. The identification and quantification of the radiolytic products thus formed were carried out utilizing HPLC. The yields found for fluorobenzene, chlorobenzene, bromobenzene, and iodobenzene were 0.609, 0.527, 0.508, and 0.501μmol/J, resp. The electron d. distribution in fluorobenzene, chlorobenzene, and bromobenzene was in the following order: for para > ortho > meta >> ipso; however, in iodobenzene, there is a higher electron d. in the “”ortho”” position than in the “”para”” position. From the total reaction rates for the halobenzenes with the •OH, the partial rate constants were obtained for the reaction of the •OH with each of the positions in the halobenzenes. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Catalytic Access to Functionalized Allylic gem-Difluorides via Fluorinative Meyer-Schuster-Like Rearrangement》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Liao, Lihao; An, Rui; Li, Huimin; Xu, Yang; Wu, Jin-Ji; Zhao, Xiaodan. Reference of 3-Iodophenol The article mentions the following:

An unprecedented approach for efficient synthesis of functionalized allylic gem-difluorides via catalytic fluorinative Meyer-Schuster-like rearrangement is disclosed. This transformation proceeded with readily accessible propargylic fluorides, and low-cost B-F reagents and electrophilic reagents by sulfide catalysis [e.g., I → II (88%) in presence of PhSPh as Lewis basic catalyst, tetrafluoroboric acid di-Et ether complex and NIS]. A series of iodinated, brominated, and trifluoromethylthiolated allylic gem-difluorides that were difficult to access by other methods were facilely produced with a wide range of functional groups. Importantly, the obtained iodinated products could be incorporated into different drugs and natural products, and could be expediently converted into many other valuable gem-difluoroalkyl mols. as well. Mechanistic studies revealed that this reaction went through a regioselective fluorination of alkynes followed by a formal 1,3-fluorine migration under the assistance of the B-F reagents to give the desired products. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Reference of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Reference of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Gagne-Boulet, Mathieu; Bouzriba, Chahrazed; Chavez Alvarez, Atziri Corin; Fortin, Sebastien published an article in Chemical Biology & Drug Design. The title of the article was 《Preparation and biological evaluation of new antimicrotubule agents: Modification of the imidazolidin-2-one moiety of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates》.Synthetic Route of C6H5IO The author mentioned the following in the article:

We prepared and biol. evaluated 32 novel mols. named Ph 4-(dioxoimidazolidin-1-yl)benzenesulfonates (PID-SOs) and Et 2-(3-(4-(phenoxysulfonyl)phenyl)ureido)acetates (EPA-SOs). The antiproliferative activity of PID-SOs and EPA-SOs was assessed on four cancer cell lines (HT-1080, HT-29, M21, and MCF7). The most potent PID-SOs bearing an imidazolidin-2,4-dione group show antiproliferative activity in the nanomolar to low micromolar range (0.066 – 6 μM) while EPA-SOs and PID-SOs bearing an imidazolidin-2,5-dione moiety are mostly not active, exhibiting antiproliferative activity over 100 μM. The most potent PID-SOs (16-18) arrest the cell cycle progression in G2/M phase and interact with the colchicine-binding site leading to the microtubule and cytoskeleton disruption. Moreover, their antiproliferative activity is not impaired in vinblastine-, paclitaxel-, and multidrug-resistant cell lines. Finally, our study confirms that PID-SOs bearing the imidazolidin-2,4-dione moiety are a new family of promising antimitotics. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Synthetic Route of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Synthetic Route of C6H5IO Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Fang, Yuying; Tan, Qingyun; Zhou, Huihao; Gu, Qiong; Xu, Jun published an article in European Journal of Medicinal Chemistry. The title of the article was 《Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents》.Electric Literature of C6H5IO The author mentioned the following in the article:

Herein, with phenotypic assays, a new diphenylbutene derivative ferroptosis inhibitor, DPT was discovered. Based on this hit, new diphenylbutene derivatives I [R1 = H, 2-OMe, 3-OH, etc.; R2 = H, 3-OH, 4-OH, etc.] synthesized via condensation of (piperazinyl)pyrimidine and (phenyl)-phenylpentadienoic acids II and evaluated their ferroptosis inhibitory activities in HT22 mouse hippocampal neuronal cells and found that three compounds exhibited improved inhibitory activities compared with DPT. Among these active compounds, compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] displayed the most potent anti-ferroptosis activity (EC50 = 1.7μM). Further studies demonstrated that compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] was a specific ferroptosis inhibitor. It was revealed that different than the classic ferroptosis inhibitors, compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] blocked ferroptosis by increasing FSP1 protein level. Compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] could penetrate blood-brain barrier (BBB). In a rat model of ischemic stroke, compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] effectively mitigated cerebral ischemic injury. Therefore, it was confirmed that compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] as a novel ferroptosis inhibitor with a new scaffold, was promising for further development as an agent against neurol. diseases. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Electric Literature of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Electric Literature of C6H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com