Category: 626-02-8

In 2022,Wessig, Pablo; Badetko, Dominik; Czarnecki, Maciej; Wichterich, Lukas; Schmidt, Peter; Brudy, Cosima; Sperlich, Eric; Kelling, Alexandra published an article in Journal of Organic Chemistry. The title of the article was 《Studies toward the Total Synthesis of Arylnaphthalene Lignans via a Photo-Dehydro-Diels-Alder (PDDA) Reaction》.COA of Formula: C6H5IO The author mentioned the following in the article:

An efficient method for the preparation of arylnaphthalene lignans (ANLs) was developed, which is based on the photo-dehydro-Diels-Alder (PDDA) reaction. While intermol. PDDA reactions turned out to be inefficient, the intramol. variant using suberic acid as tether linking two aryl propiolic esters smoothly provided naphthalenophanes. The irradiations were performed with a previously developed annular continuous-flow reactor and UVB lamps. In this way, the natural products Alashinol D, Taiwanin C, and an unnamed ANL could be prepared In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8COA of Formula: C6H5IO) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C6H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Single-Electron Transfer from Dimsyl Anion in the Alkylation of Phenols》 was written by Rohe, Samantha; Revol, Guillaume; Marmin, Thomas; Barriault, Daniel; Barriault, Louis. Synthetic Route of C6H5IO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

While attempting to synthesize biaryl ethers we discovered the inadvertent formation of a methylsulfoxylmethyl ether byproduct. Formation of this unexpected byproduct presented an opportunity to streamline the synthesis of methylsulfoxylmethyl ethers. Mechanistic studies suggest a radical pathway with dimsyl potassium as a reducing agent. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Synthetic Route of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides.Synthetic Route of C6H5IO The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Koley, Suvajit; Cayton, Kaylee T.; Gonzalez-Montiel, Gisela A.; Yadav, M. Ramu; Orsi, Douglas L.; Intelli, Andrew J.; Cheong, Paul Ha-Yeon; Altman, Ryan A. published an article in Journal of Organic Chemistry. The title of the article was 《Cu(II)-Catalyzed Unsymmetrical Dioxidation of gem-Difluoroalkenes to Generate α,α-Difluorinated-α-phenoxyketones》.Safety of 3-Iodophenol The author mentioned the following in the article:

A Cu-based catalyst system convergently couples gem-difluoroalkenes with phenols under aerobic conditions to deliver α,α-difluorinated-α-phenoxyketones, an unstudied hybrid fluorinated functional group. Composed of α,α-difluorinated ketone and α,α-difluorinated ether moieties, these compounds have rarely been reported as a synthetic intermediate. Computational predictions and later exptl. corroboration suggest that the phenoxy-substituted fluorinated ketone’s sp3-hybridized hydrate form is energetically favored relative to the resp. nonether variant and that perturbation of the electronic character of the ketone can further encourage the formation of the hydrate. The more facile conversion between ketone and hydrate forms suggests that analogs should readily covalently inhibit proteases and other enzymes. Further functionalization of the ketone group enables access to other useful fluorinated functional groups.3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Influence of Substituents in the Aromatic Ring on the Strength of Halogen Bonding in Iodobenzene Derivatives》 was written by Chernysheva, Maria V.; Bulatova, Margarita; Ding, Xin; Haukka, Matti. Name: 3-Iodophenol And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

The halogen-bonding properties of 3,4,5-triiodobenzoic acid (1, 2), 1,2,3-triiodobenzene (3), 4-iodobenzoic acid (4), pentaiodobenzoic acid ethanol solvate (5), hexaiodobenzene (6a-c), 4-iodobenzonitrile (7), 3-iodobenzonitrile (8), 2,4-diiodoaniline (9), 4-iodoaniline (10), 2-iodoaniline (11), 2-iodophenol (12), 4-iodophenol (13), 3-iodophenol (14), 2,4,6-triiodophenol (15), 4-iodoanisole (16), and 3,4,5-triiodoanisole (17) have been studied. The results suggested that substituents other than halogen in the aromatic ring affect the XB properties of iodide substituents in ortho, meta, and para positions. The effect depends on the electron-withdrawing/electron-donating properties of the substituent. Thus, electron-donating substituents with a pos. mesomeric effect favor m-iodines to act as XB donors. In contrast, electron substituents with a neg. mesomeric effect favor o- and p-iodines to act as XB donors. Furthermore, the stronger the mesomeric effect of the EWG or EDG substituent, the higher the effect it has on the size of the σ-hole and, consequently, on the XB donor ability of the iodide substituent. Structural and computational MEP analyses of 3,4,5-triiodobenzoic acid (1, 2), 1,2,3-triiodobenzene (3), 4-iodobenzoic acid (4), pentaiodobenzoic acid ethanol solvate (5), hexaiodobenzene (6a-c), 4-iodobenzonitrile (7), 3-iodobenzonitrile (8), 2,4-diiodoaniline (9), 4-iodoaniline (10), 2-iodoaniline (11), 2-iodophenol (12), 4-iodophenol (13), 3-iodophenol (14), 2,4,6-triiodophenol (15), 4-iodoanisole (16), and 3,4,5-triiodoanisole (17) have been conducted. The results show that the mesomeric effect of the substituents other than halogen in the benzene ring has an effect on the XB donor-acceptor properties of the iodide substituents in ortho, meta, and para positions. Thus, electron-withdrawing (EWG) substituents with a neg. mesomeric effect, e.g. carboxyl (-COOH) and nitrile (-CN), favor iodines in ortho and para positions to act as halogen-bond donors. On the other hand, electron-donating (EDG) substituents, such as amino (-NH2), hydroxy (-OH), and methoxy (-OCH3) groups, which have a pos. mesomeric effect, increase the ability of m-iodines to act as halogen bond donors. Furthermore, EWG and EDG substituents with stronger mesomeric effects have a greater effect on the XB donor ability of the iodide substituents. Such a correlation is reflected in the size of the σ hole on the iodine atoms. Thus, the σ holes on o- and p-iodine atoms are larger than on m-iodine atoms in the presence of an EWG, making o- and p-iodines favorable XB donors. Similarly, the size of the σ hole on m-iodines is larger than those on o- and p-iodines in the presence of an EDG, causing m-iodines to favor XB donor behavior. This is confirmed by our MEP calculations, in which the size of the σ hole is expressed by the value of the maximum electrostatic potential (VS,max), being a maximum in the case of strong EWG substituents and a min. in the case of strong EDG substituents.3-Iodophenol(cas: 626-02-8Name: 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Name: 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes》 was published in Journal of Organic Chemistry in 2020. These research results belong to Orsi, Douglas L.; Douglas, Justin T.; Sorrentino, Jacob P.; Altman, Ryan A.. Quality Control of 3-Iodophenol The article mentions the following:

Gem-Difluoroalkenes represent valuable synthetic handles for organofluorine chem.; however, most reactions of this substructure proceed through reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products. Taking advantage of the distinct reactivity of gem-difluoroalkenes, we present a cobalt-catalyzed regioselective unsym. dioxygenation of gem-difluoroalkenes using phenols and mol. oxygen, which retains both fluorine atoms and provides β-phenoxy-β,β-difluorobenzyl alcs. Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O2/phenol and quenched by the Co-based catalyst. This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-catalyzed reactions of gem-difluoroalkenes that typically involve defluorination. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2021 ,《Selective Modification for Red-Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry》 was published in Chemistry – A European Journal. The article was written by Becker, Yvonne; Roth, Sina; Scheurer, Maximilian; Jakob, Andreas; Gacek, Daniel A.; Walla, Peter J.; Dreuw, Andreas; Wachtveitl, Josef; Heckel, Alexander. The article contains the following contents:

We developed three bathochromic, green-light activatable, photolabile protecting groups based on a nitrodibenzofuran (NDBF) core with D-π-A push-pull structures. Variation of donor substituents (D) at the favored ring position enabled us to observe their impact on the photolysis quantum yields. Comparing our new azetidinyl-NDBF (Az-NDBF) photolabile protecting group with our earlier published DMA-NDBF, we obtained insight into its excitation-specific photochem. While the “”two-photon-only”” cage DMA-NDBF was inert against one-photon excitation (1PE) in the visible spectral range, we were able to efficiently release glutamic acid from azetidinyl-NDBF with irradiation at 420 and 530 nm. Thus, a minimal change (a cyclization adding only one carbon atom) resulted in a drastically changed photochem. behavior, which enables photolysis in the green part of the spectrum. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocksIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Li; Tang, Huali; Zou, Feihua; Cai, Mingzhong published their research in Polymer Bulletin (Heidelberg, Germany) in 2021. The article was titled 《Synthesis of novel aromatic polyamides containing cardo groups and triphenylphosphine oxide structures by a heterogeneous palladium-catalyzed carbonylation and condensation reaction》.Synthetic Route of C6H5IO The article contains the following contents:

Abstract: New aromatic polyamides containing cardo groups and triphenylphosphine oxide structures were synthesized by a heterogeneous palladium-catalyzed carbonylation and condensation of bis(4-(3-iodophenoxy)phenyl)phenylphosphine oxide (BIPPO), aromatic diamines bearing cardo groups, and carbon monoxide. Polycondensations were carried out in N,N-dimethylacetamide under 1 atm of CO at 120°C in the presence of a magnetically recyclable heterogeneous palladium catalyst and 1,8-diaza-bicyclo[5,4,0]-7-undecene (DBU) and afforded novel aromatic polyamides with inherent viscosities between 0.72 and 0.76 dL/g. All the polyamides were quite soluble in dipolar aprotic solvents and pyridine and could be converted into transparent, flexible, and tough polyamide films by casting from DMAc solutions These polymers exhibited high thermal and thermooxidative stability with the glass transition temperatures of 237°C-256°C, the temperatures at 5% weight loss of 448°C-465°C in air. All the phosphorus-containing polyamides self-extinguished as soon as the flame was removed, and the limited oxygen indexes (LOIs) of these polymers were in the range of 39%-44%. The polymer films also showed good mech. properties and high optical transparency. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Synthetic Route of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides.Synthetic Route of C6H5IO The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Diaz, Jose Luis; Cuevas, Felix; Pazos, Gonzalo; Alvarez-Bercedo, Paula; Oliva, Ana I.; Sarmentero, M. Angeles; Font, Daniel; Jimenez-Aquino, Agustin; Moron, Maria; Port, Adriana; Pascual, Rosalia; Dordal, Albert; Portillo-Salido, Enrique; Reinoso, Raquel F.; Vela, Jose Miguel; Almansa, Carmen published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter》.Electric Literature of C6H5IO The article contains the following contents:

The synthesis and pharmacol. activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the positions amenable for substitution on a nonaminoacidic Cavα2δ-1 scaffold allowed the identification of favorable positions for the attachment of NET pharmacophores. Among the patterns explored, attachment of the 2-ethylamino-9-methyl-6-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin-5-one framework to the meta-position of the Ph ring of the 3-methylamino-1-phenylpropoxy and 3-methylamino-1-thienylpropoxy moieties provided dual compounds with excellent NET functionality. Alternative bicyclic frameworks were also explored, and some lead mols. were identified, which showed a balanced dual profile and exhibited good ADMET properties. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Electric Literature of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C6H5IOIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Mechanochromic Luminescence from Crystals Consisting of Intermolecular Hydrogen-Bonded Sheets》 was written by Sagara, Yoshimitsu; Takahashi, Kiyonori; Nakamura, Takayoshi; Tamaoki, Nobuyuki. HPLC of Formula: 626-02-8 And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

Introduction of functional groups that can form intermol. hydrogen bonds into highly-emissive luminophores is a promising way to induce mechanochromic luminescence. Herein, we report that a 9,10-bis(phenylethynyl)anthracene derivative featuring two amide groups forms green-emissive crystals based on two-dimensional hydrogen-bonded mol. sheets. Mech. grinding changed the emission from green to yellow, owing to a transition from a crystalline to an amorphous phase. IR spectroscopy revealed that mech. stimuli disrupted the linear hydrogen-bonding formation. A thermal treatment recovered the original green photoluminescence. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8HPLC of Formula: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Liang-Neng; Tang, Pan-Ting; Li, Ming; Li, Jia-Wei; Liu, Yue-Jin; Zeng, Ming-Hua published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Double Ligands Enabled Ruthenium Catalyzed ortho-C-H Arylation of Dialkyl Biarylphosphines: Straight and Economic Synthesis of Highly Steric and Electron-Rich Aryl-Substituted Buchwald-Type Phosphines》.Application of 626-02-8 The article contains the following contents:

A double-ligands enabled Ru catalyzed C(sp2)-H arylation of dialkyl phosphines is described, which provides a straight access to aryl-substituted dialkyl phosphine ligands. The combination of 1,3-diketone and amino acid ligands is essential for this transformation. An important six-membered cycloruthenium intermediate was successfully isolated and characterized by x-ray diffraction. Mechanistic studies showed that the 1,3-diketone promoted the process of oxidative addition of cycloruthenium intermediate. Some of modified CyJohnPhos ligands exhibited highly catalytic activity in Pd catalyzed C-N bond formation. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides.Application of 626-02-8 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com