Category: 626-02-8

Shi, Qinjie; Ji, Yuanyuan; Shi, Yanxia; Zhao, Zhenjiang; Zhu, Weiping; Xu, Yufang; Li, Baoju; Qian, Xuhong published an article in 2021. The article was titled 《Fluoro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system》, and you may find the article in Phytochemistry (Elsevier).Application of 626-02-8 The information in the text is summarized as follows:

Plants are known to develop a multi-faceted innate immune system for pathogenic defense. Systemic acquired resistance (SAR) and induced systemic resistance (ISR) are the two main pathways. Many chem. inducers known as plant activators that activate innate immunity to defend against pathogens have been discovered. Currently, the exploitation of new plant activators is mainly done to develop analogs of salicylic acid as SAR-signaling mols.; however, the ISR pathway is hardly investigated for new plant activators. Based on recent studies on 1-methylpyrazolo[3,4-d]pyrimidine bioactivity and ATP-induced resistance to biotrophic and necrotrophic pathogens, a new lead compound, 1-methyl-4-amino-pyrazolo[3,4-d]pyrimidine, was obtained as a new scaffold of plant activators for possible inducing ISR immunity system. Addnl., fluorine atom plays an important role in the design and development of new pesticides due to the unique phys. chem. effect, a series of pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized. Several compounds showed good broad-spectrum induced resistance in vivo, but there was no direct antibacterial activity in vitro. Notably, the introduction of fluorine atom at the para-position of the benzene ring greatly enhanced the induction activity of I both involved in SAR and ISR pathways, which implied the inducing resistance both in defending pathogens and insects. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Application of 626-02-8 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 626-02-8In 2021 ,《Breathing Room: Restoring Free Rotation in a Schiff-Base Macrocycle through Endoperoxide Formation》 appeared in Organic Letters. The author of the article were Chaudhry, Mohammad T.; Ota, Seiya; Lelj, Francesco; MacLachlan, Mark J.. The article conveys some information:

Macrocyclization is a popular method for preparing hosts, but it can have unintended effects, like limiting mol. free rotation to yield mixtures of inseparable isomers. We report a [3 + 3] Schiff-base macrocycle I (1) with anthracene bridges. Restricted rotation about the phenyl-anthracene bonds leads 1 to exist as a mixture of conformations (1Cs and 1C3v). Macrocycle 1 was photooxidized to tris(endoperoxide) adduct 4, alleviating restricted rotation. These results were supported by spectroscopic, structural, and computational analyses. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mertens, R. Tyler; Greif, Charles E.; Coogle, James T.; Berger, Gilles; Parkin, Sean; Watson, Mark D.; Awuah, Samuel G. published an article in 2022. The article was titled 《Stable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes》, and you may find the article in Journal of Catalysis.Electric Literature of C6H5IO The information in the text is summarized as follows:

Herein, the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling was reported. The unsym. character of the Au(I) catalyst was critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Electric Literature of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Electric Literature of C6H5IO Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Pd-Catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents》 was written by Rao, Maddali L. N.; Meka, Suresh. Product Details of 626-02-8This research focused onunsym hydroxybiaryl preparation; iodophenol triarylbismuth reagent cross coupling palladium catalyst. The article conveys some information:

An efficient protocol for the protecting-group-free synthesis of unsym. hydroxybiaryls ArAr1 [Ar = Ph, 4-MeC6H4, 4-FC6H4, etc.; Ar1 = 2-HOC6H4, 4-HOC6H4, 2-HO-5-BrC6H3, etc.] via the Pd-catalyzed cross-couplings of unprotected iodophenols with triarylbismuth reagents was described. The presented protocols exhibited good to high yields of hydroxybiaryls. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Product Details of 626-02-8) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Product Details of 626-02-8 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Jiang, Rui; Ismiyarto; Abe, Tsukasa; Zhou, Da-Yang; Asano, Kaori; Suzuki, Takayoshi; Sasai, Hiroaki; Suzuki, Takeyuki published an article in Journal of Organic Chemistry. The title of the article was 《Using α- and β-Epimerizations of cis-2,3-Bis(hydroxymethyl)-γ-butyrolactone for the Synthesis of Both Enantiomers of Enterolactone》.Category: iodides-buliding-blocks The author mentioned the following in the article:

The use of the epimerization of cis-2,3-bis(hydroxymethyl)-γ-butyrolactone for the synthesis of enterolactones with anticarcinogenic, anti-inflammatory, antiangiogenic, and antioxidant activity were described . Selective α- or β-epimerization of a γ-butyrolactone was used to selectively synthesize both enantiomers of enterolactone. Theor. and kinetic studies were performed to elucidate the epimerization mechanism. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocksIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Gentili, Valentina; Turrin, Giulia; Marchetti, Paolo; Rizzo, Sabrina; Schiuma, Giovanna; Beltrami, Silvia; Cristofori, Virginia; Illuminati, Davide; Compagnin, Greta; Trapella, Claudio; Rizzo, Roberta; Bortolotti, Daria; Fantinati, Anna published an article in Bioorganic Chemistry. The title of the article was 《Synthesis and biological evaluation of novel rhodanine-based structures with antiviral activity towards HHV-6 virus》.Related Products of 626-02-8 The author mentioned the following in the article:

An increased awareness of diseases associated with Human herpesvirus 6 (HHV-6) infection or reactivation has resulted in a growing interest in the evaluation of the best treatment options available for the clin. management of HHV-6 disease. However, no compound has yet been approved exclusively for HHV-6 infection treatment. For this reason, the identification of anti-HHV6 compounds provides a valuable opportunity for developing efficient antiviral therapies. A possible target for antiviral drugs is the virus-cell fusion step. In this study, we synthesized potential fusion intermediates inhibitors based on the rhodanine structure. The obtained derivatives were tested for cytotoxicity and for antiviral activity in human cells infected with HHV6. Level of infection was monitored by viral DNA quantification at different time points up to 7 days post infection. Among the synthesized derivatives, 9e showed a significative inhibitory effect on viral replication that lasted over 7 days, probably attributable to the particular combination of hydrophilic and hydrophobic substituents to the rhodanine moiety. Our results support the use of these amphipathic fusion inhibitors for the treatment of HHV-6 infections. In the experiment, the researchers used 3-Iodophenol(cas: 626-02-8Related Products of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Related Products of 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Jing; Wang, Hui; Wang, Zihan; Li, Linqiang; Qin, Cheng; Luan, Xinjun published their research in Chinese Journal of Chemistry in 2021. The article was titled 《Trifunctionalization of Aryl Iodides with Two Distinct Nitrogen and Carbon Electrophiles by Palladium/Norbornene Catalysis》.Application In Synthesis of 3-Iodophenol The article contains the following contents:

Herein, a highly chemo- and regioselective vicinal trifunctionalization of aryl iodides by palladium/norbornene (Pd/NBE) catalysis is reported. The key feature of this new method is the introduction of two distinct nitrogen and carbon electrophiles, with a large gap in reactivity, for ortho-unsubstituted aryl iodides via an intermol. and intramol. C-H functionalization, resp. Eight types of ipso terminations can be coupled with both ortho-amination and ortho-alkylation, affording a variety of polysubstituted benzoheterocyclic scaffolds. Silicon-tethered substrates can lead to polyfucntional arenes via a single-step operation. Noteworthy, these products exhibit full-color-tunable strong fluorescence emissions with large Stokes shifts, and product I can serve as a fluorescent probe to specifically target lysosome in living cells. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Application In Synthesis of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Application In Synthesis of 3-IodophenolIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Pd-catalyst Anchored on Schiff Base-modified Chitosan-CNT Nanohybrid for the Suzuki-Miyaura Coupling Reaction》 was written by Joo, Seong-Ryu; Kim, Seung-Hoi; Shin, Ueon Sang; Kim, Han-Sem. Reference of 3-Iodophenol And the article was included in Current Organic Chemistry in 2020. The article conveys some information:

A novel Pd-nanoparticle-catalyst supported on chitosan-pyridine-modified carbon nanotube (CNT) was prepared The obtained Pd-catalytic platform (Pd@CS-Py@CNT) was fully characterized and employed to the Suzuki-Miyaura coupling reaction as a heterogeneous catalyst, showing an excellent catalytic activity in aqueous media in the absence of phase transfer agents. Moreover, the easy recoverability and reusability of the catalytic system after a simple manipulation is a great benefit. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Reference of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Reference of 3-Iodophenol Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A bright two-photon fluorescent probe for real-time monitoring autophagy in living cells》 was written by Jiang, Chuankun; Li, Longchun; Jiang, Jiacheng; Hou, Lilin; Fang, Gemin; Haizhu, Yu; Meng, Xiangming. Name: 3-IodophenolThis research focused ontwo photon fluorescent probe autophagy cell. The article conveys some information:

A novel donor-acceptor (D-A) type of two-photon (TP) fluorescent probe, i.e. Lyso-OSC, based on the lysosome-targeting morpholine group was developed. The polarity sensing coumarin group was functionalized as the acceptor and the 1-vinyl-4-methoxybenzene group was engineered as the donor. The fluorescence intensity and emission maximum wavelength of Lyso-OSC are highly sensitive to the polarity changes of solvent. The two-photon absorption cross-section and tissue penetration depth are up to 254 GM and 150μm, resp. The strong fluorescence, high sensitivity to polarity, low cytotoxicity, and accurate lysosome-targeting ability entail Lyso-OSC the excellent performance in detecting the polarity changes of cellular environment. To this end, a bright, real-time imaging autophagy of living cells has been achieved. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8Name: 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Name: 3-Iodophenol In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Iodinated Choline Transport-Targeted Tracers》 was written by Svec, Pavel; Novy, Zbynek; Kucka, Jan; Petrik, Milos; Sedlacek, Ondrej; Kuchar, Martin; Liskova, Barbora; Medvedikova, Martina; Kolouchova, Kristyna; Groborz, Ondrej; Loukotova, Lenka; Konefal, Rafal L.; Hajduch, Marian; Hruby, Martin. Formula: C6H5IO And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

We present a novel series of radioiodinated tracers and potential theranostics for diseases accompanied by pathol. function of proteins involved in choline transport. Unlike choline analogs labeled with 11C or 18F that are currently used in the clinic, the iodinated compounds described herein are applicable in positron emission tomog., single-photon emission computed tomog., and potentially in therapy, depending on the iodine isotope selection. Moreover, favorable half-lives of iodine isotopes result in much less challenging synthesis by isotope exchange reaction. Six of the described compounds were nanomolar ligands, and the best compound possessed an affinity 100-fold greater than that of choline. Biodistribution data of 125I-labeled ligands in human prostate carcinoma bearing (PC-3) mice revealed two compounds with a biodistribution profile superior to that of [18F]fluorocholine. In the experiment, the researchers used 3-Iodophenol(cas: 626-02-8Formula: C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Formula: C6H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com