Category: 626-02-8

In 2022,Yang, Zhenjiao; Zhang, Yongsheng; Lv, Xingxian; Yang, Yang; Jiang, Chunhao; He, Xiaoyan; Chen, Guoliang; Huang, Gang; Lu, Xiuhong published an article in Green Chemistry. The title of the article was 《Copper and neocuproine catalysed synthesis of cinnamyl ether derivatives directly from secondary and tertiary cinnamyl alcohols》.Recommanded Product: 626-02-8 The author mentioned the following in the article:

A new method for the synthesis of secondary and tertiary cinnamyl ether derivatives, e.g., (E)-1-(3-ethoxy-3-methylbut-1-en-1-yl)-4-methylbenzene employing copper sulfate pentahydrate (CuSO4.5H2O) as a catalyst and neocuproine as a ligand, was developed. Interestingly, this method enabled the efficient connection of the long alkoxy chain with secondary or tertiary cinnamyl alcs.e.g., (E)-2-methyl-4-(p-tolyl)but-3-en-2-ol. Through this method, PEG-modified secondary and tertiary cinnamyl alcs. containing natural products and small mol. drugs were realized, providing a green method to generate functional cinnamyl ether derivatives directly. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miller, Eric M.; Walczak, Maciej A. published their research in Organic Letters in 2021. The article was titled 《Light-Mediated Cross-Coupling of Anomeric Trifluoroborates》.Quality Control of 3-Iodophenol The article contains the following contents:

Stereoselective reactions at the anomeric carbon constitute the cornerstone of preparative carbohydrate chem. Here, we report stereoselective C-arylation and etherification reactions of anomeric trifluoroborates derived from BMIDA esters. These reactions are characterized by high anomeric selectivities for 2-deoxysugars and broad substrate scope (24 examples), including disaccharides and trifluoroborates with free hydroxyl groups. Taken together, this new class of carbohydrate reagents adds the palette of anomeric nucleophile reagents suitable for efficient installation of C-C bonds. The experimental part of the paper was very detailed, including the reaction process of 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Quality Control of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Huiqin; Wu, Mei published an article in 2021. The article was titled 《Photocatalytic synthesis of phenols mediated by visible light using KI as catalyst》, and you may find the article in Tetrahedron Letters.Quality Control of 3-Iodophenol The information in the text is summarized as follows:

A transition-metal-free hydroxylation of iodoarenes to afford substituted phenols was described. The reaction was promoted by KI under white LED light irradiation and uses atm. oxygen as oxidant. By the use of triethylamine as base and solvent, the corresponding phenols are obtained in moderate to good yields. Mechanistic studies suggested that KI and catalysis synergistically promote the cleavage of C-I bond to form free aryl radicals. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Quality Control of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jun, Joomyung V.; Raines, Ronald T. published their research in Organic Letters in 2021. The article was titled 《Two-Step Synthesis of α-Aryl-α-diazoamides as Modular Bioreversible Labels》.COA of Formula: C6H5IO The article contains the following contents:

α-Aryl-α-diazoamides were synthesized in two steps under mild conditions. This expeditious route employs Pd-catalyzed C-H arylation of N-succinimidyl 2-diazoacetate to obtain N-succinimidyl 2-aryl-2-diazoacetates, followed by aminolysis. The ensuing diazo compounds can esterify carboxyl groups in aqueous solution, and the ester products are substrates for an esterase. The broad scope of the synthetic route enables the continued development of diazo compounds in chem. biol. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8COA of Formula: C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C6H5IOIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Redox-neutral photochemical Heck-type arylation of vinylphenols activated by visible light》 was published in Chemical Science in 2020. These research results belong to Liang, Kangjiang; Li, Tao; Li, Na; Zhang, Yang; Shen, Lei; Ma, Zhixian; Xia, Chengfeng. Category: iodides-buliding-blocks The article mentions the following:

Disclosed herein is a photochem. Heck-type arylation of vinylphenols with non-activated aryl and heteroaryl halides under visible light irradiation Preliminary mechanistic studies suggested that the colored vinylphenolate anions acted as a strong reducing photoactivator to directly activate (hetero)aryl halides without the need for any sacrificial reductants. The photochem. generated aryl radicals coupled with another mol. of vinylphenol to afford the Heck-type arylation product in a regiospecific and stereoselective manner. The developed photochem. arylation protocol showed exceptional functional group tolerance and was successfully applied in the challenging late-stage modification of natural products without any protection-deprotection procedures. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Category: iodides-buliding-blocks Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mcnamee, Ryan E.; Haugland, Marius M.; Nugent, Jeremy; Chan, Rachel; Christensen, Kirsten E.; Anderson, Edward A. published their research in Chemical Science in 2021. The article was titled 《Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes via directed bridgehead functionalization》.Application In Synthesis of 3-Iodophenol The article contains the following contents:

Bicyclo[1.1.0]butanes (BCBs) are increasingly valued as intermediates in ‘strain release’ chem. for the synthesis of substituted four membered rings and bicyclo[1.1.1]pentanes, with applications including bioconjugation processes. Variation of the BCB bridgehead substituents can be challenging due to the inherent strain of the bicyclic scaffold, often necessitating linear syntheses of specific BCB targets. Here authors report the first palladium catalyzed cross-coupling on pre-formed BCBs which enables a ‘late stage’ diversification of the bridgehead position, and the conversion of the resultant products into a range of useful small ring building blocks. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Application In Synthesis of 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Application In Synthesis of 3-Iodophenol Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tripathy, Alisha Rani; Yedase, Girish Suresh; Yatham, Veera Reddy published their research in RSC Advances in 2021. The article was titled 《Cerium photocatalyzed radical Smiles rearrangement of 2-aryloxybenzoic acids》.Application of 626-02-8 The article contains the following contents:

A cerium photocatalyzed aryl migration from an aryl ether to a carboxylic acid group through radical-Smiles rearrangement was reported. This operationally simple protocol utilized inexpensive CeCl3 as a photocatalyst and converted a variety of 2-aryloxybenzoic acids into aryl-2-hydroxybenzoates in good yields. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application of 626-02-8Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Wu, Wei; Han, Xiaoyan; Weng, Zhiqiang. Application of 626-02-8 The article mentions the following:

A new strategy for the construction of pertrifluoromethyl pyridazine derivatives is presented. The tandem reaction starts from the condensation of arenediazonium salts with hexafluoroacetylacetone leading to the formation of pertrifluoromethyl pyridazinols, which readily underwent electrophilic substitution reactions with phenols to afford benzo[5,6]chromeno[3,4-c]pyridazine products in the presence of concd H2SO4. In the experiment, the researchers used 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Greener, Andrew J.; Ubysz, Patrycja; Owens-Ward, Will; Smith, George; Ocana, Ivan; Whitwood, Adrian C.; Chechik, Victor; James, Michael J. published an article in 2021. The article was titled 《Radical-anion coupling through reagent design: hydroxylation of aryl halides》, and you may find the article in Chemical Science.Application In Synthesis of 3-Iodophenol The information in the text is summarized as follows:

The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions was described. Key to the success of this approach was the identification of a reducing oxime anion which can interact and couple with open-shell aryl radicals. Exptl. and computational studies support the proposed radical-nucleophilic substitution chain mechanism. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Application In Synthesis of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Application In Synthesis of 3-Iodophenol In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques》 was published in Molecular Pharmaceutics in 2020. These research results belong to Jia, Jianhua; Zhang, Longfei; Song, Jia; Dai, Jiapei; Cui, Mengchao. Category: iodides-buliding-blocks The article mentions the following:

The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki < 100 nM) for Aβ1-42 aggregates, and some ligands even showed values of Ki less than 10 nM. Structure-activity relationship anal. revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Category: iodides-buliding-blocks In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com