Category: 625-99-0

In 2019,Journal of the American Chemical Society included an article by Yang, Qi-Liang; Xing, Yi-Kang; Wang, Xiang-Yang; Ma, Hong-Xing; Weng, Xin-Jun; Yang, Xiang; Guo, Hai-Ming; Mei, Tian-Sheng. Application of 625-99-0. The article was titled 《Electrochemistry-Enabled Ir-Catalyzed Vinylic C-H Functionalization》. The information in the text is summarized as follows:

Herein, the development of electrochem. vinylic C-H functionalization of acrylic acids with alkynes is reported. In this reaction an iridium catalyst enables C-H/O-H functionalization for alkyne annulation, affording α-pyrones with good to excellent yields in an undivided cell. Preliminary mechanistic studies show that anodic oxidation is crucial for releasing the product and regeneration of a Ir(III) intermediate from a diene-Ir(I) complex, which is a coordinatively saturated, 18-electron complex. Importantly, common chem. oxidants such as Ag(I) or Cu(II) did not give significant amounts of the desired product in the absence of elec. current under other-wise identical conditions.1-Chloro-3-iodobenzene(cas: 625-99-0Application of 625-99-0) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Application of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Enantioselective Carboetherification/Hydrogenation for the Synthesis of Amino Alcohols via a Catalytically Formed Chiral Auxiliary》 was published in Journal of the American Chemical Society in 2020. These research results belong to Buzzetti, Luca; Purins, Mikus; Greenwood, Phillip D. G.; Waser, Jerome. Product Details of 625-99-0 The article mentions the following:

Chiral auxiliaries and asym. catalysis are the workhorses of enantioselective transformations, but they still remain limited in terms of either efficiency or generality. Herein, we present an alternative strategy for controlling the stereoselectivity of chem. reactions. Asym. catalysis is used to install a transient chiral auxiliary starting from achiral precursors, which then directs diastereoselective reactions. We apply this strategy to a palladium-catalyzed carboetherification/hydrogenation sequence on propargylic amines, providing fast access to enantioenriched chiral amino alcs., important building blocks for medicinal chem. and drug discovery. All stereoisomers of the product could be accessed by the choice of ligand and substituent on the propargylic amine, leading to a stereodivergent process. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Product Details of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Product Details of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Salerno, Silvia; Amendola, Giorgio; Angeli, Andrea; Baglini, Emma; Barresi, Elisabetta; Marini, Anna Maria; Ravichandran, Rahul; Viviano, Monica; Castellano, Sabrina; Novellino, Ettore; Da Settimo, Federico; Supuran, Claudiu T.; Cosconati, Sandro; Taliani, Sabrina published an article in 2021. The article was titled 《Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of 1-Chloro-3-iodobenzene The information in the text is summarized as follows:

Synthesis of a set of new bicyclic tetrahydroindazoles featuring a secondary sulfonamide I [R1 = H, Me, C6H5; R2 = H, Me: R3 = H, 3-Me, 4-Cl, etc.] were described. Biol. evaluation of the inhibitory activity against the hCA I, II, IV, and IX isoforms allowed drawing a structure-activity relationship profile that was rationalized through theor. studies. The new mols. I into the single portions influencing the zinc chelation properties and the selectivity profile thereby which offerred a new platform for the discovery of new isotype selective CA inhibitors. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-3-iodobenzene(cas: 625-99-0Quality Control of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.Quality Control of 1-Chloro-3-iodobenzene The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Aleman-Ponce de Leon, Diego; Sanchez-Chavez, Anahi C.; Polindara-Garcia, Luis A.. Synthetic Route of C6H4ClI. The article was titled 《Pd-Mediated γ-C(sp3)-H Bond Activation in Ammonia-Ugi 4-CR Adducts by Using Picolinamide as Directing Group》. The information in the text is summarized as follows:

The development of a novel protocol for the fast introduction of the picolinamide directing group in aliphatic ketones by using the ammonia-Ugi 4-CR reaction and the subsequent evaluation of the Pd-mediated γ-C(sp3)-H bond activation is described. The methodol. allows the efficient construction of a series of γ-arylated α-aminoamides bearing a congested carbon in two steps.1-Chloro-3-iodobenzene(cas: 625-99-0Synthetic Route of C6H4ClI) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C6H4ClIIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Spatial Anion Control on Palladium for Mild C-H Arylation of Arenes》 was published in Journal of the American Chemical Society in 2020. These research results belong to Dhankhar, Jyoti; Gonzalez-Fernandez, Elisa; Dong, Chao-Chen; Mukhopadhyay, Tufan K.; Linden, Anthony; Coric, Ilija. SDS of cas: 625-99-0 The article mentions the following:

C-H arylation of arenes without the use of directing groups is a challenge, even for simple mols., such as benzene. We describe spatial anion control as a concept for the design of catalytic sites for C-H bond activation, thereby enabling nondirected C-H arylation of arenes at ambient temperature The mild conditions enable late-stage structural diversification of biol. relevant small mols., and site-selectivity complementary to that obtained with other methods of arene functionalization can be achieved. These results reveal the potential of spatial anion control in transition-metal catalysis for the functionalization of C-H bonds under mild conditions. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0SDS of cas: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.SDS of cas: 625-99-0 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sukowski, Verena; van Borselen, Manuela; Mathew, Simon; Fernandez-Ibanez, M. Angeles published an article in Angewandte Chemie, International Edition. The title of the article was 《S,O-Ligand Promoted meta-C-H Arylation of Anisole Derivatives via Palladium/Norbornene Catalysis》.Computed Properties of C6H4ClI The author mentioned the following in the article:

Here, a new catalytic system based on palladium/norbornene and an S,O-ligand for the meta-C-H arylation of aryl ethers that significantly outperforms previously reported systems has been developed. The unique ability of this system to employ alkoxyarene substrates bearing electron donating and withdrawing substituents is demonstrated. Addnl., ortho-substituted aryl ethers are well tolerated, overcoming the “”ortho constraint””, which is the necessity to have a meta-substituent on the alkoxyarene to achieve high reaction efficiency, by enlisting novel norbornene mediators. Remarkably, for the first time the monoarylation of alkoxyarenes is achieved efficiently enabling the subsequent introduction of a second, different aryl coupling partner to rapidly furnish unsym. terphenyls. Further insight into the reaction mechanism was achieved by isolation and characterization of some Pd-complexes-before and after meta C-H activation-prior to evaluation of their resp. catalytic activities. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Computed Properties of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Computed Properties of C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Dan; Hao, Wen-Juan; Rao, Qian; Lu, Yi; Tu, Shu-Jiang; Jiang, Bo published an article in 2021. The article was titled 《Engaging 1,7-diynes in a photocatalytic Kharasch-type addition/1,5-(SN”)-substitution cascade toward β-gem-dihalovinyl carbonyls》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).COA of Formula: C6H4ClI The information in the text is summarized as follows:

A new and general photocatalytic Kharasch-type addition/1,5-(SN”)-substitution cascade of 1,7-diynes with alkyl halides such as BrCCl3 and CBr4 was reported for the first time, and used to produce 65 hitherto unreported β-gem-dihalovinyl ketones/aldehydes with moderate to excellent yields in a highly regioselective manner. This reaction tolerates a wide scope of substrates, which offers a green and efficient entry to fabricate synthetically important β-gem-dihalovinyl carbonyl scaffolds. Notably, the late-stage application of these resulting β-gem-dihalovinyl carbonyls shows high and unique reactivity profiles and demonstrates the versatility of their derivatization. Thus, e.g., treatment of diyne I with CBrCl3 under blue irradiation in presence of fac-Ir(ppy)3 and NaOAc base in EtOH afforded II (80%). In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0COA of Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.COA of Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《γ-Carboline synthesis enabled by Rh(III)-catalyzed regioselective C-H annulation》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Jiang, Bo; Jia, Jingwen; Sun, Yufei; Wang, Yichun; Zeng, Jing; Bu, Xiubin; Shi, Liangliang; Sun, Xiaoying; Yang, Xiaobo. Computed Properties of C6H4ClI The article mentions the following:

A redox-neutral Rh(III)-catalyzed C-H annulation of indolyl oximes were developed. The reaction exhibited a reverse regioselectivity, thus gave an exclusive and easy way for the synthesis of a wide range of substituent free γ-carbolines at C3 position with high efficiency. Deuterium-labeling experiments and kinetic anal. were preliminarily shed light on the working mode of this catalytic system. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Computed Properties of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Computed Properties of C6H4ClI Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 625-99-0In 2022 ,《Enantioselective C-H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Maji, Kakoli; Thorve, Pradip Ramdas; Rai, Pramod; Maji, Biplab. The article conveys some information:

An enantioselective ortho-C(sp2)-H functionalization of ketones/esters, e.g., I (R1 = Me, Et, Ph, OMe; R2 = H, 4-F, 3-MeO, 3,4-benzo, etc.) with 1,6-enynes II [Ar = Ph, X = NTs, O, C(COOMe)2; Ar = 3-ClC6H4, 4-MeOC6H4, 3,5-Me2C6H3, etc., X = NTs] is demonstrated via photoredox/cobalt dual catalysis. The method provides the corresponding arylmethylene-substituted carbo- and heterocycles III in high yields with functional group tolerance and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramol. cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0SDS of cas: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.SDS of cas: 625-99-0 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

HPLC of Formula: 625-99-0In 2022 ,《Diastereoselective palladium-catalyzed C(sp3)-H cyanomethylation of amino acid and carboxylic acid derivatives》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Garai, Sumit; Ghosh, Krishna Gopal; Biswas, Ashik; Chowdhury, Sushobhan; Sureshkumar, Devarajulu. The article conveys some information:

In this study, an efficient protocol for Pd-catalyzed methylene β-C(sp3)-H cyanomethylation of 8-aminoquinoline-directed α-amino acids using inexpensive chloroacetonitrile was reported. Iodoacetonitrile generated in situ from chloroacetonitrile reacts with methylene C(sp3)-H bonds of α-amino acids with excellent diastereoselectivity, enabling access to a wide range of important γ-cyano-α-amino acids. The protocol works well with different amino acid and carboxylic acid derivatives with good chem. yields and high functional group tolerance. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0HPLC of Formula: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.HPLC of Formula: 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com