Category: 625-99-0

Dalal, Arup; Babu, Srinivasarao Arulananda published their research in Synthesis in 2021. The article was titled 《Pd(II)-Catalyzed Directing-Group-Aided C-H Arylation and Alkylation of Pyrene Core: Synthesis of C1,C2- and C1,C10-Disubstituted Pyrene Motifs》.Related Products of 625-99-0 The article contains the following contents:

The application of the Pd(II)-catalyzed, directing-group-aided C-H arylation/alkylation tactics to functionalize the pyrene core, especially, the relatively inaccessible C2 I (R = H; R1 = quinolin-8-yl, 2-(methylsulfanyl)phenyl) and K-region C10 II (R2 = H) positions of the pyrene core and augmentation of the library of pyrene derivatives with C1,C2- I (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, thiophen-2-yl, etc.) and C1,C10-disubstituted pyrene II (R2 = 3,4-dimethylphenyl, 5-bromopyridin-2-yl, Ph, etc.) motifs was reported. The Pd(II)-catalyzed β-C-H arylation/alkylation of the C2-position of pyrene-1-carboxamide I possessing an 8-aminoquinoline directing group yielded various C1,C2-disubstituted pyrenes I. Similarly, the Pd(II)-catalyzed selective γ-C-H arylation/alkylation of the C10-position of N-(pyren-1-yl)picolinamide, possessing a picolinamide directing group, yielded various C1,C10-disubstituted pyrenes II. Examples of C(9)-H arylation of pyrene-1-carboxamide I (R1 = tert-butyl) and the removal of the directing group after the C-H arylation/alkylation reactions were also shown. The structures of representative pyrene derivatives were confirmed by the X-ray structure anal. Given the importance of the pyrene derivatives in various fields of chem. sciences, this report is a contribution towards augmentation of the library of pyrene derivatives with C1,C2- I and C1,C10-disubstituted pyrene amide motifs II. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Related Products of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Shirase, Yuto; Matsumoto, Akinobu; Lim, Kean Long; Tryk, Donald A.; Miyatake, Kenji; Inukai, Junji published an article in ACS Omega. The title of the article was 《Properties and Morphologies of Anion-Exchange Membranes with Different Lengths of Fluorinated Hydrophobic Chains》.Recommanded Product: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

An anion-exchange electrolyte membrane, QPAF(C6)-4, polymerized with hydrophobic 1,4′-bis(3-chlorophenyl)perfluorohexane and hydrophilic 6,6′-(2,7-dichloro-9H-fluorene-9.9-diyl)bis(N,N-dimethylhexan-1-amine) is phys. flexible and chem. stable. The drawbacks are relatively large water swelling and lower OH- conductivity at higher water uptakes, which are considered to be due to the entanglement of the flexible hydrophobic structure of the membrane. In this study, a QPAF(C4)-4 membrane was newly synthesized with shortened hydrophobic fluoroalkyl chains. Unexpectedly, QPAF(C4)-4 showed a higher water uptake and a lower bulk/surface conductivity than QPAF(C6)-4 possibly due to the decrease in hydrophobicity with a smaller number of fluorine atoms. The thermal stability of QPAF(C4)-4 was higher than that of QAPF(C6)-4, possibly due to the rigidity of the QAPF(C4)-4 structure. A higher mech. strength of QAPF(C6)-4 than that of QPAF(C4)-4 could be explained by the larger interactions between mols., as shown in the UV-visible spectrum. The interactions of mols. were understood in more detail with d. functional theory calculations Both the chem. structures of the polymers and the arrangements of the polymers in the membranes were found to influence the membrane properties. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 1-Chloro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Shi, Guanying; Dong, Zhenhua published an article in Molecules. The title of the article was 《Palladium Supported on Porous Organic Polymer as Heterogeneous and Recyclable Catalyst for Cross Coupling Reaction》.Name: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

Palladium immobilized on an amide and ether functionalized porous organic polymer (Pd@AEPOP) is reported to be an effective heterogeneous catalyst for the Heck cross-coupling reaction of aryl iodides with styrene for the synthesis of diphenylethene derivatives Excellent yields can be obtained using a 0.8 mol% Pd catalyst loading under the optimized reaction condition. The heterogeneous Pd@AEPOP catalyst can also be applied on the Suzuki reaction and the reduction of nitroarene. In addition to this study using 1-Chloro-3-iodobenzene, there are many other studies that have used 1-Chloro-3-iodobenzene(cas: 625-99-0Name: 1-Chloro-3-iodobenzene) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 1-Chloro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Das, Ashis; Buzzetti, Luca; Purins, Mikus; Waser, Jerome published an article in ACS Catalysis. The title of the article was 《Palladium-Catalyzed trans-Hydroalkoxylation: Counterintuitive Use of an Aryl Iodide Additive to Promote C-H Bond Formation》.Application In Synthesis of 1-Chloro-3-iodobenzene The author mentioned the following in the article:

Authors report an enantioselective palladium-catalyzed trans-hydroalkoxylation of propargylic amines with a trifluoroacetaldehyde-derived tether to build chiral oxazolidines. Diastereoselective hydrogenation using a heterogeneous palladium catalyst then gave access to protected benzylic amino alcs. in 45-87% yields and 84-94% ee values. Hydroalkoxylation of the alkynes required a catalytic amount of aryl iodide, highlighting the counterintuitive key role played by a putative Pd(II)/ArI oxidative addition complex to promote oxypalladation/protodemetalation. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0Application In Synthesis of 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application In Synthesis of 1-Chloro-3-iodobenzeneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Bisht, Narendra; Singh, Prabhakar; Babu, Srinivasarao Arulananda published an article in Synthesis. The title of the article was 《Pd(II)-Catalyzed, Picolinamide-Aided γ-(sp2)-C-H Functionalization of Racemic and Enantiopure α-Methylbenzylamine and Phenylglycinol Scaffolds》.Recommanded Product: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

In this paper, the Pd(II)-catalyzed, picolinamide DG-aided sp2γ-C-H functionalization and expansion of the library of enantiopure α-methylbenzylamine and phenylglycinol scaffolds RCH(CH2R1)NHC(O)R2 (R = Ph, 4-methylphenyl, 2-chlorophenyl, 4-chlorophenyl; R1 = H, OAc; R2 = Ph, pyridin-2-yl, 5-methyl-1,2-oxazol-3-yl, etc.) were reported. The synthesis of a wide range of racemic and enantiopure ortho-C-H arylated, alkylated, brominated, and iodinated α-methylbenzylamine and phenylglycinol scaffolds e.g., N-(1-(4,4”-dimethoxy-[1,1′:3′,1”-terphenyl]-2′-yl)ethyl)picolinamide was shown. Various racemic and Rand S(chiral) sp2γ-C-H functionalized α-methylbenzylamine and phenylglycinol scaffolds were synthesized with good enantiopurities. Racemic and enantiopure α-methylbenzylamine and phenylglycinol derivatives are important building blocks in organic synthesis and medicinal chem. Accordingly, this work contributes to the expansion of the libraries of α-methylbenzylamine and phenylglycinol motifs and substrate scope development through the Pd(II)-catalyzed bidentate directing group picolinamide-aided site-selective C-H activation and functionalization method. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1-Chloro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Pan, Pan; Liu, Shihan; Lan, Yu; Zeng, Huiying; Li, Chao-Jun published an article in Chemical Science. The title of the article was 《Visible-light-induced cross-coupling of aryl iodides with hydrazones via an EDA-complex》.Electric Literature of C6H4ClI The author mentioned the following in the article:

A visible-light-induced, transition-metal and photosensitizer-free cross-coupling of aryl iodides RI (R = Ph, naphthalen-1-yl, thiophen-3-yl, 4-phenylmorpholine, etc.) with hydrazones R1CH=NNH2 (R1 = Ph, naphthalen-1-yl, pyridin-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) was developed. In this strategy, hydrazones were used as alternatives to organometallic reagents, in the absence of a transition metal or an external photosensitizer, making this cross-coupling mild and green. The protocol was compatible with a variety of functionalities, including Me, methoxy, trifluoromethyl, halogen, and heteroaromatic rings. Mechanistic investigations showed that the association of the hydrazone anion with aryl halides formed an electron donor-acceptor complex, which when excited with visible light generated an aryl radical via single-electron transfer. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0Electric Literature of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Electric Literature of C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sun, Deli; Tao, Xianghua; Ma, Guobin; Wang, Jifen; Chen, Yunrong published an article in Chemical Science. The title of the article was 《Asymmetric synthesis of aryl/vinyl alkyl carbinol esters via Ni-catalyzed reductive arylation/vinylation of 1-chloro-1-alkanol esters》.Name: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

An asym. Ni-catalyzed cross-electrophile coupling approach to prepare enantioenriched aryl/vinyl alkyl carbinol esters RC(O)OC(R1)R2 [R = 4-methylphenyl, iso-Pr, naphthalen-2-yl, etc.; R1 = 4-(methoxycarbonyl)phenyl, 2H-1,3-benzodioxol-5-yl, cyclopent-1-en-1-yl, etc; R2 = Et, 2-phenylethyl, 4-methoxy-4-oxobutyl, etc.] through arylation/vinylation of easily accessible racemic 1-chloro-1-alkanol esters RC(O)OC(Cl)R2 with aryl/vinyl electrophiles R1X (X = Br, I, OTf) was reported. The method features a broad substrate scope as demonstrated by more than 60 examples including the challenging chiral allylic esters. It tolerates a wide array of functional groups including alkenyl, carbonyl and free hydroxyl groups that may not survive in conventional carbonyl reduction and addition methods. The synthetic utility of the present work was showcased by facile preparation of a few key intermediates and the modification of chiral drugs and naturally occurring compounds Finally, an efficient one-pot procedure for this method was described. In the experimental materials used by the author, we found 1-Chloro-3-iodobenzene(cas: 625-99-0Name: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Name: 1-Chloro-3-iodobenzeneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Chen, Yuli; Yang, Shuai; Zhang, Taojun; Xu, Mengdie; Zhao, Jing; Zeng, Minfeng; Sun, Kailang; Feng, Ruokun; Yang, Zhen; Zhang, Peng; Wang, Baoyi; Cao, Xingzhong published an article in Polymer Testing. The title of the article was 《Positron annihilation study of chitosan and its derived carbon/pillared montmorillonite clay stabilized Pd species nanocomposites》.Recommanded Product: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

To establish the structure-properties relations of an organic polymer-inorganic hybrid nanocomposite, insightful investigation of the mols. packing and interfacial interactions is essential. Positron annihilation lifetime spectroscopy (PALS) has been proven as one of the most suitable technique to characterize the free volume structure (mol. packing) of polymer matrixes. However, most of the attentions were paid limitedly in organic polymer-based hybrid systems rather than inorganic-based hybrid systems. Classic spherical model was the most frequently used model in free volume holes size calculation of polymer matrix. In the present study, mol. level micro-defects within inorganic-based hybrid systems encaging polymers and carbon species, i.e. novel biol. macromols. of chitosan and its derived carbon/Al pillared montmorillonite clay (CS/PILC and CS-derived C/PILC) stabilized palladium species hybrid nanocomposites, have been investigated by PALS. Besides the classic spherical model, cuboidal and cylindrical models were used to evaluate the mols. packing behavior within the interlayer space of PILC matrixes encaging of polymers of CS or CS-derived carbons. The layered porous structure of the nanocomposites was also characterized with other methods, such as X-ray diffraction, N2 adsorption/desorption, and high-resolution transmission electron microscopy, etc. The correlations of the microstructure and catalytic properties applied in Sonogashira coupling reactions of the nanocomposites were discussed. In the experiment, the researchers used 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: 1-Chloro-3-iodobenzeneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,He, Dandan; Zhong, Wentao; Zhou, Miaomiao; Wang, Bowen; Li, Meng; Jiang, Huanfeng; Wu, Wanqing published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed Regio- and Stereoselective Coupling of Alkynylsulfones with Alkenes: Access to Dichlorinated Vinyl Sulfones》.COA of Formula: C6H4ClI The author mentioned the following in the article:

A palladium-catalyzed coupling reaction of alkynylsulfones with alkenes/ester was described, which provided an efficient and practical entry to various functionalized dichlorinated vinyl sulfones I [R1 = H, 4-Me, 3-F, etc.; R2 = Me, Ph, 4-ClC6H4, etc.]. This method featured excellent regio- and stereoselectivities, good functional group compatibility, as well as mild reaction conditions. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0COA of Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cui, Wenwen; Li, Xufeng; Guo, Guoju; Song, Xiuyan; Lv, Jian; Yang, Daoshan published an article in 2022. The article was titled 《Radial Type Ring Opening of Sulfonium Salts with Dichalcogenides by Visible Light and Copper Catalysis》, and you may find the article in Organic Letters.Computed Properties of C6H4ClI The information in the text is summarized as follows:

Herein, a copper-catalyzed, blue-light-induced free radical type ring opening of sulfonium salts with dichalcogenides has been initially developed. The developed method features an inexpensive copper catalyst and a broad substrate scope, affording practical access to alkyl chalcogenides in high yields. This reaction presents a novel ring-opening model of sulfonium salts, which breaks the limitation that only the nucleophilic ring-opening reaction could form C-heteroatom bonds and C-C bonds. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Computed Properties of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Computed Properties of C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com