Category: 624-76-0

Related Products of 624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.

To a solution of carbazole 1 (2.0 g, 11.96 mmol) in distilled DMF (20 mL) was added NaH (60% dispersion in mineral oil, 956.9 mg, 23.92 mmol) under nitrogen condition and stirred at 0 C for 30 min. To the reaction mixture was added dropwise 2-iodoethanol (4.1 g, 23.92 mmol) and stirred at 70 C for 24 h. The mixture was extracted with EtOAc and washed with water and dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent, n-hexane/ EtOAc = 3:1) to afford 1.64 g (7.84 mmol , 65%) of the title compound 2.: Rf = 0.18 (n-hexane/EtOAc = 2:1); IR (neat, cm-1) 3253, 3048, 2914, 1492, 1483, 1457, 1348, 1325; 1H NMR d (400 MHz, CDCl3) d 8.07 (2H, td, J = 7.6, 1.2 Hz), 7.44-7.39 (4H, m), 7.22 (2H, td, J = 7.6, 1.2 Hz), 4.38 (2H, t, J = 5.2 Hz); 13C NMR (100 MHz, CDCl3) d 140.9, 126.0, 123.1, 120.6, 119.4, 109.0, 61.6, 45.6.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jin, Guo Hua; Lee, Hwa Jin; Gim, Hyo Jin; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry Letters; vol. 22; 9; (2012); p. 3301 – 3304;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Iodoethanol

To a solution of compound 3 (2.00g, 6.43mmol) in acetone (20mL) was added potassium carbonate (1.33g, 9.64mmol), 2-iodoethanol (0.60mL, 7.72mmol) and stirred overnight at room temperature. After completion of the reaction, 120 water (150mL) and ethyl acetate (150mL) were added and the mixture was extracted with ethyl acetate twice. The combined extracts were washed with water (50mL¡Á2) and brine (50mL¡Á2), and dried over Na2SO4. After filtration, the solvent was removed under vacuum to obtain the crude compound. The crude compound was then purified by column chromatography on silica (60% EA/PE) to give compound 24 4 as a yellow oil (2.10g, yield 92.0%). 1H NMR (400MHz, CDCl3) delta 7.35 (s, 5H), 5.51 – 5.47 (m, 1H), 5.30 – 5.26 (m, 1H), 5.24 – 5.12 (m, 2H), 4.60 – 4.54 (m, 1H), 3.69 – 3.63 (m, 2H), 3.02 – 2.90 (m, 2H), 2.68 – 2.64 (m, 2H), 1.43 (s, 9H). 13C NMR (150MHz, CDCl3) delta 170.96, 155.46, 135.12, 128.76, 128.72, 128.62, 80.45, 67.63, 60.76, 53.77, 53.56, 36.29, 34.91, 28.39. ESI-MS: [M+Na]+ m/z 378.2

The synthetic route of 2-Iodoethanol has been constantly updated, and we look forward to future research findings.

Reference:
Article; Du, Xinming; Qian, Jiawen; Wang, Yujie; Zhang, Mingming; Chu, Yiwei; Li, Yingxia; Bioorganic and Medicinal Chemistry; vol. 27; 13; (2019); p. 2784 – 2800;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 624-76-0, name is 2-Iodoethanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-76-0, category: iodides-buliding-blocks

1.57 g (3 mmol) of the compound (4d) and 1.24 g (9 mmol) of potassium carbonate were added to a 50 ml round bottom flask,Add 25ml double distilled DMF, slowly add iodoethanol 0.7ml (9mmol), the reaction was stirred at 50 for 12h.After the reaction was completed, the reaction mixture was diluted with 100 ml of ethyl acetate and washed with water (25 ml ¡Á 4) to remove DMF. The organic phase was dried over anhydrous Na 2 SO 4 for 1 h, filtered and the filtrateRotate the column to give a pale yellow solid (5d) 1.11g, 65% yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Yantai University; Wang Hongbo; Hong Xuechuan; Fu Fenghua; Tian Jingwei; Lv Zhenbin; Lei Lei; Ma Jinbo; Zhai Rong; Lv Guangyao; (11 pag.)CN106317050; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 624-76-0, name is 2-Iodoethanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 624-76-0

Step 2 tert-Butyl-(2-iodo-ethoxy)-dimethyl-silane To 2-iodoethanol (20 gm, 116 mmol) suspended in methylene chloride (500 mL) was added dimethylaminopyridine (100 mg) followed by diisopropylethylamine (30 mL, 174 mmol) and tert-butyldimethylsilyl chloride (19 gm, 128 mmol). The reaction was stirred overnight and the solvent was removed in vacuo and the residue was passed through a short column of silica gel and eluted with 95:5 methylene chloride: methanol. The desired fractions were combined and the solvent was removed in vacuo to give the desired product. 1 H NMR (400 MHz, CDCl3) delta 3.84 (dd, 2H); 3.20 (dd, 2H); 0.9 (m, 9H); 0.1 (m, 6H).

According to the analysis of related databases, 624-76-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck & Co., Inc.; US5939439; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 624-76-0, name is 2-Iodoethanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-76-0, category: iodides-buliding-blocks

To the mixture of 4-iodopyridin-2(1H)-one (50 mg, 0.213 mmol) in DMF (3 mL) was added 2-iodoethanol (73 mg, 0.426 mmol), K2CO3 (88 mg, 0.638 mmol) at rt. The mixture was stirred for 2 h at rt. After the reaction was finished, the mixture was washed with water and extracted with EtOAc. The organic phase was washed with brine, dried over Na2SO4, filtered, and concentrated to give the crude product, which was purified by TLC to provide 1-(2-hydroxyethyl)-4-iodopyridin-2(1H)-one (60 mg 100%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH; US2010/331320; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 624-76-0,Some common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, molecular formula is C2H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

taking theobromine 540mg (3mmoL), NaH 720mg (30mmol) dissolved in 80mL DMF, adding 2mmol of 2-iodoethanol under the drop, after 4 hours of reaction, quenching the reaction with water, spin dry, oil Ether: CH3CH2OCOCH3 = 3:1 (v/v) as a mobile phase over silica gel to give compound 1-ethylhydroxy-3-7-dimethylxanthine, yield 94%.

The synthetic route of 624-76-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan University Huaxi Hospital; Huang Wen; (18 pag.)CN109912598; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

624-76-0, name is 2-Iodoethanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 624-76-0

Example XII 2-(adamantan-1-ylamino)ethanol 1-Adamantylamine (1 g, 6.05 mmol) and 2-iodoethanol (1.20 g, 7.00 mmol) were dissolved in benzonitrile (2 ml). The mixture was heated at 120 C. for 12 h. After this, the precipitate was filtered off and carefully washed with petrolether (3*20 ml). The white solid was dissolved in DCM (30 ml) and washed with a saturated solution of Na2CO3 (3*50 ml). The organic layer was separated, dried with Na2SO4 and the solvent was removed under reduced pressure to yield the title compound as colourless oil (950 mg, 4.86 mmol, 80%). 1H NMR (250 MHz, CD2Cl2): delta=1.55 (m, 12H, -CH2-), 1.99 (bs, 5H, -CH- and over-lapping OH, NH), 2.65 (t, 2H, J=5 Hz, -CH2-), 3.44 (t, 2H, J=5.1 Hz, -CH2-); all spectroscopic data are in good agreement with previously reported ones, e.g. P. E. Aldrich, E. C. Herrmann, W. E. Meier, M. Paulshock, W. W. Prichard, J. A. Snyder, J. C. Watts, J. Med. Chem. 1971, 14, 535-543.

Statistics shows that 624-76-0 is playing an increasingly important role. we look forward to future research findings about 2-Iodoethanol.

Reference:
Patent; BASF SE; BASF (CHINA) COMPANY LIMITED; HASHMI, A., Stephen K.; LOTHSCHUeTZ, Christian; WO2012/56419; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 624-76-0, name is 2-Iodoethanol, This compound has unique chemical properties. The synthetic route is as follows., 624-76-0

A solution of 2,3,3-trimethyl-3H-indole (1 ml, 6.3 mmol) and 2-iodoethanol (0.56 ml, 8.8 mmol) in MeCN (4 mL) was refluxed for 1 day. After being cooled to r.t., the reaction mixture was suspended in hexane, and the precipitated solid was sonicated and filtered. A part of the obtained purple solid (53 mg out of 1.37 g) was dissolved in 1N KOH (2 mL) and stirred at r.t. for 30 min. After extraction with ether, the organic layer was evaporated to afford 4 as yellow oil, which was used for the next reaction without further purification. A solution of 5-nitrososalicylaldehyde (38 mg, 0.23 mmol) and the obtained 4 in EtOH (5 mL) was refluxed for 4 hours. The mixture was evaporated and purified by column chromatography (silica gel; eluent, hexane_AcOEt=1:1) to afford purple crystal 5 (56 mg, 66% based on 2,3,3-trimethyl-3H-indole). MS(EI): 352(M+, 15), 337(5), 321(9), 83(100); HRMS(EI): M+352.1411 (calc.352.1423); 1H NMR(CDCl3) delta1.20 (s, 3H), 1.30 (s, 3H), 3.34 (ddd, J=5.1, 5.1, 14.7 Hz, 1H), 3.47 (ddd, J=5.5, 7.3, 14.7 Hz, 1H), 3.69-3.82 (m, 2H), 5.89 (d, J=10.5 Hz, 1H), 6.67 (d, J=7.5 Hz, 1H), 6.77 (d, J=8.5 Hz, 1H), 6.90 (dd, J=7.5, 7.5 Hz, 1H), 6.91 (d, J=10.5 Hz, 1H), 7.10 (dd, J=1.1, 7.5 Hz, 1H), 7.50 (ddd, J=1.1, 7.5, 7.5 Hz, 1H), 8.00 (d, J=2.5, 1H), 8.03 (dd, J=2.5, 8.5 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; US2007/195309; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 624-76-0

General procedure: To a stirred solution of compound 42 (1.0 eq) and the corresponding alkyl iodide (1.0 eq) in THF (0.1 M) was added Et3N (2.0 eq) and themixture was stirred at room temperature for 20 h. The reaction mixture was purified by preparative HPLC (direct injection of reaction mixture) and the combined HPLC fractions were concentrated. The residue was dissolved in DCM and then washed with 2M aqueous NaOH, brine, dried over anhydrous Na2SO4 and then concentrated to give the product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 624-76-0.

Reference:
Article; Arns, Steve; Balgi, Aruna D.; Shimizu, Yoko; Pfeifer, Tom A.; Kumar, Nag; Shidmoossavee, Fahimeh S.; Sun, Sharon; Tai, Sheldon S.-H.; Agafitei, Olga; Jaquith, James B.; Bourque, Elyse; Niikura, Masahiro; Roberge, Michel; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 64 – 73;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.

Compound 5 (1.41 g, 0.0043 mol) and potassium carbonate (1.78 g, 0.0129 mol) were added into a round bottom flask. The flask was made free of water and oxygen. The mixture was dissolved with DMF (60 ml). Then 2-iodo-ethanol (0.67 ml, 0.0086 mol) was slowly added dropwise. The reaction was raised to 50 C. and stirred. After completion of the reaction, the reaction was dissolved with ethyl acetate (250 ml), and then extracted with water (3¡Á60 ml) to remove DMF, and washed with saturated brine, dried with anhydrous magnesium sulfate, filtered, evaporated to dryness, and dried by pumping to provide a white solid 6 (1.475 g, 93.35%).

The chemical industry reduces the impact on the environment during synthesis 624-76-0. I believe this compound will play a more active role in future production and life.

Reference:
Patent; YANTAI UNIVERSITY; WANG, Hongbo; HONG, Xuechuan; ZHU, Xi; WANG, Pengyu; LV, Guangyao; FU, Jie; LUO, Huairong; ZHANG, Jianqiao; WEN, Meng; QU, Chunrong; ZHU, Jinmei; HU, Xianming; (7 pag.)US2016/102066; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com