Category: 624-73-7

In 2018,Ali, Safaa H.; Deacon, Glen B.; Junk, Peter C.; Hamidi, Shima; Wiecko, Michal; Wang, Jun published 《Lanthanoid Pseudo-Grignard Reagents: A Major Untapped Resource》.Chemistry – A European Journal published the findings.Recommanded Product: 624-73-7 The information in the text is summarized as follows:

Pseudo-Grignard reagents PhLnI (Ln = Yb, Eu), readily prepared by the oxidative addition of iodobenzene to Yb or Eu metal at -78° in THF or 1,2-dimethoxyethane (DME), react with a range of bulky N,N’-bis(aryl)formamidines to generate an extensive series of LnII or more rarely LnIII complexes, [Eu(DippForm)I(THF)4]·THF (1), [{EuI2(dme)2}2] (2), [Eu(XylForm)I(dme)2]·0.5 dme (3a), [Eu(XylForm)I(dme)(μ-dme)]n (3b), [{Eu(XylForm)I(μ-OH)(THF)2}2] (4), [Yb(DippForm)I(THF)3]·THF (5 a), [Yb(DippForm)I2(THF)3]·2 THF (5 b), [{Yb(MesForm)I(THF)2}2] (6), [{Yb(XylForm)I(THF)2}2] (7a), and [Yb(XylForm)2I(dme)]·dme (7b) {Form = ArNCHNAr; XylForm (Ar = 2,6-Me2C6H3), MesForm (Ar = 2,4,6-Me3C6H2), DippForm (Ar = 2,6-iPr2C6H3)}. Reaction of PhEuI and MesFormH in DME consistently gave 2, and reaction with XylFormH in THF gave 4. Eu complexes 1 and 3a are seven-coordinate divalent monomers, while 3b is a seven-coordinate dme-bridged polymer. Complex 5a of the smaller YbII is a six-coordinate monomer, but the related 6 and 7a are six-coordinate iodide-bridged dimers. 4 Is a trivalent seven-coordinate hydroxide-bridged dimer, whereas complexes 5b and 7b are seven-coordinate monomeric YbIII derivatives A characteristic structural feature is that iodide ligands are cisoid to the formamidinate ligand. To illustrate the synthetic scope of the pseudo-Grignard reagents, [Yb(Ph2pz)I(THF)4] (Ph2pz = 3,5-diphenylpyrazolate) was oxidized with 1,2-diiodoethane to afford seven-coordinate monomeric pyrazolato-Yb(III) iodide [Yb(Ph2Pz)I2(THF)3] (8) in high yield, while metathesis between [Yb(Ph2pz)I(THF)4] and NaCp gave [Yb(C5H5)(Ph2pz)(THF)]n (9), a nine-coordinate η5:η5-Cp-bridged coordination polymer. Reaction of the pseudo-Grignard reagent MeYbI with KN(SiMe3)2 gave [K(dme)4][Yb{N(SiMe3)2}3] (10) with a charge-separated three-coordinate homoleptic [Yb{N(SiMe3)2}3]- anion, a complex that could be obtained in high yield by deliberate synthesis from YbI2 and KN(SiMe3)2 in DME. In addition to this study using 1,2-Diiodoethane, there are many other studies that have used 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Ito, Masahiro; Tanaka, Toshio; Cary, Douglas R.; Iwatani-Yoshihara, Misa; Kamada, Yusuke; Kawamoto, Tomohiro; Aparicio, Samuel; Nakanishi, Atsushi; Imaeda, Yasuhiro published 《Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors》.Journal of Medicinal Chemistry published the findings.Reference of 1,2-Diiodoethane The information in the text is summarized as follows:

Eukaryotic initiation factor 4A3 (eIF4A3), a member of the DEAD-box RNA helicase family, is one of the core components of the exon junction complex (EJC). The EJC is known to be involved in a variety of RNA metabolic processes typified by nonsense-mediated RNA decay (NMD). In order to identify mol. probes to investigate the functions and therapeutic relevance of eIF4A3, a search for selective eIF4A3 inhibitors was conducted. Through the chem. optimization of 1,4-diacylpiperazine derivatives identified via high-throughput screening (HTS), we discovered the first reported selective eIF4A3 inhibitor 53a exhibiting cellular NMD inhibitory activity. A surface plasmon resonance (SPR) biosensing assay ascertained the direct binding of 53a and its analog 52a to eIF4A3 and revealed that the binding occurs at a non-ATP binding site. Compounds 52a and 53a represent novel mol. probes for further study of eIF4A3, the EJC, and NMD. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Reference of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Graff, Julien; Lastawiecka, Elzbieta; Guenee, Laure; Leroux, Frederic; Alexakis, Alexandre published 《Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands》.Advanced Synthesis & Catalysis published the findings.Application of 624-73-7 The information in the text is summarized as follows:

The desymmetrization of the prochiral tetrabromobiphenyl via asym. bromine-lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Application of 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation》 was written by Takeuchi, Issei; Ishizuka, Yukiko; Uchiro, Hiromi; Makino, Kimiko. Safety of 1,2-DiiodoethaneThis research focused ontumor antitumor boron neutron capture therapy liposome PEGylation. The article conveys some information:

Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of 10B into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40-43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 μg/g of tissue and over 5 at 8-24 h, resp. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 μg/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral 10B amount without replacing the 11B with 10B. In the experiment, the researchers used many compounds, for example, 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 1,2-DiiodoethaneIn 2021 ,《Cooperative Catalysis of Ru(III)-Porphyrin in CO2-Involved Synthesis of Oxazolidinones》 appeared in Chemistry – An Asian Journal. The author of the article were Chen, Xiao-Chao; Yao, Yin-Qing; Zhao, Kai-Chun; Liu, Lei; Lu, Yong; Liu, Ye. The article conveys some information:

Herein, a Ru(III)-porphyrin catalyst (RuCl3·3H2O-H2TPP) was found highly efficient in the three-component reaction of CO2, aliphatic amines and dichloroethane (or its derivative) for synthesis of oxazolidinones in the yields of 71∼91%. It was indicated by means of the control experiments and UV-vis spectra that CO2 was stoichiometrically activated by the involved aliphatic amine substrates to form a stable carbamate salt while 1,2-dichloroethane (or its derivative) was independently activated by the involved Ru(III)-porphyrin catalyst. The combination of CO2-activation by aliphatic amines with 1,2-dichloroethane activation by Ru(III)-porphyrin catalyst cooperatively contributed to this successful transformation. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Chemistry – A European Journal included an article by Tahara, Takuma; Suzuki, Shuichi; Kozaki, Masatoshi; Shiomi, Daisuke; Sugisaki, Kenji; Sato, Kazunobu; Takui, Takeji; Miyake, Yota; Hosokoshi, Yuko; Nojiri, Hiroyuki; Okada, Keiji. Quality Control of 1,2-Diiodoethane. The article was titled 《Triplet Diradical-Cation Salts Consisting of the Phenothiazine Radical Cation and a Nitronyl Nitroxide》. The information in the text is summarized as follows:

The spin-spin and magnetic properties of two (nitronyl nitroxide)-(di-p-anisylamine-phenothiazine) diradical cation salts, (DAA-PTZ)+-NN·MBr4- (M = Ga, Fe), have been investigated. These diradical-cation species were prepared by the cross-coupling of iodophenothiazine DAA-PTZ-I with NN-AuPPh3 followed by oxidation with the thianthrenium radical cation (TA+·MBr4-). These salts are highly stable under aerobic conditions. For the GaBr4 salt, large ferromagnetic intramol. and small antiferromagnetic intermol. interactions (J1/kB=+320 K and J2/kB=-2 K, resp.) were observed The magnetic property of the Fe3+ salt was analyzed by using a six-spin model assuming identical intramol. exchange interaction (J3/kB=+320 K) and the other exchange interactions (J4/kB=-7 K and J5/kB=-4 K). A significant color change was observed in the UV/visible/NIR absorption spectra upon electrochem. oxidation of the doublet DAA-PTZ-NN to the triplet (DAA-PTZ)+-NN. In the experiment, the researchers used 1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《ImX-MCM-41 (X = Cl, Br and I): Active catalysts for the solvent free synthesis of phenyl glycidyl carbonate》 were Appaturi, Jimmy Nelson; Adam, Farook. And the article was published in Surfaces and Interfaces in 2019. Computed Properties of C2H4I2 The author mentioned the following in the article:

The ImX-MCM-41 (X = Cl, Br and I) catalysts were synthesized via grafting technique using MCM-41 synthesized by simple sol-gel method. These catalysts were characterized using FT-IR, N2-sorption, 13C CP/MAS NMR, XRD, TEM and SEM/EDS techniques. 13C CP/MAS NMR and FT-IR discovered the effective anchorage of imidazole and 1,2-dihaloethane on the MCM-41. SEM anal. images demonstrated that the catalysts comprise worm-like agglomerated structure which was alike to MCM-41. The catalysts were then used in cycloaddition of carbon dioxide and Ph glycidyl ether under solvent less and co-catalyst free conditions. Among the prepared catalyst, ImBr-MCM-41 showed higher catalytic activity (96.7%) under ambient reaction conditions (100 °C, 20 bar initial CO2 pressure, 300 mg catalyst mass and 3 h). It was found that the use of ImI-MCM-41 and ImCl-MCM-41 resulted in a conversion of 77.3% and 26.4% resp. under the same reaction conditions. These results verified that the synergic effect owing to the strong nucleophilic characteristics of Br- and amine could have promoted the reaction efficiently. The catalyst was reproduced and reused four times without a substantial decrease in performance or product selectivity. A possible site for CO2 activation by ImBr-MCM-41 catalyst has been proposed. In the experiment, the researchers used many compounds, for example, 1,2-Diiodoethane(cas: 624-73-7Computed Properties of C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Xiao-Chao; Zhao, Kai-Chun; Yao, Yin-Qing; Lu, Yong; Liu, Ye published an article in 2021. The article was titled 《Synergetic activation of CO2 by the DBU-organocatalyst and amine substrates towards stable carbamate salts for synthesis of oxazolidinones》, and you may find the article in Catalysis Science & Technology.Quality Control of 1,2-Diiodoethane The information in the text is summarized as follows:

The development of an efficient methodol. to transform CO2 into valuable chems. has attracted increasing attention concerning the challenging issues of CO2-utilization. Herein, an efficient approach for the preparation of oxazolidinones from CO2, primary (aliphatic/aromatic) amines and 1,2-dichloroethane (or its derivatives) catalyzed by DBU organo-superbase was achieved with yields of 47-97% under mild conditions (80-100°C, 12 h, 1.0 MPa CO2). Control experiments demonstrated that the formation of an ion-pair carbamate salt intermediate IS-B derived from the reaction of CO2, DBU (catalyst) and an amine (substrate) was the key step for this three-component reaction. The available DBU-amine-CO2 adduct intermediate (like IS-B-2) with fair stability will evolve into the thermodynamically stable product oxazolidinones upon attack of 1,2-dichloroethane (or its derivatives), along with the regeneration of the DBU catalyst. Alternatively, the decomposition of the DBU-aryl amine-CO2 adduct (like IS-B-1) with relatively poor stability also could result in the competitive substitution reaction of 1,2-dichloroethane (or its derivatives) with the aryl amine. This work provides insights into synergetic CO2-activation by the DBU-catalyst and a nucleophilic amine-substrate via the formation of robust carbamate salt intermediates responsible for the final production of oxazolidinones. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Toontom, N.; Posri, W.; Lertsiri, S.; Meenune, M. published 《Effect of drying methods on Thai dried chilli’s hotness and pungent odour characteristics and consumer liking》.International Food Research Journal published the findings.Formula: C2H4I2 The information in the text is summarized as follows:

Dried chilli is widely used for its hotness and pungent odor enhancing properties. In an attempt to get a broad overview of drying effects on hotness and pungent odor characteristics contributing to dominant features of various types of Thai dried chilli, major volatile flavor compounds responsible for perceived hotness and pungent odor of the dried chilli-(freeze (FD), hot air (HD) and sun (SD) dried samples) were identified by trained panel (n = 15) in conjunction with HS-SPME/GC-MS and LLE/GC-MS. Consumer liking of the three dried chilli was assessed on the basis of pungent odor and hotness characteristics by Thai consumers (n = 120) using 9 point-category hedonic scale. The GC-MS and trained panel data were analyzed by PLS and results show that capsaicin was the main compound responsible for the oral hotness sensation, while 1-penten-3-one compound was found to be an indicator of strong pungent odor. The FD sample presented the highest intensity of hotness characteristic (p≤0.05). The content of 1-penten-3-one in FD was also higher than that of HD and SD. Although trained panellists could not differentiate between the intensities of pungent odor of FD and HD (p>0.05), consumers had a tendency to prefer HD. This research proposes that there is substantial value to anal. such as this that integrates human sensorial perception with objective measurement. The outputs of this research can be used to provide guidance on dried chilli product development based on consumer acceptance criteria. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Formula: C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Formula: C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Wangoli, Panyako Asman; Kinunda, Grace published 《The effect of alkyl chain tethers on the kinetics and mechanistic behaviour of bifunctional dinuclear platinum(II) complexes bearing N,N’-dipyridylamine ligands》.New Journal of Chemistry published the findings.Reference of 1,2-Diiodoethane The information in the text is summarized as follows:

In the current paper, the authors report the kinetics of bifunctional dinuclear Pt(II) complexes, viz., {1,2-bis(di-2-pyridylamino)alkane}tetraaquadiplatinum(II), alkane = (CH2)2 (PtL2), (CH2)3 (PtL3), (CH2)4 (PtL4), (CH2)5 (PtL5) and (CH2)6 (PtL6). The substitution reactions were carried out on tetraaqua complexes with thiourea nucleophiles under pseudo-first-order conditions as a function of nucleophile concentration and temperature by stopped-flow and UV-visible spectrophotometric techniques. An exptl. study was conducted with the aim of determining the influence of alkyl chains on the steric and electronic structure of dinuclear Pt(II) complexes. The reactivity of these complexes was dependent on the length of the alkylene spacer. The results obtained herein demonstrate the intriguing odd-even effects induced by the alkyl chain on the complexes. Artificial constraints imposed by the alkyl chain significantly affect their conformational structure to be either synperiplanar (syn-) or antiperiplanar (anti-) characterized by the odd and even effect. The kinetic, mechanistic and conformational behavior was influenced by the size of the alkyl chain in accordance with odd-even alterations of the spacer. Computational modeling using d. functional theory (DFT) calculations supplemented exptl. findings that structural features and the reactivity pattern of these metal complexes are governed by both steric and electronic effects arising from the flexibility and inductive nature of the alkyl spacer. The strong σ-donicity of longer alkyl chains favors sufficient accumulation of electron d. at the metal center and stabilizes a 14-electron intermediate. The study shows the HOMO-LUMO energy (ΔE) is affected by the length of the spacer. Kinetic and DFT data indicate electron donation by the alkyl spacer. The low pos. values of enthalpy of activation and significantly large neg. values of entropy of activation indicate an associative mechanism of substitution. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Reference of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com