Category: 624-31-7

《Polarity-Reversal Strategy for the Functionalization of Electrophilic Strained Molecules via Light-Driven Cobalt Catalysis》 was published in Journal of the American Chemical Society in 2020. These research results belong to Ociepa, Michal; Wierzba, Aleksandra J.; Turkowska, Joanna; Gryko, Dorota. Safety of 1-Iodo-4-methylbenzene The article mentions the following:

Strain-release-driven methodol. is a powerful tool for accessing structural motifs, highly desirable by the pharmaceutical industry. The reactivity of spring-loaded cyclic reagents is dominated by transformations relying on their inherent electrophilic reactivity. Herein, we present a polarity-reversal strategy based on light-driven cobalt catalysis, which enables the generation of nucleophilic radicals through strain release. The applicability of this methodol. is demonstrated by the design of two distinct types of reactions: Giese-type addition and Co/Ni-catalyzed cross-coupling. Moreover, a series of electrochem., spectroscopic, and kinetic experiments as well as X-ray structural anal. of the intermediate alkylcobalt(III) complex give deeper insight into the mechanism of the reaction. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Safety of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Safety of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Green tea extract-modified silica gel decorated with palladium nanoparticles as a heterogeneous and recyclable nanocatalyst for Buchwald-Hartwig C-N cross-coupling reactions》 was written by Veisi, Hojat; Tamoradi, Taiebeh; Karmakar, Bikash; Hemmati, Saba. Application of 624-31-7 And the article was included in Journal of Physics and Chemistry of Solids in 2020. The article conveys some information:

A novel green tea extract-encapsulated silica gel decorated with in situ-generated Pd nanoparticles is reported as an efficient, green heterogeneous catalyst in the Buchwald-Hartwig C-N cross-coupling reaction. It was characterized by several anal. techniques. Thereafter, a wide range of aryl amines were synthesized in good to excellent yields by reaction of different substituted aryl halides and secondary amines over the catalyst. The material is sufficiently stable and could be used at least six times in a model Buchwald-Hartwig reaction without noticeable change in its catalytic activity. Heterogeneity of the catalyst was examined by a hot filtration test. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Application of 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Application of 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks》 was written by Derosa, Joseph; Kang, Taeho; Tran, Van T.; Wisniewski, Steven R.; Karunananda, Malkanthi K.; Jankins, Tanner C.; Xu, Kane L.; Engle, Keary M.. Quality Control of 1-Iodo-4-methylbenzene And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

A nickel-catalyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides, and aryl/alkenyl boronic esters is reported. The reaction delivers the desired 1,2-diarylated and 1,2-arylalkenylated products with excellent regiocontrol. To demonstrate the synthetic utility of the method, a representative product is prepared on gram scale and then diversified to eight 1,2,3-trifunctionalized building blocks using two-electron and one-electron logic. Using this method, three routes toward bioactive mols. are improved in terms of yield and/or step count. This method represents the first example of catalytic 1,2-diarylation of an alkene directed by a native carboxylate group. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Quality Control of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Quality Control of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qin, Yangzhong; Sun, Rui; Gianoulis, Nikolas P.; Nocera, Daniel G. published an article in 2021. The article was titled 《Photoredox Nickel-Catalyzed C-S Cross-Coupling: Mechanism, Kinetics, and Generalization》, and you may find the article in Journal of the American Chemical Society.Computed Properties of C7H7I The information in the text is summarized as follows:

Photoredox-mediated nickel-catalyzed cross-couplings have evolved as a new effective strategy to forge carbon-heteroatom bonds that are difficult to access with traditional methods. Exptl. mechanistic studies are challenging because these reactions involve multiple highly reactive intermediates and perplexing reaction pathways, engendering competing, but unverified, proposals for substrate conversions. Here, we report a comprehensive mechanistic study of photoredox nickel-catalyzed C-S cross-coupling based on time-resolved transient absorption spectroscopy, Stern-Volmer quenching, and quantum yield measurements. We have (i) discovered a self-sustained productive Ni(I/III) cycle leading to a quantum yield Φ > 1; (ii) found that pyridinium iodide, formed in situ, serves as the dominant quencher for the excited state photocatalyst and a critical redox mediator to facilitate the formation of the active Ni(I) catalyst; and (iii) observed critical intermediates and determined the rate constants associated with their reactivity. Not only do the findings reveal a complete reaction cycle for C-S cross-coupling, but the mechanistic insights have also allowed for the reaction efficiency to be optimized and the substrate scope to be expanded from aryl iodides to include aryl bromides, thus broadening the applicability of photoredox C-S cross-coupling chem. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Computed Properties of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-rich Substrates》 was written by Doobary, Sayad; Sedikides, Alexi T.; Caldora, Henry P.; Poole, Darren L.; Lennox, Alastair J. J.. HPLC of Formula: 624-31-7This research focused onvicinal difluoroalkane preparation difluorination unactivated alkene hypervalent iodine mediator; electrochem difluorination unactivated alkene hypervalent iodine mediator; electrochemistry; fluorination; green chemistry; hypervalent iodine; oxidation. The article conveys some information:

Fluorinated alkyl groups are important motifs in bioactive compounds, pos. influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochem. generation of a hypervalent iodine mediator using an “”ex-cell”” approach, which avoids oxidative substrate decomposition The more sustainable conditions give good to excellent yields in up to decagram scales. Of note, when handling HF reagents, personal protection is of utmost importance. In the experimental materials used by the author, we found 1-Iodo-4-methylbenzene(cas: 624-31-7HPLC of Formula: 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.HPLC of Formula: 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed Carboxylate O-Arylations》 was published in Journal of the American Chemical Society in 2020. These research results belong to Malik, Jamal A.; Madani, Amiera; Pieber, Bartholomaeus; Seeberger, Peter H.. Synthetic Route of C7H7I The article mentions the following:

Dual photocatalysis and nickel catalysis can effect cross-coupling under mild conditions, but little is known about the in situ kinetics of this class of reactions. We report a comprehensive kinetic examination of a model carboxylate O-arylation, comparing a state-of-the-art homogeneous photocatalyst (Ir(ppy)3) with a competitive heterogeneous photocatalyst (graphitic carbon nitride). Exptl. conditions were adjusted such that the nickel catalytic cycle is saturated with excited photocatalyst. This approach was designed to remove the role of the photocatalyst, by which only the intrinsic behaviors of the nickel catalytic cycles are observed The two reactions did not display identical kinetics. Ir(ppy)3 deactivates the nickel catalytic cycle and creates more dehalogenated side product. Kinetic data for the reaction using Ir(ppy)3 supports a turnover-limiting reductive elimination. Graphitic carbon nitride gave higher selectivity, even at high photocatalyst-to-nickel ratios. The heterogeneous reaction also showed a rate dependence on aryl halide, indicating that oxidative addition plays a role in rate determination The results argue against the current mechanistic hypothesis, which states that the photocatalyst is only involved to trigger reductive elimination. The experimental process involved the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Synthetic Route of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Synthetic Route of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Swyka, Robert A.; Zhang, Wandi; Richardson, Jeffery; Ruble, J. Craig; Krische, Michael J.. Computed Properties of C7H7I. The article was titled 《Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki-Hiyama-Kishi-Type Addition》. The information in the text is summarized as follows:

The first intermol. carbonyl arylations via transfer hydrogenative reductive coupling are described. Using rhodium catalysts modified by tBu2PMe, sodium formate-mediated reductive coupling of aryl iodides with aldehydes occurs in a chemoselective fashion in the presence of protic functional groups and lower halides. This work expands the emerging paradigm of transfer hydrogenative coupling as an alternative to pre-formed carbanions or metallic reductants in C=X addition The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Computed Properties of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A novel magnetically recoverable palladium nanocatalyst containing organoselenium ligand for the synthesis of biaryls via Suzuki-Miyaura coupling reaction》 was published in Journal of Physics and Chemistry of Solids in 2020. These research results belong to Rangraz, Yalda; Nemati, Firouzeh; Elhampour, Ali. Electric Literature of C7H7I The article mentions the following:

In the present work, a novel heterogeneous catalytic system involving palladium(II) complex as moisture- and air-stable organoselenium ligand supported on Fe3O4 nanoparticles modified by SiO2/azidopropyltrimethoxy silane was designed, synthesized and characterized using various physicochem. methods inclusive of VSM, EDX, FE-SEM, TG, XRD, and FT-IR spectroscopy. The catalytic activity of the synthesized magnetic nanocatalyst which named Fe3O4@SiO2-T-Se/Pd(II) was evaluated in Suzuki-Miyaura coupling reactions for the preparation of corresponding biaryls RR1 (R = Ph, 1-naphthyl, 2-thiophenyl, etc.; R1 = Ph, 4-fluorophenyl, 4-methylphenyl) using diverse aryl halides RX (X = I, Br) and arylboronic acids R1B(OH)2. The mild reaction conditions, variety of substrate scope, good yield, low reaction time, high stability, utilization of organoselenium compound as an air and moisture insensitive ligand and its immobilization on solid support, and more importantly effortless recovery and recyclability of the catalyst up to seven consecutive runs with no remarkable change in its activity are some of the interesting features of this protocol that makes it more beneficial from both industrial and environmental points of view. After reading the article, we found that the author used 1-Iodo-4-methylbenzene(cas: 624-31-7Electric Literature of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Electric Literature of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Asian Journal of Organic Chemistry included an article by Padmavathi, Rayavarapu; Babu, Srinivasarao Arulananda. Synthetic Route of C7H7I. The article was titled 《Palladium-Catalyzed 8-Aminoquinoline-Aided sp2 δ-C-H Intramolecular Amidation/Annulation: A Route to Tricyclic Quinolones》. The information in the text is summarized as follows:

Systematic investigations of a Pd(II)-catalyzed, 8-aminoquinoline directing group (DG)-aided sp2 δ-C-H amidation (C-N bond formation) of different biaryl carboxamides were reported. Various biaryl carboxamides with suitably positioned sp2 δ-C-H bond with respect to the DG were assembled via β-C-H arylation and then they were subjected to Pd(II)-catalyzed sp2 δ-C-H intramol. amidation/annulation reactions. While the intramol. amidation of the sp2 δ-C-H bond of some carboxamides was not fruitful, several biaryl carboxamides underwent intramol. amidation of their sp2 δ-C-H bonds to afford various tricyclic quinolone motifs such as, phenanthridin-6(5H)-ones and thieno-/furo-/pyrrolo-[2,3-c]quinolin-4(5H)-ones. The assembly of the required biaryl carboxamides possessing the sp2 δ-C-H bond via the β-C-H arylation and the successive intramol. amidation (C-N bond formation) of the resulting biaryl carboxamides were also performed in one-pot reaction conditions to afford tricyclic quinolones. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Synthetic Route of C7H7I) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Synthetic Route of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Swyka, Robert A.; Zhang, Wandi; Richardson, Jeffery; Ruble, J. Craig; Krische, Michael J.. Computed Properties of C7H7I. The article was titled 《Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki-Hiyama-Kishi-Type Addition》. The information in the text is summarized as follows:

The first intermol. carbonyl arylations via transfer hydrogenative reductive coupling are described. Using rhodium catalysts modified by tBu2PMe, sodium formate-mediated reductive coupling of aryl iodides with aldehydes occurs in a chemoselective fashion in the presence of protic functional groups and lower halides. This work expands the emerging paradigm of transfer hydrogenative coupling as an alternative to pre-formed carbanions or metallic reductants in C=X addition The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Computed Properties of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com