Category: 624-31-7

《Ligand-Controlled Direct γ-C-H Arylation of Aldehydes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Li, Bijin; Lawrence, Brianna; Li, Guigen; Ge, Haibo. Product Details of 624-31-7 The article mentions the following:

The first example of PdII-catalyzed γ-C(sp3)-H functionalization of aliphatic and benzoheteroaryl aldehydes was developed using a transient ligand and an external ligand, concurrently. A wide array of γ-arylated aldehydes were readily accessed without preinstalling internal directing groups. The catalytic mechanism was studied by performing deuterium-labeling experiments, which indicated that the γ-C(sp3)-H bond cleavage is the rate-limiting step during the reaction process. This reaction could be performed on a gram scale, and also demonstrated its potential application in the synthesis of new mechanofluorochromic materials with blue-shifted mechanochromic properties. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Product Details of 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Product Details of 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium(II)-Catalyzed Sp3/Sp2 γ- and δ-C-H Functionalization of Aryl Amines using 5-Methylisoxazole-3-Carboxamide as Directing Group》 was written by Singh, Prabhakar; Dalal, Arup; Babu, Srinivasarao Arulananda. Electric Literature of C7H7IThis research focused ontoluidine iodoarene palladium catalyst methylisoxazole carboxamide directed regioselective arylation; benzylamine iodoarene palladium catalyst methylisoxazole carboxamide directed regioselective arylation; diacetoxyiodo benzene toluidine palladium methylisoxazole carboxamide directed regioselective acetoxylation; iodosobenzene diacetate benzylamine palladium methylisoxazole carboxamide directed regioselective acetoxylation; phenethylamine palladium catalyst methylisoxazole carboxamide directed regioselective amidation heterocyclization; aminoethyl benzene palladium catalyst methylisoxazole carboxamide directed regioselective alkenylation. The article conveys some information:

The study comprising exploration of 5-methylisoxazole-3-carboxamide as a directing group (DG) for the Pd(II)-catalyzed sp3/sp2 γ- and δ-C-H activation/functionalization of aryl amines and assembling of various MICA motifs were reported. The Pd(II)-catalyzed MICA-aided γ-C(sp3)-H arylation/acetoxylation of ortho-toluidines gave various 2-aminodiphenylmethanes and 2-aminobenzyl acetates resp. The Pd(II)-catalyzed MICA-aided γ-C(sp2)-H arylation/acetoxylation of benzylamines gave the corresponding arylated/acetoxylated products. Furthermore, the Pd(II)-catalyzed MICA-aided δ-C(sp2)-H amidation/alkenylation of phenethylamines were also explored. Representative control reactions were done to assessed the relative effectiveness of MICA for the γ-C(sp3)-H arylation and MICA was a removable DG. Apart from the usage of MICA as a DG for the sp2/sp3 C-H functionalization of aryl amines, indirectly this process was led to the construction of a library of MICA motifs. This is an added advantage to note as the MICA-based motifs were valuable small mols. in medicinal chem. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Electric Literature of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Electric Literature of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Pd(II)-Catalyzed Enantioselective γ-C(sp3)-H Functionalizations of Free Cyclopropylmethylamines》 was written by Zhuang, Zhe; Yu, Jin-Quan. Formula: C7H7I And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Herein, the Pd-catalyzed enantioselective C(sp3)-H functionalization of free aliphatic amines (cyclopropylmethylamines) enabled by a chiral bidentate thioether ligand was reported. This ligand’s privileged bidentate coordination mode and thioether motif favor the generation of the requisite mono(amine)-Pd(II) intermediate, thus enabling the enantioselective C-H activation of free amines. The resulting C-Pd(II) species could engage in either Pd(II)/Pd(IV) or Pd(II)/Pd(0) catalytic cycles, enabling access to a diverse range of products I [R1 = n-pentyl, 2,6-di-FC6H3, Bn, etc.; R2 = H, Boc, Bz; Ar = Ph, 4-MeC6H4, 4-pyridyl, etc.], II [R1 = H, Bn; R2 = H, 2,6,-di-FC6H3, 2,6,-di-ClC6H3, 2,6,-di-MeC6H3, (CH2)3C6H5] and III [R1 = H, CH2CH2CH(Me)2; R2 = Boc, 2,6,-di-FC6H3, 2,6,-di-ClC6H3, 2,6,-di-MeC6H3] through (hetero)arylation, carbonylation and olefination reactions. Consequently, this versatile reactivity offered medicinal chemists a general strategy to rapidly prepare and functionalize biol. relevant amines. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Formula: C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Formula: C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 1-Iodo-4-methylbenzeneIn 2021 ,《Sensitive and Repeatable Photoinduced Luminescent Radicals from A Simple Organic Crystal》 was published in Angewandte Chemie, International Edition. The article was written by Mu, Yingxiao; Liu, Yanyan; Tian, Haiyan; Ou, Depei; Gong, Li; Zhao, Juan; Zhang, Yi; Huo, Yanping; Yang, Zhiyong; Chi, Zhenguo. The article contains the following contents:

Photoinduced organic radicals are important for chem. and phys. processes of organic materials, which are extensively investigated and applied in organic synthesis, photoelectronic devices and biotechnol. However, there are rare reports of the luminescence for these photoinduced radicals, especially in the condensed state. Herein, an unexpected and interesting luminescent radical is described, which can be rapidly and reversibly generated from a simple organic crystal by gentle light irradiation in air. It was revealed that the twist and asym. conformation of isolated mol. in its crystal with only weak C-H···π intermol. interactions, which led to the generation of such photoinduced luminescent radicals. In addition, dual-channel photosensitive device with rapid response and well repeatability can be obtained based on the thin film of this organic crystal, showing both photoswitching on luminescence and conducting. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Recommanded Product: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the Iranian Chemical Society included an article by Gaikwad, D. S.; Undale, K. A.; Patil, D. B.; Pore, D. M.. Safety of 1-Iodo-4-methylbenzene. The article was titled 《Multi-functionalized ionic liquid with in situ-generated palladium nanoparticles for Suzuki, Heck coupling reaction: a comparison with deep eutectic solvents》. The information in the text is summarized as follows:

A new catalytic system for Suzuki and Heck coupling for the synthesis of biaryls and olefins I [R = H, 4-OMe, 4-C(O)Me, etc.; R1 = Ph, CO2Me, CN, etc.] was developed from multi-functionalized task specific ionic liquid and in situ formed palladium nanoparticles(PdNPs). These PdNPs were found size below 10 nm and exhibited a excellent catalytic activity in the cross-coupling of aryl halide without using external phosphine ligand. Along with electron deficient olefins, electron rich olefins were also undergo smooth reaction giving excellent yield. The results obtained in ionic liquid were compared with results obtained in deep eutectic solvents. Progress of reaction was found very smooth in ionic liquid rather than in deep eutectic solvents. The aqueous system containing ionic liquid along with PdNPs was recycled for seven times, without any significant loss.1-Iodo-4-methylbenzene(cas: 624-31-7Safety of 1-Iodo-4-methylbenzene) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Safety of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Palladium Catalyzed Regioselective C4-Arylation and Olefination of Indoles and Azaindoles》 were Thrimurtulu, Neetipalli; Dey, Arnab; Singh, Anurag; Pal, Kuntal; Maiti, Debabrata; Volla, Chandra M. R.. And the article was published in Advanced Synthesis & Catalysis in 2019. Formula: C7H7I The author mentioned the following in the article:

A convergent strategy for the synthesis of biol. relevant C4-substituted indole scaffolds was demonstrated using Pd(II)-catalyzed remote C-H functionalization of indoles and azaindoles. The reaction displayed high regioselectivity for the C4-position of indole-3-carbaldehydes using glycine as an inexpensive transient directing group. Notable features of this transformation included the selective formation of six-membered palladacyle and excellent functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-4-methylbenzene(cas: 624-31-7Formula: C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Formula: C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Ligand-Enabled PdII-Catalyzed Iterative γ-C(sp3)-H Arylation of Free Aliphatic Acid》 were Dolui, Pravas; Das, Jayabrata; Chandrashekar, Hediyala B.; Anjana, S. S.; Maiti, Debabrata. And the article was published in Angewandte Chemie, International Edition in 2019. Recommanded Product: 1-Iodo-4-methylbenzene The author mentioned the following in the article:

C-H functionalization of aliphatic carboxylic acids without attaching exogenous auxiliary has been so far limited at the proximal β-position. In this work, we demonstrate a ligand enabled palladium catalyzed first regioselective distal γ-C(sp3)-H functionalization of aliphatic carboxylic acids without incorporating an exogenous directing group. Aryl iodides containing versatile functional groups including complex organic mols. are well tolerated with good to excellent yields during the γ-C(sp3)-H arylation reaction. Interestingly, weak coordination of carboxylate group can be further extended for sequential hetero di-arylation. Application of the protocol has been showcased by synthesizing substituted α-tetralone. Mechanistic investigations have been carried out to shed light on the reaction pathway. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Recommanded Product: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel/Photoredox-Catalyzed Asymmetric Reductive Cross-Coupling of Racemic α-Chloro Esters with Aryl Iodides》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Guan, Haixing; Zhang, Qianwen; Walsh, Patrick J.; Mao, Jianyou. Recommanded Product: 1-Iodo-4-methylbenzene The article mentions the following:

A unique nickel/organic photoredox co-catalyzed asym. reductive cross-coupling between α-chloro esters and aryl iodides is developed. This cross-electrophile coupling reaction employs an organic reductant (Hantzsch ester), whereas most reductive cross-coupling reactions use stoichiometric metals. A diverse array of valuable α-aryl esters is formed under these conditions with high enantioselectivities (up to 94%) and good yields (up to 88%). α-Aryl esters represent an important family of nonsteroidal anti-inflammatory drugs. This novel synergistic strategy expands the scope of Ni-catalyzed reductive asym. cross-coupling reactions. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Recommanded Product: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Intermolecular Alkene Difunctionalization via Gold-Catalyzed Oxyarylation》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Zhang, Shuyao; Wang, Chenhuan; Ye, Xiaohan; Shi, Xiaodong. Quality Control of 1-Iodo-4-methylbenzene The article mentions the following:

The gold-catalyzed intermol. oxyarylation of alkenes is reported. This work employed the oxidative addition of aryl iodides to Me-DalphosAu+ for the formation of a AuIII-Ar intermediate. The better binding ability of alkenes over O nucleophiles ensured the success of intermol. oxyarylation, giving desired products with a broad substrate scope and high efficiency (>50 examples with up to 95% yield). One-pot converting of methoxy groups into other nucleophiles allowed achieving alkene difunctionalization with the construction of C-N, C-S, and C-C bonds under mild conditions. In the experimental materials used by the author, we found 1-Iodo-4-methylbenzene(cas: 624-31-7Quality Control of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Quality Control of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 1-Iodo-4-methylbenzeneIn 2020 ,《Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling》 appeared in Journal of the American Chemical Society. The author of the article were Wei, Xiaofeng; Shu, Wei; Garcia-Dominguez, Andres; Merino, Estibaliz; Nevado, Cristina. The article conveys some information:

Alkene dicarbofunctionalizations enable the streamlined construction of aliphatic structures and have thus been the subject of intense research efforts. Despite significant progress, catalytic asym. variants remain scarce. Inspired by the advantages of reductive cross-coupling approaches, we present here a highly efficient asym. intermol. Ni-catalyzed reductive dicarbofunctionalization of alkenes. Two distinct readily available electrophiles, namely, Csp2- and Csp3-halides, are added simultaneously across a variety of olefins (vinyl amides, vinyl boranes, vinyl phosphonates) at room temperature in a highly regio- and enantioselective manner. The reaction, devoid of sensitive organometallic reagents, takes advantage of an in situ generated chiral alkyl Ni(III)-intermediate to ensure a stereodefined outcome in the Csp3-Csp2 bond-forming reaction. An (L)-(+)-isoleucine chiral bisoxazoline ligand and the presence of coordinating sites on the alkene are key for the successful outcome in these “”asym. radical relayed reductive couplings”” (ARRRCs). Further, multiple transformations of the chiral amides obtained in this process showcase the potential of this new methodol. for the straightforward assembly of chiral building blocks such as primary and secondary amines and oxazolines, highlighting its synthetic utility. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Recommanded Product: 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com