Category: 620-05-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 620-05-3, name is (Iodomethyl)benzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H7I

General procedure: To a stirred solution of compound 12 (120 mg, 0.25 mmol, 1 equiv.) in THF (10 mL) was added freshly prepared Ag2O (174 mg, 0.75 mmol, 3 equiv.) and MeI (51 muL, 1.25 mmol, 5 equiv.), then the resulting reaction mixture was stirredat 50 C for 3 hours. After been cooled to room temperature, the reaction mixture was filtered, and the filtrate was concentrated in vacuo. The resulting residue was purified by silica gel flash chromatography (hexanes : EtOAc = 2:1) to give the desired products. Compound 15 (79 mg, 63%): 1H NMR (500 MHz, CDCl3) delta 7.80 (d, J = 7.5 Hz, 2H),7.64 (d, J = 7.5 Hz, 2H), 7.49 – 7.28 (m, 9H), 5.78 (d, J = 8.7 Hz, 1H), 5.20 (dd,J = 31.7, 12.1 Hz, 2H), 5.02 (dd, J = 8.7, 3.1 Hz, 1H), 4.45 (dd, J = 7.1, 1.5 Hz,2H), 4.32 – 4.21 (m, 2H),3.90 – 3.79 (m, 1H), 3.61 (s, 3H), 3.54 – 3.44 (m, 2H), 1.25 (t, J = 7.5 Hz, 3H);13C NMR (126 MHz, CDCl3) delta 169.70, 168.45, 155.83, 143.87, 143.69, 141.34,134.82, 128.57, 128.53, 127.78, 127.12, 125.13, 120.03, 78.77, 67.90, 67.55,67.32, 56.08, 52.08, 47.14, 14.97; HRMS: calculated for C29H30NO7+ [M+H+]: 504.2017; found: 504.2023. Compound 16 (128 mg, 91%): 1H NMR (500 MHz, CDCl3) delta 7.86 – 7.75 (m, 2H), 7.70 – 7.55 (m, 2H), 7.47 – 7.30 (m, 14H), 5.75 (d, J = 8.6 Hz, 1H), 5.22(dd, J = 30.8, 12.1 Hz, 2H), 5.06 (dd, J = 8.6, 2.9 Hz, 1H), 4.95 (d, J = 11.9 Hz,1H), 4.56 (s, 1H), 4.48 – 4.31 (m, 3H), 4.25 (t, J = 7.2 Hz, 1H), 3.64 (s, 3H); 13CNMR (126 MHz, CDCl3) delta 169.55, 168.37, 155.68, 143.91, 143.72, 141.35, 141.32, 136.76, 134.78, 128.62, 128.58, 128.57, 128.23, 128.21, 127.81, 127.15,125.21, 125.17, 120.07, 73.21, 68.01, 67.37, 56.13, 52.17, 47.12, 26.57; HRMS: calculated for C34H32NO7+ [M+H+]: 566.2173; found: 566.2175.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Liu, Long; Wang, Bo; Bi, Cheng; He, Gang; Chen, Gong; Chinese Chemical Letters; vol. 29; 7; (2018); p. 1113 – 1115;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 620-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 620-05-3, name is (Iodomethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure for the synthesis of diorganyl selenides and sulfides: commercially available Zn dust (33 mg, 0.5 mmol) and PhSeSePh/PhSSPh (0.5 mmol) and 15 muL of HCl 1N were added to BMIM-BF4 (0.5 mL) at room temperature under nitrogen. The mixture was allowed to stir for 2-3 min. Then corresponding organic halides (1 mmol) was slowly added. The reaction mixture was allowed to stir until the color change (monitored by TLC and assisted by visual observation). The mixture was then extracted with ether (3×15 mL), and the combined ether extract was washed with brine, dried (MgSO4), and evaporated to leave the crude product. Purification by column chromatography over silica gel (hexane/ethyl acetate 98:2) furnished the corresponding products.

The synthetic route of (Iodomethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Narayanaperumal, Senthil; Alberto, Eduardo E.; Gul, Kashif; Kawasoko, Cristiane Yuriko; Dornelles, Luciano; Rodrigues, Oscar E.D.; Braga, Antonio Luiz; Tetrahedron; vol. 67; 25; (2011); p. 4723 – 4730;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 620-05-3, name is (Iodomethyl)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: 620-05-3

General procedure: In a flame-dried round-bottom flask, beta-amidoester (9) (1 mmol; 1 equiv) was taken in DMF (5 mL) at room temperature. To this reaction mixture KOt-Bu (1.2 mmol; 1.2 equiv) was added. After 5 minutes of stirring at same temperature alkyl halide (1.05 mmol; 1.05 equiv) was added and stirring was continued for 15 minutes. Upon completion of the alkylation (judged by TLC), it was diluted with 10 mL of EtOAc and quenched with water. The organic extracts were dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by flash chromatography (hexane and EtOAc as eluents) to afford compounds 10.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kumar, Nivesh; Ghosh, Santanu; Bhunia, Subhajit; Bisai, Alakesh; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1153 – 1169;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 620-05-3, name is (Iodomethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H7I

General procedure: A mixture of benzyl bromide (171 mg, 1 mmol), diphenyl disulfide (131 mg, 0.6 mmol), PPh3 (184 mg, 0.7 mmol), and [pmIm]Br21 (94 mg, 0.4 mmol) was stirred at 75 C for 1.5 h (TLC). The reaction mixture was extracted with Et2O, and the organic layer was washed with brine (2 × 5 mL) and dried (Na2SO4). Evaporation of solvent left the crude product which was purified by column chromatography over silica gel (hexane) to afford the pure product, benzyl phenyl sulfide (168 mg, 84%) as a colorless liquid. The remaining ionic liquid was washed with ether, dried under vacuum, and reused five times without appreciable loss of catalytic activity.

According to the analysis of related databases, 620-05-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Banerjee, Subhash; Adak, Laksmikanta; Ranu, Brindaban C.; Tetrahedron Letters; vol. 53; 17; (2012); p. 2149 – 2152;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 620-05-3, name is (Iodomethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 620-05-3, COA of Formula: C7H7I

General procedure: A mixture of 4-oxo-1,4-dihydroquinoline-2-carboxylic acid alkylester (1, 1 mmol), base (1.3 mmol), the corresponding alkylatingagent (alkyl iodide, 1.5 mmol; others, 1.2 mmol) and anhydrousDMF (5 mL) was stirred at the appropriate temperature andmonitored by TLC (DCM:MeOH 4.7:0.3). After a specified time(Table 2), the mixture was carefully poured into ice-water. Thecompounds obtained were isolated and purified as was indicatedabove. Alkylating agents, bases and solvents are presented inTable 2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Iodomethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shmidt, Maria S.; Arroyo Manez, Pau; Stortz, Carlos A.; Perillo, Isabel A.; Vega, Daniel; Blanco, Maria M.; Journal of Molecular Structure; vol. 1128; (2017); p. 142 – 150;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 620-05-3, name is (Iodomethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., name: (Iodomethyl)benzene

General procedure: A mixture of p-tert-butylcalix[4]arene (1 mmol), potassium carbonate (4 mmol), potassium iodide (20 mol%) in acetonitrile (30 mL) was refluxed at 85 C temperature for 30 min. The reaction mixture was cooled to room temperature and alkyl halide (2.1 mmol) was added to it followed by refluxing (4 mmol for 2m, 2p). The progress of the reaction was monitored byTLC (ethyl acetate/hexane 3:7). After completion, the reaction was cooled to room temperature and the contents were filtered. Solvent was evaporated on a rotary evaporator. The residue obtained was dissolved in chloroform and extracted with water.Chloroform layer was washed with NaCl (brine) and dried over sodium sulfate. Chloroform was evaporated under reduced pressure by using rotary evaporator and the precipitate obtained was recrystallized (chloroform/methanol, 3:7) to afford pure calixarene derivatives.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 620-05-3.

Reference:
Article; Arora, Lakhbeer Singh; Chawla, Har Mohindra; Shahid, Mohammad; Pant, Nalin; Organic Preparations and Procedures International; vol. 49; 3; (2017); p. 228 – 235;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 620-05-3, name is (Iodomethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 620-05-3, category: iodides-buliding-blocks

General procedure: A solution of iodomethyl compound (30 mmol) and ionic liquid [bmpy]PF6 (15 mL) was taken in a round bottom flask, and then H5IO6 (36 mmol) and V2O5 (0.9 mmol) were added to reaction solution at r.t. Reaction content was heated at 70 C with continuous stirring for about 4-9 h. Reaction progress was monitored by means of TLC using EtOAc/n-hexane 1:9 as an eluent. After completion of reaction, the product was extracted with DCM (3 × 10 mL). The organic layer was isolated and washed with 5% NaHCO3 solution (3 × 10 mL) and water (3 × 10 mL) to make the pH neutral. Then, the organic layer was dried over Na2SO4 and filtered. The carbonyl compound was purified through recrystallization from hexane and ethyl acetate (solid product) or by distillation (liquid product). In some cases, column chromatography was required to purify product. In these cases, the solvent was removed followed by column chromatography using hexane/ethyl acetate (8:1) as eluent which afforded carbonyl compound (83-94%). The rest of the ionic liquid and the catalyst were recovered by decantation of aqueous hydrogen halide produced in the reaction and concentrated under vacuum. Fresh substrates were then recharged to the recovered catalytic system and then recycled under specified reaction parameters.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 620-05-3, name is (Iodomethyl)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: (Iodomethyl)benzene

General procedure: In a flame-dried round-bottom flask, beta-amidoester (9) (1 mmol; 1 equiv) was taken in DMF (5 mL) at room temperature. To this reaction mixture KOt-Bu (1.2 mmol; 1.2 equiv) was added. After 5 minutes of stirring at same temperature alkyl halide (1.05 mmol; 1.05 equiv) was added and stirring was continued for 15 minutes. Upon completion of the alkylation (judged by TLC), it was diluted with 10 mL of EtOAc and quenched with water. The organic extracts were dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by flash chromatography (hexane and EtOAc as eluents) to afford compounds 10.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 620-05-3, name is (Iodomethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 620-05-3

General procedure: A mixture of benzyl bromide (171 mg, 1 mmol), diphenyl disulfide (131 mg, 0.6 mmol), PPh3 (184 mg, 0.7 mmol), and [pmIm]Br21 (94 mg, 0.4 mmol) was stirred at 75 C for 1.5 h (TLC). The reaction mixture was extracted with Et2O, and the organic layer was washed with brine (2 × 5 mL) and dried (Na2SO4). Evaporation of solvent left the crude product which was purified by column chromatography over silica gel (hexane) to afford the pure product, benzyl phenyl sulfide (168 mg, 84%) as a colorless liquid; IR (neat) 3058, 3028, 2923, 1581, 1495, 1479, 1452, 1438, 1238, 1090, 1068, 1024 cm-1; 1H NMR (300 MHz, CDCl3) delta 4.21 (s, 2H), 7.32-7.41 (m, 10H); 13C NMR (75 MHz, CDCl3) delta 39.5, 127.6, 128.0, 129.0 (2C), 129.3 (2C), 129.5 (2C), 130.3 (2C), 136.9, 137.9. The spectroscopic (FT-IR, 1H NMR and 13C NMR) data are in good agreement with the reported values.9b The remaining ionic liquid was washed with ether, dried under vacuum, and reused five times without appreciable loss of catalytic activity.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 620-05-3.

Reference of 620-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 620-05-3, name is (Iodomethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a flame-dried round-bottom flask, beta-amidoester (9) (1 mmol; 1 equiv) was taken in DMF (5 mL) at room temperature. To this reaction mixture KOt-Bu (1.2 mmol; 1.2 equiv) was added. After 5 minutes of stirring at same temperature alkyl halide (1.05 mmol; 1.05 equiv) was added and stirring was continued for 15 minutes. Upon completion of the alkylation (judged by TLC), it was diluted with 10 mL of EtOAc and quenched with water. The organic extracts were dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by flash chromatography (hexane and EtOAc as eluents) to afford compounds 10.

The synthetic route of (Iodomethyl)benzene has been constantly updated, and we look forward to future research findings.