Category: 619-58-9

Reference of 619-58-9,Some common heterocyclic compound, 619-58-9, name is 4-Iodobenzoic acid, molecular formula is C7H5IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100-mL resealable reaction tube, 4-iodobenzoic acid (10.0 g, 40.03 mmol) and furan-2- ylboronic acid (8.95 g, 80.06 mmol) were dissolved in degassed DMF (250 mL) and water (50 mL) at rt under nitrogen atmosphere. Pd(PPli3)4 (4.65 g, 3.99 mmol), K2CO3 (16.6 g, 120.09 mmol) were sequentially added to the above solution under nitrogen atmosphere. The resulting mixture was degassed by purging argon gas for 15 min, and reaction mixture was heated to 90C until completion of the reaction (TLC). The reaction mixture was cooled to rt, diluted with cold water and washed with ethyl acetate (3 x 30 mLl.The aqueous layer was separated and acidified to pH 3 with concentrated HC1, before extracting with EtOAc (100 mL x 2). The combined extract was washed with brine and concentrated under reduced pressure to get title compound (6.92 g, 92%) as light yellow solid. LCMS (m/: 187 (M-l)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobenzoic acid, its application will become more common.

Reference:
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; MITOKYNE, INC.; EVANS, Ronald; BAIGA, Thomas, J.; BOCK, Mark, G.; DOWNES, Michael; EMBLER, Emi, Kanakubo; FAN, Weiwei; KEANA, John, F.W.; KLUGE, Arthur, F.; NOEL, Joseph, P.; PATANE, Mike, A.; WO2014/165827; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 619-58-9, name is 4-Iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

General procedure: A typical method for preparation of phenols: A Schlenk test tube with a magnetic stirring bar was charged with CuSO4·5H2O (13 mg, 5 mol %), NaAsc (20 mg, 10 mol %), benzene halide (1.0 mmol), KOH (168-336 mg, 3.0-6.0 equiv) in DMSO/H2O (v/v=1:1, 3.0 mL) at 120 C for 24h. After cooling to room temperature, carefully acidified with dilute aqueous HCl to pH=2-3 and the mixture were stirred for half hour. Then the resultant mixture was extracted with EtOAc (3×20 mL). The combined organic layers were washed with brine (20 mL) and dried over Na2SO4. Purification via silica gel column chromatography with a mixture of ethyl acetate/petroleum ether. Details as follows:

The synthetic route of 4-Iodobenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Song, Guang-Lin; Zhang, Zhang; Da, Yu-Xia; Wang, Xi-Cun; Tetrahedron; vol. 71; 46; (2015); p. 8823 – 8829;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 619-58-9, name is 4-Iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodobenzoic acid

To a solution of 4-iodobenzoic acid (2.0g, 1.0mmol), copper (I) iodide (1.7g, 1.13mmol), palladium chloride (0.02g, 0.15mmol) and triphenylphosphine (2.1g, 1.0mmol) in triethylamine (7ml), was added ethynyltrimethylsilane (1.2g, 1.5mmol) dropwise over 30min. The resulting reaction mixture was then refluxed at 80C for 24h under an atmosphere of argon and monitored by TLC. After the completion of reaction, as indicated by the complete disappearance of starting material on TLC, the mixture was cooled and filtered through a Buchner funnel. The volatile solvents were removed under reduced pressure. The resulting crude light brown coloured material was extracted into ether, washed with brine solution, dried over anhydrous sodium sulphate, and concentrated. Finally the silylated product was purified by column chromatography on silica gel with 3% ethyl acetate in hexane as an eluent yielding 86% of pure 4-[2-(trimethylsilyl)ethynyl]benzoic acid (2). Off white solid, 1.53g; IR: 2953, 2156, 1681, 1604, 1454, 1377, 1251, 858cm-1; 1H NMR (500MHz, CDCl3): 8.0 (d, J=8.6, 2H, Ar-H), 7.6 (d, J=8.4, 2H, Ar-H), 0.27 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 619-58-9.

Application of 619-58-9, The chemical industry reduces the impact on the environment during synthesis 619-58-9, name is 4-Iodobenzoic acid, I believe this compound will play a more active role in future production and life.

EXAMPLE 10: (E)-3- [4- (8, 8-Dimethyl-5-p-tolyl-7,8- dihydro-2-naphthylselanyl) phenyl] acrylic acid a. 2-(4-IODOPHENYL) ETHANOL 12.5 g (50.4 mmol) of 4-iodobenzoic acid are dissolved in 125 ml of. tetrahydrofuran, and 112 ml (122 mmol) of a 1M solution of borane in tetrahydrofuran are then added dropwise. The reaction medium is stirred for 4 hours, acidified with 2N hydrochloric acid solution and then extracted with ethyl acetate. A white solid is obtained (11.49 g ; yield = 97%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 619-58-9, The chemical industry reduces the impact on the environment during synthesis 619-58-9, name is 4-Iodobenzoic acid, I believe this compound will play a more active role in future production and life.

A flame dried, 300-ml three-necked, round-bottomed flask equipped with a magnetic stirring bar was charged with 4-iodobenzoic acid 9 (10.0 g, 40.3 mmol) and THF (20.0 mL). To the solution were slowly added BH3·THF (1.06 M solution in THF, 60.0 mL, 63.6 mmol) at -20 C. After stirring for 12 h at 50 C, an additional portion of BH3·THF (1.06 M solution in THF, 60.0 mL, 63.6 mmol) was added at -20 C and the reaction mixture was refluxed for 2 h. The reaction was quenched with ice-H2O (100 mL) and K2CO3. The reaction mixture was concentrated under reduced pressure and the residue was extracted with EtOAc. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified on a short pad of silica gel (Hexanes/EtOAc, 10:1) to give the titled alcohol S-1 (9.90 g, quant) as a white solid. Its spectral data were identical with those reported1 ; IR (KBr) 3500-3000, 1483, 1400, 1005, 791 cm-1; 1H NMR (500 MHz, CDCl3) d 7.66 (2H, d, J = 8.0 Hz), 7.07 (2H, d, J = 8.0 Hz), 4.59 (2H, s), 2.11 (1H, s); 13C NMR (125 MHz, CDCl3) d 140.4, 137.5, 128.7, 92.9, 64.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Application of 619-58-9,Some common heterocyclic compound, 619-58-9, name is 4-Iodobenzoic acid, molecular formula is C7H5IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a test tube containing a magnetic bar was added aryl iodide(1 mmol), copper powder (6.35 mg, 0.1 mmol), Na2S¡¤9H2O(720.54 mg, 3 mmol), and DMSO (2 mL). After flushing withargon, 1,2-ethanedithiol (8.4 muL, 0.1 mmol) was added. Themixture was stirred in the oil bath at 100 C for 20 h. Aftercooled to ambient temperature, the reaction mixture was distributedin aq HCl (5%) and EtOAc. The organic layer was separated and washed with water and brine, dried, and concentratedunder vacuum. The crude product was further purifiedby column chromatography using ethyl acetate/n-hexane aseluent to provide the desired aryl thiol.

The synthetic route of 619-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xue, Hongyu; Jing, Bing; Liu, Shasha; Chae, Junghyun; Liu, Yajun; Synlett; vol. 28; 17; (2017); p. 2272 – 2276;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 619-58-9, Name is 4-Iodobenzoic acid, molecular formula is , belongs to iodides-buliding-blocks compound. In a document, author is Kabalka, GW, SDS of cas: 619-58-9.

A facile synthesis of radioiodinated (Z)-vinyl iodides via vinylboronates

A direct radioiodination of (Z)-vinylboronic acid esters to the corresponding vinyl iodides using (NaI)-I-123 and chloramine-T is described. The boronates were prepared from vinyl iodides via palladium coupling reactions. (C) 2003 Elsevier Inc. All rights reserved.

If you are hungry for even more, make sure to check my other article about 619-58-9, SDS of cas: 619-58-9.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 619-58-9, Name is 4-Iodobenzoic acid, formurla is C7H5IO2. In a document, author is Fujiwara, Syozo, introducing its new discovery. HPLC of Formula: C7H5IO2.

New iodide-based molten salt systems for high temperature molten salt batteries

Novel multi-component molten salt systems containing iodides, LiF-LiBr-Lil, LiF-NaBr-Lil, and LiF-LiCl-LiBr-Lil, were investigated for use as electrolytes in high temperature molten salt batteries to improve the discharge rate-capability. The iodide-based molten salts showed higher ionic conductivity (similar to 3 S cm(-1) at 500 degrees C) than conventional LiCl-KCl, and had low enough melting points (below 400 degrees C that can be used in practical high temperature molten salt batteries. The iodide-based salts showed instability at temperatures higher than 280 degrees C in dried air. The decomposition mechanism of iodide-based molten salts was discussed, and it was found that elimination of oxygen from the environment is effective to stabilize the iodide-based molten salts at high temperatures. (C) 2009 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 619-58-9 help many people in the next few years. HPLC of Formula: C7H5IO2.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 619-58-9, Name is 4-Iodobenzoic acid, molecular formula is C7H5IO2. In an article, author is Feng, Xiujuan,once mentioned of 619-58-9, Recommanded Product: 4-Iodobenzoic acid.

Stereoselective Synthesis of Vinyl Iodides through Copper(I)-Catalyzed Finkelstein-Type Halide-Exchange Reaction

An efficient method for the stereoselective synthesis of vinyl iodides is described. The reactions of vinyl bromides with potassium iodide proceed smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding vinyl iodides stereospecifically and in satisfactory to excellent yields.

If you are hungry for even more, make sure to check my other article about 619-58-9, Recommanded Product: 4-Iodobenzoic acid.

Reference of 619-58-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 619-58-9, Name is 4-Iodobenzoic acid, SMILES is O=C(O)C1=CC=C(I)C=C1, belongs to iodides-buliding-blocks compound. In a article, author is Rowe, E., introduce new discover of the category.

Double Salts Iodide Scintillators: Cesium Barium Iodide, Cesium Calcium Iodide, and Barium Bromine Iodide

In this study we review the state-of-the-art for double salt iodide scintillators, in particular cesium barium iodide (CBI), cesium calcium iodide (CCI) and barium bromine iodide (BBI), as well as report on their scintillation and optical properties. Double salt iodides inherently have high density and atomic number which translates to good stopping power for energetic particles, in particular gamma rays. Light yields of 54,000 ph/MeV for CBI, 51,000 ph/MeV for CCI, and 46,000 ph/MeV for BBI were measured. A FWHM energy resolution for the 662 keV full absorption peak was observed at 5.7% for CBI, 16.3% for CCI and 3.56% for BBI. The principal scintillation decay timing for CBI was 840 ns, 462 ns for BBI, and two distinct time components of 9 ns and 1900 ns were observed for CCI.

Reference of 619-58-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 619-58-9 is helpful to your research.