Category: 619-58-9

Reference of 4-Iodobenzoic acidIn 2020 ,《Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Yamasaki, Toshihide; Azuma, Risa; Sano, Kohei; Munekane, Masayuki; Matsuoka, Yuta; Yamada, Ken-ichi; Mukai, Takahiro. The article conveys some information:

Thus far, no accurate measurement technol. has been developed to detect lipid alkyl radicals (lipid radicals), which cause lipid peroxidation Therefore, we aimed to develop a nuclear medical imaging probe that can be taken up in the lipophilic site in cells such as biol. membranes, by reacting specifically with the lipid radicals generated there. We designed and synthesized 4-(4-[125I]iodobenzamido)-2,2,6,6-tetramethylpiperidine-1-oxyl (I), which shows high reactivity to lipid radicals with a high radiochem. yield and purity. Intracellular retention was found to increase significantly when lipid radicals were produced. In the experiment, the researchers used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Reference of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 619-58-9In 2021 ,《A Strategy for Site- and Chemoselective C-H Alkenylation through Osmaelectrooxidative Catalysis》 appeared in Angewandte Chemie, International Edition. The author of the article were Choi, Isaac; Messinis, Antonis M.; Hou, Xiaoyan; Ackermann, Lutz. The article conveys some information:

Osmaelectrocatalyzed C-H activations that set the stage for electrooxidative alkynes e.g., 1-methoxy-4-[2-(4-methoxyphenyl)ethynyl]benzene annulations by benzoic acids e.g., 2-methylbenzoic acid were described. The osmium electrocatalysis enables site- and chemoselective electrooxidative C-H activations with unique levels of selectivity. The isolation of unprecedented osmium(0) I and osmium(II) intermediates [OsCl2(p-cymene)]2, along with crystallog. characterization and analyses by spectrometric and spectroscopic in operando techniques delineate a synergistic osmium redox catalyst regime. Detailed mechanistic studies revealed a facile C-H cleavage, which allows for an ample substrate scope, providing provide robust and user-friendly access to annulated heterocycles II. In the experiment, the researchers used 4-Iodobenzoic acid(cas: 619-58-9SDS of cas: 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. SDS of cas: 619-58-9 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Agafonova, Anastasiya V.; Sakharov, Pavel A.; Smetanin, Ilia A.; Rostovskii, Nikolai V.; Khlebnikov, Alexander F.; Novikov, Mikhail S. published an article in Organic Chemistry Frontiers. The title of the article was 《Stannyl radical-mediated synthesis of 6H-1,3-oxazin-6-ones from 2-acyloxyazirines or whether free radicals can open the azirine ring》.Reference of 4-Iodobenzoic acid The author mentioned the following in the article:

A fundamentally new radical cascade reaction of 2-acyloxyazirines provides an effective one-step method for the preparation of 5-hydroxy-6H-1,3-oxazin-6-ones from Me 2-acyloxy-2H-azirine-2-carboxylates using a Bu3SnH/ACHN system as a source of stannyl radicals. The method provides high product yields from a variety of 2-aroyloxy-, 2-hetaroyloxy-, and 2-tert-alkylcarbonyloxy-substituted Me azirine-2-carboxylates. The decreasing volume of the acyloxy substituent causes a side reaction leading to the formation of Me oxazole-2-carboxylates. According to the DFT calculations, the switch between these reaction pathways occurs when changing the C1-substituent in the 2-azabuta-1,3-dien-4-oxyl intermediate, the volume of which controls further stabilization routes: radical-radical recombination or Z,E isomerization followed by recombination. The hydroxyl group in 5-hydroxy-6H-1,3-oxazin-6-ones can be easily replaced, through a triflation step, with aryl, pyridyl, alkenyl, alkynyl, and cyano groups by palladium-catalyzed cross-coupling reactions. 5-Hydroxy-6H-1,3-oxazin-6-ones were converted to pyridine-2,3(1H,4H)-diones in good yields via copper-catalyzed transannulation with 3-tolyl-2H-azirine. The key step of this new domino reaction is the copper-catalyzed pyrrolooxazine-oxazolopyridine isomerization, which, according to the DFT calculations, proceeds via a concerted mechanism. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Reference of 4-Iodobenzoic acidHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Capilato, Joseph N.; Pellegrinelli, Peter J.; Bernard, Josephine; Schnorbus, Logan; Philippi, Shane; Mattiucci, Joseph; Hoy, Erik P.; Perez, Lark J. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives》.Reference of 4-Iodobenzoic acid The article contains the following contents:

The development of a novel acetyl nitrate mediated oxidative conversion of Me ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by exptl. and computational investigation authors propose a mechanism for this transformation. In the experiment, the researchers used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Reference of 4-Iodobenzoic acidHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Green and Efficient Liquid-Phase Exfoliation of BiI3 Nanosheets for Catalytic Carbon-Carbon Cross-Coupling Reactions》 was published in ACS Sustainable Chemistry & Engineering in 2020. These research results belong to Wang, Huiyong; Song, Tao; Su, Xin; Li, Zhiyong; Wang, Jianji. Quality Control of 4-Iodobenzoic acid The article mentions the following:

BiI3 nanosheet dispersions were prepared by ultrasound-mediated exfoliation of BiI3 in the green solvents Me salicylate, triacetin, di-Et phthalate, Et benzoate, or in mixtures of the solvents. BiI3 nanosheets were formed in up to 30% yields and as dispersions containing up to 1.56 mg/mL of BiI3; the thickness of the BiI3 nanosheets is 5-10 nm and their lateral dimensions are around 1μm. Solvent-cosolvent interactions in the mixed solvents are a critical factor in the liquid-phase exfoliation. The BiI3 nanosheets were used as a catalyst for the Suzuki coupling of aryl iodides with phenylboronic acid mediated by TMEDA and KOH in THF to yield 4-substituted biphenyls in 75-91% yields. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzoic acid(cas: 619-58-9Quality Control of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Quality Control of 4-Iodobenzoic acid In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Excimer formation of aryl iodides chemisorbed on gold nanoparticles for the significant enhancement of photoluminescence》 was published in Journal of Physical Chemistry Letters in 2020. These research results belong to Maity, Prasenjit; Sasai, Kenji; Dhital, Raghu Nath; Sakai, Hayato; Hasobe, Taku; Sakurai, Hidehiro. Quality Control of 4-Iodobenzoic acid The article mentions the following:

The photoluminescence properties of aryl iodides chemisorbed on gold nanoparticles were examined Chemisorption of a series of aryl iodides onto poly(N-vinylpyrrolidone)-protected Au nanoparticles (Au:PVP) in solution resulted in highly enhanced luminescence. Kinetic studies revealed that the photoluminescence is derived from the excimer formation of aryl iodides on Au:PVP, and the process is significantly faster than intersystem crossing by the heavy atom. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Quality Control of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Quality Control of 4-Iodobenzoic acid Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Xing Xing; Diao, Liang Zhuo; Chen, Liu Zeng; Ma, Duo; Wang, Yu Meng; Jiang, Han; Ruan, Ban Feng; Liu, Xin Hua published an article in European Journal of Medicinal Chemistry. The title of the article was 《Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis》.Safety of 4-Iodobenzoic acid The author mentioned the following in the article:

A series of pterostilbene derivatives I [R1 = tert-Bu, Ph, 2-furyl, etc] were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound I [R1 = 2-furyl] showed high inhibitory efficacy (against IL-1 β: IC50 = 1.23μM) and almost no toxicity (against IL-1 b: IC50 > 100μM). Further mechanism studies have showed that compound I [R1 = 2-furyl] directly targets the NLRP3 and affects the assembly of inflammasomes to inhibit the activation of NLRP3 inflammasomes. More importantly, in vitro experiments show that compound I [R1 = 2-furyl] has a significant therapeutic effect on DSS-induced colitis in mice with good metabolic stability to liver microsomes (t1/2 = 138.6 min). This research encourages the further development of more effective NLRP3 inflammasome inhibitors based on this chem. scaffold. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Xing Xing; Diao, Liang Zhuo; Chen, Liu Zeng; Ma, Duo; Wang, Yu Meng; Jiang, Han; Ruan, Ban Feng; Liu, Xin Hua published an article in European Journal of Medicinal Chemistry. The title of the article was 《Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis》.Safety of 4-Iodobenzoic acid The author mentioned the following in the article:

A series of pterostilbene derivatives I [R1 = tert-Bu, Ph, 2-furyl, etc] were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability. Among them, the most effective compound I [R1 = 2-furyl] showed high inhibitory efficacy (against IL-1 β: IC50 = 1.23μM) and almost no toxicity (against IL-1 b: IC50 > 100μM). Further mechanism studies have showed that compound I [R1 = 2-furyl] directly targets the NLRP3 and affects the assembly of inflammasomes to inhibit the activation of NLRP3 inflammasomes. More importantly, in vitro experiments show that compound I [R1 = 2-furyl] has a significant therapeutic effect on DSS-induced colitis in mice with good metabolic stability to liver microsomes (t1/2 = 138.6 min). This research encourages the further development of more effective NLRP3 inflammasome inhibitors based on this chem. scaffold. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 619-58-9In 2021 ,《Merging Supramolecular and Covalent Helical Polymers: Four Helices Within a Single Scaffold》 was published in Journal of the American Chemical Society. The article was written by Fernandez, Zulema; Fernandez, Berta; Quinoa, Emilio; Freire, Felix. The article contains the following contents:

Supramol. and covalent polymers share multiple structural effects such as chiral amplification, helical inversion, Sergeants and Soldiers or Majority Rules, among others. These features are related to the axial helical structure found in both types of materials, which are responsible for their properties. Herein a novel material combining information and characteristics from both fields, supramol. -oligo(p-phenyleneethynylene) (OPE)- and covalent -poly(acetylene) (PA)- helical polymers, is presented. To achieve this goal, the poly(acetylene) must adopt a dihedral angle between conjugated double bonds (ω1) higher than 165°. In such cases, the tilting degree (Θ) between the OPE units used as pendant groups is close to 11°, like that observed in supramol. helical arrays of these mols. Polymerization of oligo[(p-phenyleneethynylene)n]phenylacetylene monomers (n= 1, 2) bearing (L)-decyl alaninate as pendant group yielded the desired scaffolds. These polymers adopt a stretched and almost planar polyene helix, where the OPE units are arranged describing a helical structure. As a result, a novel multihelix material was prepared, the ECD spectra of which is dominated by the OPE axial array.4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Application of 619-58-9 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Tarrio, Juan Jose; Rodriguez, Rafael; Fernandez, Berta; Quinoa, Emilio; Freire, Felix published an article in Angewandte Chemie, International Edition. The title of the article was 《Dissymmetric Chiral Poly(diphenylacetylene)s: Secondary Structure Elucidation and Dynamic Luminescence》.Synthetic Route of C7H5IO2 The author mentioned the following in the article:

The secondary structure of a dissym. and chiral poly(diphenylacetylene) (PDPA) is elucidated by combining the data from NMR experiments (regioregular head to tail structure), Raman and IR studies (E configuration of the polyene double bonds), and high-resolution AFM images (helical pitch, packing angle and orientation of the external helix). As a result, an E-transoidal polyene backbone describing 3 coaxial helixes is obtained. Theor. electronic CD (ECD) studies of the structure show a good correspondence between exptl. and theor. data and allow one to decipher that the first Cotton band is generated by the poly(diphenylacetylene) core and not only by the polyene backbone. The dynamic behavior of poly-(S)-2 is also demonstrated by a helix inversion effect produced by conformational changes at the pendant groups when annealed in solvents with different donor abilities. This phenomenon is accompanied by an inversion of the circular polarized luminescence of the PDPA (CPL switch). In the experimental materials used by the author, we found 4-Iodobenzoic acid(cas: 619-58-9Synthetic Route of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Synthetic Route of C7H5IO2Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com