Category: 619-58-9

Matos, Catiucia R. M. O.; Sarmiento, Charlie V.; C. Silva, Henrique; Ferreira, Glaucio B.; Guedes, Guilherme P.; Nunes, Wallace C.; Ronconi, Celia M. published their research in Dalton Transactions in 2021. The article was titled 《Field-induced single-ion magnets exhibiting tri-axial anisotropy in a 1D Co(II) coordination polymer with a rigid ligand 4,4′-(buta-1,3-diyne-1,4-diyl)dibenzoate》.Product Details of 619-58-9 The article contains the following contents:

Herein a 1-dimensional Co(II) coordination polymer [Co(η1-L1)(η2-L1)(py)2(H2O)]n (CoCP) was synthesized using the rigid H2L1 proligand, containing a long spacer bearing two triple bonds. Single-crystal x-ray diffraction showed that Co(II) adopts a distorted octahedral geometry. The state-averaged complete active SCF (SA-CASSCF) calculation showed that the ground state of CoCP is a high spin quartet with a highly multiconfigurational character of its electronic structure. Due to the large intra- and intermol. distances between the spin carriers, the magnetic interactions are negligible and the zero-field splitting (ZFS) effects of Co(II) ions are predominant. This behavior was confirmed by d.c. (d.c.) magnetic measurements and theor. calculations using the broken-symmetry approach. Quantum chem. calculations indicate that CoCP has a neg. axial component possessing mixed tri-axial anisotropy. The d.c. magnetic susceptibility data were fitted with a Griffith-Figgis Hamiltonian and the obtained parameters are in good agreement with those simulated by the ab initio calculation A.c. (a.c.) magnetic measurements showed a field induced slow magnetic relaxation in CoCP, which is attributed to the hyperfine interaction effects. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Product Details of 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Product Details of 619-58-9 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A Mild and Versatile Friedel-Crafts Methodology for the Diversity-Oriented Synthesis of Redox-Active 3-Benzoylmenadiones with Tunable Redox Potentials》 was published in Chemistry – A European Journal in 2020. These research results belong to Cotos, Leandro; Donzel, Maxime; Elhabiri, Mourad; Davioud-Charvet, Elisabeth. COA of Formula: C7H5IO2 The article mentions the following:

A series of highly diversified 3-aroylmenadiones I [R = 4-F, 4-CF3, 3-NO2, etc.] was prepared by a new Friedel-Crafts acylation variant/oxidative demethylation strategy. A mild and versatile acylation was performed between 1,4-dimethoxy-2-methylnaphthalene and various activated/deactivated benzoic and heteroaromatic carboxylic acids, in the presence of mixed trifluoroacetic anhydride and triflic acid, at room temperature and in air. The 1,4-dimethoxy-2-methylnaphthalene-derived benzophenones II were isolated in high yield, and submitted to oxidative demethylation with cerium ammonium nitrate to produce 3-aroylmenadiones I. All 1,4-naphthoquinone derivatives were investigated as redox-active electrophores by cyclic voltammetry. The electrochem. data recorded for 3-acylated menadiones were characterized by a second redox process, the potentials of which cover a wide range of values (500 mV). These data emphasize the ability of the generated structural diversity at the 3-aroyl chain of these electrophores to fine-tune their corresponding redox potentials. These properties were of significance in the context of antimalarial drug development and understanding of the mechanism of bioactivation/action. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzoic acid(cas: 619-58-9COA of Formula: C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.COA of Formula: C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Analyst (Cambridge, United Kingdom) included an article by Li, Yannan; Yang, Li; Du, Mengqi; Chang, Guanjun. Related Products of 619-58-9. The article was titled 《Rational design of a boron-dipyrromethene-based fluorescent probe for detecting Pd2+ sensitively and selectively in aqueous media》. The information in the text is summarized as follows:

A novel fluorescent probe for Pd2+ based on the BODIPY fluorophore exploiting the PET (Photoinduced Electron Transfer) mechanism was designed and successfully synthesized. The fluorescent probe 1 was prepared by introducing m-bisimidazolylbenzene which was connected by Ph acetylene to the BODIPY dye at the meso position. It exhibited a rapid response and high sensitivity and selectivity toward Pd2+. Probe 1 presented a rapid quenched fluorescence response in aqueous buffer media (pH 5.5) and the detection limit estimated from the titration results was 2.9 × 10-7 M. Meanwhile, other common metal ions did not interfere with the recognition process. The DFT calculation proved that coordination of bisimidazole ligands with Pd2+ effectively decreases the LUMO energy of m-bisimidazolylbenzene which was located between the HOMO and LUMO energies of the BODIPY dye leading to fluorescence quenching via the d-PET mechanism.4-Iodobenzoic acid(cas: 619-58-9Related Products of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Related Products of 619-58-9 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 619-58-9In 2019 ,《A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis》 was published in ACS Combinatorial Science. The article was written by Ratnayake, Anokha S.; Flanagan, Mark E.; Foley, Timothy L.; Smith, Justin D.; Johnson, Jillian G.; Bellenger, Justin; Montgomery, Justin I.; Paegel, Brian M.. The article contains the following contents:

DNA-encoded chem. library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the identification of “”DNA-compatible”” reaction conditions is critical for the development of DECL designs that explore previously inaccessible chem. space, reports measuring such compatibility have been largely restricted to methods that do not faithfully capture the impact of reaction conditions on DNA fidelity in solution phase. Here we report a comprehensive methodol. that uses soluble DNA substrates that exactly recapitulate DNA’s exposure to the chem. reactive species of DECL synthesis. This approach includes the assessment of chem. fidelity (reaction yield and purity), encoding fidelity (ligation efficiency), and readability (DNA compatibility), revealing the fate of the DNA tag during DECL chem. from a single platform. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Related Products of 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Related Products of 619-58-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Direct synthesis of chain-end-functionalized poly(3-hexylthiophene) without protecting groups using a zincate complex》 was published in Macromolecular Rapid Communications in 2020. These research results belong to Inagaki, Shin; Yamamoto, Takuya; Higashihara, Tomoya. Reference of 4-Iodobenzoic acid The article mentions the following:

Chain-end-functionalized poly(3-hexylthiophene)s (P3HTs) with benzyl alc. (-PhCH2OH), phenol (-PhOH), and benzoic acid (-PhCOOH) groups are directly synthesized based on the Negishi catalyst-transfer polycondensation method utilizing the zincate complex of tBu4ZnLi2. In this system, neither protection nor deprotection steps are required, and also providing a living polymerization system to control the mol. weight while maintaining a low molar mass dispersity (DM) of the obtained P3HT derivatives Indeed, the chain-end-functionalized P3HTs can be synthesized along with controlled number-average mol. weights (Mn = 5100-20 000), low DM (1.06-1.14), and high chain-end functionality (Fn = 46-86%). The Fn values for the alc. and phenol groups are found to be high (86% for-PhCH2OH and 71% for -PhOH based on 1H NMR, resp.), as also confirmed by matrix-assisted laser desorption/ionization time of flight mass spectroscopy. The easily synthesizable chain-end-functionalized P3HTs will be applicable for the facile synthesis of block and branched polymers containing P3HT as well as its related semiconducting polymer segments. In the experiment, the researchers used many compounds, for example, 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Reference of 4-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Biodegradable and biocompatible radiopaque iodinated poly-3-hydroxy butyrate: synthesis, characterization and in vitro/in vivo X-ray visibility》 was published in Polymer Bulletin (Heidelberg, Germany) in 2020. These research results belong to Erol, Arzu; Rosberg, Derya B. Hazer; Hazer, Baki; Goncu, Beyza S.. Name: 4-Iodobenzoic acid The article mentions the following:

Some novel radiopaque biodegradable and biocompatible iodinated polymers based on poly-3-hydroxy butyrate (PHB) were obtained. Following the attachment of diethanol amine to PHB, the hydroxyl ends were capped with 4-iodobenzoic acid and 2,3,5-tri-iodobenzoic acid. In this manner, tri-novel radiopaque polymers were obtained. The resulting polymers were structurally characterized by NMR technique. They were evaluated with respect to their possible use as radiopaque implant biomaterials indicating X-ray visibility in a noninvasive manner using routine X-ray absorption imaging techniques. These polymers exhibited good radiopacity with conventional imaging X-ray techniques in vivo. Addnl., biocompatibility of these iodinated polymers was also evaluated. There were no signs of infection or abscess formation on the surgical area. These novel radiopaque PHBs should be promising biomaterials for a new-generation radiopaque materials. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Name: 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Name: 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy》 was written by Jenni, Sebastien; Sour, Angelique; Bolze, Frederic; Ventura, Barbara; Heitz, Valerie. Synthetic Route of C7H5IO2This research focused ontumor photosensitizer photon excitation photodynamic therapy. The article conveys some information:

Despite the advantages of photodynamic therapy (PDT) over chemotherapy or radiotherapy such as low side effects, lack of treatment resistance and spatial selectivity inherent to light activation of the drug, several limitations especially related to the photosensitizer (PS) prevent PDT from becoming widespread in oncol. Herein, new folic acid- and biotin-conjugated PSs for tumor-targeting PDT are reported, with promising properties related to PDT such as intense absorption following one-photon excitation in the red or two-photon excitation in the near-IR, and also high singlet oxygen quantum yield (close to 70% in DMSO). Cellular studies demonstrated that both targeted PSs induced phototoxicity, the folate-targeted PS being the most effective one with 80% of cell death following 30 min of irradiation and a phototoxicity four times higher than that of the non-targeted PS. This result is in accordance with the uptake of the folate-targeted PS in HeLa cells, mediated by the folate receptors. Moreover, this folate-targeted PS was also phototoxic following two-photon excitation at 920 nm, opening new perspectives for highly selective PDT treatment of small and deep tumors. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Synthetic Route of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Synthetic Route of C7H5IO2 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ethyl 2-Cyano-2-(2-Nitrophenylsulfonyloximino)Acetate (ortho-NosylOXY) Mediated One-Pot Racemization Free Synthesis of Ureas, Carbamates, and Thiocarbamates via Curtius Rearrangement》 was written by Kalita, Tapasi; Dev, Dharm; Mondal, Sandip; Giri, Rajat Subhra; Mandal, Bhubaneswar. Synthetic Route of C7H5IO2This research focused onurea preparation; carbamate preparation; thiocarbamate preparation; carboxylic acid ethyl cyano nitrophenylsulfonyloximino acetate Curtius rearrangement. The article conveys some information:

A detailed NMR-based mechanism study is incorporated here. Direct conversion of to ureas RNHC(O)NHR1 (R = Ph, 4-methylphenyl, 4-methoxybenzyl, (tert-butoxycarbonylamino)(phenyl)methyl, etc.; R1 = 4-chlorophenyl, tert-Bu, methoxycarbonylmethyl, etc.), carbamates RNHC(O)OR1 (R = 4-methoxyphenyl, 4-bromophenyl; R1 = 4-nitrobenzyl, 4-methoxybenzyl), and thiocarbamate RNHC(O)SR1 (R = Ph, undecan-1-yl, 2-methoxyphenyl; R1 = 4-chlorobenzyl) in a single pot via Curtius rearrangement is accomplished. One recently established coupling reagent, ethyl-2-cyano-2-(2-nitrophenylsulfonyloximino)acetate (ortho-NosylOXY), is successfully used for the racemization free synthesis of ureas, di-peptidyl ureas, and carbamates with moderate to good yield (82-69%). This single-pot hassle-free procedure works with a diverse range of N-protecting groups Fmoc, Boc, and Cbz. Various amines R1NH2, including aromatic, Me esters of amino acids, tert-butylamine, benzyl alcs. (such as 4-nitrobenzyl alc., 4-methoxybenzyl alc.), and (4-chlorophenyl)-methanethiol, are used as nucleophiles. Racemization suppression, easy removal of byproducts, and less waste generation make this methodol. useful. The experimental process involved the reaction of 4-Iodobenzoic acid(cas: 619-58-9Synthetic Route of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 4-Iodobenzoic acidIn 2019 ,《Sensing Temperature in Vitro and in Cells Using a BODIPY Molecular Probe》 was published in Journal of Physical Chemistry B. The article was written by Ogle, Meredith M.; Smith McWilliams, Ashleigh D.; Ware, Matthew J.; Curley, Steven A.; Corr, Stuart J.; Marti, Angel A.. The article contains the following contents:

Boron dipyrromethene (BODIPY) mol. rotors have shown sensitivity toward viscosity, polarity, and temperature Here, we report a 1,3,5,7-tetramethyl-8-phenyl-BODIPY modified with a polyethylene glycol (PEG) chain, for temperature sensing and live cell imaging. This new PEG-BODIPY dye presents an increase in nonradiative decay as temperature increases, which directly influences its lifetime. This change in lifetime is dependent on changes in both temperature and viscosity at low viscosity values, but is only dependent on temperature at high viscosity values. The dependence of fluorescence lifetime with temperature allows for temperature monitoring in vitro and in cells, with sub degree resolution When in contact with cells, the PEG-BODIPY spontaneously penetrates and stains the cell but not the nucleus. Furthermore, no significant cell toxicity was found even at 100 μM concentration Using fluorescence lifetime imaging microscopy (FLIM), we were able to observe the changes in the lifetime of PEG-BODIPY within the cell at different temperatures The use of FLIM and mol. probes such as PEG-BODIPY can provide important information about cellular temperature and heat dissipation upon medically relevant stimuli, such as radiofrequency ablation and photodynamic therapy. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Recommanded Product: 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Dethe, Dattatraya H.; Beeralingappa, Nagabhushana C.; Siddiqui, Salman A.; Chavan, Prakash N. published an article in Journal of Organic Chemistry. The title of the article was 《Asymmetric Ru/Cinchonine Dual Catalysis for the One-Pot Synthesis of Optically Active Phthalides from Benzoic Acids and Acrylates》.SDS of cas: 619-58-9 The author mentioned the following in the article:

Herein, asym. Ru/cinchonine dual catalysis that provided straightforward access to enantioselective synthesis of C-3 substituted phthalides, e.g., I via tandem C-H activation/Michael addition was reported. The use of readily accessible and less expensive [RuCl2 (p-cym)]2 and cinchonine catalyst for the one-pot assembly of chiral phthalides greatly overcame the present trend of using highly sophisticated catalysts. The developed method provided access to both enantiomers of a product using pseudo enantiomeric cinchona alkaloids as catalysts streamlining the synthesis of phthalide in both the optically active forms. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9SDS of cas: 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. SDS of cas: 619-58-9 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com