Category: 619-58-9

Samadi, Saadi; Ashouri, Akram; Rashid, Hersh I.; Majidian, Shiva; Mahramasrar, Mahsa published their research in New Journal of Chemistry in 2021. The article was titled 《Immobilization of (L)-valine and (L)-valinol on SBA-15 nanoporous silica and their application as chiral heterogeneous ligands in the Cu-catalyzed asymmetric allylic oxidation of alkenes》.Application of 619-58-9 The article contains the following contents:

SBA-15 nanoporous silica was synthesized by hydrothermal method using P123 surfactant and tetraethoxyortosilicate in acidic condition and then functionalized by 3-chloropropyltrimethoxysilane. Next, by immobilization of chiral amino acid (S)-2-amino-3-Me butanoic acid (L-valine) and chiral amino alc. (S)-2-amino-3-methylbutane-1-ol (L-valinol), prepared via the reduction of L-valine by NaBH4/I2 in THF, on functionalized-SBA-15, chiral heterogeneous ligands AL*-i-Pr-SBA-15 and AA*-i-Pr-SBA-15 were prepared and characterized by FT-IR, XRD, TGA, EDX, SEM, BET-BJH techniques. The asym. allylic oxidation of alkenes was done using copper-complexes of these ligands and the as-synthesized peresters. The reactions were optimized by varying various parameters such as temperature, solvent, amount of chiral heterogeneous ligand, as well as the type and amount of copper salt. Under optimized conditions, 6 mg of AL*-i-Pr-SBA-15 and 3.2 mol% of Cu(CH3CN)4PF6 in acetonitrile at 50°C, the chiral allylic ester was obtained with 80% yield and 39% enantiomeric excess in 24 h. The recyclability of the chiral heterogeneous catalysts was also evaluated without significant reduction in the reaction results up to three runs.4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Application of 619-58-9 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alizadeh, Abdolali; Farajpour, Behnaz published their research in Heterocyclic Letters in 2021. The article was titled 《Efficient synthesis of coumarin-based α-acyloxy amides as promising starting materials for diverse post-condensation reactions》.Reference of 4-Iodobenzoic acid The article contains the following contents:

The passerini three-component reaction for the straight-forward synthesis of coumarin-based α-acyloxy amides by employing 4-chloro-3-formylcoumarin were described. This reaction was compatible with various isocyanides and carboxylic acids. Furthermore, synthesized products can be rendered as potential starting materials for divergent post-condensation reactions and was efficiently converted into precious follow-up structures. Simple and available starting materials, catalyst-free selective process, valuable and diverse structures, and easy purification are some highlighted advantages of the synthesized coumarin-based α-acyloxy amides. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Reference of 4-Iodobenzoic acidIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Microwave-Assisted Synthesis of Core-Crosslinked Star Polymers with Benzophenone Derivatives in the Core》 were Kang, Tae-Hyeon; Lee, Hyung-il. And the article was published in Macromolecular Research in 2019. Recommanded Product: 4-Iodobenzoic acid The author mentioned the following in the article:

Core-crosslinked star polymers, which have polyethylene oxide (PEO) as a shell and cross-linked poly(2-{4′-iodobenzoyloxy}-Et methacrylate) (PIEMA) with benzophenone derivatives as a core, have been successfully synthesized by an “”arm-first”” method. PEO-b-PIEMA was prepared via atom transfer radical polymerization (ATRP) of 2-{4′-iodobenzoyloxy}-Et methacrylate (4-IEMA) with preformed PEO-Br as a macroinitiator. Core-crosslinked star polymers (CCSP) were efficiently synthesized by ultrafast carbonylation reactions under air by flash microwave irradiation in the presence of dicobalt octacarbonyl in 6 min. Gel permeation chromatog. (GPC) trace of CCSP showed a drastic shift to a higher mol. weight when compared to precursor polymer, PEO-b-PIEMA diblock copolymer, indicating that the carbonylation reaction was fully progressed. The CCSP with benzophenone was successfully immobilized on a silicon wafer through a photochem. reaction under UV irradiation The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Recommanded Product: 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Recommanded Product: 4-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhu, Yueyue; Dai, Rupeng; Huang, Chaoqun; Zhou, Wang; Zhang, Xiaoyuan; Yang, Kundi; Wen, Hongmei; Li, Wei; Liu, Jian published an article in Journal of Organic Chemistry. The title of the article was 《Synthesis of Isoquinolone, 1,2-Benzothiazine, and Naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine Derivatives via Rhodium(III)-Catalyzed (4 + 2) Annulation》.Application of 619-58-9 The author mentioned the following in the article:

A novel and efficient synthetic method to construct isoquinolone e.g., I scaffold via the Rh(III)-catalyzed (4 + 2) annulation of benzamide RC(O)NHOMe (R = Ph, naphthalen-2-yl, 2-OMeC6H4) with an unreported coupling reagent Me 2-chloroacrylate was reported. Accordingly, other valuable 1,2-benzothiazine II (R1 = Me, Et, Ph; R2 = OMe, H, F, etc.; R3 = OMe, H, Cl; R4 = Cl, H, Br) and naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine e.g., III derivatives are also obtained through a similar synthetic protocol. Thus, the developed method is highlighted by high yield and reaction versatility. In the experiment, the researchers used many compounds, for example, 4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Application of 619-58-9 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Braddock, D. Christopher; Davies, Joshua J.; Lickiss, Paul D. published an article in 2022. The article was titled 《Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids》, and you may find the article in Organic Letters.Category: iodides-buliding-blocks The information in the text is summarized as follows:

Methyltrimethoxysilane [MTM, CH3Si(OMe)3] was demonstrated an effective, inexpensive, and safe reagent for direct amidation of carboxylic acids with amines. Two simple workup procedures that provided the pure amide product R1C(O)N(R2)R3 [R1 = Ph, Bn, 4-IC6H4, etc.; R2 = Me, Et, Ph, etc.; R3 = H, Me, Et, MeO; R2R3 = (CH2)5, O(CH2)4]without the need for further purification was developed. First employed an aqueous base-mediated annihilation of MTM. Second involved simple product crystallization from the reaction mixture provides a low process mass intensity direct amidation protocol. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzoic acid(cas: 619-58-9Category: iodides-buliding-blocks)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Man; Liang, Gan; Wang, Yunhao; Fan, Tao; Yuan, Baoling; Liu, Mingxian; Yin, Ying; Li, Liangchun published an article in 2021. The article was titled 《Merging N-Hydroxyphthalimide into Metal-Organic Frameworks for Highly Efficient and Environmentally Benign Aerobic Oxidation》, and you may find the article in Chemistry – A European Journal.Computed Properties of C7H5IO2 The information in the text is summarized as follows:

Two highly efficient metal-organic framework catalysts TJU-68-NHPI and TJU-68-NDHPI have been successfully synthesized through solvothermal reactions of which the frameworks are merged with N-hydroxyphthalimide (NHPI) units, resulting in the decoration of pore surfaces with highly active nitroxyl catalytic sites. When t-Bu nitrite (TBN) is used as co-catalyst, the as-synthesized MOFs are demonstrated to be highly efficient and recyclable catalysts for a novel three-phase heterogeneous oxidation of activated C-H bond of primary and secondary alcs., and benzyl compounds under mild conditions. Based on the high efficiency and selectivity, an environmentally benign system with good sustainability, mild conditions, simple work-up procedure has been established for practical oxidation of a wide range of substrates. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Computed Properties of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Computed Properties of C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Ma, Huan; Li, Feize; Shen, Guohua; Pan, Lili; Liu, Weihao; Liang, Ranxi; Lan, Tu; Yang, Yuanyou; Yang, Jijun; Liao, Jiali; Liu, Ning published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《In vitro and in vivo evaluation of 211At-labeled fibroblast activation protein inhibitor for glioma treatment》.Related Products of 619-58-9 The author mentioned the following in the article:

Glioma is the most common primary intracranial tumor without effective treatment. Positron emission tomog. tracers labeled with 68Ga targeting fibroblast activation protein (FAP) have shown favorable characteristics in the diagnosis of glioma. However, to the best of our knowledge, FAP-targeted endoradiotherapy has never been explored in glioma. Hence, in this study, we investigated the therapeutic effect of 211At-labeled fibroblast activation protein inhibitor (FAPI) for glioma in vitro and in vivo. By astatodestannylation reaction, we prepared 211At-FAPI-04 with a radiochem. yield of 45 ± 6.7% and radiochem. purity of 98%. With good stability in vitro, 211At-FAPI-04 showed fast and specific binding to FAP-pos. U87MG cells, and could significantly reduce the cell viability, arrested cell cycle at G2/M phase and suppressed cell proliferative efficacy. Biodistribution studies revealed that 6-fold higher accumulation in tumor sites was achieved by intratumoral injection in comparison with i.v. injection. In U87MG xenografts, 211At-FAPI-04 obviously suppressed the tumor growth and prolonged the median survival in a dose-dependent manner without obvious toxicity to normal organs. In addition, reduced proliferation and increased apoptosis were also observed after 211At-FAPI-04 treatment. All these results suggest that targeted alpha-particle therapy (TAT) mediated by 211At-FAPI-04 can provide an effective and promising strategy for the treatment of glioma. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Related Products of 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 619-58-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Haiwei; Lu, Changhui; Herbert, Simon; Zhang, Wei; Shen, Qilong published their research in Journal of Organic Chemistry in 2021. The article was titled 《Difluoromethylation of Alkyl Bromides and Iodides with TMSCF2H》.Application of 619-58-9 The article contains the following contents:

For the first time, two protocols for direct difluoromethylation of unactivated alkyl bromides and iodides RCH2X [R = 4-phenylbutyl, 3-[(5-methylthiophen-2-yl)carbonyloxy]propyl, dodecyl, etc.; X = Br, I, OTs] were described. Reactions of alkyl iodides with TMSCF2H were mediated by a copper catalyst using CsF as the activator, while reactions of less reactive alkyl bromides required a combination of palladium and a stoichiometric amount of CuI as the catalysts. Preliminary mechanistic studies of the synergistic Pd/Cu-catalyzed difluoromethylation of alkyl bromides suggest that it proceeds likely via a Pd(I)/Pd(III) catalytic cycle. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application of 619-58-9Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kato, Daiki; Murase, Tomoya; Talode, Jalindar; Nagae, Haruki; Tsurugi, Hayato; Seki, Masahiko; Mashima, Kazushi published an article in Chemistry – A European Journal. The title of the article was 《Diarylcuprates for Selective Syntheses of Multifunctionalized Ketones from Thioesters under Mild Conditions》.Quality Control of 4-Iodobenzoic acid The author mentioned the following in the article:

Ketones were selectively synthesized from thioesters by using diarylcuprates(I) generated in situ from copper(I) salts and aryl Grignard reagents in a 1 : 1.3-1.5 ratio under ambient temperature During the ketone synthesis, various functional groups, such as carbonyl (ketones, esters, and amides), O-protecting groups, halogens, and heteroarenes, were tolerated to afford multifunctionalized ketones in excellent yields. This copper-mediated ketone synthesis could be applied to the synthesis of not only gluconolactone-derived ketone, a synthetic intermediate in the transformation to the SGLT2 inhibitor canagliflozin, but also thiolactol, a valuable synthetic intermediate for (+)-biotin. Control experiments on an isolated diphenylcuprate(I), [CuPh2]-, and DFT calculations revealed that this ketone synthesis proceeded by oxidative addition of the C-S bond of thioesters to [CuPh2]-, while reductive elimination from the CuIII intermediate produced the corresponding ketone and an inactive species [(RS)CuPh]-, the latter reacted with [CuPh]4 to regenerate the reactive diphenylcuprate(I). In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Quality Control of 4-Iodobenzoic acid) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Quality Control of 4-Iodobenzoic acidIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tironi, Matteo; Dix, Stefan; Hopkinson, Matthew N. published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Deoxygenative nucleophilic difluoromethylselenylation of carboxylic acids and alcohols with BT-SeCF2H》.Reference of 4-Iodobenzoic acid The article contains the following contents:

The benzothiazolium salt BT-SeCF2H is introduced as an efficient nucleophilic reagent for transferring difluoromethylselenyl groups onto organic mols. SeCF2H-Containing selenoesters could be prepared upon deoxygenative substitution of readily available carboxylic acids, while silver catalysis allowed for efficient formation of (difluoromethyl)selenoethers, including the established electrophilic reagent BnSeCF2H, directly from simple alcs. To the best of knowledge, these deoxygenative reactions represent the first reported nucleophilic difluoromethylselenylation processes and thus open up new approaches to prepare valuable fluorinated compounds In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Reference of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com