Category: 619-58-9

《Lewis Acid-Free Ynoate-Mediated Chemoselective Reduction of Carboxylic Acids to Primary Alcohols》 was published in ChemistrySelect in 2020. These research results belong to Sun, Feixiang; Feng, Huangdi; Huang, Liliang; Liu, Weiping. Formula: C7H5IO2 The article mentions the following:

Economical and facile catalytic reduction process of carboxylic acids for the synthesis of alcs was reported. This pyridine-catalyzed strategy operates through addition of carboxylic acids with Me propiolate followed by NaBH4 reduction or unexpected ester exchange, provided the corresponding primary alcs. and esters, resp. A range of carboxylic acids bearing other reductive groups (e. g., halogen, cyano, nitro, ester and double bond) were accessed with uniformly high chemoselectivity. The use of environmentally benign, convenient and safe procedure also makes this catalytic protocol attractive for practical application. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Formula: C7H5IO2) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zou, Zhenlei; Li, Heyin; Huang, Mengjun; Zhang, Weigang; Zhi, Sanjun; Wang, Yi; Pan, Yi published an article in 2021. The article was titled 《Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides》, and you may find the article in Organic Letters.Product Details of 619-58-9 The information in the text is summarized as follows:

This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides ArX (Ar = biphenyl-4-yl, benzothiophen-3-yl, benzodioxol-5-yl, etc.; X = Br, I) under electrochem. conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates NaSO2CF2H, NaSO2CH2F and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Product Details of 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 619-58-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Xu, Ji-Hang; Gao, Yang published an article in 2021. The article was titled 《Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis》, and you may find the article in Organic Letters.Reference of 4-Iodobenzoic acid The information in the text is summarized as follows:

The merger of strain-release of 1,2-oxazetidines I (R = 4-Me, 2,4,5-(OMe)3, 4-Br, etc.) with carboxylic acids 2-R1-3-R2-4-R3-5-R4C6HC(O)OH [R1 = H, Me, Bn, I, etc.; R2 = H, Ph, Br, Me, etc.; R1R2 = -(CH2)4-; R3 = H, Me, t-Bu, Br, etc.; R2R3 = -CH=CH-CH=CH-; R4 = H, OMe] directed C-H activation in catalytic synthesis of isoindolinones II was reported for the first time. This reaction opens a new and sustainable avenue to prepare a range of structurally diverse isoindolinone skeletons II from readily available benzoic acids. The success of late-stage functionalization of some bioactive acids II, and concise synthesis of biol. important skeletons demonstrated its great synthetic potential in drug discovery. Mechanistic studies indicated a plausible C-H activation/β-carbon elimination/intramol. cyclization cascade pathway. In the experimental materials used by the author, we found 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Reference of 4-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Pingfan; Wang, Yu; Chen, Weizhou; Hu, Xunliang; Huang, Bo; Xiao, Zicheng published an article in 2021. The article was titled 《Structural and Magnetical Studies of Mixed-Valence Hexavanadate Hybrids: How Organic Ligands Affect the Magnetism of Polyoxometalates?》, and you may find the article in Inorganic Chemistry.COA of Formula: C7H5IO2 The information in the text is summarized as follows:

In this Communication, authors illustrate the influence of organic ligands on magnetic structure and behavior by employing a mixed-valence Lindqvist-type hexavanadate as a research platform. Through covalently attaching to different halogen-containing organic ligands, the derived hybrid materials have different magnetism compared to their parent structure. Single-crystal x-ray analyses show that the introduction of organic ligands can modify the crystal packing manners of the derivatives, leading to further changes of the interaction between magnetic units. This work demonstrates that organic functionalization can remarkably affect the magnetism of polyoxometalates by adjusting the distance and location of the magnetic fractions. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9COA of Formula: C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.COA of Formula: C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 619-58-9In 2022 ,《Supramolecular interaction controlled and calix[4]arene ligand assisted Pd-catalyzed C(sp3)-H arylation of aliphatic aldehydes》 was published in Chinese Chemical Letters. The article was written by Wu, Yao; Ma, Zhiyan; Shi, Jing; Sun, Xiaoqiang; Yang, Ke; Li, Zheng-Yi. The article contains the following contents:

A calix[4]arene ligand assisted direct β-C-H arylation of tertiary aliphatic aldehydes has been developed via a Pd-catalyzed C(sp3)-H functionalization process. This strategy exhibited good functional group compatibility and C-H bond site-selectivity. Mechanism studies have shown that both synergistic effect and cationic-π supramol. interaction between calixarene cavity and transition-metal catalytic center may play an important role in this catalytic cycle. This complementary method would be used in organic and medical chem. due to the importance of tertiary aliphatic aldehydes. In the experiment, the researchers used many compounds, for example, 4-Iodobenzoic acid(cas: 619-58-9Recommanded Product: 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Recommanded Product: 619-58-9 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs》 were Liu, Yingguo; Chen, Qiao; Mou, Chengli; Pan, Lutai; Duan, Xiaoyong; Chen, Xingkuan; Chen, Hongzhong; Zhao, Yanli; Lu, Yunpeng; Jin, Zhichao; Chi, Yonggui Robin. And the article was published in Nature Communications in 2019. Product Details of 619-58-9 The author mentioned the following in the article:

Carboxylic acids are common moieties in medicines. They can be converted to phthalidyl esters as prodrugs. Unfortunately, phthalidyl esters are now mostly prepared in racemic forms. This is not desirable because the two enantiomers of phthalidyl esters likely have different pharmacol. effects. Here, the authors address the synthetic challenges in enantioselective modification of carboxylic acids via asym. acetalizations. The key reaction step involves asym. addition of a carboxylic acid to the catalyst-bound intermediate. This addition step enantioselectively constructs a chiral acetal unit that leads to optically enriched phthalidyl esters. A broad range of carboxylic acids react effectively under mild and transition metal-free conditions. Preliminary bioactivity studies show that the two enantiomers of chlorambucil phthalidyl esters exhibit different anti-cancer activities to inhibit the growth of Hela cells. Our catalytic strategy of asym. acetalizations of carboxylic acids shall benefit future development of chiral phthalidyl ester prodrugs and related mols. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Product Details of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Product Details of 619-58-9 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Garg, Utsav; Azim, Yasser; Alam, Mahboob; Kar, Aranya; Pradeep, Chullikkattil P. published an article in Crystal Growth & Design. The title of the article was 《Extensive Analyses on Expanding the Scope of Acid-Aminopyrimidine Synthons for the Design of Molecular Solids》.Recommanded Product: 619-58-9 The author mentioned the following in the article:

The acid-aminopyrimidine synthon is a well-known robust synthon for cocrystal synthesis that exists both in heterotrimer (HT) and linear heterotetramer (LHT) assemblies. A rational coformer screening methodol. was adopted to predict the HT and LHT for the first time. The Cambridge Structural Database (CSD) and a modified site-pair interaction energy difference (ΔEsite-pair), based on mol. electrostatic potential (MESP), were computed to propose a generalization for better predictability. Based on the generalization, four cocrystals of 4-halobenzoic acid (-F, -Cl, -Br, and -I at the para position of benzoic acid) with 2-aminopyrimidine (2-AP) were predicted and obtained using a neat grinding method. Different characterization methods, viz., Fourier transform IR (FT-IR) spectroscopy, powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC) anal., were used to confirm the formation of cocrystals. Single-crystal XRD was used for structural confirmations. Geometrical coordinates of cocrystals and their ingredients were optimized using d. functional theory (DFT) calculations at the B3LYP-D3/6-311++G(d,p) level for -F-, -Cl-, and -Br-substituted cocrystals and the B3LYP-D3/6-311++G(d,p)/LANL2DZ level for the -I-substituted cocrystal. Extensive computational studies, viz., Frontier MOs (FMOs), MESP values, natural bond orbitals (NBO), quantum theory of atoms in mols. (QTAIM), and reduced d. gradient noncovalent interaction (RDG-NCI) analyses, were done on optimized structures to gain more insights into cocrystals and the effect of halogens on the acid-aminopyrimidine synthon and strength and nature of intermol. interactions present in the cocrystals. Moreover, the strong and weak intermol. interactions present in the crystal structure were examined qual. and quant. using Hirshfeld surface anal. on different parameters, interaction energy calculations, and total energy frameworks. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Recommanded Product: 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 619-58-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dutta, Shubham; Shandilya, Shashank; Yang, Shengwen; Gogoi, Manash Protim; Gandon, Vincent; Sahoo, Akhila K. published an article in 2022. The article was titled 《Cationic-palladium catalyzed regio- and stereoselective syn-1,2-dicarbofunctionalization of unsymmetrical internal alkynes》, and you may find the article in Nature Communications.Safety of 4-Iodobenzoic acid The information in the text is summarized as follows:

The discovery of a regio- and stereoselective syn-1,2-dicarbofunctionalization of unsym. internal alkynes was reported. A cationic Pd-catalyzed three-component coupling of aryl diazonium salts, aryl boronic acids (or olefins) and yne-acetates enables access to all-carbon substituted unsym. olefins. The transformation features broad scope with labile functional group tolerance, building broad chem. space of structural diversity (94 mols.). The value of this synthetic method was demonstrated by the direct transformation of natural products and drug candidates containing yne-acetates, to enable highly substituted structurally complex allyl acetate analogs of biol. important compounds Synthetic versatility of the carboxylate bearing highly substituted olefins was also presented. The reaction outcome was attributed to the in situ formation of stabilized cationic aryl-Pd species, which regulated regioselective aryl-palladation of unsym. yne-acetates. Control experiments reveal the synergy between the carboxylate protecting group and the cationic Pd-intermediate in the regioselectivity and reaction productivity; d. functional theory (DFT) studies rationalize the selectivity of the reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Safety of 4-Iodobenzoic acid Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ruthenium(II)-catalyzed synthesis of CF3-isoquinolinones via C-H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides》 was written by Wen, Si; Zhang, Yuqing; Tian, Qingyu; Chen, Yanhui; Cheng, Guolin. Category: iodides-buliding-blocksThis research focused ontrifluoromethyl isoquinolinone preparation; benzoic acid trifluoromethyl sulfoxonium ylide activation annulation ruthenium catalyst. The article conveys some information:

A ruthenium(II)-catalyzed C-H activation/annulation reaction of benzoic acids and CF3-imidoyl sulfoxonium ylides enabled by weak O-coordination was achieved. A series of 3-trifluoromethyl-isoquinolinones I [R = Ph, 2-MeC6H4, CH2CH2Ph, etc.; R1 = 8-Me, 7-F, 6-I, etc.; R2 = F, CF2CF3, CF2CF2CF3] were synthesized in 37-75% yields under redox-neutral reaction conditions. In the experimental materials used by the author, we found 4-Iodobenzoic acid(cas: 619-58-9Category: iodides-buliding-blocks)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocksIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 4-Iodobenzoic acidIn 2021 ,《A Three-Component Ugi-Type Reaction of N-Carbamoyl Imines Enables a Broad Scope Primary α-Amino 1,3,4-Oxadiazole Synthesis》 appeared in Organic Letters. The author of the article were Matheau-Raven, Daniel; Boulter, Elizabeth; Rogova, Tatiana; Dixon, Darren J.. The article conveys some information:

A general synthesis of N-protected primary α-amino 1,3,4-oxadiazoles from N-carbamoyl imines, N-isocyaniminotriphenylphosphorane (NIITP) and carboxylic acids was described. Featuring an isocyanide addition reaction with N-carbamoyl imines, this efficient three-component Ugi-type reaction was found to be broad in scope with respect to imine and carboxylic acid coupling partners. Furthermore, versatility of this method was demonstrated by α-amino 1,2,4-triazole synthesis, late-stage functionalization of seven drug mols. and five divergent derivatizations of a primary α-amino 1,3,4-oxadiazole. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Quality Control of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Quality Control of 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com