Category: 610-97-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 610-97-9, name is Methyl 2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 610-97-9

General procedure: A 50 cm3 Schlenk flask was charged with an ortho-substituted iodoarene(1¡Á10-3 mol), an amine (1.1-5¡Á10-3 mol), K2CO3(2¡Á10-3 mol), a catalyst (5¡Á10-6 mol), and a stirring bar. Next, 5cm3 of DMF was added. Under balloon pressure of CO, the reactionmixture was stirred at 100 C for 1-6 h. After the reaction, the Schlenkflask was cooled down, and the organic products were extracted with3¡Á7 cm3 of diethyl ether (3¡Á15 min with stirring) and then GCanalyzed with dodecane as the internal standard (0.076 cm3, 5.46¡Á10-4 mol). Each reaction was repeated minimum twice and the averagevalue from two experiments was reported. The difference between tworesults was below 5%.After the solvents were evaporated, the crude product was purifiedby flash chromatography on silica gel using hexane/ethyl acetate (10:4)as the eluent, and the corresponding N-substituted phthalimides wereobtained

The synthetic route of 610-97-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wojcik, Przemys?aw; Trzeciak, Anna M.; Applied Catalysis A: General; vol. 560; (2018); p. 73 – 83;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 610-97-9, A common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2.27 g (15 mmol) was added sequentially to a 250 mL round bottom flask.Methyl 2-aminobenzoate, 3.93 g (15 mmol) of methyl 2-iodobenzoate,2.49 g (18 mmol) of potassium carbonate, 0.19 g (3 mmol) of activated copper powder and100mL of o-dichlorobenzene, degassing the reaction system, and then protecting with argon gas,The mixture was heated to 180 C with stirring and the reaction was continued for 48 h. After the reaction is complete,The system was cooled to room temperature, suction filtered under reduced pressure and the residue was washed with dichloromethane.After the filtrate was spin-dried, it was separated and purified on a silica gel column using an eluent of dichloromethane: petroleum ether = 3:1 (volume ratio).Obtained a yellow-green solid 3.66g,The yield was 85.6%.

The synthetic route of 610-97-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Soochow University (Suzhou); Liao Liangsheng; Yuan Yi; Jiang Zuoquan; (46 pag.)CN109456326; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 610-97-9, A common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 50 cm3 Schlenk flask was charged with an ortho-substituted iodoarene(1¡Á10-3 mol), an amine (1.1-5¡Á10-3 mol), K2CO3(2¡Á10-3 mol), a catalyst (5¡Á10-6 mol), and a stirring bar. Next, 5cm3 of DMF was added. Under balloon pressure of CO, the reactionmixture was stirred at 100 C for 1-6 h. After the reaction, the Schlenkflask was cooled down, and the organic products were extracted with3¡Á7 cm3 of diethyl ether (3¡Á15 min with stirring) and then GCanalyzed with dodecane as the internal standard (0.076 cm3, 5.46¡Á10-4 mol). Each reaction was repeated minimum twice and the averagevalue from two experiments was reported. The difference between tworesults was below 5%.After the solvents were evaporated, the crude product was purifiedby flash chromatography on silica gel using hexane/ethyl acetate (10:4)as the eluent, and the corresponding N-substituted phthalimides wereobtained

The synthetic route of 610-97-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wojcik, Przemys?aw; Trzeciak, Anna M.; Applied Catalysis A: General; vol. 560; (2018); p. 73 – 83;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 610-97-9

General procedure: ReBr(CO)5, ReCl(CO)5, (C5H5)ReO3, Re2(CO)10, and ReCl5 were commercially available andwere used without further purification. 2-(Arylethynyl)benzoic acids were prepared by the hydoration ofcorresponding methyl esters, which were prepared by the Sonogashira coupling of methyl 2-iodobenzoateand arylethyny, 1-pentyne, 1-hexyne, ethynylcyclohexane or 3,3-dimethyl-1-butyne. Other chemicalagents were obtained commercially and were purified if necessary by distillation.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 610-97-9, its application will become more common.

Reference:
Article; Umeda, Rui; Yoshikawa, Shunya; Yamashita, Kouji; Nishiyama, Yutaka; Heterocycles; vol. 91; 11; (2015); p. 2172 – 2179;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 610-97-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 610-97-9, name is Methyl 2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Methyl 2-iodobenzoate (25 g, 95 mmol), prop-2-yn-1-ol (8.02 g, 143 mmol) and TEA (26.6 ml, 191 mmol) were added to a deareated mixture of Pd(PPh3)4 (0.220 g, 0.191 mmol), copper(I) iodide (0.073 g, 0.382 mmol) in DMF (60 ml). The resulting mixture was stirred at 90 C. for 5 hrs and then at 40 C. overnight. The reaction mixture was poured into EtOAc (600 ml) and washed with brine (600 ml). Organic phase was then concentrated and the dark oil was rinsed with Et2O (600 ml). The mixture was filtered, and then concentrated to give the title compound as deeply brown oil (13.0 g). This compound was used in the next step without any further purification and characterization. UPLC-MS: 1.53 min, [M+H-18]+. (Method 4)

The synthetic route of Methyl 2-iodobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; Biagetti, Matteo; Capelli, Anna Maria; Accetta, Alessandro; Carzaniga, Laura; US2015/166549; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 610-97-9, name is Methyl 2-iodobenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C8H7IO2

30 g (114 mmol) methyl 2-iodobenzoate, N, N-dimethylformamide in 1 L round bottom flaskAfter adding 360ml, trimethylsilylacetylene 22.5g (229mmol), 114.9 ml (801 mmol) triethylamineNitrogen was bubbled for 20 minutes by addition of 8 g (11 mmol) of dichloro (bistriphenylphosphine) palladium (II),I put 2.2 g (11 mmol) of Cooper (I) iodideHeat stirred at 80 C. for 3 h.When the reaction was terminated, the reaction solution was purified by a column to obtain 23 g (yield: 86%) of the compound represented by [Formula 191-d].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SFC Ltd.; Park Seok-bae; Lee Se-jin; Kim Jeong-su; (92 pag.)KR101996647; (2019); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

610-97-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 610-97-9 name is Methyl 2-iodobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A 50 mL round-bottomed flask, equipped with a gas inlet tube, a refluxcondenser and a magnetic stirring bar was charged with MCM-41-2PPdCl2 (102 mg, 0.05 mmol Pd), aryl halide (5.0 mmol) and HCOONa(7.5 mmol). The flask was flushed with CO. DMF (5 mL) was addedby syringe and a slow stream of CO was passed into the suspension.The mixture was vigorously stirred at 110-130 C for 2-20 h, cooledto room temperature and diluted with diethyl ether (50 mL). Thepalladium catalyst was separated from the mixture by filtration,washed with distilled water (2 ¡Á 10 mL), ethanol (2 ¡Á 10 mL) and ether(2 ¡Á 10 mL) and reused in the next run. The ethereal solution waswashed with water (3 ¡Á 20 mL), and dried over anhydrous magnesiumsulfate and concentrated under reduced pressure. The residue waspurified by flash column chromatography on silica gel (hexane-ethylacetate = 10 : 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-iodobenzoate, and friends who are interested can also refer to it.

Reference:
Article; Jiang, Jianwen; Wang, Pingping; Cai, Mingzhong; Journal of Chemical Research; vol. 38; 4; (2014); p. 218 – 222;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 610-97-9

General procedure: To a solution of the corresponding aryl iodide (0.01 mol) in EtOAc (50 mL), activated Cu85 (2.5 g, 0.04 mol) was added and the solvent was removed under vacuum.? A reflux condenser was connected and the mixture was heated for 30 min at 205-220 C, under N2 atm, with stirring. The mixture was allowed to cool under N2 atm. EtOAc (100 mL) was added and the mixture was vigorously stirred at rt under N2 atm until a fine suspension was obtained. The suspension was filtered through a sintered glass pad and washed with EtOAc (250 mL, in portions) until absence of product (checked by TLC in the mother liquors). The solvent was removed under vacuum and the compound was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 610-97-9, its application will become more common.

Reference:
Article; Sagrera, Gabriel; Bertucci, Ana; Vazquez, Alvaro; Seoane, Gustavo; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3060 – 3073;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 610-97-9.

To a solution of methyl 2-iodobenzoate in a 2:1 mixture of drytetrahydrofuran/triethylamine was added Pd(PPh3)4 (6 mol %) followed by CuI (3mol %) and propargyl alcohol (3 equiv), under argon atmosphere. The above solutionwas stirred at 40 C and the reaction progress was monitored by TLC. After completion,the reaction mixture was concentrated in vacuo and the crude residue was purifiedthrough flash column chromatography to obtain the cross-coupled products

The synthetic route of Methyl 2-iodobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Bin; Shi, Bing-Feng; Synlett; vol. 27; 16; (2016); p. 2396 – 2400;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 610-97-9

Example 15A Methyl 5-bromo-2-iodobenzoate To a stirred slurry of methyl 2-iodo-benzoate (5.0 g, 0.019 mol) and N-bromosuccinimide (3.74 g, 0.021 mol) in acetic acid (10 mL) was added concentrated H2SO4 (10 mL) dropwise, keeping the temperature at 20-40 C. The mixture was stirred at room temperature for 88 hours and then heated at 50 C. for 4 hours. The mixture was cooled to 10 C., treated with 40 g of ice water, and extracted with 50 mL of CH2Cl2. The organic phase was washed in succession with 2*50 mL 5% NaHCO3, 50 mL 10% Na2S2O3, 50 mL water, and concentrated to colorless oil. The residue was purified by column chromatography (silica gel, 10:90 EtOAc:hexane) to provide the title compound. 1H NMR (CDCl3, 400 MHz) delta 7.92 (d, J=4 Hz, 1H), 7.83 (d, J=8 Hz, 1H), 7.27 (dd, J=8, 4 Hz, 1H), 3.92 (s, 3H); MS (DCl/NH3) [M+NH4]+at 358, [M+NH3.NH4]+ at 375.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 610-97-9.

Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-Yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Curtis, Michael P.; US2005/272736; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com