Category: 610-97-9

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 610-97-9, Name is Methyl 2-iodobenzoate, SMILES is O=C(OC)C1=CC=CC=C1I, in an article , author is Eng, PHK, once mentioned of 610-97-9, Computed Properties of C8H7IO2.

Regulation of the sodium iodide symporter by iodide in FRTL-5 cells

Objective: The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses of iodide given to rats chronically decrease the sodium/iodide symporter (NIS) mRNA and protein, suggesting that escape is due to a decrease in NIS and subsequent iodide transport. We have now studied the effect of excess iodide on NIS in FRTL-5 cells to further explore the mechanisms whereby excess iodide decreases NIS. Design: FRTL-5 cells were employed and were incubated in the presence or absence of various concentrations of iodide. NIS mRNA and protein and the turnover of NIS were assessed. Methods: NIS mRNA was measured by Northern analysis. NIS protein by Western analysis and NIS turnover by pulse-chase labeling experiments. Results: Iodide (10(-3) mol/l) had no effect on NIS mRNA in FRTL-5 cells at 24 and 48 h compared with cells cultured in the absence of iodide. However, excess iodide decreased NIS protein by 50%, of control values at 24 h and by 70%, at 48 h. This effect of iodide was dose dependent. Pulse-chase experiments demonstrated that there was no effect of iodide on new NIS protein synthesis and that the turnover of NIS protein in the presence of iodide was 27% faster than in the absence of added iodide. Conclusions: Excess iodide does not decrease NIS mRNA in FRTL-5 cells but does decrease NIS protein, suggesting that in this in vitro thyroid cell model iodide modulates NIS, at least in part, at a posttranscriptional level. This iodide-induced decrease in NIS protein appears to he due, at least partially, to an increase in NIS protein turnover.

Interested yet? Read on for other articles about 610-97-9, you can contact me at any time and look forward to more communication. Computed Properties of C8H7IO2.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: iodides-buliding-blocks, 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, belongs to iodides-buliding-blocks compound. In a document, author is Pesce, Liuska, introduce the new discover.

TSH Regulates Pendrin Membrane Abundance and Enhances Iodide Efflux in Thyroid Cells

Thyroid hormones are essential for normal development and metabolism. Their synthesis requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux of iodide into the follicular lumen are poorly elucidated. The discovery of mutations in the SLC26A4 gene in patients with Pendred syndrome (congenital deafness, goiter, and defective iodide organification) suggested a possible role for the encoded protein, pendrin, as an apical iodide transporter. We determined whether TSH regulates pendrin abundance at the plasma membrane and whether this influences iodide efflux. Results of immunoblot and immunofluorescence experiments reveal that TSH and forskolin rapidly increase pendrin abundance at the plasma membrane through the protein kinase A pathway in PCCL-3 rat thyroid cells. The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin. Elimination of the putative protein kinase A phosphorylation site T717A results in a diminished translocation to the membrane in response to forskolin. These results demonstrate that pendrin translocates to the membrane in response to TSH and suggest that it may have a physiological role in apical iodide transport and thyroid hormone synthesis. (Endocrinology 153: 512-521, 2012)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 610-97-9. Category: iodides-buliding-blocks.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2. In an article, author is Namer, V,once mentioned of 610-97-9, Safety of Methyl 2-iodobenzoate.

Urinary iodide excrecion and others thyroid function and thyroid autoimmunity parameters during pregnancy

The urinary iodide excretion of pregnant women of Buenos Aires was investigated using a potenciometric method. Furthermore; serum TSH, free T4 and anti-thyroid antibodies were analyzed to correlate iodide intake with the thyroid function and autoimmunity fenomena. We observed a high average urinary iodide level (740 mu g/24 h) similar to American and Japanese populations. The hormones levels and autoimmunity parameters agree with the consulted publications. We conclude there is no iodide deficiency in the tested patients and we discuss the effect that a high iodide intake might have on thyroid function and the development of autoimmune thyroid pathologies during pregnancy.

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Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is , belongs to iodides-buliding-blocks compound. In a document, author is Haberkorn, U, Name: Methyl 2-iodobenzoate.

Gene therapy with sodium/iodide symporter in hepatocarcinoma

The ability of thyroid cells to accumulate iodide is a prerequisite for successfull radioiodide therapy of benign thyroid diseases and differentiated thyroid carcinoma. The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Employing a bicistronic retroviral vector for the transfer of the hNIS coding sequence and the hygromycin resistence gene stable hNIS expressing rat Morris hepatoma (MH3924A) cell lines were generated by hygromycin selection. Genetically modified MH3924A cell lines accumulated up to 235 times more iodide when compared to non-infected hepatoma cells with a maximal iodide uptake after 60 minutes incubation. Competition experiments in the presence of sodium perchlorate revealed a dose dependent decrease of the iodide uptake, FCCP led to a loss of accumulated I-, whereas DIDS increased the I- uptake into the cells. However, a rapid efflux of the radioactivity (80%) was observed during the first 10 minutes after the I-125(-) containing medium had been replaced by non-radioactive medium. In rats, the hNIS-expressing tumors accumulated six times more iodide as compared to the contralateral wild type tumor as monitored by scintigraphy. An ex vivo quantitation of the iodide content performed 1 hour after tracer administration in Ig tumor tissue revealed a 17-fold higher iodide accumulation in the genetically modified tumors. In vivo also a rapid efflux of the radioactivity out of the tumor was observed. Therefore, the transduction of the hNIS gene per se is sufficient to induce I-125(-) transport in Morris hepatoma cells in vitro and in vivo. For a therapeutic application of the hNIS gene, however, additional conditions need to be defined which inhibit the iodide efflux.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 610-97-9, in my other articles. Name: Methyl 2-iodobenzoate.

Related Products of 610-97-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 610-97-9, Name is Methyl 2-iodobenzoate, SMILES is O=C(OC)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Haltner-Ukomadu, Eleonore, introduce new discover of the category.

In Vitro Bioavailability Study of an Antiviral Compound Enisamium Iodide

An investigation into the biopharmaceutics classification and a study of the in vitro bioavailability (permeability and solubility) of the antiviral compound enisamium iodide (4-(benzylcarbamoyl)-1-methylpyridinium iodide) were carried out. The solubility of enisamium iodide was determined in four different buffers. Apparent intestinal permeability (P-app) of enisamium iodide was assessed using human colon carcinoma (Caco-2) cells at three concentrations. The solubility of enisamium iodide in four buffer solutions from pH 1.2 to 7.5 is about 60 mg/mL at 25 degrees C, and ranges from 130 to 150 mg/mL at 37 degrees C, depending on the pH. Based on these results, enisamium iodide can be classified as highly soluble. Enisamium iodide demonstrated low permeability in Caco-2 experiments in all tested concentrations of 10-100 mu M with permeability coefficients between 0.2 x 10(-6) cm s(-1) and 0.3 x 10(-6) cm s(-1). These results indicate that enisamium iodide belongs to class III of the Biopharmaceutics Classification System (BCS) due to its high solubility and low permeability. The bioavailability of enisamium iodide needs to be confirmed in animal and human studies.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2. In an article, author is Xu, F,once mentioned of 610-97-9, Computed Properties of C8H7IO2.

Catalysis of novel enzymatic iodide oxidation by fungal laccase

A fungal laccase (Myceliophthora thermophila) has been shown to function as an iodide oxidase. Unlike other halides which interact with the type 2 copper site and are inhibitors for the laccase, iodide interacts with the type 1 copper site and serves as a substrate capable of donating an electron to the laccase. Under anaerobic conditions, the interaction between the laccase and iodide results in the reduction of the laccase type 1 copper and the concomitant oxidation of iodide to form iodide. In aerated solutions, the laccase catalyzes the oxidation of iodide to iodine and the concomitant reduction of dioxygen to water. The reaction exhibits typical Michaelis kinetics with a Km of 0.16 +/- 0.02 M and a k(cat) of 2.7 +/- 0.2 turnovers per min at the optimal pH (3.4). The catalysis can be enhanced by 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid), which shuttles electrons rapidly between iodide and the laccase. Bilirubin oxidase also demonstrates significant iodide oxidase activity, suggesting that the property could be a common feature for copper-containing oxidases. Possible industrial and medicinal applications for a laccase-based iodine production system are discussed.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2. In an article, author is Gigauri, RD,once mentioned of 610-97-9, Application In Synthesis of Methyl 2-iodobenzoate.

Reaction of bis[trialkyl(aryl)arsonium]-1,4-dihydronaphtalene iodides with mercuric iodide in water-ethanol solutions of potassium iodide

The reaction of bis[trialkyl(aryl)arsonium]-1,4-dihydronaphtalene iodides with mercuric iodide in water-alcohol solutions in the presence of excess potassium iodide gives rise to bisarsonium triiodomercurates.

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Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 610-97-9, Name is Methyl 2-iodobenzoate, SMILES is O=C(OC)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a document, author is QI, PH, introduce the new discover, HPLC of Formula: C8H7IO2.

ELECTROCHEMICAL-BEHAVIOR OF GOLD IN IODIDE SOLUTIONS

The electrochemistry of gold in different halide solutions, with special emphasis on iodide is presented. The electrochemical techniques used during this investigation included cyclic and linear sweep voltammetry. A glassy carbon rotating disk electrode was used to investigate the electrochemistry of the iodide and a gold rotating disk electrode to explore the oxidation behavior of gold in iodide solutions. The effects of iodide concentration, electrode rotation and sweep rate on the electrochemical behavior of gold were examined. In addition, reduction of iodine species at the gold electrode was also investigated. Iodide is shown to be a powerful complexing agent for gold. Cyclic voltammograms of gold in the presence of 10(-2) M chloride, bromide and iodide, respectively, show that the anodic currents for the oxidation of gold in iodide solution are much greater than that in either bromide or chloride. Two oxidation peaks, which represent the oxidations of Au to Au(I) and to Au(III), were observed. It is confirmed that iodide is oxidized sequentially to tri-iodide and then to iodine and both of these reactions are reversible. At high concentrations of iodide and/or a slow scan rate, passivation, which is caused by the formation of solid iodine at the gold electrode surface, was found. The cathodic reduction curves show that reduction of iodide species on gold is a function of iodine concentrations but it is insensitive to iodide concentration.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 610-97-9 is helpful to your research. HPLC of Formula: C8H7IO2.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is MOORE, JS, once mentioned the application of 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, molecular weight is 262.0445, MDL number is MFCD00016351, category is iodides-buliding-blocks. Now introduce a scientific discovery about this category, SDS of cas: 610-97-9.

A CONVENIENT MASKING GROUP FOR ARYL IODIDES

1-Aryl-3,3-dialkyltriazenes give excellent yields of easily isolated aryl iodides upon treatment with methyl iodide.

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 610-97-9, Name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, belongs to iodides-buliding-blocks compound. In a document, author is Kong, Weimin, introduce the new discover, Safety of Methyl 2-iodobenzoate.

Controllable deposition of regular lead iodide nanoplatelets and their photoluminescence at room temperature

In this work, the synthesis of regular single crystalline lead iodide nanoplatelets are carried out based on the physical vapor phase deposition method. Different lead iodide nanoplatelets are obtained by tuning the location of the mica substrate along with the temperature of the tube furnace. The rules of size, thickness, density of the lead iodide nanoplatelets at varied deposition conditions are analyzed according to the crystal growth principles. It was claimed in literature that the photoluminescence of lead iodide could be obtained only at a low temperature (lower than 200 K). Here, at room temperature, we successfully obtained the photoluminescence spectra of the prepared lead iodide nanoplatelets, which possess two apparent peaks due to the biexcitons and the inelastic scattering of excitons, respectively. Our present study contributes to the development of nanoscaled high performance optoelectronic devices.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 610-97-9. Safety of Methyl 2-iodobenzoate.