Category: 60827-45-4

Synthetic Route of C3H7ClO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Enhancing the detection sensitivity of trace analysis of pharmaceutical genotoxic impurities by chemical derivatization and coordination ion spray-mass spectrometry. Author is Bai, Lin; Sun, Mingjiang; An, Jianguo; Liu, David Q.; Chen, Ted K.; Kord, Alireza S..

Many pharmaceutical genotoxic impurities are neutral mols. Trace level anal. of these neutral analytes is hampered by their poor ionization efficiency in mass spectrometry (MS). Two anal. approaches including chem. derivatization and coordination ion spray-MS were developed to enhance neutral analyte detection sensitivity. The chem. derivatization approach converts analytes into highly ionizable or permanently charged derivatives, which become readily detectable by MS. The coordination ion spray-MS method, on the other hand, improves ionization by forming neutral-ion adducts with metal ions such as Na+, K+, or NH4 + which are introduced into the electrospray ionization source. Both approaches have been proven to be able to enhance the detection sensitivity of neutral pharmaceuticals dramatically. This article demonstrates the successful applications of the two approaches in the anal. of four pharmaceutical genotoxic impurities identified in a single drug development program, of which two are non-volatile alkyl chlorides and the other two are epoxides.

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Safety of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Catalytic behavior of wool-osmium tetroxide complex for asymmetric dihydroxylation of olefins. Author is Miao, Ju-Hong; Yang, Ji-Huo; Chen, Li-Yi; Tu, Bu-Xin; Huang, Mei-Yu; Jiang, Ying-Yan.

A new chiral polymer-metal complex, wool-osmium tetroxide (wool-OsO4) complex was prepared by a very simple method. This complex was able to catalyze the asym. dihydroxylation of allylamine to (R)-(+)-3-amino-1,2-propanediol and allyl chloride to (S)-(+)-3-chloro-1,2-propanediol. The optical yields amounted to 83.7 and 57.2%, and the product yields were 80.2 and 68.5% resp. The exptl. results showed that OsO4 content in the complex, reaction time, allylamine/OsO4 molar ratio and solvent all have an effect on the product and optical yields. Addnl., wool-OsO4 complex catalyst could be reused without any remarkable change in optical catalytic activity.

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Category: iodides-buliding-blocks. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about The effect of the isomers of α-chlorohydrin and racemic β-chlorolactate on the rat kidney. Author is Porter, K. E.; Jones, A. R..

The (R)- [57090-45-6] and (S)-isomers [60827-45-4] of the male antifertility agent α-chlorohydrin have been synthesized. When administered to rats, the (R)-isomer induced a period of diuresis and glucosuria, whereas the (S)-isomer, which possesses the antifertility activity, had no detrimental action on the kidney. Neither of the isomers of α-chlorohydrin nor those of an active analog, 3-amino-1-chloropropan-2-ol, had any inhibitory activity on the oxidative metabolism of glucose  [50-99-7] or lactate  [50-21-5] in isolated kidney tubules. However, (RS)-β-chlorolactate  [1713-85-5], a metabolite common to both compounds, inhibited the oxidation of glucose, lactate, pyruvate  [127-17-3], and glutamate  [56-86-0] to CO2. It is proposed that the antifertility action of the (S)-isomers of α-chlorohydrin and 3-amino-1-chloropropan-2-ol is unrelated to the renal toxicity of the (R)-isomers, a toxic action involving the inhibition of oxidative metabolism by (S)-β-chlorolactate or a further product of this metabolite.

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Jackson, H.; Rooney, F. R.; Fitzpatrick, R. W.; Gibson, K. H. published the article 《Characterization and antifertility activity in rats of S(+)-α-chlorohydrin》. Keywords: chlorohydrin stereoisomer antifertility activity.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).HPLC of Formula: 60827-45-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.

In male rats, a single oral dose of S(+)α-chlorohydrin (I) [60827-45-4] (12.5 mg/kg) produced temporary infertility following pairing with females from matings between days 2 and 6 after the I dose. A similar dose of the racemic mixture [96-24-2] was ineffective and the antifertility effect of the active isomer was comparable to that produced by a mixture of similar amounts of the S(+)- and R(-) [57090-45-6]-isomer or the corresponding dose of the racemate (25 mg/kg). However, the latter dose of the S(+)-isomer induced sterility during week 1, some degree of recovery of fertility in weeks 2-3 followed by permanent sterility. The S(+) isomer also maintained the reversible antifertility effect on epididymal spermatozoa at a daily oral dose of 5-10 mg/kg. Preparation of derivatives of I may provide compounds with high antifertility potency and low toxicity.

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Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, A. R.; Du Toit, J. I. published an article about the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4,SMILESS:OC[C@H](O)CCl ).Reference of (2S)-(+)-3-Chloropropane-1,2-diol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:60827-45-4) through the article.

(S)-α-Chlorohydrin  [60827-45-4] interferes with glycolysis in bovine spermatozoa, whereas the (R)-isomer is ineffective. The action of the (S)-isomer, which involves inhibition of the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase  [9001-50-7], is not immediate but is evident only after a brief period of incubation with the spermatozoa. This inhibitory action is prevented when glycerol  [56-81-5] is present, suggesting that the mechanism of action of (S)-α-chlorohydrin requires its oxidation to (S)-3-chlorolactaldehyde  [86747-03-7], which is the active metabolite. Addition of (R,S)-3-chlorolactaldehyde  [84709-24-0] to bovine spermatozoa caused immediate inhibition of glycolysis. The action of (S)-α-chlorohydrin in bovine spermatozoa may be similar to that observed in the spermatozoa of other species in being a 2-stage process: 1st, its oxidation to (S)-3-chlorolactaldehyde, and then inhibition of the glycolytic enzyme by this metabolite.

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Kulig, Katarzyna; Boba, Agnieszka; Bielejewska, Anna; Gorska, Magdalena; Malawska, Barbara published an article about the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4,SMILESS:OC[C@H](O)CCl ).COA of Formula: C3H7ClO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:60827-45-4) through the article.

The synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one derivatives, i.e. I, is described. These enantiomers were synthesized starting from (R)- or (S)-1-chloro-2,3-dihydroxypropane using relevant cyclic sulfates as chiral intermediates. The enantiomeric purities of the final compounds were in the range of 99.3-100.0%, as determined by high performance liquid chromatog. The final compounds were found to display moderate potency as ligands for α1-adrenoreceptors.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Novel S1P1 Receptor Agonists – Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes, published in 2014-01-09, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, SDS of cas: 60827-45-4.

Previously, we reported on the discovery of a novel series of bicyclo[3.1.0]hexane fused thiophene derivatives that serve as potent and selective S1P1 receptor agonists. Here, we discuss our efforts to simplify the bicyclohexane fused thiophene head. In a first step the bicyclohexane moiety could be replaced by a simpler, less rigid cyclohexane ring without compromising the S1P receptor affinity profile of these novel compounds In a second step, the thiophene head was simplified even further by replacing the cyclohexane ring with an iso-Bu group attached either to position 4 or position 5 of the thiophene. These structurally much simpler headgroups again furnished potent and selective S1P1 agonists (e.g., 87), which efficiently and dose dependently reduced the number of circulating lymphocytes upon oral administration to male Wistar rats. For several compounds discussed in this report lymphatic transport is an important route of absorption that may offer opportunities for a tissue targeted approach with minimal plasma exposure.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Heterocycles called A formal synthesis of (+)-α-allokainic acid via sulfanyl radical addition-cyclization reaction, Author is Miyata, Okiko; Ozawa, Yoshiki; Ninomiya, Ichiya; Aoe, Keiichi; Hiramatsu, Hajime; Naito, Takeaki, the main research direction is allokainic acid total synthesis radical cyclization; sulfanyl radical addition cyclization diallylamine; pyrrolidine preparation radical addition cyclization diallylamine.Product Details of 60827-45-4.

Sulfanyl radical addition-cyclization of diallylamine I in the presence of thiophenol and AIBN gave the 2,3,4-trisubstituted pyrrolidines II (R = PhSCH2, R1 = H; R = H, R1 = PhSCH2) which were effectively converted into the known key intermediate for the synthesis of (+)-α-allokainic acid via conversion of the phenylsulfanylmethyl group into the isopropenyl group at the 4-position.

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HPLC of Formula: 60827-45-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Inhibition of fructolysis in boar spermatozoa by the male antifertility agent (S)-α-chlorohydrin.

The male antifertility agent (S)-α-chlorohydrin  [60827-45-4] strongly inhibited the oxidative metabolism of fructose  [57-48-7] by boar spermatozoa in vitro. The result of this action, which has been deduced to be an inhibition of glyceraldehyde phosphate dehydrogenase, caused an accumulation of fructose 1,6-bisphosphate  [488-69-7] and the triose phosphates, and a decrease in substrate-level phosphorylation with a concomitant lowering of the energy charge potential of the spermatozoa. (R)-α-chlorohydrin  [57090-45-6] Had no inhibitory activity on fructolysis. A study of the comparative metabolism of (R)-[3-36Cl]-α-chlorohydrin and (R,S)-[3-36Cl]-α-chlorohydrin by boar spermatozoa showed that it is the (S)-isomer that specifically undergoes a process of oxidative metabolism to (R)-3-chlorolactaldehyde  [84607-54-5]. This endogenous oxidation product, which has the same absolute configuration as the substrate for glyceraldehyde phosphate dehydrogenase, may be the active metabolite of (S)-α-chlorohydrin that inhibits this enzyme. Exogenous (R,S)-3-chlorolactaldehyde  [84709-24-0] inhibited the oxidative metabolism of fructose by boar spermatozoa, apparently by a mechanism similar to that of (S)-α-chlorohydrin.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol.Kwon, Mi-Ae; Kim, Geon-Joong published the article 《Synthesis of polymeric salen complexes and application in the enantioselective hydrolytic kinetic resolution of epoxides as catalysts》 about this compound( cas:60827-45-4 ) in Catalysis Today. Keywords: polymeric chiral salen cobalt complex preparation epoxide resolution catalyst; terminal epoxide hydrolytic kinetic resolution chiral polymeric salen cobalt; epoxide enantioselective preparation; chiral diol enantioselective preparation. Let’s learn more about this compound (cas:60827-45-4).

The polymeric (salen) Co(III) catalysts containing various counter anions have been synthesized, and the asym. catalytic activities of these newly synthesized polymer-type salen complexes were investigated in the HKR of terminal epoxides. The polymeric chiral salen Co(III) complexes catalyze the hydrolysis of epichlorohydrin, 1,2-epoxybutane, 1,2-epoxyhexane and epoxystyrene with very high enantioselectivities under mild conditions. The catalysts could be recovered and reused several times without further treatment after reaction, showing no loss of activity and enantioselectivity.

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