Category: 60577-34-6

Related Products of 60577-34-6,Some common heterocyclic compound, 60577-34-6, name is 4-Iodo-N-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

46.6 mg (0.2 mmol) of N-methyl 4-iodoaniline, 81.2 mg of ethyl bromodifluoroacetate (0.4 mmol), 2.5 mg (0.02 mmol) of cuprous acetate, 19.1 mg (0.04 mmol) of X-phos, 32.7 mg (0.2 mmol) of cesium carbonate were added to 2 mL of DMF solvent. The reaction was carried out at 110 C for 12 hours, after the reaction was completed, it was cooled, filtered, and the filtrate was evaporated. The solvent was removed and the residue was chromatographed on silica gel. It was washed with a mixed solution of petroleum ether and ethyl acetate in a volume ratio of 8:1. The effluent was collected according to the actual gradient, detected by TLC, and the effluent containing the product was combined. The solvent was distilled off by a rotary evaporator. Vacuum drying to give a yellow liquid N-(p-iodophenyl)-N-methylformamide 27.1 mg, yield 52%.

The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wenzhou University; Zhang Xiaohong; Li Xiaofang; Zhang Xingguo; (15 pag.)CN108774147; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 60577-34-6,Some common heterocyclic compound, 60577-34-6, name is 4-Iodo-N-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part D: The product obtained above was dissolved in dichloromethane (100 mL), to which DIEA (12 mL) and chloroacetyl chloride (12 mL) were slowly added at 0 C. The reaction was stirred from 0 C. to rt for 4 hours, washed with 1.0 N HCl (2*) and brine, and dried over magnesium sulfate. After solvent removal, the crude product was purified by chromatography using ethyl acetate/hexane as eluent (2:8 to 4:6 ethyl acetate:hexane) to give the desired 2-chloro-N-(4-iodo-phenyl)-N-methyl-acetamide as a brown solid. MS found: (M+1)+=310.23.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-N-methylaniline, its application will become more common.

Reference:
Patent; Smallheer, Joanne M.; Pinto, Donald J.; Wang, Shuaige; Qiao, Jennifer X.; Han, Wei; Hu, Zilun; US2004/6062; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 60577-34-6, These common heterocyclic compound, 60577-34-6, name is 4-Iodo-N-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 50 mL round bottom flask was charged with compound 12 (1 equivalent), CuI (0.40.5 equivalents), anhydrous K2CO3 (2-4 equivalents), pipecolinic acid (0.81.0 equivalents) and appropriate iodobenzene (2-3 equivalents). The flask was connected to a vacuum for 3 min, followed by addition of anhydrous DMF using a syringe. The flask was purged with argon for 5 min and then heated in an oil bath maintained at 110 C. On heating, the color of the suspension turned orange/pink, and this color change lasted for about 2 h. The reaction was stirred for an additional 22 h at 110 C. The reaction mixture was then allowed to cool to room temperature. Ethyl acetate (25 mL) was added, and the mixture was poured into water (100 mL). The product was extracted with ethyl acetate (100 mL × 2). The combined organic extracts were washed with brine (100 mL) and dried (anhydrous Na2SO4) and concentrated under reduced pressure. Silica gel (500 mg) was added and the solvent evaporated to obtain a plug, which was purified by column chromatography using hexanes and ethyl acetate (10:1 to 2:1). Fractions containing the product (TLC) were pooled and evaporated to afford 14, 17, and 18 in 27-36% yield.

The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Devambatla, Ravi Kumar Vyas; Choudhary, Shruti; Ihnat, Michael; Hamel, Ernest; Mooberry, Susan L.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry Letters; vol. 28; 18; (2018); p. 3085 – 3093;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60577-34-6, name is 4-Iodo-N-methylaniline, A new synthetic method of this compound is introduced below., Safety of 4-Iodo-N-methylaniline

(4) 7.7 g (33 mmol) of 4-iodo-N-methylaniline, 3.9 g (38 mmol) of acetic anhydride and 3.0 g (38 mmol) of pyridine,After reacting at room temperature for 1 hour, 50 ml of water was added to the reaction mixture, and the product was extracted with chloroform.After the reaction, usual post-treatment was performed to obtain 8.6 g of a yellow solid.This yellow solid was recrystallized using a mixed solvent of diethyl ether: ethanol = 5: 1 (v / v),7.6 g (84% yield) of 4-iodo-N-methylacetanilide was obtained as a yellow solid.

The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Unimatec Co., Ltd.; Saito, Satoshi; (9 pag.)JP5895454; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 60577-34-6,Some common heterocyclic compound, 60577-34-6, name is 4-Iodo-N-methylaniline, molecular formula is C7H8IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7.1. Methyl 6-cyano-1-methyl-2-oxo-1,2-dihydro-4-quinolineacetate 1.1 ml of trimethylsilyl cyanide (8.4 mmol) followed by 0.15 g (0.13 mmol) of tetrakistriphenylphosphinepalladium are added to a solution of 0.50 g (1.4 mmol) of methyl 6-iodo-1-methyl-2-oxo-1,2-dihydro-4-quinolineacetate (prepared from N-methyl-4-iodoaniline according to the method described in Example 1) in 6 ml of anhydrous triethylamine. The reaction medium is then heated to reflux for 4 hours under a nitrogen atmosphere. After cooling to room temperature, the medium is poured into 60 ml of toluene and 60 ml of water. The organic phase is washed with water and the initial aqueous phase is re-extracted with dichloromethane. The organic phases are combined, dried over sodium sulphate and concentrated under vacuum. The residue is purified by flash chromatography on silica, eluding with a methanol/dichloromethane (5:95) mixture. 0.313 g of the expected nitrile is obtained. Yield=87%; Melting point=202-203 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-N-methylaniline, its application will become more common.

Reference:
Patent; SYNTHELABO; US5958924; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

60577-34-6, name is 4-Iodo-N-methylaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 60577-34-6

To a 250?mL round-bottomed flask equipped with a magnetic stir bar was added 4-iodo-N-methylaniline (2, 35.0?g, 150? mmol, 1 equiv) and 100?mL DCM. tBuONO (26.8?mL, 225?mmol, 1.5 equiv) was added dropwise into the flask under ice bath in 15?min. Then the reaction was allowed to proceed under stirring at r.t. for 4?h until the completion of reaction. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography on silica gel with PE/EA (4:1) as the eluent and recrystallized in PE and DCM. The product 3 was obtained as a light yellow solid in 94% yield (37.0?g, 141?mmol). 1H NMR (500?MHz, CDCl3) delta 7.82-7.77 (m, 2H), 7.34-7.29 (m, 2H), 3.42 (s, 3H). 13C NMR (126?MHz, CDCl3) delta 142.01, 138.50, 120.53, 91.62, 30.97.

The synthetic route of 60577-34-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Zhongsu; Zeng, Hua; Zhang, Wenjing; Song, Chao; Yang, Fan; Liu, Yun; Zhu, Jin; Polymer; vol. 172; (2019); p. 152 – 159;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com