Category: 60166-93-0

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Quality Control of Iopamidol, 60166-93-0, Name is Iopamidol, molecular formula is C17H22I3N3O8, belongs to iodides-buliding-blocks compound. In a document, author is Zeng, Chaoyuan, introduce the new discover.

Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of lodoalkanes

The preparation of anhydrous hydrogen iodide directly from molecular hydrogen and iodine using a rhodium catalyst is reported for the first time. The anhydrous hydrogen iodide generated was proven to be highly active in the transformations of alkenes, phenyl aldehydes, alcohols, and cyclic ethers to the corresponding iodoalkanes. Therefore, the present methodology not only has provided convenient access to anhydrous hydrogen iodide but also offers a practical preparation method for various iodoalkanes in excellent atom economy.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 60166-93-0. Quality Control of Iopamidol.

Adding a certain compound to certain chemical reactions, such as: 60166-93-0, name is Iopamidol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60166-93-0, Recommanded Product: 60166-93-0

Add iopamidol (Substance II) to 40 mL of anhydrous N,N-dimethylacetamide10.0 g, concentrated sulfuric acid 0.520 g,Then, a hydroxyl protective agent 2,2-dimethoxypropane 6.40 mL was added dropwise with stirring.The reaction temperature was maintained at about 55 C, and the reaction was stopped after stirring for 24 h.Neutralize the reaction solution with a sodium carbonate solution of 3% by mass.Most of the solvent was removed by rotary evaporation to give a pale yellow oil.150 mL of distilled water was added to the oil, stirred at room temperature for 2 h, and then centrifuged to obtain a white solid.It was washed twice with distilled water to remove unreacted raw materials and impurities.The obtained product was dried in a vacuum oven at 50 C to give 8.0 g of crude product.The crude product was purified by silica gel column chromatography (dichloromethane:methanol = 15:1)5 g of white compound III were obtained with a final yield of 45.6%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Iopamidol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tianjin Medical University; Yang Xiaoying; Gao Chunhui; Zhang Yinghua; Wang Li; Xing Chao; Wang Yinsong; Chen Yan; (16 pag.)CN108452327; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com