Category: 59382-39-7

Adding a certain compound to certain chemical reactions, such as: 59382-39-7, name is 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59382-39-7, Formula: C7H3F4I

(69-1) Synthesis of 3-(4-fluoro-3-trifluoromethylphenyl)-2-propyne-1-ol (compound 69-1) A mixture of 2-fluoro-5-iodobenzotrifluoride (5.00 g), copper(I) iodide (65.5 mg), triphenylphosphine (226 mg), tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (356 mg), propargyl alcohol (1.12 ml), diisopropylethylamine (12.0 ml) and tetrahydrofuran (80 ml) was stirred at room temperature for 11 hr. The reaction mixture was added to brine, and the mixture was extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=99:1 – 80:20) to give the object product (3.26 g) as a brown oil. 1H-NMR(CDCl3) delta (ppm): 1.69(1H, t, J=6.2Hz), 4.50(2H, d, J=6.2Hz), 7.16(1H, t, J=9.3Hz), 7.58-7.62(1H, m), 7.69(1H, dd, J=1.4, 6.8Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59382-39-7, name is 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H3F4I

Dissolve 1-fluoro-4-iodo-2-trifluoromethylbenzene (813 mg, 2. 8 mmol) in triethylamine (6 mL). Add 3-ethynyl-5-methoxypyridine, (prepared as described in PREPARATION 10), (400 mg, 3. 0 mmol) followed by bis (triphenylphosphine) palladium (II) dichloride (0. 100 g, 0. 14 mmol) and copper (I) iodide (53 mg, 0. 28 mmol). Heat at 70 C for 16 h, concentrate, and purify using silica gel chromatography, eluting with 100 : 0 to 90 : 10 methylene chloride : ethyl acetate, to give the title compound as a pale yellow solid (820 mg, 99%). 1HNMR (300 MHz, CDCl3) 6 3. 89 (s, 3H), 7. 19-7. 26 (m, 1H), 7. 30-7. 31 (m, 1H), 7. 69- 7. 74 (m, 1H), 7. 79-7. 82 (m, 1H), 8. 30 (d, J = 2. 8 Hz, 1H), 8. 38 (d, J = 1. 3 Hz, 1H) ; MS (APCI) : m/z = 296 [M+H] +.

The synthetic route of 59382-39-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 59382-39-7, name is 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59382-39-7, Computed Properties of C7H3F4I

(69-1) Synthesis of 3-(4-fluoro-3-trifluoromethylphenyl)-2-propyne-1-ol (compound 69-1) A mixture of 2-fluoro-5-iodobenzotrifluoride (5.00 g), copper(I) iodide (65.5 mg), triphenylphosphine (226 mg), tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (356 mg), propargyl alcohol (1.12 ml), diisopropylethylamine (12.0 ml) and tetrahydrofuran (80 ml) was stirred at room temperature for 11 hr. The reaction mixture was added to brine, and the mixture was extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=99:1 – 80:20) to give the object product (3.26 g) as a brown oil. 1H-NMR(CDCl3) delta (ppm): 1.69(1H, t, J=6.2Hz), 4.50(2H, d, J=6.2Hz), 7.16(1H, t, J=9.3Hz), 7.58-7.62(1H, m), 7.69(1H, dd, J=1.4, 6.8Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59382-39-7, name is 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., name: 1-Fluoro-4-iodo-2-(trifluoromethyl)benzene

Sequentially add 3-chloro-5-ethynylpyridine, (prepared as described in PREPARATION 27), (300 mg, 2. 2 mmol), (bis (triphenylphosphine) palladium (II) dichloride (69 mg, 0. 10 mmol), and copper (I) iodide (38 mg, 0. 198 mmol) to a solution of 1-fluoro-4-iodo-2-trifluoromethylbenzene (575 mg, 1. 98 mmol) in triethylamine (4 mL) under nitrogen. Heat at 70 C for 2. 5 h and concentrate. Purify the residue by silica gel chromatography, eluting from 0 : 100 to 20 : 80 using ethyl acetate : hexanes, to give the title compound as a white solid (520 mg, 88%). 1HNMR (300 MHz, CDCl3) 8 7. 19-7. 23 (m, 1H), 7. 67-7. 74 (m, 1H), 7. 79-7. 87 (m, 2H), 8. 55 (d, J = 2. 3 Hz, 1H), 8. 63 (d, J = 1. 7 Hz, 1H) ; MS (APCI) m/z= 300 [M+H] +.

The synthetic route of 59382-39-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com