The important role of 5-Iodobenzo[d][1,3]dioxole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference of 5876-51-7, The chemical industry reduces the impact on the environment during synthesis 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, I believe this compound will play a more active role in future production and life.

A 20 ml vial charged with 1-iodo-3,4-methylenedioxybenzene (0.13 ml, 1.001mmol), (R)-pyrrolidin-2-ylmethanol (0.11 ml, 1.115 mmol), copper (1) iodide (0.153g,0.803 mmol) and 2-propanol (3.5 ml) was evacuated and backfilled with nitrogen four times and cooled at 0C in an ice-water bath. Powdered sodium hydroxide (0.08 1 g, 2.025 mmol) was then added and the mixture was stirred for 10 minutes at 0C (solution became purple) and 16 hours at 90C (solution became orange). The reaction mixture wascooled down to room temperature, diluted with ethyl acetate, washed with water, and the water layer was back extracted twice with ethyl acetate. Combined organic layers were washed once with saturated aqueous NaHCO3 solution, once with water, once with brine, dried on anhydrous Na2SO4, filtrated and concentrated. The residue was purified on ISCO using a 25g Innoflash column (Hex/EtOAc) to give title material (0.166 g, 75%) as yellowish oil. LC (Method A): 0.886 mm. MS (APCI) calcd for C12H16N03 [M+H] rn/z 222.11, found 222.2. ?H NMR (400 MHz, acetone-d6) oe ppm 6.67 (d, J 8.2 Hz, 1 H),6.31 (d, J = 2.3 Hz, 1 H), 6.04 (dd, J = 2.5, 8.4 Hz, 1 H), 5.83 (d, J = 1.2 Hz, 1 H), 5.82 (d,J = 0.8 Hz, 1 H), 3.74 (t, J 5.7 Hz, 1 H), 3.69 – 3.58 (m, 2 H), 3.41 – 3.29 (m, 2 H), 3.02 (dt, J = 5.9, 9.0 Hz, 1 H), 2.12 – 1.87 (m, 4 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITE DE MONTREAL; MARTEL, Alain; TREMBLAY, Francois; (207 pag.)WO2017/66863; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sources of common compounds: 5876-51-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5876-51-7, HPLC of Formula: C7H5IO2

General procedure: To a solution of tetrabutylammonium bromide (1.100 g, 3.33mmol), potassium acetate (0.586 g, 3.57 mmol), and palladium acetate (0.025 g, 0.11mmol) in DMF (20 mL) were added substituted iodobenzene (2.21mmol) and substituted styrene (2.44 mmol). The reaction mixture was recharged with argon and stirred at 80C for 5 h in a sealed tube. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 10:3) to afford pure product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Liang, Jian-Hua; Yang, Liang; Wu, Si; Liu, Si-Si; Cushman, Mark; Tian, Jing; Li, Nuo-Min; Yang, Qing-Hu; Zhang, He-Ao; Qiu, Yun-Jie; Xiang, Lin; Ma, Cong-Xuan; Li, Xue-Meng; Qing, Hong; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 382 – 392;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Research on new synthetic routes about 5876-51-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 5876-51-7, The chemical industry reduces the impact on the environment during synthesis 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, I believe this compound will play a more active role in future production and life.

General procedure: Anhydrous CoBr2 (5.5 mg, 0.025 mmol) and Mn (27.5 mg, 0.5 mmol) wereplaced in a 20-mL Schlenk tube and heated with heat-gun (400 C) under thevacuum conditions for 30 min. After cooling to room temperature, the tubewas filled with N2 gas, and then PPh3 (6.6 mg, 0.025 mmol), aryl iodide(0.25 mmol), and acetonitrile (0.5 mL) were sequentially added. Alkyne(0.55 mmol) was successively added to the mixture. After stirring at 25 Cfor several hours, the reaction mixture was poured saturated NH4Cl solution and ether. Aqueous phase was extracted with ether. The combined etherealphases were dried over anhydrous MgSO4, filtered, and concentrated to affordcrude product. Silica-gel column purification of the crude product provided thecorresponding naphthalenes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Komeyama, Kimihiro; Kashihara, Tetsuya; Takaki, Ken; Tetrahedron Letters; vol. 54; 42; (2013); p. 5659 – 5662;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The important role of 5876-51-7

According to the analysis of related databases, 5876-51-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Iodobenzo[d][1,3]dioxole

[00216] This example demonstrates that palladium catalysts can be activated by treatment with a base prior to their use in promoting the reaction of an organic halide with a dialkoxyborane. In particular, the catalytic activity of PdCl2(dppf).CH2Cl2 can be increased significantly, especially the initial activity, by treatment, in the reaction solvent, with triethylamine prior to the addition of the pinacolborane and substrate. Besides the rate enhancement observed in the formation of the required product boronic acid ester (e.g. pinacol ester of 3,4-methylenedioxyphenylboronic acid) there is a further advantage in the prior activation of the catalyst in that the amount of bi-product formed in the reaction (viz. 1,3-benzodioxole through dehalogenation of the substrate and the pinacol ester of phenylboronic acid in which the phenyl groups are from the catalyst ligand) is significantly reduced. Formation of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole [00217] [C00024] [00218] To 24.6 mg PdCl2(dppf).CH2Cl2 in a reaction tube under nitrogen was added 4 ml dioxane and 0.42 ml (3 mmol) triethylamine. The mixture was heated at 80 C. for ca 17 h. The red-orange suspension of PdCl2(dppf).CH2Cl2 dissolved to give a dark red-brown solution. To this solution, at room temperature, was added 0.23 ml (1.5 mmol) pinacolborane and 253 mg (1.02 mmol) 1-iodo-3,4-methylenedioxybenzene. The reaction solution was warmed to 80 C. with stirring for 1 h in an oil bath. The solution remained a dark red-brown in colour. An aliquot (ca. 0.25 ml) of the reaction solution was removed, extracted into ethyl acetate and washed several times with water and brine solution and analysed by gc (fid detector, SGE HT5 capillary column). Apart from a small amount of 1,3-benzodioxole (5% of uncorrected gc peak area) and pinacol ester of phenylboronic acid (3%), the only other product peak in the gc (area of 92%, uncorrected) was that due to the desired arylboronic acid pinacol ester. There was no evidence of biaryl formation. The rate of reaction of 1-iodo-3,4-methylenedioxybenzene with pinacolborane at 80 C. with activated catalyst is indicated also in Table 17.1. Table 17.2 shows that side product formation can be reduced still further by carrying out the reaction at 30 C. [TABLE-US-00002] TABLE 17.1 Rate of product formation on reaction* of 1-iodo-3,4-methylenedioxybenzene with pinacolborane at 80 C. in which the catalyst, PdCl2(dppf).CH2Cl2, was activated, prior to employment in the reaction, with triethylamine. The concentrations are expressed in area % (uncorrected for response factors) determined by gc analysis of aliquots of the reaction solution taken at selected reaction times. Reaction Time (mins) [C00025] [C00026] [C00027] [C00028] 6 4.4 0.74 54 40 10 4.4 1.0 40 55 15 5.2 2.1 26 66 20 5.9 2.9 16.3 75 25 5.7 2.9 9.2 82 30 6.0 3.2 3.6 87 35 5.9 3.4 1.2 89 40 5.7 3.4 0.7 90 50 5.6 3.4 0 91 180 5.7 3.5 0 91 *Used 25.5 mg of PdCl2(dppf).CH2Cl2. 4 ml dioxane, 0.43 ml (3.0 mmol) triethylamine and warmed to 80 C. for 16 h. Then added 0.23 ml (1.5 mmol) pinacolborane and 247 mg (1.0 mmol) 1-iodo-3,4-methylenedioxybenzene at room temp. before warming the reaction to 80 C. The reaction was quenched at the selected reaction time by addition of the aliquot of reaction solution to a water/ethyl acetate mixture. [TABLE-US-00003] TABLE 17.2 Rate of product formation on reaction* of 1-iodo-3,4-methylenedioxybenzene with pinacolborane at 30 C. in which the catalyst, PdCl2(dppf).CH2Cl2, was activated, prior to employment in the reaction, with triethylamine. The concentrations are expressed in area % (uncorrected for response factors) determined by gc analysis of aliquots of the reaction solution taken at selected reaction times Reaction Time (h) [C00029] [C00030] [C00031] [C00032] 1 1.6 0 94 4.8 2 1.7 0 89 9.7 3 2 0 84 13.8 4 2 0 81 17 7 2.3 0 71 26 28 4 0.6 27 68 71.5 4.2 1.9 0 94 *Used 25 mg of PdCl2(dppf).CH2Cl2, 4 ml dioxane, 0.43 ml (3.0 mmol) triethylamine and warmed to 80 C. for 16 h. Then added 0.23 ml (1.5 mmol) pinacolborane and 262 mg (1.05 mmol) 1-iodo-3,4-methylenedioxybenzene at room temp. before warming the reaction to 80 C. The reaction was quenched at the selected reaction time by addition of the aliquot of reaction solution to a water/ethyl acetate mixture. [00219] When the catalyst PdCl2(dppf).CH2Cl2 is treated with the amine together with the borane ester prior to use in the reaction, the initial reaction rate is enhanced, indicating that some catalyst has been activated. The overall reaction, however, is slower than that when the catalyst receives no pretreatment. Catalyst presumably unactivated by the pretreatment with triethylamine and pinacolborane appears to be more resistant to activation during the progress of the boronation reaction. This can be seen by comparison of Tables 17.3 and 17.4. In Table 17.3, the catalyst was not activated prior to use and the reaction rate over the first 1 to 2 hours is slow. In T…

According to the analysis of related databases, 5876-51-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery of 5876-51-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Iodobenzo[d][1,3]dioxole, its application will become more common.

Reference of 5876-51-7,Some common heterocyclic compound, 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, molecular formula is C7H5IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00230] To 27.7 mg PdCl2(dppf).CH2Cl2 in a reaction tube under nitrogen were added 4 ml dioxane, 0.14 ml (1.0 mmol) of 2,6-dimethylpiperidine, 0.23 ml (1.5 mmol) pinacolborane (crimson solution) and 261 mg (1.05 mmol) 1-iodo-3,4-methylenedioxybenzene. The crimson reaction solution was warmed to 80 C. with stirring in an oil bath. Analysis of the reaction solution by gc, as described above, was carried out at intervals (see Table 19.1). The reaction is fast and is complete after 4 h reaction time. The initial reaction rate with 1 mmol of 2,6-dimethylpiperidine as base exceeds that found using 3 mmol of triethylamine (see Table 17.3; catalyst not activated prior to reaction) and the final product distribution is essentially the same. This is not the case if one compares the reactions in which either 1 mmol of 2,6-dimethylpiperidine or 1 mmol of triethylamine is used as base. As noted above, dehalogenation in reactions using 1 mmol of triethylamine is considerable (23% of peak area in the gc is due to 1,3-benzodioxole) and the desired product, the pinacol ester of 3,4-methylenedioxyphenylboronic acid is only 69% of peak area. [00231] The results are different when 3 mmol of 2,6-dimethylpiperidine is used in the reaction. The reaction rate is reduced, especially after the first 1 to 2 hours (see Table 19.2). The results suggest that in situ catalyst activation may be initially enhanced using 2,6-dimethylpiperidine but excess of this base also retards the reaction. Dehalogenation occurs predominantly during the earlier part of the reaction. [TABLE-US-00007] TABLE 19.1 Rate of product formation on reaction of 1-iodo-3,4-methylenedioxybenzene with pinacolborane at 80 C., catalyst PdCl2(dppf).CH2Cl2, base 2,6-dimethylpiperidine (1.0 mmol). The concentrations are expressed in area % (uncorrected for response factors) determined by gc analysis of aliquots of the reaction solution taken at selected reaction times*. Reaction Time (h) [C00047] [C00048] [C00049] [C00050] 1 8.7 2 70 20 2 8.4 4.3 42 44 3 8.5 6.2 16 67 4 11.5 6.5 0.3 80 5 11.6 6.4 0 80 *The reaction was quenched at the selected reaction time by addition of the aliquot of reaction solution to a water/ethyl acetate mixture. [TABLE-US-00008] TABLE 19.2 Rate of product formation on reaction of 1-iodo-3,4-methylenedioxybenzene with pinacolborane at 80 C., catalyst PdCl2(dppf).CH2Cl2, base 2,6-dimethylpiperidine (3.0 mmol). The concentrations are expressed in area % (uncorrected for response factors) determined by gc analysis of aliquots of the reaction solution taken at selected reaction times*. Reaction Time (h) [C00051] [C00052] [C00053] [C00054] 1 8.9 1.3 69 20 2 9.2 2.8 49 38 3 9.6 3.5 33 53 4 11 5.1 25 58 5 10 5.6 18 66 6 10 5.9 13 71 25.5 12 6.1 2.2 78 *The reaction was quenched at the selected reaction time by addition of the aliquot of reaction solution to a water/ethyl acetate mixture.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Iodobenzo[d][1,3]dioxole, its application will become more common.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple exploration of 5876-51-7

The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H5IO2

[00212] 8.1 mg of Pd(OAc)2 (0.036 mmol) and 16 mg (0.033 mmol) of bis(1,2-diphenylarsino)ethane were placed in a reaction tube under nitrogen together with 4 ml of dioxane and 0.45 ml of triethylamine. The tube was heated in an oil bath at 80 C. for 15.5 h and the yellow solution became brown in colour. Then added at room temperature 262 mg (1.06 mmol) of 1-iodo-3,4-methylenedioxybenzene and 0.22 ml (1.5 mmol) of pinacolborane. The reaction mixture was then warmed to 80 C. After 3 h, 45% of the total peak areas was due to the desired product. This increased to 73% after 24 h.

The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extended knowledge of 5876-51-7

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5876-51-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5876-51-7

[00221] This example demonstrates that there is an inverse relationship between the amount of base (triethylamine) used in the reaction and the extent of dehalogenation of 1-iodo-3,4-methylenedioxybenzene. It also demonstrates that the amount of pinacolborane required for the complete reaction of the aryl halide can be less than 1.5 equivalents. Unreacted pinacolborane was found at the completion of the reaction when 1.1 equivalents were used. Formation of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole [00222] [C00045] [00223] To 25.1 mg PdCl2(dppf).CH2Cl2 in a reaction tube under nitrogen were added 4 ml dioxane, 0.42 ml (3 mmol) triethylamine, 0.16 ml (1.1 mmol) pinacolborane and 256 mg (1.03 mmol) 1-iodo-3,4-methylenedioxybenzene. The reaction solution was warmed to 80 C., with stirring, for 16 h in an oil bath. An aliquot (ca. 0.25 ml) of the reaction solution was removed, extracted into ethyl acetate and washed several times with water and brine solution and analysed by gc (fid detector, SGE HT5 capillary column). Hydrogen evolution was observed on the initial contact of the reaction sample with water, indicative that excess pinacolborane was present at the completion of the reaction even though only 1.1 equivalents had been used. Besides the 1,3-benzodioxole (10% of gc peak area) and pinacol ester of phenylboronic acid (7%), the only other product peak in the gc (area of 81%) was that due to the desired arylboronic acid pinacol ester. In a parallel reaction in which the only change was a reduction in the amount of triethylamine used, from 3.0 equivalents to 1.0 equivalents, the product distribution found was 1,3-benzodioxole (23% of gc peak area), the pinacol ester of phenylboronic acid (6%) and the desired arylboronic acid pinacol ester (peak area 69%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5876-51-7.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extended knowledge of 5876-51-7

According to the analysis of related databases, 5876-51-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 5876-51-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5876-51-7 as follows.

[00411] In a reaction tube under nitrogen, a mixture of PdCl2(dppf)CH2Cl2 (24 mg; 0.029 mmol) and triethylamine (0.36 ml; 2.58 mmol) in dimethylsulphoxide (4 ml; dried over 4 A sieves) was sealed and stirred at 80 C. for 18 hours. After cooling to room temperature HB(pin) (0.19 ml; 1.31 mmol) was added followed by 1-iodo-3,4-methylenedioxybenzene (211. mg; 0.851 mmol). The reaction mixture was stirred at 80 C. GC analysis after 18 hours showed that the desired arylborate compound had formed.

According to the analysis of related databases, 5876-51-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Research on new synthetic routes about 5876-51-7

The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.

5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H5IO2

Under an argon atmosphere,5-iodo-1,3-benzodioxole (2.09 mL, 15.0 mmol), 4-bromoaniline (1.03 g, 6.0 mmol) synthesized in Reference Example 1 was charged in a 50 mL flask with a Dean Stark. 00 mmol),1,10-phenanthroline (108 mg, 0.60 mmol),Copper iodide (114 mg, 0.60 mmol) and potassium hydroxide (5.39 g, 96.0 mmol) were taken, toluene (30 mL) was added, and the mixture was heated under reflux at 125 C. for 16 hours. After standing to cool, chloroform was added to the reaction mixture, followed by filtration through silica gel. The filtrate was concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (elution solvent: hexane / chloroform = 2/1) to obtain the objective N, N-bis (1,3-benzodioxole -5-yl) -4-bromoaniline as a brown viscous solid (1.44 g, 3.49 mmol, 51%).

The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; (45 pag.)JP2015/163597; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some scientific research about 5876-51-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5876-51-7, name: 5-Iodobenzo[d][1,3]dioxole

To a solution of tetrabutylammonium bromide (1.100 g, 3.33 mmol), potassium acetate (0.586 g, 3.57 mmol), palladium acetate (0.025 g, 0.11 mmol) in DMF (20 mL) were added 3,4-methylenedioxy-iodobenzene (2.21 mmol) and 4-ethenylpyridine (2.44 mmol). The reaction mixture was recharged with Argon and stirred at 80C for 5 h in a sealed tube. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 10:3) to afford the desired product (E)-4-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)pyridine (71) (Yield 37.5%, Purity 96.2%, CAS: 651741-80-9) as a yellow amorphous solid.HRMS (ESI) (M+H)+m/z226.0861, calcd for C14H12NO2226.0863.1H NMR (CDCl3, 500 MHz) delta: 8.51 (d,J= 5.0 Hz, 2H), 7.22 (d,J= 5.5 Hz, 2H), 7.11 (d,J= 16.5 Hz, 1H), 7.00 (s, 1H), 6.90 (d,J= 8.0 Hz, 1H), 6.72-6.76 (m, 2H), 5.91 (s, 2H).13C NMR (CDCl3, 125 MHz) delta: 149.7, 147.9, 147.9, 144.3, 132.3, 130.2, 123.7, 122.1, 120.2, 108.1, 105.4, 101.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Liang, Jian-Hua; Yang, Liang; Wu, Si; Liu, Si-Si; Cushman, Mark; Tian, Jing; Li, Nuo-Min; Yang, Qing-Hu; Zhang, He-Ao; Qiu, Yun-Jie; Xiang, Lin; Ma, Cong-Xuan; Li, Xue-Meng; Qing, Hong; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 382 – 392;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com