Category: 5460-32-2

Photo-Induced Ruthenium-Catalyzed C-H Arylations at Ambient Temperature was written by Korvorapun, Korkit;Struwe, Julia;Kuniyil, Rositha;Zangarelli, Agnese;Casnati, Anna;Waeterschoot, Marjo;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2020.Category: iodides-buliding-blocks This article mentions the following:

Ambient temperature ruthenium-catalyzed C-H arylations were accomplished by visible light without addnl. photocatalysts. The robustness of the ruthenium-catalyzed C-H functionalization protocol was reflected by a broad range of sensitive functional groups and synthetically useful pyrazoles, triazoles and sensitive nucleosides and nucleotides, as well as multifold C-H functionalizations. Biscyclometalated ruthenium complexes were identified as the key intermediates in the photoredox ruthenium catalysis by detailed computational and exptl. mechanistic anal. Calculations suggested that the in situ formed photoactive ruthenium species preferably underwent an inner-sphere electron transfer. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Category: iodides-buliding-blocks).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols was written by Satkar, Yuvraj;Yera-Ledesma, Luisa F.;Mali, Narendra;Patil, Dipak;Navarro-Santos, Pedro;Segura-Quezada, Luis A.;Ramirez-Morales, Perla I.;Solorio-Alvarado, Cesar R.. And the article was included in Journal of Organic Chemistry in 2019.Safety of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K₃PO₄. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chem. calculations revealed PhII(OH)·NH₃ to be the most plausible iodinating active species as a reactive “I⁺” synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Safety of 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: synthesis and ROS/RNS scavenging activities was written by Sousa, Joana L. C.;Proenca, Carina;Freitas, Marisa;Fernandes, Eduarda;Silva, Artur M. S.. And the article was included in European Journal of Medicinal Chemistry in 2016.COA of Formula: C8H9IO2 This article mentions the following:

New polyhydroxylated flavon-3-ols I (R = OH, OMe; R¹ = OH, OMe) and 3-hydroxy-2-styrylchromones II were prepared and assessed as reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavengers. The synthetic strategy involved the preparation of 2′-hydroxychalcones (E)-XC(O)CH:CHY [X = 2-HO-3,4-(C₆H₅CH₂O)₂C₆H₂, 2-HO-3,4-(H₃CO)₂C₆H₂; Y = 3,4-(C₆H₅CH₂O)₂C₆H₃, 3,4-(H₃CO)₂C₆H₃] and 2′-hydroxycinnamylidenoacetophenones (E),(E)-XC(O)CH:CHCH:CHY from base-catalyzed aldol reaction of appropriate 2′-hydroxyacetophenones such as 3′,4′-bis(benzyloxy)-2′-hydroxyacetophenone, 2′-hydroxy-3′,4′-dimethoxyacetophenone and benzaldehydes such as 3,4-dimethoxybenzaldehyde, 3,4-bis(benzyloxy)benzaldehyde/cinnamaldehydes such as (E)-3,4-dimethoxycinnamaldehyde, (E)-3,4-bis(benzyloxy)cinnamaldehyde, followed by an Algar-Flynn-Oyamada (AFO) reaction to give the polyalkoxy(flavon-3-ols I and 3-hydroxy-2-styrylchromones II). The last step of this synthetic route consisted of the cleavage of the protecting groups affording the expected polyhydroxylated derivatives I and II. The present work consisted of the study of the in vitro scavenging activities of the synthesized compounds against the most physiol. relevant ROS [superoxide radical (O₂·^–), hydrogen peroxide (H₂O₂), hypochlorous acid (HOCl), singlet oxygen (¹O₂) and peroxyl radical (ROO·)] and RNS [nitric oxide (·NO) and peroxynitrite anion (ONOO^–)]. Generally, all the tested new polyhydroxylated flavon-3-ols I and 3-hydroxy-2-styrylchromones II exhibited scavenging effects dependent on the concentration, and with IC₅₀ values found within the micromolar range. This work allowed the establishment of new structure-activity relationships and brought out the knowledge about the selective choice of a structure depending on the targeted reactive species. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-Catalyzed Regio- and Stereoselective sp³ C-H Arylation of Primary Aliphatic Amines: Mechanistic Studies and Synthetic Applications was written by Ha, Hyeonbin;Choi, Ho Jeong;Park, Hahyoun;Gwon, Yunyeong;Lee, Jiin;Kwak, Jaesung;Kim, Min;Jung, Byunghyuck. And the article was included in European Journal of Organic Chemistry in 2021.Name: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

The Pd-catalyzed γ-position sp³-C-H arylation of primary amines bearing an aliphatic chain or cycloalkyl substituent and related mechanistic studies are disclosed. 3-Bromo-2-hydroxybenzaldehyde plays a key role in γ-position sp³-C-H arylation as a transient directing group (TDG) to assist the regio- and stereoselective C-H activation of a Pd catalyst, and the development of a tandem reaction to transform 1°-amines into γ-aryl-substituted ketones demonstrates synthetic utility. D. functional theory (DFT)-based calculations revealed the detailed reaction mechanism and the origins of the high selectivity (γ-position and cis-only). The X-ray crystal structure of the isolated endo-palladacycle intermediate supported the DFT results, and a kinetic isotope experiment confirmed the results of DFT calculations indicating that the C-H activation step via simultaneous palladation and deprotonation is rate-determining In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Name: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Name: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

[Ni(NHC)]-Catalyzed Cycloaddition of Diynes and Tropone: Apparent Enone Cycloaddition Involving an 8π Insertion was written by Kumar, Puneet;Thakur, Ashish;Hong, Xin;Houk, K. N.;Louie, Janis. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 5460-32-2 This article mentions the following:

A Ni/N-heterocyclic carbene catalyst couples diynes to the C(α)-C(β) double bond of tropone, a type of reaction that is unprecedented for metal-catalyzed cycloadditions with aromatic tropone. Many different diynes were efficiently coupled to afford [5-6-7] fused tricyclic products, e.g., I, while [5-7-6] fused tricyclic compounds, e.g., II, were obtained as minor byproducts in a few cases. The reaction has broad substrate scope and tolerates a wide range of functional groups, and excellent regioselectivity is found with unsym. diynes. Theor. calculations show that the apparent enone cycloaddition occurs through a distinctive 8π insertion of tropone. The initial intramol. oxidative cyclization of diyne produces the nickelacyclopentadiene intermediate. This intermediate undergoes an 8π insertion of tropone, and subsequent reductive elimination generates the [5-6-7] fused tricyclic product. This initial product undergoes two competing isomerizations, leading to the observed [5-6-7] and [5-7-6] fused tricyclic products. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iridium-Catalyzed Asymmetric Hydrogenation of 2,3-Diarylallyl Amines with a Threonine-Derived P-Stereogenic Ligand for the Synthesis of Tetrahydroquinolines and Tetrahydroisoquinolines was written by Rojo, Pep;Molinari, Medea;Cabre, Albert;Garcia-Mateos, Clara;Riera, Antoni;Verdaguer, Xavier. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C8H9IO2 This article mentions the following:

The synthesis of a family of P-stereogenic phosphinooxazoline iridium catalysts from L-threonine Me ester and their use in the asym. hydrogenation of N-Boc-2,3-diarylallyl amines, achieving very high enantioselectivity was reported. Furthermore, the synthetic utility of the 2,3-diarylpropyl amines obtained was demonstrated by their transformation to 3-aryl-tetrahydroquinolines and 4-benzyl-tetrahydroisoquinolines, which had not yet been obtained in an enantioselective manner by direct reduction of the corresponding aromatic heterocycles. This strategy allowed the preparation of these types of alkaloids with the highest enantioselectivity reported up to date. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Electric Literature of C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metal free ipso iodination of arylboronic acids using CTAB/I₂ in aqueous media: green and regioselective synthesis of aryliodides under mild conditions was written by Tale, Rajesh H.;Toradmal, Gopal K.;Gopula, Venkatesh B.;Rodge, Atish H.;Pawar, Rajendra P.;Patil, Kalpana M.. And the article was included in Tetrahedron Letters in 2015.COA of Formula: C8H9IO2 This article mentions the following:

The metal free and green protocol for the synthesis of aryliodides via ipso iodination of arylboronic acids using mol. iodine in the presence of cetyltrimethyl ammonium bromide (CTAB) in water as green reaction media has been developed. The present protocol is mild and regioselective, and provides the corresponding iodoarenes in good to excellent yields. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids was written by Ding, Shao-Lei;Ji, Yang;Su, Yan;Li, Rui;Gu, Peiming. And the article was included in Journal of Organic Chemistry in 2019.Formula: C8H9IO2 This article mentions the following:

The Schmidt reaction of ω-azido valeryl chlorides in the presence of an addnl. nucleophile was explored. The arenes, alcs., and amines were demonstrated as the intermol. trapping reagents for isocyanate ion and N-acyliminium ion from the Schmidt rearrangement, affording the corresponding products with moderate to excellent yields. Two 2-oxoindoles from the reaction were successfully converted into four natural alkaloids, namely, assoanine, anhydrolycorine, oxoassoanine, and anhydrolycorinone. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-Enabled Gold-Catalyzed C(sp²)-S Cross-Coupling Reactions was written by Tathe, Akash G.;Patil, Nitin T.. And the article was included in Organic Letters in 2022.COA of Formula: C8H9IO2 This article mentions the following:

C(sp²)-S cross-coupling reactions of aryl iodides and arylsulfonyl hydrazides under ligand-enabled, Au(I)/Au(III) redox catalysis was reported. This strategy operates under mild reaction conditions, requires no prefunctionalized aryl coupling partner and works across several aryl iodides. The reaction mechanism was supported with control experiments, mass spectrometry, and NMR studies. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photocatalytic C-H silylation of heteroarenes by using trialkylhydrosilanes was written by Liu, Shihui;Pan, Peng;Fan, Huaqiang;Li, Hao;Wang, Wei;Zhang, Yongqiang. And the article was included in Chemical Science in 2019.Application of 5460-32-2 This article mentions the following:

The efficient and selective C-H silylation of heteroarenes, especially the pharmaceutically relevant electron-deficient heteroarenes, represents a great challenge in organic synthesis. Herein we wish to report a distinctive visible light-promoted photocatalytic C-H silylation approach that enables the direct coupling of trialkylhydrosilanes with both electron-deficient and -rich heteroarenes as well as with cyano-substituted arenes in moderate to high yields and with good regioselectivity. The protocol features operational simplicity, mild reaction conditions, and the use of safe and readily available Na₂S₂O₈, bis(trimethylsilyl) peroxide (BTMSPO) or ⁱPr₃SiSH as the radical initiators. Notably, the challenging bulky and inert trialkylhydrosilanes, such as (t-butyldimethyl)silane (^tBuMe₂SiH) and (triisopropyl)silane (ⁱPr₃SiH), work smoothly with the protocol. Moreover, despite the higher stability of ^tBuMe₂Si silylation products, our studies revealed their great reactivity and versatility in diverse C-Si-based chem. transformations, providing an operationally simple, low-cost, and environmentally benign synthetic technol. for mol. construction and elaboration. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application of 5460-32-2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 5460-32-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com