Category: 54507-44-7

Reference of 54507-44-7,Some common heterocyclic compound, 54507-44-7, name is 2-Iodo-4-(trifluoromethyl)benzoic acid, molecular formula is C8H4F3IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate AI: S-trifluoromethyl-biphenyM-carboxylic acidA mixture of 2-iodo-4-trifluoromethyl-benzoic acid (CAS: 54507-44-7) (300 mg, 0.949 mmol) phenylboronic acid (239 mg, 1.898 mmol), sodium carbonate (302 mg, 2.847 mmol) and palladium (II) acetate (10.7 mg, 0.0475 mmol) in 4.5 ml water was stirred at room temperature for 48 hours. The mixture was filtered and the filtrate was acidified with HCl 37%. The mixture was stirred at room temperature for 30 minutes. The solid was filtered, washed with water and dried in vacuo to provide 225 mg (89 %) of the title compound as a brown solid. MS(m/e): 264.9 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodo-4-(trifluoromethyl)benzoic acid, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; KOLCZEWSKI, Sabine; PINARD, Emmanuel; WO2011/23667; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 54507-44-7,Some common heterocyclic compound, 54507-44-7, name is 2-Iodo-4-(trifluoromethyl)benzoic acid, molecular formula is C8H4F3IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-iodo-4-trifluoromethyl-benzoic acid (CAS: 54507-44-7) (300 mg, 0.949 mmol) phenylboronic acid (239 mg, 1.898 mmol), sodium carbonate (302 mg, 2.847 mmol) and palladium (II) acetate (10.7 mg, 0.0475 mmol) in 4.5 ml water was stirred at room temperature for 48 hours. The mixture was filtered and the filtrate was acidified with HC137%. The mixture was stirred at room temperature for 30 minutes. The solid was filtered, washed with water and dried in vacuo to provide 225 mg (89%) of the title compound as a brown solid. MS (m/e): 264.9 (M+H+).

The synthetic route of 54507-44-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kolczewski, Sabine; Pinard, Emmanuel; US2011/53904; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54507-44-7, name is 2-Iodo-4-(trifluoromethyl)benzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Iodo-4-(trifluoromethyl)benzoic acid

4) Synthesis of 2-[(3-chloro-4-methoxyphenyl)thio]-4-(trifluoromethyl)benzoic acid (compound 211-4) [0358] N,N-dimethylformamide (90 ml) was added copper powder (360 mg), and the mixture was stirred at 120C for 3 hr. The reaction mixture was cooled, 1M hydrochloric acid and ethyl acetate were added, an insoluble material was filtered off, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography and the obtained solid was washed with hexane to give compound 211-4 (12.6 g) as a white solid. 1H-NMR(DMSO-d6)delta(ppm):3.95(3H,s), 6.90(1H,s), 7.33(1H,d,J=8.6Hz), 7.55-7.61(2H,m), 7.71(1H,d,J=2.4Hz), 8.12(1H,d,J=8.6Hz), 13.8(1H,brs).

The synthetic route of 54507-44-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; HAMADA, Maiko; TASHIRO, Kaoru; SAKASHITA, Hiroshi; KIUCHI, Masatoshi; TAKEDA, Shuzo; ADACHI, Kunitomo; EP2842937; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com