Category: 54435-09-5

Adding a certain compound to certain chemical reactions, such as: 54435-09-5, name is 2-Iodo-4-methoxybenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54435-09-5, Application In Synthesis of 2-Iodo-4-methoxybenzoic acid

(c) K2 CO3 (13.94 g, 0.101 mol) was dissolved in water (67 ml) and then 2-iodo-4-methoxybenzoic acid (25.3 g, 0. 091 mol) was added, followed by 5-amino-1-ethylpyrazole (11.2 g, 0.101 mol) and finally copper (2.7 g). The reaction mixture was refluxed for 20 hours, cooled to room temperature and then water (350 ml) was added and the mixture was refluxed for 0.75 hours. The reaction mixture was cooled, and the product was collected by filtration, recrystallized from ethanol, and dried in an oven at 40 C. to afford 13.37 g (56%) of N-(1-ethylpyrazol-5-yl) -4-methoxyanthranilic acid, m.p. 130-135 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-4-methoxybenzoic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 54435-09-5, A common heterocyclic compound, 54435-09-5, name is 2-Iodo-4-methoxybenzoic acid, molecular formula is C8H7IO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(c) A mixture of 2-iodo-4-methoxybenzoic acid (13.6 g, 48.9 mmol), 5-amino-1-ethylpyrazole (5.5 g, 49 mmol), DMF (100 ml), K2 CO3 (6.9 g, 0.05 mol) and Cu(OAc)2 (0.5 g) was refluxed overnight. The reaction mixture was poured into water (500 ml) and acidified with acetic acid to a pH of 5-6. The product slowly crystallized from the solution and was collected by filtration and washed with water. The solid was taken up in CH2 Cl2 /methanol, dried, filtered and evaporated. The residue was combined with POCl3 (60 ml) and refluxed overnight. The reaction mixture was cooled, poured into water and neutralized with concentrated NH4 OH. The mixture was extracted with CH2 Cl2, and the CH2 Cl2 extracts were evaporated and the residue was purified by column chromatography on silica gel eluding with ethyl acetate to afford 5 g of 1-ethyl-4-chloro-7-methoxy-1H-pyrazolo[3,4-b]quinoline, m.p. 114-115 C.

The synthetic route of 54435-09-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanofi Winthrop Inc.; US5488055; (1996); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54435-09-5, name is 2-Iodo-4-methoxybenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 54435-09-5

(c) A mixture of 2-iodo-4-methoxybenzoic acid (13.6 g, 48.9 mmol), 5-amino-1-ethylpyrazole (5.5 g, 49 mmol), DMF (100 ml), K2 CO3 (6.9 g, 0.05 mol) and Cu(OAc)2 (0.5 g) is refluxed overnight. The reaction mixture is poured into water (500 ml) and acidified with acetic acid to a pH of 5-6. The product slowly crystallized from the solution and is collected by filtration and washed with water. The solid is taken up in CH2 Cl2 /methanol, dried, filtered and evaporated. The residue is combined with POCl3 (60 ml) and refluxed overnight. The reaction mixture is cooled, poured into water and neutralized with concentrated NH4 OH. The mixture is extracted with CH2 Cl2, and the CH2 Cl2 extracts are evaporated, and the residue is purified by column chromatography on silica gel eluding with ethyl acetate to afford 5 g of 1-ethyl-4-chloro-7-methoxy-1H-pyrazolo[3,4-b]quinoline, m.p. 114-115 C.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54435-09-5.

Reference:
Patent; Cell Pathways, Inc.; US5942520; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com