Category: 53279-83-7

Cronk, W. Cole published the artcileIntramolecular Photoassisted Cycloadditions of Azaxylylenes and Postphotochemical Capstone Modifications via Suzuki Coupling Provide Access to Complex Polyheterocyclic Biaryls, Application In Synthesis of 53279-83-7, the publication is Journal of Organic Chemistry (2014), 79(3), 1235-1246, database is CAplus and MEDLINE.

Modular preassembly of azaxylylene photoprecursors, halogen-substituted in the aromatic ring, their intramol. [4 + 4] or [4 + 2] cycloadditions to tethered unsaturated pendants, and subsequent postphotochem. capstone modification of the primary photoproducts via Suzuki coupling provides rapid access to diverse biaryls of unprecedented topol. [e.g., I �(II + III) �(IV + V)]. This synthetic sequence allows for rapid growth of mol. complexity and is well aligned with methodol. of diversity-oriented synthesis.

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application In Synthesis of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Das, Sanju published the artcileSynthesis of Polysubstituted Quinolines from α-2-Aminoaryl Alcohols Via Nickel-Catalyzed Dehydrogenative Coupling, Quality Control of 53279-83-7, the publication is Journal of Organic Chemistry (2018), 83(4), 2309-2316, database is CAplus and MEDLINE.

This study reports a nickel-catalyzed sustainable synthesis of polysubstituted quinolines, e.g. I, from α-2-aminoaryl alcs. by a sequential dehydrogenation and condensation process that offers the advantages of a low catalyst loading and wide substrate scope. In contrast to earlier reported methods, this strategy allows the use of both primary as well as secondary α-2-aminoaryl alcs. in combination with either ketones or secondary alcs. for desired product formation. Using this methodol., 30 substituted quinoline derivatives were synthesized with up to 93% isolated yields.

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Quality Control of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gaux, Bernard published the artcilePartial deiodination of polyiodo compounds with lithium aluminum hydride, COA of Formula: C7H8INO, the publication is Bulletin de la Societe Chimique de France (1974), 505-9, database is CAplus.

Triiodobenzoic acids reacted with LiAlH4 to give the resp. diiodobenzyl alcs. 3,5-Diiodanthranilic and -salicylic acids gave the resp. diiodobenzyl alcs. as well as monoiodobenzyl alcs. 4-Amino-3,5-diioidobenzoic acid gave only 3,5,4-I2(H2N)-C6H2CH2OH.

Bulletin de la Societe Chimique de France published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, COA of Formula: C7H8INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tatevosyan, Stepan S. published the artcileFacile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling, Related Products of iodides-buliding-blocks, the publication is Synthesis (2022), 54(2), 369-377, database is CAplus.

A convenient approach to assemble 1,2,3-triazole-fused 4 H-3,1-benzoxazines I (R = H, 6-Me, 7-I, 7,8-dimethoxy, etc.; R¹ = H, Me, Ph; R² = Bu, cyclopropyl, Ph, etc.) has been developed. Diverse alc.-tethered 5-iodotriazoles II (R³ = H, 6-Me, 5-I, 4,5-dimethoxy, etc.), readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles I. The intramol. C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products I in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na₂CO₃ in acetonitrile at 100°C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

Synthesis published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C13H10F2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhuang, Zhi-Ping published the artcileBiphenyls labeled with technetium 99m for imaging β-amyloid plaques in the brain, Category: iodides-buliding-blocks, the publication is Nuclear Medicine and Biology (2005), 32(2), 171-184, database is CAplus and MEDLINE.

Formation and accumulation of excess aggregates of β-amyloid (Aβ) plaques in the brain are critical factors contributing to the development and progression of Alzheimer’s disease (AD). There is an urgent need for in vivo imaging agents that can specifically demonstrate the location and d. of Aβ plaques in the brain. The aim of this study was to develop potential technetium 99m (^99mTc)-labeled diagnostic imaging agents specific for the detection of Aβ plaques. Based on previously obtained Aβ plaque-specific biphenyls containing a p-N, N-dimethylaminophenyl group, a series of ^99mTc and Re-N₂S₂-biphenyl derivatives was prepared The stable neutral and lipophilic ^99mTc complexes, [^99mTc]19 and [^99mTc]23, A+B, were successfully obtained. As surrogates for the ^99mTc complexes, the corresponding surrogates, Re complexes of 23, were also prepared Surprisingly, it was found that the Re complexes showed distinctively different retention profiles as compared with the corresponding ^99mTc complexes. Biodistribution studies indicated that [^99mTc]23A readily passed through the blood-brain barrier (1.18% dose/brain at 2 min) in contrast to the low brain penetration of [^99mTc]19 (0.29% dose/brain at 2 min). Initial results suggested that [^99mTc]23A showed selective binding to the Aβ plaque-like structures in the brain sections from transgenic mice but not in the postmortem human brain tissue of patients with confirmed AD. The results provide encouraging evidence that development of a ^99mTc-labeled agent for imaging Aβ plaques in the brain may be feasible. Caution should be taken when comparing these ^99mTc complexes with the corresponding surrogates – the Re complexes.

Nuclear Medicine and Biology published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C8H10S, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhuang, Zhi-Ping published the artcileSyntheses of two potential ligands for Tc-99m labeling as diagnosis agents of Alzheimer’s disease, Formula: C7H8INO, the publication is Chinese Journal of Chemistry (2003), 21(7), 824-832, database is CAplus.

Two ligands, I and II, which can be labeled with Tc-99m for the diagnosis of Alzheimer’s disease (AD) have been synthesized. The key steps in these two syntheses involved Suzuki and Wittig reactions, resp. A newly discovered debromination reaction may be extended to compounds with a double or triple bond adjacent to the carbon atom bearing the bromine atoms. These syntheses provide a route to biphenyl and stilbene derivatives that will benefit the search of new imaging agents for AD.

Chinese Journal of Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C14H7F3OS, Formula: C7H8INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com