Category: 53279-83-7

Sivakumar, Ganesan published the artcileSingle-Molecular Mn(I)-Complex-Catalyzed Tandem DoubleDehydrogenative Cross-Coupling of (Amino)Alcohols under Solventless Conditions with the Liberation of H₂ and H₂O, Recommanded Product: (2-Amino-5-iodophenyl)methanol, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(22), 7362-7373, database is CAplus.

Sustainable chem. production requires fundamentally new types of catalysts and catalytic technologies. The development of coherent and robust catalytic systems based on earth-abundant transition metals is essential but extremely challenging. Herein, authors report the first report on a single Mn(I)-PNP catalyzed tandem C-C and C-N bond formation via double dehydrogenative coupling of amino alcs. with primary alcs. The current method covers a wide range of substrates, including aryl, aliphatic acyclic, and cyclic primary alcs., as well as amino alcs., to provide diverse N-heterocyclic compounds (pyridine and quinoline derivatives) in good to excellent yields (50 examples). The reaction proceeds under benign, solventless conditions with the liberation of mol. hydrogen and water as the only byproducts. Various control and labeling experiments and kinetic, NMR, and mechanistic studies suggest that the reaction operates via the acceptorless double dehydrogenative coupling pathway, selectively assimilating to provide desired N-heterocycles. Several selective bond activation/formation reactions occur sequentially via amine-amide metal-ligand cooperation.

ACS Sustainable Chemistry & Engineering published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C8H7ClO3, Recommanded Product: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Butler, Jeffrey D. published the artcileA Facile Synthesis of New 5H-Indazolo[3,2-b]benzo[d]-1,3-oxazines via One-Pot Intramolecular Bis-heterocyclizations, Safety of (2-Amino-5-iodophenyl)methanol, the publication is Journal of Organic Chemistry (2008), 73(1), 234-240, database is CAplus and MEDLINE.

The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle (I) as well as a series of novel analogs have been synthesized utilizing two subsequent intramol. heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biol. screening (no data).

Journal of Organic Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Safety of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Naidu, Shivaji published the artcileCopper-catalyzed tandem reaction in ionic liquid: an efficient reusable catalyst and solvent media for the synthesis of fused poly heterocyclic compounds, HPLC of Formula: 53279-83-7, the publication is RSC Advances (2016), 6(67), 62742-62746, database is CAplus.

A copper catalyzed tandem reaction for the synthesis of therapeutically important pyrrolo-/pyrido[2,1-b] benzo[d][1,3]oxazin-1-ones I (R = H, 7-F, 8-Cl, 6-Cl, 7,8-(OCH₃)₂, etc.; n = 1,2) from 2-aminobenzyl alcs. such as (2-aminophenyl)methanol, (2-amino-5-methylphenyl)methanol, (2-amino-6-chlorophenyl)methanol, etc. using alkynoic acids CC(CH₂)_nCH₂C(O)OH under ligand and base free conditions in the presence of a green solvent medium [bmim]OTf is reported. The catalyst and solvent were successfully recycled and reused.

RSC Advances published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, HPLC of Formula: 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reddy, C. B. Rajashekar published the artcileChemoselective oxidation of benzyl, amino and propargyl alcohols to aldehydes and ketones under mild reaction conditions, Application of (2-Amino-5-iodophenyl)methanol, the publication is ChemistryOpen (2015), 4(2), 107-110, database is CAplus and MEDLINE.

An efficient, aerobic, chemoselective and simplified approach for the oxidation of a broad range of benzyl and propargyl alcs. containing diverse functional groups to their corresponding aldehydes and ketones in excellent yields under mild reaction conditions was reported. Optimal yields were obtained at room temperature using 1 mmol substrate, 10 mol% copper(I) iodide, 10 mol% 4-dimethylaminopyridine (DMAP) and 1 mol% 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) in acetonitrile under an oxygen balloon. The catalytic system can be applied even when sensitive and oxidizable groups such as alkynes, amines and phenols are present and also starting materials and products containing such groups were found to be stable under the developed conditions.

ChemistryOpen published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Yu published the artcileGold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones, Name: (2-Amino-5-iodophenyl)methanol, the publication is Advanced Synthesis & Catalysis (2010), 352(2+3), 373-378, database is CAplus.

A highly efficient method has been developed for the one-pot synthesis of multiring heterocyclic compounds, e.g. I (R¹ = H, Ph, etc.; R² = H, Me; R³ = H, n-C₆H₁₃) and II (R⁴ = H, Cl, Ph, etc.) via a gold(I)-catalyzed tandem coupling/cyclization reaction of o-aminobenzyl alcs. with HCCCH₂CH(R³)CO₂H and HCC(CH₂)₃CO₂H, resp. The strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic mol. architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Advanced Synthesis & Catalysis published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C3H3Br2ClO, Name: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Ling published the artcilePreparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement, Quality Control of 53279-83-7, the publication is Organic Letters (2021), 23(17), 6819-6824, database is CAplus and MEDLINE.

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Organic Letters published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Quality Control of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jiang, Baifeng published the artcileOne-pot synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a]isoquinolines via a silver(I)-catalyzed cascade approach, Application of (2-Amino-5-iodophenyl)methanol, the publication is Molecules (2013), 814-831, database is CAplus and MEDLINE.

An efficient approach for the synthesis of biol. interesting fused tetracyclic isoquinoline derivatives in high yield and with a broad substrate scope was developed. The strategy features an AgNO₃ catalyzed one-pot cascade process involving formation of two new C-N bonds and one new C-O bond. The title compounds thus formed included 12-phenyl-4bH,6H-isoquino[2,1-a][3,1]benzoxazine (I) and related substances, such as a pyridooxazinoisoquinoline derivative (II). The synthesis of the target compounds was achieved using 2-(2-phenylethynyl)benzaldehyde, 5-fluoro-2-(2-phenylethynyl)benzaldehyde, 2-(1-octyn-1-yl)benzaldehyde, 2-aminobenzenemethanol, 3-amino-2-naphthalenemethanol, 2-amino-3-pyridinemethanol (amino arenemethanol derivatives) as starting materials.

Molecules published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lazaro-Milla, Carlos published the artcileMetal-Free C-C/C-N/C-C Bond Formation Cascade for the Synthesis of (Trifluoromethyl)sulfonylated Cyclopenta[b]indolines, Formula: C7H8INO, the publication is Organic Letters (2021), 23(8), 2921-2926, database is CAplus and MEDLINE.

A bis(triflyl)ethylation [triflyl = (trifluoromethyl)sulfonyl] inserted into a sequential cyclization cascade resulted in the direct formation of gem-bis(triflyl)ated cyclopenta[b]indolines from anilide-derived allenols and alkenols. This catalyst- and irradiation-free sequence facilitated the efficient preparation of functionalized tricyclic indoline cores bearing two contiguous stereocenters. The formed cyclopenta[b]indolines was easily transformed into a wide variety of triflylated indolines, including the tetracycle ring system found in polyveoline.

Organic Letters published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Formula: C7H8INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sabbatini, Paola published the artcileDesign, Synthesis, and in Vitro Pharmacology of New Radiolabeled γ-Hydroxybutyric Acid Analogues Including Photolabile Analogues with Irreversible Binding to the High-Affinity γ-Hydroxybutyric Acid Binding Sites, Quality Control of 53279-83-7, the publication is Journal of Medicinal Chemistry (2010), 53(17), 6506-6510, database is CAplus and MEDLINE.

γ-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiol. significance, the complete mol. mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first ¹²⁵I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.

Journal of Medicinal Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Quality Control of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jha, Amitabh published the artcileTransition metal-free one-pot cascade synthesis of 7-oxa-2-azatricyclo[7.4.0.0^2,6]trideca-1(9),10,12-trien-3-ones from biomass-derived levulinic acid under mild conditions, Recommanded Product: (2-Amino-5-iodophenyl)methanol, the publication is Organic & Biomolecular Chemistry (2013), 11(43), 7559-7565, database is CAplus and MEDLINE.

An efficient, environmentally benign, transition-metal free, tandem C-N, C-O bond formation reaction is developed for the synthesis of tricyclic 7-oxa-2-azatricyclo[7.4.0.0^2,6]trideca-1(9),10,12-trien-3-ones and their homologs from easily available starting materials, including renewable levulinic acid, a keto acid. The reaction of keto acids with Me chloroformate and variously substituted o-aminobenzyl alcs. using triethylamine as a base in toluene at room temperature gave good to excellent yields. This newly developed protocol was successfully utilized for the synthesis of a variety of polycyclic 7-oxa-2-azatricyclo[7.4.0.0^2,6]trideca-1(9),10,12-trien-3-ones and related compounds

Organic & Biomolecular Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Recommanded Product: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com