Category: 5326-47-6

5326-47-6, These common heterocyclic compound, 5326-47-6, name is 2-Amino-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Concentrated H2SO4 (3.7 mL) was added dropwise at 20 C under argon atmosphere to a stirred solution of 5-iodoanthranilic acid (5.0 g, 19 mmol) in MeOH (20 mL), and the mixture was refluxed for 7 h. The mixture was then concentrated in vacuo to the volume of 10 mL, poured into a vigorously stirred saturated solution of NaHCO3 (80 mL), and extracted with EtOAc. The organic layer was washed with a brine solution, dried over Na2SO4, and concentrated in vacuo; the residue was purified by chromatography on SiO2 (eluent was benzene). Ester 6 (3.68 g) was isolated as yellow crystals, m.p. 80-82 C (LP). 1H NMR (CDCl3), delta: 3.87 (s, 3 H, MeO); 5.76 (br.s, 2 H, H2N); 6.46 (d, 1 H, HC(3), J = 8.7 Hz); 7.48 (dd, 1 H, HC(4), J = 8.7 Hz, J = 2.2 Hz); 8.14 (d, 1 H, 2 HC(6), J = 2.2 Hz); which is similar to that reported previously.24

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5326-47-6.

Reference:
Article; Lozanova; Stepanov; Mel?nik; Zlokazov; Veselovsky; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 64 – 67; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 64 – 67,4;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5326-47-6, name is 2-Amino-5-iodobenzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Amino-5-iodobenzoic acid

a) 2-Amino-5-iodo-benzoic acid methyl ester; 2-Amino-5-iodo-benzoic acid (10.00 g) was dissolved in methanol (200 ml_). To this solution, Amberlist-15 (16.00 g) was added and the resulting mixture was heated under reflux under nitrogen for 48 h. After cooling to room temperature the mixture was filtered and the solid was washed with 5% 2OM ammonia/MeOH (2 x 100 ml_). The organic phase was dried and the solvent evaporated in vacuo. The residue was purified by flash chromatography (silica gel, ethyl acetate / hexane from 1 / 15 to 1 / 12) to give the title compound (7.00 g); ESMS m/z 277.9 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; PLIVA-ISTRAZIVACKI INSTITUT D.O.O.; WO2006/50943; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5326-47-6, name is 2-Amino-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5326-47-6

The starting material 2-amino-5-iodo benzoic acid (1) (15mmol, 4 . 0g) is added to 15 ml of anhydrous methanol solution, then added to this solution in 3M the mass fraction of the 70% concentrated sulfuric acid. Heating to reflux 6h, then room temperature stirring 12h. After the completion of reaction, reducing pressure and evaporating solvent, then added to the residues in the bottle 100 ml saturated sodium bicarbonate solution, ethyl acetate (3×30 ml) extraction. Obtaining organic layer, saturated salt water (3×20 ml) washing, layered takes organically phase is dried with anhydrous sodium sulfate. Filtering, by reduced pressure evaporation to dry solvent to obtain 2-amino-5-iodo benzoic acid methyl ester (2) crude 3.96g, yield: 94.5%

The synthetic route of 5326-47-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong University; Liu, Xinyong; Zhan, Peng; Kang, Dongwei; (22 pag.)CN105669653; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 5326-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5326-47-6, name is 2-Amino-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-amino-5-iodobenzoicacid (17) (15 mmol, 4.0 g) in methanol(16 mL) was added concentrated H2SO4 (3.0 mL). Thereaction mixture was refluxed for 6 h and stirred at room temperature for additional12h. After removal of the solvent, the residue was poured into 100 mL saturatedNaHCO3 solution and extracted with ethyl acetate(3¡Á15 mL). The organic layer was separated, washed with brine (3¡Á15 mL), driedover anhydrous Na2SO4, filteredand concentrated to give the product methyl 2-amino-5-iodobenzoate (18) as yellow solid, Yield: 94%, mp:70-73C. 1H NMR (400 MHz, DMSO-d6, ppm) delta: 8.13 (1H,d, J = 2.16 Hz), 7.47 (1H, dd, J = 8.68, 2.16 Hz), 6.45 (1H, d, J = 8.72 Hz), 5.42 (2H, s, NH2),3.86 (3H, s, O-CH3). C8H8INO2.

The synthetic route of 2-Amino-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kang, Dongwei; Zhang, Heng; Zhou, Zhongxia; Huang, Boshi; Naesens, Lieve; Zhan, Peng; Liu, Xinyong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 21; (2016); p. 5182 – 5186;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 5326-47-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5326-47-6, name is 2-Amino-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

2-Amino-5-iodoben- zoic acid (0.6616 g, 2.52 mmol) was refluxed overnight in CH3OH with TMSC1 (1.3689 g, 12.60 mmol) to esteriFy the carboxylic group. The solvent was evaporated. Afier that EtOAc was added, and it was extracted with saturated NaHCO3, water, and brine solution. After that it was purified with column chromatography (5% EtOAc in hexane) to yield yellow solid (3 9.29%). ?H-NMR (500 MHz, CDC13) oe 8.14 (d, J=2.2 Hz, 1H), 7.47 (dd, J=8.7, 2.2 Hz, 1H), 6.46 (d, J=8.7 Hz, 1H), 3.86 (s, 3H); ?3C-NMR (126 MHz, CDC13) oe 167.5, 149.9, 142.4, 139.6, 119.0, 113.0, 76.1, 51.9. Theterminal alkyne was prepared by method described above and purified by column chromatography (5% EtOAc in hexane) to obtain yellow solid (84.78%). Then, itwas desilylated before purification by column chromatography (10% EtOAc in hexane) to obtain pale yellow solid(50.72%).

The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-iodobenzoic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE SCRIPPS RESEARCH INSTITUTE; MAHIDOL UNIVERSITY; TAYLOR, Palmer; YAMAUCHI, John; TALLEY, Todd T.; ARUNRUNGVICHIAN, Kuntarat; VAJRAGUPTA, Opa; FOKIN, Valery; (79 pag.)US2018/244653; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

5326-47-6, These common heterocyclic compound, 5326-47-6, name is 2-Amino-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Concentrated H2SO4 (3.7 mL) was added dropwise at 20 C under argon atmosphere to a stirred solution of 5-iodoanthranilic acid (5.0 g, 19 mmol) in MeOH (20 mL), and the mixture was refluxed for 7 h. The mixture was then concentrated in vacuo to the volume of 10 mL, poured into a vigorously stirred saturated solution of NaHCO3 (80 mL), and extracted with EtOAc. The organic layer was washed with a brine solution, dried over Na2SO4, and concentrated in vacuo; the residue was purified by chromatography on SiO2 (eluent was benzene). Ester 6 (3.68 g) was isolated as yellow crystals, m.p. 80-82 C (LP). 1H NMR (CDCl3), delta: 3.87 (s, 3 H, MeO); 5.76 (br.s, 2 H, H2N); 6.46 (d, 1 H, HC(3), J = 8.7 Hz); 7.48 (dd, 1 H, HC(4), J = 8.7 Hz, J = 2.2 Hz); 8.14 (d, 1 H, 2 HC(6), J = 2.2 Hz); which is similar to that reported previously.24

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5326-47-6.

Reference:
Article; Lozanova; Stepanov; Mel?nik; Zlokazov; Veselovsky; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 64 – 67; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 64 – 67,4;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com