Category: 51839-15-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51839-15-7 as follows. Safety of Dimethyl 5-iodoisophthalate

Dimethyl 5-iodoisophthalate(2.9 g, 8.9 mmol) and THF (50 mL) was cooled to -20 C.,A THF solution (about 14% by mass, 8.4 mL, 8.1 mmol) of isopropyl magnesium chloride-lithium chloride complex was added dropwise.The obtained mixture was stirred at -20 C. for 1 hour,Copper (I) bromide-dimethyl sulfide complex (1.9 g, 9.1 mmol) was added.The resulting mixture was heated to 30 C. and a solution of C60 fullerene (0.72 g, 1.0 mmol) in ODCB (50 mL) was added.The obtained mixture was stirred at 60 C. for 4 hours,Saturated aqueous ammonium chloride solution (1 mL) was added.The resulting mixture was filtered and the volume of the solution was reduced with a rotary evaporator.By adding methanol to the obtained mixture,As a reddish brown solid substance, Compound 7 (C7)(1.5 g, 0.90 mmol,Yield: 90%) was precipitated

According to the analysis of related databases, 51839-15-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Showa Denko; Watanabe, Kentaro; Ueda, Yoshiyuki; Hanawa, Kenzo; (53 pag.)JP2018/203686; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 51839-15-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 51839-15-7 name is Dimethyl 5-iodoisophthalate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A 15 mL heavy walled pressure tube sealable with a gasketed Teflon screwcap was charged with a diaryl iodonium triflate (0.2 mmol, 1 equiv), an aryl iodide (1.0 mmol, 5 equiv.), and 1,2-dicholoroethane (2 mL, 0.1 M iodonium triflate concentration). The tube was sealed (Teflon screw cap) and immersed in an oil bath maintained at 80 C. After the indicated time, the tube was retrieved and cooled to rt and the contents were concentrated under reduced pressure. The crude material was purified by silica gel flash chromatography (gradient 10 ? 50% acetone/CH2Cl2).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dimethyl 5-iodoisophthalate, and friends who are interested can also refer to it.

Reference:
Article; Racicot, Leanne; Ciufolini, Marco A.; Tetrahedron; vol. 73; 50; (2017); p. 7067 – 7072;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 51839-15-7, These common heterocyclic compound, 51839-15-7, name is Dimethyl 5-iodoisophthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate LXII: Dimethyl-5-trifluoromethyl isophthalate; To a solution of dimethyl 5-iodoisophthalate (1 g, 3.12 mmol) in 1:1 DMF/HMPA was added Methyl- 2,2-difluoro-2( fluorosulfonyl) acetate (3 g, 15.6 mmol) and Copper (I) Iodide (2.9 mg, 15.6 mmol) and the reaction mixture heated to. 80 C for 16 h. The reaction was cooled to rt and diluted with ethyl acetate (200 mL) The solvent was decanted and the copper salts washed with an additional 100 mL of ethyl acetate. The organics were poured into water (200 mL ) the phases separated and the aqueous extracted with Ethyl acetate ( 100mL) dried over anhydrous sodium sulfate, filtered and concentrated at reduced pressure. The residue was chromatographed on silica gel eluting with dichloromethane. to give dimethyl-5-trifluoromethyl isophthalate. : :¹H NMR (400 MHz, CDC13) No. 8.85 (s, 1H), 8.48 (s, 2H), 4.01 (s, 6H). LCMS [(M) +H]+ = 263.

The synthetic route of 51839-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2005/103020; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 51839-15-7, name is Dimethyl 5-iodoisophthalate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51839-15-7, Application In Synthesis of Dimethyl 5-iodoisophthalate

To a solution of dimethyl 5-iodoisophthalate (13 g, 40.6 mmol) in 100 mL THF was added 2-cyano- phenyl zinc bromide (97.5 mL, 48.7 mmol, 0.5 M THF) and tetrakis (triphenylphosphine) palladium (214 mg, 0.2 mmol) and the reaction mixture was stirred at room temperature for 2 h. The precipitated solid was filtered, the filtrate was diluted with MEOH to provide after filtration of a second crop dimethyl 5- (2-CYANOPHENYL) isophthalate which was hydrolyzed to the corresponding monoacid 2′-cyano-5- (methoxycarbonyl)-1, 1-BIPHENYL-3-CARBOXYLIC acid following a similar procedure as described in intermediate A preparation, step C. LH NMR (400 MHz, d6-DMSO) 8 13.55 (br s, 1H), 8.60-8. 55 (m, 1H), 8.38-8. 31 (m, 2H), 8.02 (d, J=8. 3HZ, LH), 7.85 (td, J = 8. 3 Hz, 1. 5 HZ 1H), 7.75 (d, J=8. 3HZ, 1H), 7. 66 (td, J = 8.3 Hz, 1.5 Hz 1H), 3.93 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 5-iodoisophthalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2005/32471; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51839-15-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 51839-15-7 name is Dimethyl 5-iodoisophthalate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A 15 mL heavy walled pressure tube sealable with a gasketed Teflon screwcap was charged with a diaryl iodonium triflate (0.2 mmol, 1 equiv), an aryl iodide (1.0 mmol, 5 equiv.), and 1,2-dicholoroethane (2 mL, 0.1 M iodonium triflate concentration). The tube was sealed (Teflon screw cap) and immersed in an oil bath maintained at 80 C. After the indicated time, the tube was retrieved and cooled to rt and the contents were concentrated under reduced pressure. The crude material was purified by silica gel flash chromatography (gradient 10 ? 50% acetone/CH2Cl2).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Dimethyl 5-iodoisophthalate, and friends who are interested can also refer to it.

Reference:
Article; Racicot, Leanne; Ciufolini, Marco A.; Tetrahedron; vol. 73; 50; (2017); p. 7067 – 7072;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 51839-15-7,Some common heterocyclic compound, 51839-15-7, name is Dimethyl 5-iodoisophthalate, molecular formula is C10H9IO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of dimethyl 5-iodo-benzerte-1,3-dicarboxylate (9) (320 mg, 1.00 mmol), bis(pinacolato)diborane (10) (279 mg, 1.10 mmol), potassium acetate (294 mg, 3.00 mmol), PdCl2(dppf)* (24 mg, 0.03 mmol) and dried DMF (6 mL) was stirred at 80C for 2 h. The reaction mixture was cooled to the room temperature. Then, dimethyl 5-iodo-benzene-1,3-dicarboxylate (9) (640 mg, 2.00 mmol), PdCl2(dppf) (24 mg, 0.03) and CsF (456 mg, 3.0 mmol; dissolved in 2.5 mL of water) were added. The mixture was stirred at 80C overnight and afterwards extracted for four times with diethylether (4 x 25 mL). The organic layer was dried with MgSO4 and the solvent was removed in vacuum. The crude product was purified by column chromatography (silica gel, ethylacetate/hexane, 3:7 v/v). Yield 82 %. M.p. 214-215 C. 1H-NMR (400 MHz, CDCl3): delta= 4.00 (s, 12H), 8.51 (d, 4H, J = 1.5 Hz), 8.72 (d, 2H, J = 1.5 Hz). 13C-NMR (100 MHz, CDCl3): delta= 52.5, 130.2, 131.5, 132.3, 139.9, 165.9. Rf= 0.50 (silica gel, othylacetate/hexane, 3:7 v/v). MS-EI, m/z (%): 386 (75) [M+], 355 (100), 327 (15), 194 (10). *[1,1′-bis(diphenylphoshino)ferrocene]dichloropalladium(II)].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Dimethyl 5-iodoisophthalate, its application will become more common.

Reference:
Patent; Technische Universitaet Carolo-Wilhelmina zu Braunschweig; EP1972338; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51839-15-7 as follows. Product Details of 51839-15-7

Dimethyl 5-iodoisophthalate(2.9 g, 8.9 mmol) and THF (50 mL) was cooled to -20 C.,A THF solution (about 14% by mass, 8.4 mL, 8.1 mmol) of isopropyl magnesium chloride-lithium chloride complex was added dropwise.The obtained mixture was stirred at -20 C. for 1 hour,Copper (I) bromide-dimethyl sulfide complex (1.9 g, 9.1 mmol) was added.The resulting mixture was heated to 30 C. and a solution of C60 fullerene (0.72 g, 1.0 mmol) in ODCB (50 mL) was added.The obtained mixture was stirred at 60 C. for 4 hours,Saturated aqueous ammonium chloride solution (1 mL) was added.The resulting mixture was filtered and the volume of the solution was reduced with a rotary evaporator.By adding methanol to the obtained mixture,As a reddish brown solid substance, Compound 7 (C7)(1.5 g, 0.90 mmol,Yield: 90%) was precipitated

According to the analysis of related databases, 51839-15-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Showa Denko; Watanabe, Kentaro; Ueda, Yoshiyuki; Hanawa, Kenzo; (53 pag.)JP2018/203686; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 51839-15-7,Some common heterocyclic compound, 51839-15-7, name is Dimethyl 5-iodoisophthalate, molecular formula is C10H9IO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of dimethyl 5-iodoisophthalate (500 mg, 1.56 mmol, 1.0 eq) inMeOH (20 mL) was added an aqueous 1 M NaOH solution (4.69 mL, 4.69 mmol,3.0 eq). After stirring at 40 C temperature for 18 h, the brown suspension was diluted with water (10mL) and acidified to pH 3 with aqueous 1M HCl solution. The aqueous layer was extracted withEtOAc (3 x 20 mL). Combined organic extracts were washed with brine (20 mL), dried overanhydrous Na2SO4 and evaporated under reduced pressure to yield product 18 as a yellowish solid(455 mg, 100% yield), which was used in subsequent step without purification. 1H-NMR spectrumwas identical to that from the literature.9

The synthetic route of 51839-15-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J.; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 344 – 352;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 51839-15-7, name is Dimethyl 5-iodoisophthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Dimethyl 5-iodoisophthalate

Step A and B: Cross-coupling and Saponification. To a solution of dimethyl 5-iodoisophthalate (13 g, 40.6 mmol) in 100 mL THF was added 2-cyano-phenyl zinc bromide (97.5 mL, 48.7 mmol, 0.5 M THF) and tetrakis(triphenylphosphine) palladium (214 mg, 0.2 mmol) and the reaction mixture was stirred at room temperature for 2 h. The precipitated solid was filtered, the filtrate was diluted with MeOH to provide after filtration a second crop for a total of 10.1 g of dimethyl 5-(2-cyanophenyl)isophthalate which was hydrolyzed to the corresponding monoacid 2′-cyano-5-(methoxycarbonyl)-1,1′-biphenyl-3-carboxylic acid following a similar procedure as described in intermediate B preparation, step C: 1H NMR (400 MHz, d6-DMSO) delta 13.55 (br s, 1H), 8.60-8.55 (m, 1H), 8.38-8.31 (m, 2H), 8.02 (d, J=8.3 Hz, 1H), 7.85 (td, J=8.3 Hz, 1.5 Hz 1H), 7.75 (d, J=8.3 Hz, 1H), 7.66 (td, J=8.3 Hz, 1.5 Hz 1H), 3.93 (s, 3H).

The synthetic route of Dimethyl 5-iodoisophthalate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Barrow, James C.; Coburn, Craig A.; Nantermet, Philippe G.; Selnick, Harold G.; Stachel, Shawn J.; Stanton, Matthew G.; Stauffer, Shaun R.; Zhuang, Linghang; Davis, Jennifer R.; US2007/142634; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51839-15-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51839-15-7, name is Dimethyl 5-iodoisophthalate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4.10 g (12.8 mmol) dimethyl 5-iodo-isophthalate were dissolved in 80 ml DMF. 3.32 g (20.1 mmol) 2-carbamoyl-phenylboric acid, 3.00 ml (21.6 mmol) TEA, 3.00 ml (167 mmol) water, 75 mg (0.33 mmol) palladium(II)-acetate as well as 102 mg (0.34 mmol) tri-ortho-tolylphosphine were added and the solution was heated to 100 C. for 2.5 h. The reaction solution was cooled and the solvent was distilled off i. vac. The residue was chromatographed on silica gel (gradient: DCM auf DCM/MeOH 7:3). 2.53 g (63%) of 11-a were obtained.RT (HPLC-MS)=2.68 min.ES-MS (M+H)+=314

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 5-iodoisophthalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fuchs, Klaus; Eickmeier, Christian; Heine, Niklas; Peters, Stefan; Dorner-Ciossek, Cornelia; Handschuh, Sandra; Nar, Herbert; Klinder, Klaus; US2010/144681; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com