Category: 51738-07-9

Reference of 51738-07-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51738-07-9, name is 2-Chloro-6-iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a flame-dried 100 mL round-bottom flask NaHMDS (2 mmol, 1 eq) in THF (5 mL) were addedand the solution was cooled down to 0 C. A solution of the corresponding benzyl phosphonate(II) (2 mmol, 1 eq) in THF (12 mL) was added dropwise under stirring. The reaction was stirred fora further 10 min at 0 C, then a solution of the haloaldehyde (I) (2 mmol, 1 eq) in THF (4 mL) wasadded dropwise. The mixture was allowed to warm from 0 C to room temperature 12-14 h understirring. The reaction mixture was quenched with water (10 mL). The aq layer was extracted withEt2O (3 x 10 mL). The combined organic layers were washed with 10% aq NaHSO3 (2 x 5 mL)and then with brine (10 mL). The combined organic layers were dried over Na2SO4 andconcentrated by evaporation in vacuo to give 10a-c. (10a: E/Z: 10:1, 10b: E, 10c: E/Z: 20:1). TheE-isomers of compounds 10a?-c? was obtained using column chromatography (2.0% EtOAc inpetroleum ether) from mixtures of 10a-c. The E/Z ratio was determined by 1H NMR.

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-6-iodobenzaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Article; Roehrig, Ute F.; Majjigapu, Somi Reddy; Caldelari, Daniela; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4330 – 4333;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 51738-07-9,Some common heterocyclic compound, 51738-07-9, name is 2-Chloro-6-iodobenzaldehyde, molecular formula is C7H4ClIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0136] To a solution of the appropriate commercially available benzaldehyde or 87 (4.31 mmol) in anhydrous MeOH (15 mL) at rt was added NaOMe (4.31 mmol, 0.5 M in MeOH) and the yellow solution was allowed to stir for 5 min. The appropriate ketone (4.31 mmol) was added dropwise as a solution in MeOH (3 mL). After stirring overnight, the solvent was removed under reduced pressure and the crude was diluted with satd. NH4C1 (20 mL). The aqueous layer was extracted with CH2CI2 (3 x 20 mL) and the combined organic extracts were dried (MgS04) and the solvent distilled off under reduced pressure to afford a crude residue. The crude product was purified by silica flash chromatography to afford the following compounds.

The synthetic route of 51738-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEWLINK GENETICKS CORPORATION; MAUTINO, Mario; KUMAR, Sanjeev; WALDO, Jesse; JAIPURI, Firoz; KESHARWANI, Tanay; WO2012/142237; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51738-07-9, The chemical industry reduces the impact on the environment during synthesis 51738-07-9, name is 2-Chloro-6-iodobenzaldehyde, I believe this compound will play a more active role in future production and life.

The mixture of TsNHNH2 (3.16 mmol, 1.0 eq) and DME (6.0 mL) was stirred and heated to 60 Cuntil a clear solution was obtained. The mixture was cooled to 25 C, and then 2-chloro-6-iodobenzaldehyde (3.2 mmol, 1 eq) dissolved in DME (2 mL) was added dropwise to the mixtureunder stirring. After approximately 1 h, CuI (0.32 mmol, 10 mol %), diethyl H-phosphonate (2.88mmol, 1.0 eq) and Cs2CO3 (4.74 mmol, 1.5 eq) were added sequentially to the reaction mixture at25 C. The mixture was then heated under stirring at 80 C for 3 h. When the reaction wascomplete (TLC control), the mixture was allowed to cool to 25 C. It was then filtered through ashort plug of SiO2 (AcOEt). The solvent was evaporated in vacuum. The residue was purified bysilica gel column chromatography (40 % EtOAc/petroleum ether) to afford an oil, 0.40 g, (35%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-iodobenzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Roehrig, Ute F.; Majjigapu, Somi Reddy; Caldelari, Daniela; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4330 – 4333;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com