Category: 51628-12-7

Application of 51628-12-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51628-12-7 as follows.

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ortar, Giorgio; Morera, Enrico; De Petrocellis, Luciano; Ligresti, Alessia; Schiano Moriello, Aniello; Morera, Ludovica; Nalli, Marianna; Ragno, Rino; Pirolli, Adele; Di Marzo, Vincenzo; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 118 – 132;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

This reaction was performed under a nitrogen atmosphere. To a 100-mE reactor were added (-)-5-meth- ylmenthyl carboxylic acid (1R,25)-lla (450mg, 2.27 mmol) obtained in Synthesis Example 15, thionyl chloride (0.25 mE, 1.50 eq.), and a few drops of DMF, followed by stirring at room temperature for 3 hours. The solution in the system was distilled oil, and toluene (2 mE) was added thereto. The inside of the system was cooled to 100 C. or lower in an ice bath, and 4-aminobenzcyanide (900 mg, 3.0 eq.) was added slowly thereto. After two and a half hours, completion of the reaction was confirmed by GC-MS, and a post-treatment was performed. The reaction solution was transferred to a separating funnel and tap water and chloroform were added thereto to effect washing. The oil layer was washed twice with dilute hydrochloric acid, and thrther washed once with a saturated saline solution, and then dried with anhydrous magnesium sulfate. The resulting solution was concentrated under reduced pressure, and then isolation and purification were performed by column chromatography, whereby an amorphous solid was obtained (545 mg, yield: 77%, 80% cc.).10429] [a]D20=_20.6 (c=0.5, EtOH)HRMS: mass: 317.2202, actual measurement value: 317.2211 (Fl) ?H-NMR (500 MHz, CDC13): oe0.86 (d, 3H, J=7.0 Hz), 0.88-1.00 (m, 9H), 1.20-1.31 (m, 3H), 1.39-1.65 (m, 4H), 1.71-1.81 (m, 1H), 2.30 (td, 1H, J=11.8, 3.8 Hz), 3.70 (s, 2H), 7.26 (d, 2H, J=8.0 Hz), 7.32 (br, 1H), 7.56 (d, 1H, J=8.0 Hz)

The synthetic route of 2-(4-Iodophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H6IN

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51628-12-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H6IN

1L pressure kettle,121.5 g (0.5 mol) of p-iodophenylacetonitrile,800 g (2 mol) of 10% sodium hydroxide,10.9 g (0.075 mol) of 8-hydroxyquinoline,12.8g (0.075mol) after adding copper chloride, the kettle heated to 50 ~ 55 , to maintain The pressure of the reactor is 0MPaG, the temperature of the reaction system is kept between 50 and 55 DEG C, and the reaction is carried out for 7 hours. The reaction solution is finished and the reaction vessel is cooled. The pH of the reaction solution is adjusted to between 7 and 8 with 36% hydrochloric acid. The mother liquor was adjusted to pH with 30% NaOH13 ~ 14, get dark red transparent liquid, sodium p-hydroxyphenylacetate solution, weighing 755g, the detection of p-hydroxyphenylacetic acid content of 9.79%, the yield was 97.3%.

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.

Application of 51628-12-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 26 Preparation of 2-{4-[4-(1-Methyl-2-{[(methylethyl)sulfonyl]amino}ethoxy)phenyl]phenyl}ethanenitrile. Preparation of 4-(cyanomethyl-phenylboronic acid, pinacol ester. Using the method of Murata, M., et al., Y. J. Org. Chem, 62 6458-6459 (1997), 4-iodophenylacetonitrile (23.9 g, 0.100 mol), Et3N (42 ML, 0.30 mol), acetonitrile (400 ML) and Pd(dppf)2Cl2 catalyst ([1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with CH2Cl2) were combined in a 1 L flask and the resulting solution was evacuated and purged with nitrogen three times.The pinacolborane (22 ML, 0.15 mol) was added and the mixture was heated at reflux for 3 h. 1H NMR analysis of an aliquot indicated complete consumption of starting 4-iodophenylacetonitrile.The mixture was cooled to room temperature, concentrated to an oil and taken up in CH2Cl2.This solution was extracted with 0.1 N HCl (3*100 ML) and the organic phase was separated, concentrated and re-dissolved in methyl tert-butyl ether (MTBE).The MTBE solution was passed through a filter packed with silica gel (300 g).The eluant was concentrated to a dark red oil.This oil was extracted with hexanes (500 ML) and the soluble fraction was decanted away from a black oil (5 g). MTBE (5 ML) was added to this oil to give a suspension that was filtered through Celite.This filtrated was combined with the hexanes fraction and the solution was concentrated to an oil.Finally, the oil was re-dissolved in di-isopropyl ether (150 ML) and was diluted with hexanes (400 ML).This mixture was allowed to stand for 2 h, and then filtered to remove a dark precipitate.The resulting amber filtrate was concentrated to an oil, re-dissolved in hexanes (400 ML) and concentrated to 75 ML without added heat.This treatment resulted in the precipitation of the desired intermediate title compound as a golden waxy solid that was air-dried to afford 23.0 g (96.2%): 1H NMR (CDCl3, 300 MHz): delta7.8 (d, 2H); 7.35 (d, 2H); 3.8 (s, 2 H) 1.15 (s, 12H).

The synthetic route of 2-(4-Iodophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Davison, Joshua Zwick; Jones, Winton Dennis; Zarrinmayeh, Hamideh; Zimmerman, Dennis Michael; US2003/225266; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51628-12-7, Safety of 2-(4-Iodophenyl)acetonitrile

By using the synthesis method described in PTL 16, the same compound was also obtained even using 5-methylmenthyl amide (14a-50) obtained in Example 1, copper iodide, phosphoric acid, and 4-iodobenzyl cyanide (yield: 43%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; ITOH, Hisanori; HORI, Yoji; OTSUKA, Masashi; MATSUMOTO, Takaji; SATO, Tomoharu; (50 pag.)US2018/57447; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 51628-12-7,Some common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, molecular formula is C8H6IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of the nitrile (50.0 g, 206 mmol) in toluene (500 mL) was cooled to -25 0C, then Ti(O1Pr)4 (60.3 mL, 206 mmol) was added. A commercial (Aldrich) solution of EtMgBr (3.0 M, 137 mL, 411 mmol) was then added dropwise at a rate which maintained the internal temperature between -20 and -25 0C (over approximately 60 minutes). The mixture was stirred for 60 minutes at this temperature, then the BF3OEt2 (52.1 mL, 411 mmol) was added dropwise maintaining a constant internal temperature (over approximately 30 minutes). After stirring the resulting solution for 60 minutes, the mixture was poured into 750 mL 3 N HCl(aq) and stirred rapidly for 30 minutes while warming to room temperature. The mixture was then transferred to a separatory funnel, and allowed to settle for 30 minutes. The thick yellow oil which separated on the bottom was carefully removed, then dissolved in CH2Cl2 (1 L), dried (Na2SO4) and concentrated in vacuo to provide 24 g of the amine salt (RE2a) of sufficient purity (approximately 80%) to be used directly.

The synthetic route of 51628-12-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK FROSST CANADA LTD.; BERTHELETTE, Carl; BOYD, Michael; BURCH, Jason; DUFRESNE, Claude; FARAND, Julie; HAN, Yongxin; STURINO, Claudio, F.; WO2010/34110; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51628-12-7, Recommanded Product: 2-(4-Iodophenyl)acetonitrile

(1) A three-necked flask was added with p-iodobenzeneacetonitrile (0.04 mol), phloroglucinol (0.02 mol) and etherAgent, zinc chloride (0.012 mol) as a catalyst, HCl gas (30 ml) was bubbled in an ice-salt bath for 1 hour to observe the reactionThe medium should change from colorless to orange. The reaction was allowed to stand in the freezer for 12 hours, and then continued to pass HCl gas (25ml)1 hour, standing in the refrigerator for 2 days, remove the reaction solution, decanting ether, water bath heated to reflux for two hours, was recrystallizedTo 2,4,6-trihydroxy-4′-iodo-phenylbenzyl ketone of general formula IIa.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Nanhua University; Zheng Xing; Zheng Qutong; Wang Zongbao; Lei Xiaoyong; Zeng Xianliang; Xiao Yan; Liu Ya; Huang Qiuxia; (23 pag.)CN106432165; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 51628-12-7, The chemical industry reduces the impact on the environment during synthesis 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, I believe this compound will play a more active role in future production and life.

General procedure: Cooling at 0 C, a solution of 4-substituted- or 3,4-disubstituted-phenylacetonitrile or of cyanolupinane42 (6 mmol) and 0.35 mL of abs. EtOH in 5 mL of CHCl3 was saturated with anhydrous HCl and left overnight at 0-5 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Iodophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tonelli, Michele; Novelli, Federica; Tasso, Bruno; Vazzana, Iana; Sparatore, Anna; Boido, Vito; Sparatore, Fabio; La Colla, Paolo; Sanna, Giuseppina; Giliberti, Gabriele; Busonera, Bernardetta; Farci, Pamela; Ibba, Cristina; Loddo, Roberta; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4893 – 4909;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

51628-12-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, A new synthetic method of this compound is introduced below.

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ortar, Giorgio; Morera, Enrico; De Petrocellis, Luciano; Ligresti, Alessia; Schiano Moriello, Aniello; Morera, Ludovica; Nalli, Marianna; Ragno, Rino; Pirolli, Adele; Di Marzo, Vincenzo; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 118 – 132;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com