Category: 51628-12-7

Some common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, molecular formula is C8H6IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H6IN

A solution of NaOH (50%, 8 ml) was added dropwise to a mixture of compound LII-1 (2 g, 8.23 mmol), l-bromo-2-chloroethane (2.37 g, 16.5 mmol) and benzyl- triethylammonium chloride (0.094 g, 0.41 mmol) at room temperature. The reaction mixture was stirred and heated to 60 C overnight. Reaction was monitored by TLC. The reaction mixture was quenched with water and extracted with CH2CI2. The organic layer was washed two times with dilute hydrochloric acid, dried over Na2S04 and concentrated. The residue was purified by column chromatography (PE: EA = 50: 1-20: 1) to give compound LII-2 (1.35 g, yield: 61%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51628-12-7, its application will become more common.

Reference:
Patent; INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.; WO2013/25733; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 51628-12-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 94 Synthesis of N-{2-[4-(3-(3-pyridyl)-4-methoxyphenyl)aminophenyl]ethyl}-(R)-2-hydroxy-2-(8-hydroxy-2(1H)-quinolinon-5-yl)ethylamine (94) Compound 94: Formula (XI) where R11 is 3-pyridyl a.Synthesis of 4-iodophenethylamine 4-Iodophenylacetonitrile (4.80 g, 19.7 mmol) was dissolved in tetrahydrofuran (25 ML) under nitrogen, and 1.0 M borane in tetrahydrofuran (29.6 ML, 29.6 mmol) was added via syringe.The reaction was heated at reflux for 1 hour, then cooled in ice and the excess borane was quenched by the addition of methanol (100 ML).When hydrogen evolution ceased, the solvents were removed under reduced pressure.The residue was dissolved in tetrahydrofuran (25 ML) and 4N HCl in dioxane (6.0 ML, 24 mmol) was added, followed by ether (75 ML).The hydrochloride salt of 4-iodophenethylamine was collected on a Buchner funnel, washed with ether (2*50 ML) and dried under reduced pressure.To generate the free base, the solid was partitioned between dichloromethane (200 ML) and 1N NaOH (100 ML).The aqueous layer was extracted with dichloromethane (2*100 ML).The combined organic layers were dried (Na2SO4) and concentrated to give 4-iodophenethylamine (4.52 g) as a colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Iodophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Moran, Edmund J.; Jacobsen, John R.; Leadbetter, Michael R.; Nodwell, Matthew B.; Trapp, Sean G.; Aggen, James; Church, Timothy J.; US2003/229058; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H6IN

To a solution of 4-iodophenylacetonitrile (6.88 g, 28.3 mmol, 1 eq.) and bis-(2-chloro-ethyl)-carbamic acid tert-butyl ester (7.2 g, 30 mmol, 1.05 eq.) in DMSO (100 mL) under argon (Ar) was added NaNH2 (2.46 g, 60 mmol, 2 eq.) in portions over 15 min. The reaction was stirred at room temperature for 0.5 h, then poured onto ice (200 g), diluted with EtOAc (250 mL) and stirred for 1 h. The organic layer was separated and the aqueous layer was washed repeatedly with EtOAc until colorless. The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated by rotary evaporation to afford an orange oil which was purified by flash column chromatography by eluding with 7-12% EtOAc/hexanes to yield 4-cyano-4-(4-iodo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester as a pale orange oil/solid (8.28 g, 18.96 mmol, 67%). 1H NMR (300 MHz, CDCl3): delta 7.82 (dd, 2H), 7.26 (dd, 2H), 4.38 (br. s, 2H), 4.28 (br. t, 2H), 2.15 (m, 2H), 2.0 (td, 2H), 1.59 (s, 9H).

The synthetic route of 51628-12-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACOPEIA, INC.; US2003/13720; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, molecular formula is C8H6IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H6IN

iodophenyl cyanide(10 mmol, 2.28 g), Na2C03 (0.5 mmol, 57 mg)Soluble in tetrahydrofuran / water(Nu: nu = 3: 1) in a mixed solvent,After the reaction was stopped for 6 hours, the reaction was stopped. After allowing to stand at room temperature, the solvent was dried and usedSilica gel column chromatography to obtain a white solid after purification of p-iodobenzamide 2. 2 g (Yield: 89%);

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51628-12-7, its application will become more common.

Reference:
Patent; Suzhou University of Science and Technology; ZHOU, YUYANG; WANG, XIAOMEI; YE, CHANGQING; ZHU, SAIJIANG; XU, PENGJIE; LIANG, ZUOQIN; (6 pag.)CN104016913; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51628-12-7, name: 2-(4-Iodophenyl)acetonitrile

Preparation 10 4-(4-Iodophenyl)-tetrahydropyrane-4-carbonitrile. To a solution of (4-iodophenyl)-acetonitrile (2.43 g, 10.0 mmol) in DMSO (50 ml) was added sodium hydride (60% in oil, 1.2 g, 30 mmol) at room temperature. After stirring for 30 min., bis-2-chloroethyl ether (1.57 g, 11 mmol) was added. After stirring for a further 1 hr. at room temperature, the solution was poured into brine/water (1:1) and extracted twice with diethyl ether. The combined organic phases were dried over magnesium sulphate and concentrated in vacuo. The residue was purified by chromatography (15% ethyl acetate in petroleum ether), giving the title compound as a solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Iodophenyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; LEO PHARMA A/S; US2012/101039; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51628-12-7, A common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, molecular formula is C8H6IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

The synthetic route of 51628-12-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ortar, Giorgio; Morera, Enrico; De Petrocellis, Luciano; Ligresti, Alessia; Schiano Moriello, Aniello; Morera, Ludovica; Nalli, Marianna; Ragno, Rino; Pirolli, Adele; Di Marzo, Vincenzo; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 118 – 132;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 51628-12-7,Some common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, molecular formula is C8H6IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 10 alpha-cyano-4-iodo-2′,4′,5′-trimethoxystilbene was obtained in the same method as in Referential Example 1 except that 392 mg (2.0 mmol) of 2,4,5-trimethoxybenzaldehyde (purchased from Lancaster) and 486 mg (2.0 mmol) of 4-iodophenylacetonitrile instead of 4-bromophenylacetonitrile were used. 4-iodophenylacetonitrile was obtained in the same method described in Referential Example 3. And 566 mg (yield: 74.4%) of the compound as a yellow crystalline represented by the following formula was obtained in the same method as in Example 1 except that 421 mg (1.0 mmol) of the above alpha-cyano-4-iodo-2′,4′,5′-trimethoxystilbene was used instead of alpha-cyano-4-bromo-2′,4′,5′-trimethoxystilbene: STR133 melting point of the obtained compound was 273-276 C.

The synthetic route of 51628-12-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Morinaga Milk Industry Co., Ltd.; US5574062; (1996); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C8H6IN

General procedure: A stirred mixture of 4-iodophenylacetonitrile (35), arylboronic acid (36-45) (1.1 equiv), Pd(PPh3)4 (0.03 equiv), KBr (1.1 equiv), and K3PO4 (2.5 equiv) in dioxane (5 mL/mmol) was purged with N2 for10 min at room temperature and then stirred overnight at 85 C under N2. The mixture was diluted with water and extracted with AcOEt. The organic phase was washed three times with water, dried (Na2SO4), and evaporated under vacuum. The residue was chromatographedon silica gel.

The synthetic route of 51628-12-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ortar, Giorgio; Morera, Enrico; De Petrocellis, Luciano; Ligresti, Alessia; Schiano Moriello, Aniello; Morera, Ludovica; Nalli, Marianna; Ragno, Rino; Pirolli, Adele; Di Marzo, Vincenzo; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 118 – 132;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51628-12-7, The chemical industry reduces the impact on the environment during synthesis 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, I believe this compound will play a more active role in future production and life.

To a stirred solution of 2-(4-iodophenyl)acetonitrile (10 g, 41 .15 mmol) in tetrahydrofuran (100 ml) was added drop wise lithium bis(trimethylsilyl)amide (103 ml of a 1 M solution in tetrahydrofuran, 103 mmol) at -78 C. The resulting mixture was allowed to stirre for 15 minutes. The 3-(chloromethyl)pyridine hydrochloride (6.75 g, 41.15 mmol) was then added. The reaction was then allowed to react overnight at room temperature. The reaction was monitored by thin layer chromatography and showed completion after one night of stirring. Water (100 ml) and ethyl acetate (100 ml) were added. The organic phase was isolated and concentrated under reduced pressure The crude product was then absorbed onto silica gel and purified by flash chromatography to give 4.7 g of 2-(4-iodophenyl)-3-(3- pyridyl)propanenitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Iodophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JEANMART, Stephane Andre Marie; RAJAN, Ramya; BONVALOT, Damien; PERRUCCIO, Francesca; WO2015/14733; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51628-12-7, The chemical industry reduces the impact on the environment during synthesis 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, I believe this compound will play a more active role in future production and life.

To a stirred solution of 2-(4-iodophenyl)acetonitrile (10 g, 41 .15 mmol) in tetrahydrofuran (100 ml) was added drop wise lithium bis(trimethylsilyl)amide (103 ml of a 1 M solution in tetrahydrofuran, 103 mmol) at -78 C. The resulting mixture was allowed to stirre for 15 minutes. The 3-(chloromethyl)pyridine hydrochloride (6.75 g, 41.15 mmol) was then added. The reaction was then allowed to react overnight at room temperature. The reaction was monitored by thin layer chromatography and showed completion after one night of stirring. Water (100 ml) and ethyl acetate (100 ml) were added. The organic phase was isolated and concentrated under reduced pressure The crude product was then absorbed onto silica gel and purified by flash chromatography to give 4.7 g of 2-(4-iodophenyl)-3-(3- pyridyl)propanenitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Iodophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JEANMART, Stephane Andre Marie; RAJAN, Ramya; BONVALOT, Damien; PERRUCCIO, Francesca; WO2015/14733; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com