Category: 51560-21-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51560-21-5, name is 1,4-Diiodo-2,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,4-Diiodo-2,5-dimethoxybenzene

Compound 4-1 (10.06 g, 25.8 mmol) was dissolved in 100 mL of dry dichloromethane,The reaction flask was then cooled in a dry ice acetone bath,A solution of 1 mol / L boron tribromide in dichloromethane (56.8 mL, 56.8 mmol) was slowly added dropwise,Natural warmingreaction4 days.100 mL of ice water was allowed to cool in an ice-water bath, and then the reaction solution was gradually dropped into it with stirring,Produce a lot of solid, standing. Filtered with a Buchner funnel, the solid was washed three times with ice water, dried in vacuo,To give white solid compound 5-1 (8.71 g, 24.1 mmol)Yield: 93%; characterization: white solid;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shenzhen Da Wu Science And Technology Co., Ltd.; Wang Ziyu; Li Baojian; Qi Tafamingrenqingqiubugongkaixingming; (12 pag.)CN106496049; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51560-21-5, name is 1,4-Diiodo-2,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,4-Diiodo-2,5-dimethoxybenzene

A two-neck round bottom flask (250ml) was cooled to -63 C in a liquid nitrogen/chloroform slush bath to which 1,4-diiodo 2,5-dimethoxybenzene (2.0g, 5.1mmol, 1.0 equiv) was dissolved in dichloromethane (40ml) under nitrogen. BBr3 (12ml, 1.0M, 12mmol) was then added dropwise through a septa seal using a syringe. The mixture was allowed to warm to room temperature and stirred for 24hrs and then carefully quenched with water (75ml). The aqueous layer was then extracted with ether (3 * 50ml). The combined organic phases were extracted with NaOH (150ml, 2N). The NaOH solution was then neutralized in dilute HCl in an ice bath to form a pink precipitate that was collected and dried. The resultant solid material was recrystallized from toluene to give light brown crystals, (1.48g, 80%).

The synthetic route of 51560-21-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tsakama, Madalitso; Shang, Yuting; He, Yonghuang; Fan, Bei; Wang, Fengzhong; Chen, Weihua; Dai, Xiaofeng; Tetrahedron Letters; vol. 57; 16; (2016); p. 1739 – 1742;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

51560-21-5, The chemical industry reduces the impact on the environment during synthesis 51560-21-5, name is 1,4-Diiodo-2,5-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

In a 100.0mL Schlenk flask equipped with astir bar, 10 (0.2500 g, 0.641mmol), PdCl2(PPh3)2 (0.0442 g, 0.0632mmol), and CuI (0.3762 g, 1.976mmol) were added. A condenser was added, and the apparatus was purged andfilled with argon. Through the sidearm of the flask, 5.0mL of distilled triethylamine and 10.0mL of distilled toluene were added via a purged and filled airtight syringe. Lastly, 15mLof TMS acetylene was placed in a small round bottom flask and was degassed with argon for about 10 min before it was added through the sidearm of the Schlenk flask (0.1916 mL,1.346mmol) with a purged and filled airtight syringe. The apparatus was lowered into an 80C oil bath and heated for 24 hours. The solvent was removed from the light orange reaction mixture via rotary evaporation, and the solid was extracted with 10 mL of ethyl acetate and 10 minutes o fsonication. The remaining solid was removed via filtration,and the filtrate was rotovapped to produce crude product 11as a grayish/gold solid. The product was purified via MPLC on silica. The product eluted at 70 : 30 hexanes : ethyl acetate in quantitative yield. 1H NMR (500MHz, CDCl3) delta 0.21 (s,CH3, 18H), 3.76 (s, OCH3, 6H), 6.86 (s, Ph, 2H).

The chemical industry reduces the impact on the environment during synthesis 1,4-Diiodo-2,5-dimethoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Basinger, Corinne A.; Sullivan, Kaitlin; Siemer, Sarah; Oehrle, Stuart; Walters, Keith A.; Journal of Chemistry; vol. 2015; (2015);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com