Category: 505084-55-9

New strategies in the synthesis of regioselectively trifluoromethyl- and trifluoromethoxy-substituted arenes as building blocks for biologically active molecules was written by Leconte, Stephane;Ruzziconi, Renzo. And the article was included in Journal of Fluorine Chemistry in 2002.Reference of 505084-55-9 This article mentions the following:

Regioisomerically pure trifluoromethyl- and trifluoromethoxy-substituted aromatic and heteroaromatic aldehydes and carboxylic acids are valuable building blocks for the synthesis of biol. active mols. They have been prepared by employing modern organometallic methods. On this basis, a novel access to 2,3-dihydro-5-(trifluoromethoxy)indole was developed which represents an intriguing example of how organometallic and radical chem. can fecundate each other. Iodination of [4-(trifluoromethoxy)phenyl]carbamic acid 1,1-dimethylethyl ester gave [2-Iodo-4-(trifluoromethoxy)phenyl]carbamic acid 1,1-dimethylethyl ester. Allylation of the latter gave [2-iodo-5-(trifluoromethoxy)phenyl]-2-propenylcarbamic acid 1,1-dimethylethyl ester which was cyclized to give 2,3-dihydro-3-methyl-5-(trifluoromethoxy)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Reference of 505084-55-9).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Reference of 505084-55-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Study on synthesis of 2-chloro-5-trifluoromethyl pyridine-4-yl-boronic acid was written by Liu, Guoquan;Wang, Shanshan;Liang, Jiudi;Li, Qiuwu;Han, Jianrong. And the article was included in Hebei Keji Daxue Xuebao in 2014.Formula: C6H2ClF3IN This article mentions the following:

2-Chloro-5-trifluoromethyl pyridine-4-yl-boronic acid was prepared with 2-chloro-4-iodo-5-trifluoromethyl pyridine as the raw material through reaction with Bu lithium reagent. Several reaction conditions of the synthesis process were studied through the experiment The purity and structure of the products were characterized by HPLC, FTIR and ¹H NMR. Exptl. result shows that when the temperature is -70°C, the reaction time is 2h, the molar ratio of n(C₆H₂ClF₃IN):n(C₁₂H₂₇BO₃):n(C₄H₉Li)is=1.00:1.20:1.20, and the pH is 9.0, the yield of 2-chloro-5-trifluoromethyl pyridine-4-yl-boronic acid reaches 83.10%, and its purity is up to 98.65%. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Formula: C6H2ClF3IN).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C6H2ClF3IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization was written by Cottet, Fabrice;Schlosser, Manfred. And the article was included in European Journal of Organic Chemistry in 2004.Name: 2-Chloro-5-(trifluoromethyl)-4-iodopyridine This article mentions the following:

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)pyridine were each converted into the three possible carboxylic acids. This was achieved by employing several, but not all of the organometallic “toolbox methods”; transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6-tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Name: 2-Chloro-5-(trifluoromethyl)-4-iodopyridine).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 2-Chloro-5-(trifluoromethyl)-4-iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com