Category: 501433-06-3

Adding a certain compound to certain chemical reactions, such as: 501433-06-3, name is 2,3-Difluoro-1,4-diiodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 501433-06-3, Product Details of 501433-06-3

General procedure: 1,2,3,4-Tetrahalobenzene (10 mmol), iron powder (0.89 equiv.),sulfur (0.66 equiv.) and NaSHnH2O (4.0 equiv.) were added to dryN,N-dimethylformamide (32 equiv.). The mixture was heated to 140 C for 16 h. The reaction mixture was cooled to room temperatureand added to water (50 mL). The mixture was filtered andair-dried to afford a black solid. The black solid was then addedto a solution of methanol (20 mL), ZnO (1.2 equiv.), NaOH(6.5 equiv.) and water (20 mL), and allowed to reflux for 2 h. Aftercooling to room temperature, the mixture was filtered with Celite.The filtrate was added to 2 M H2SO4 and then extracted withdichloromethane. The organic phase was washed with brine anddried with MgSO4. After filtration, evaporation and drying, the corresponding3,6-dihalo-1,2-benzenedithiol was afforded as a solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Difluoro-1,4-diiodobenzene, and friends who are interested can also refer to it.

Reference:
Article; Tsukada, Satoru; Kondo, Masataka; Sato, Hironobu; Gunji, Takahiro; Polyhedron; vol. 117; (2016); p. 265 – 272;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 501433-06-3,Some common heterocyclic compound, 501433-06-3, name is 2,3-Difluoro-1,4-diiodobenzene, molecular formula is C6H2F2I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen atmosphere, 2,3-difluoro-1,4-diiodobenzene (7, 430 mg, 1.18 mmol), bis-(triphenylphospino)dichloropalladium(II) (85.1 mg, 121 mumol) and copper(I) iodide (23.2 mg,122 mumol) were dissolved in anhydrous THF (20 mL) and triethylamine (20 mL).Trimethylsilylacetylene (0.41 mL, 2.96 mmol) was added and the solution stirred at 70 C for16 h. Subsequently, the reaction mixture was filtered through a bed of Celite, the solvent wasevaporated in vacuo and the crude product purified by column chromatography using silicaand n-hexane as eluent (Rf = 0.44) to obtain a colourless solid (332 mg, 1.08 mmol, 92%).Melting point: 78 C;1H NMR (500MHz, CDCl3, 300 K): delta = 7.12-7.10 (m, 2H) ppm;13C NMR (125 MHz, CDCl3, 300 K): delta = 151.4 (dd, 1JC,F = 255.9 Hz, 2JC,F = 15.0 Hz, 2C), 127.9 (mc,2C), 114.2 (mc, 2C), 103.7 (mc, 2C), 96.4 (mc, 2C), 0.1 (6C) ppm.IR (ATR): = 2960 (w), 2900 (w), 2165 (m), 1549 (w), 1489 (m), 1466 (s), 1310 (w), 1249 (s),1228 (m), 1170 (w), 1044 (m), 963 (s), 838 (vs), 817 (vs), 758 (vs), 702 (s) cm-1;MS (EI, 70 eV): m/z (%) = 306 (45) [M]+, 293 (100) [M-Me]+, 112 (41) [M-2I]+;HR-MS (EI, 70 eV): m/z = calcd. for C16H20F2Si2 [M]+ 306.1072, found 306.1072.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3-Difluoro-1,4-diiodobenzene, its application will become more common.

Reference:
Article; Hamer, Sebastian; Roehricht, Fynn; Jakoby, Marius; Howard, Ian A.; Zhang, Xianghui; Naether, Christian; Herges, Rainer; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1331 – 1338;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 501433-06-3, These common heterocyclic compound, 501433-06-3, name is 2,3-Difluoro-1,4-diiodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,2-difluoro-3,6-diiodobenzene (7.3 g, 20.0 mmol), Compound 45 (12.8 g, 42.0 mmol), a 2 M aqueous solution of Na2CO3 (40 mL, 80.0 mmol), DME (40 mL), toluene (40 mL), and Pd[PPh3]4 (1.2 g, 1.0 mmol) were loaded into a three-necked flask, and the mixture was refluxed under an Ar atmosphere for 8 hours. After the completion of the reaction, the resultant was cooled to room temperature. The resultant sample was transferred to a separating funnel, and water (100 mL) was charged into the funnel. Then, the mixture was extracted with CH2Cl2. The extract was dried with MgSO4, and was then filtered and concentrated. The resultant sample was purified by silica gel column chromatography, whereby a white solid was obtained in an amount of 8.2 g in 65% yield-FD-MS analysis C44H32F2O2: theoretical value 630, observed value 630

Statistics shows that 2,3-Difluoro-1,4-diiodobenzene is playing an increasingly important role. we look forward to future research findings about 501433-06-3.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2301926; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com