Category: 4897-68-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 4897-68-1

Example 1 Synthesis of 2-bromo-4-methoxybiphenyl A mixture of 38 g (121 mmol) of 1-bromo-2-iodo-4-methoxy benzene, 14.8 g (121 mmol) of phenylboronic acid, 2.8 g (2.4 mmol) of tetrakis(triphenylphosphine)palladium, 2M Na2CO3 (29 g, 266 mmol), 135 ml of EtOH and 270 ml toluene was degassed and placed under nitrogen, and then heated at 90 C. for 16 h. After finishing the reaction, the mixture was allowed to cool to room temperature. The organic layer was extracted with ethyl acetate and water, dried with anhydrous magnesium sulfate, the solvent was removed and the residue was purified by column chromatography on silica(hexane-dichloromethane) to give product (24 g, 63.0 mmol, 75%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Luminescence Technology Corp.; YEN, FENG WEN; CHANG, CHENG HAO; TENG, CHIN MIN; LIN, I FENG; (46 pag.)US2016/155949; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 4897-68-1, A common heterocyclic compound, 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, molecular formula is C7H6BrIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In an oven dried Schlenk tube under nitrogen atmosphere, were added allylic alcohol 6 (500.0mg, 1.76-3.38mmol), aryl halide 1 (2.11-4.06mmol), Pd(OAc)2 (11.8-22.7mg, 3mol%), triethylamine (356.2-684.1mg, 3.52-6.76mmol), followed by dry acetonitrile (4mL), at room temperature. The resulted reaction mixture was stirred for 24h at 80C. Progress of the reaction was monitored by TLC. The reaction mixture was quenched with the aqueous NH4Cl solution and extracted with ethyl acetate (3×20mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification of the residue on a silica gel column chromatography using petroleum ether/ethyl acetate as eluent furnished the ketone 7 (46-58%).

The synthetic route of 4897-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramulu, B. Venkat; Mahendar; Krishna; Reddy, A. Gopi Krishna; Suchand; Satyanarayana; Tetrahedron; vol. 69; 38; (2013); p. 8305 – 8315;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 4897-68-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In an oven dried Schlenk tube under nitrogen atmosphere, were added allylic alcohol 6 (500.0mg, 1.76-3.38mmol), aryl halide 1 (2.11-4.06mmol), Pd(OAc)2 (11.8-22.7mg, 3mol%), triethylamine (356.2-684.1mg, 3.52-6.76mmol), followed by dry acetonitrile (4mL), at room temperature. The resulted reaction mixture was stirred for 24h at 80C. Progress of the reaction was monitored by TLC. The reaction mixture was quenched with the aqueous NH4Cl solution and extracted with ethyl acetate (3×20mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification of the residue on a silica gel column chromatography using petroleum ether/ethyl acetate as eluent furnished the ketone 7 (46-58%).

The synthetic route of 1-Bromo-2-iodo-4-methoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramulu, B. Venkat; Mahendar; Krishna; Reddy, A. Gopi Krishna; Suchand; Satyanarayana; Tetrahedron; vol. 69; 38; (2013); p. 8305 – 8315;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 4897-68-1,Some common heterocyclic compound, 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, molecular formula is C7H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 135mg (1mmol) benzothiazole, 376mg (1.2mmol) 1- bromo-2-iodo-4-methoxybenzene, 2.5mg (0.01mmol) CuSO4·5H2O, 19.4mg (0.1mmol) ligand L4,240mg (6mmol) NaOH, 2gPEG-600, was added 10mL reaction tube, sealed, under the reaction condition of 80 14h.After the reaction was stopped, extraction with ethyl acetate, washed with water, brine, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated under reduced pressure, purified by silica gel column chromatography separation and purification, to give 3-methoxy-phenothiazine 172mg, yield 75%.

The synthetic route of 4897-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Wan, Yiqian; Huang, Manna; Huang, Dongting; Zhu, Xinhai; (11 pag.)CN104529938; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 4897-68-1, A common heterocyclic compound, 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, molecular formula is C7H6BrIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In an oven dried Schlenk tube under nitrogen atmosphere, were added allylic alcohol 6 (500.0mg, 1.76-3.38mmol), aryl halide 1 (2.11-4.06mmol), Pd(OAc)2 (11.8-22.7mg, 3mol%), triethylamine (356.2-684.1mg, 3.52-6.76mmol), followed by dry acetonitrile (4mL), at room temperature. The resulted reaction mixture was stirred for 24h at 80C. Progress of the reaction was monitored by TLC. The reaction mixture was quenched with the aqueous NH4Cl solution and extracted with ethyl acetate (3×20mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification of the residue on a silica gel column chromatography using petroleum ether/ethyl acetate as eluent furnished the ketone 7 (46-58%).

The synthetic route of 4897-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramulu, B. Venkat; Mahendar; Krishna; Reddy, A. Gopi Krishna; Suchand; Satyanarayana; Tetrahedron; vol. 69; 38; (2013); p. 8305 – 8315;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H6BrIO

To a flame-dried two-necked flask (100mL) containing a magnetic stirrer, 65 CuI (0.183g, 0.96mmol), 66 dl-pipecolic acid (0.124g, 0.96mmol) and 67 Cs2CO3 (4.18g, 12.80mmol) in 50 68 mLof DMF/69 1,4-dioxane (1/9) was added 70 4-methoxylbenzyl mercaptan (1.07mL, 7.69mmol) and the reaction mixture was stirred at room temperature for 3min 9 4-Bromo-3-iodoanisole (4)(2.0g, 6.41mmol) was then added into the mixture and the resulting solution was heated to 100C and stirred at this temperature for 24h. After cooling to room temperature, the mixture was filtrated through celite and washed with EtOAc (20mL), the organic layer was added saturated 71 aqueous NaCl solution (100mL) and was extracted with EtOAc (50mL×3). The combined organic extracts were dried over anhydrous MgSO4(S). After filtration and removal of solvent, the residue was purified by column chromatography on silica gel using 10/1 (Hexane/EtOAc) as elution to give 11 compound 5 (1.60g, 75%) as a red oil. Rf=0.30 (20:1 Hex/EtOAc); 1H NMR (500MHz, CDCl3) delta 3.72 (s, 3H), 3.79 (s, 3H), 4.10 (s, 2H), 6.58 (dd, J=9.0, 3.0Hz, 1H), 6.78 (d, J=3.0Hz, 1H), 6.85 (d, J=9.0Hz, 2H), 7.29 (d, J=9.0Hz, 2H), 7.41 (d, J=9.0Hz, 1H); 13C{H} NMR (125MHz, CDCl3) delta 37.3, 55.2, 55.4, 112.3, 113.6, 113.9, 114.4, 127.8, 130.0, 133.2, 138.9, 158.9, 159.0; MS (EI, m/z) 340 (M+, 7), 338 (6), 138 (7), 121 (100), 71 (8), 57 (8); HRMS (EI-magnetic sector) m/z: calcd for C15H15BrO2S 339.9956, found 339.9979.

The synthetic route of 4897-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wen, Shi-Ming; Lin, Cheng-Han; Chen, Chin-Chau; Wu, Ming-Jung; Tetrahedron; vol. 74; 20; (2018); p. 2493 – 2499;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1-Bromo-2-iodo-4-methoxybenzene

GP-1 carried out, to an oven dried Schlenk tube under nitrogen atmosphere, were added allyl alcohol 6a (100 mg, 0.61 mmol), arylhalide 5b (228 mg, 0.73 mmol), Pd(OAc)2 (4.1 mg, 3 mol%), triethylamine (123 mg, 1.22 mmol) followed by dry acetonitrile (1 mL). The resulted reaction mixture was stirred for 24 h at 80 C. The reaction mixture was quenched with the aqueous NH4Cl solution and extracted with ethyl acetate (3 × 20 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification of the residue on a silica gel column chromatography (petroleum ether/ethyl acetate 92:8 to 85:15) eluent furnished the ketone 7ba (153 mg, 72%) as product. [TLC control Rf(6a)=0.50, Rf(7ba)=0.6, Rf(5b)=0.9 (petroleum ether/ethyl acetate 8:2, UV detection)]. IR (MIR-ATR, 4000-600 cm-1): nmax=3001, 2924, 2852, 1683, 1581, 1467, 1429, 1358, 1243, 1164, 1126, 1042, 1018, 872, 800, 772 cm-1. 1H NMR (CDCl3, 400 MHz): delta=7.55 (d, 1H, J=8.0 Hz, ArH), 7.50 (d, 1H, J=2.6 Hz, Ar-H), 7.42 (d, 1H, J=8.7 Hz, Ar-H), 7.35 (dd, 1H, J=8.0 and 8.0 Hz, ArH), 7.09 (dd, 1H, J=8.0 and 2.6 Hz, ArH), 6.85 (d, 1H, J=3.0 Hz, ArH), 6.64 (dd, 1H, J=8.7 and 3.0 Hz, ArH), 3.28 (t, 2H, J=8.0 Hz, ArCOCH2), 3.12 (t, 2H, J=8.0 Hz, ArCOCH2CH2) ppm. 13C NMR (CDCl3, 100 MHz): delta=198.8 (s, ArCO), 159.8 (s, ArC), 159.1 (s, ArC), 141.5 (s, ArC), 138.1 (s, ArC), 133.4 (d, ArCH), 129.6 (d, ArCH), 120.7 (d, ArCH), 119.7 (d, ArCH), 116.3 (d, ArCH), 114.7 (s, ArC), 113.7 (d, ArCH), 112.3 (d, ArCH), 55.5 (s, 2C, 2 × ArOCH3), 38.7 (t, ArCOCH2), 31.4 (t, ArCOCH2) ppm. HR-MS (APCI+) m/z calculated for [C17H18BrO3]+=[M+H]+: 349.0434; found: 349.0418.

The synthetic route of 4897-68-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suchand; Krishna; Venkat Ramulu; Dibyendu; Gopi Krishna Reddy; Mahendar; Satyanarayana; Tetrahedron Letters; vol. 53; 30; (2012); p. 3861 – 3864;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 4897-68-1,Some common heterocyclic compound, 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, molecular formula is C7H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of Pd(OAc)2 (101 mg, 0.45 mmol ), PPh3 (354 mg, 1.35 mmol), K2CO3 (2.76 g, 20.0 mmol) in DME (30 mL) and H2O (10 mL) at room temperature under argon was added 9c (3.0 g, 11 mol). The resulting solution was stirred for 10 min, then 8 (2.83 g, 10.0 mmol) was added, and the solution was heated at reflux for 23 h and monitored by TLC. The resulting solution was cooled to room temperature, EtOAc (100 mL) was added, and the solution was washed with a saturated brine solution and water, and dried over anhydrous Na2SO4. Following evaporation of the solvent under reduced pressure, the residue was purified by chromatography on a silica gel column eluted with hexane/EtOAc (150:1) to yield 10c (2.84 g, 91%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-iodo-4-methoxybenzene, its application will become more common.

Reference:
Article; Wu, Anhui; Xu, Daiwang; Lu, Ding; Penning, Trevor M.; Blair, Ian A.; Harvey, Ronald G.; Tetrahedron; vol. 68; 35; (2012); p. 7217 – 7233;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4897-68-1 as follows. SDS of cas: 4897-68-1

Step 40a. 2-(2-Bromo-5-methoxyphenylthio)-1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-amine (Compound 0205-53) A mixture of compound 0204 (1.549 g, 5.41 mol), 1-bromo-2-iodo-4-methoxybenzene (Compound 0104-13) (2.54 g, 8.115 mol), neocuproine hydrate (113 mg, 0.541 mmol), CuI (103 mg, 0.541 mmol) and NaOt-Bu (519 mg, 5.41 mmol) in anhydrous DMF (50 mL) was stirred for 24 h at 110 C. (oil bath) under nitrogen atmosphere. The solvent was removed under high vacuum and the crude purified by column chromatography on silica gel (CH2Cl2/MeOH at 100/1) to give the title compound 0205-53 as a brown solid (1.67 g, 65%): LCMS: 471 [M+1]+.

According to the analysis of related databases, 4897-68-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; US2008/234314; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4897-68-1, name is 1-Bromo-2-iodo-4-methoxybenzene, A new synthetic method of this compound is introduced below., Product Details of 4897-68-1

Example 1 Synthesis of 2-bromo-4-methoxybiphenyl A mixture of 38 g (121 mmol) of 1-bromo-2-iodo-4-methoxy benzene, 14.8 g (121 mmol) of phenylboronic acid, 2.8 g (2.4 mmol) of tetrakis(triphenylphosphine)palladium, 2M Na2CO3 (29 g, 266 mmol), 135 ml of EtOH and 270 ml toluene was degassed and placed under nitrogen, and then heated at 90 C. for 16 h. After finishing the reaction, the mixture was allowed to cool to room temperature. The organic layer was extracted with ethyl acetate and water, dried with anhydrous magnesium sulfate, the solvent was removed and the residue was purified by column chromatography on silica(hexane-dichloromethane) to give product (24 g, 63.0 mmol, 75%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Luminescence Technology Corp.; YEN, FENG WEN; CHANG, CHENG HAO; TENG, CHIN MIN; LIN, I FENG; (46 pag.)US2016/155949; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com