Category: 461-17-6

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 461-17-6 as follows. Product Details of 461-17-6

[00106] To a solutiion of 6-bromo-benzo[cd]indol-2(1H)-one (1 g, 4 mmol) in N,N-dimethyl formamide was added K2CO3 (5.53 g, 40 mmol) and the resulting mixture was stirred for 0.5 hour under nitrogen. 4,4,4-trifluorobutyl iodide (915 mg, 4 mmol ) was next injected to the solution and the mixture was heated at 60 C. for 18 hours. The reaction media was next poured into 200 ml water and extracted with trichloromethane (3×100 ml). Column chromatography using gradient ethyl acetate in hexane (1020%) gave the desired product (1.225 g, 85%).

According to the analysis of related databases, 461-17-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wyeth; US6667303; (2003); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461-17-6, Formula: C4H6F3I

250g gamma-butyrolactone, 62.5g (440mmol) potassium 4-hydroxybutyrate, and 95.2g (400mmol) 4,4,4-trifluorobutyliodide were placed in a 500ml four-necked flask equipped with a stirrer, a reflux cooler, and a thermometer. By heating, the mixture was maintained at 75C for 5 hours while being stirred. At this point, it was determined by a gas chromatography that 98.6% of the 4,4,4-trifluorobutyliodide had been converted. Subsequently, the temperature was raised to 140C and the reaction was allowed to continue for another 2 hours. Upon completion of the reaction, the mixture was again analyzed by a gas chromatography. The results of the analysis revealed that 4,4,4-trifluorobutyliodide was converted at 100% conversion rate, and the selectivity for 4,4,4-trifluorobutanol, trifluorobutyl 4-hydroxybutyrate, and 4,4,4-trifluoro-1-butene were 86.5%, 13.3%, and 0.2%, respectively. The reaction mixture was then subjected to distillation: it was transferred to a 500ml flask equipped with a Claisen connector tube and a Liebig’s cooling tube, and was distilled at 120 to 140C under a pressure of 20 to 6kPa while the degree of vacuum was increased over a 3-hour period. As a result, 70.4g distillate was collected containing 49.2g (96.0% yield) of 4,4,4-trifluorobutanol. The gas chromatography analysis performed on the solution remaining in the flask indicated that it contained 0.8% trifluorobutyl 4-hydroxybutyrate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-4-iodobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tosoh F-Tech, Inc.; EP1403238; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 461-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of silver nitrite (9 g, 58.5 mmol) in diethyl ether (25 mL) at 0C was added a solution of 4-iodo-1, 1, 1-trifluorobutane, 15.02 (10 g, 42.0 mmol) in diethyl ether (25 mL) slowly through an addition funnel (approx. 15 min). The resulting mixture was vigorously stirred at 0C and warmed to rt. After 50 h, the solid material was filtered off through a celite pad. The resulting diethyl ether solution was concentrated in vacuo to give 15.03 as colorless oil, which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-4-iodobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SCHERING CORPORATION; WO2005/85197; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 461-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The alcohol of Example A2 (0.50 g, 1.38 mmol), tetrabutylammonium bromide (89 mg, 0.0.276 mmol), and KOH (232 mg, 4.14 mmol) were slurried in xylene (5.5 mL). Afterward, 1,1,1-trifluoro-4-iodobutane (0.98 g, 4.14 mmol) was added, and the resulting mixture was stirred in a sealed vial at 80 C. over the weekend. Subsequently, the mixture was filtered through celite and concentrated under N2. Chromatography (on silica, ethyl acetate/hexanes) afforded the ether in the form of a colorless oil (430.5 mg, 65.8% yield). NMR (CDCl3) delta 1.22-1.36 (m, 2H), 1.51 (s, 9H), 1.66-1.74 (m, 5H), 2.06-2.22 (m, 4H), 2.32 (d, 2H), 2.94 (t, 2H), 3.24 (d, 2H), 3.40 (t, 2H), 3.43 (t, 2H), 3.79 (d, 2H), 3.96 (dd, 2H). ESMS m/z=491.42 (M+NH4)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-4-iodobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Grapperhaus, Margaret L.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej, Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A.; US2005/9838; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461-17-6, Recommanded Product: 461-17-6

Preparation of Intermediate 15.01 Step 1 To a suspension of silver nitrite (9 g, 58.5 mmol) in diethyl ether (25 mL) at 0C was added a solution of 4-iodo-1, 1, 1-trifluorobutane, 15.02 (10 g, 42.0 mmol) in diethyl ether (25 mL) slowly through an addition funnel (approx. 15 min). The resulting mixture was vigorously stirred at 0C and warmed to rt. After 50 h, the solid material was filtered off through a celite pad. The resulting diethyl ether solution was concentrated in vacuo to give 15.03 as colorless oil, which was used without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SCHERING CORPORATION; WO2005/85242; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 69 fluoro-4-(4,4,4-trifluorobutoxy)benzoic acid By operating in the same manner as in Reference Example 68 and using 1,1,1-trifluoro-4-iodobutane, the title compound was obtained as colorless powder.1H-NMR (DMSO-d6) delta: 1.97 (2H, m), 2. 44 (2H, m), 4.13 (2H, t, J=6.3Hz), 6.89 (1H, t, J=2.0Hz), 6.90 (1H, m) 7.84 (1H, t, J=9.0Hz), 14.44 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1447402; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 461-17-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 461-17-6 as follows.

Example 2; 1-(2,4-Dichlorophenyl)-4-methyl-5-[4-(4,4,4-trifluorobutoxy)-phenyl]-1H-pyrazole-3- carboxylic acid piperidin-1-ylamide; 1- (2, 4-Dichlorophenyl)-5- (4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-l-yl amide from Ex 1, Step F (250 mg, 0.56 mmol) was dissolved in acetone (10 ml) and potassium carbonate (77 mg, 0.56 mmol) was added followed by 1-iodo-4, 4,4- trifluorobutane (140 mg, 0.56 mmol). The reaction mixture was boiled under reflux overnight, concentrated and purified by flash chromatography (hexane : EtOAc 70: 30- 60: 40) afforded 130 mg (42%) of a white solid that was triturated with hexane: EtOAc 95 : 5 and filtered. ‘H NMR (CDC13) : 5 7.63 (1H, broad s), 7.43 (1H, m), 7.30 (2H, m), 7.10-7. 00 (2H, m), 6.85-6. 78 (2H, m), 4.05 (2H, t), 2.90 (4H, m), 2.40-2. 19 (SH, s and m), 2.15-1. 97 (2H, m), 1. 78 (4H, m), 1.45 (2 H, m) MS m/z 577 (M+Na). HPLC: 98.4%

According to the analysis of related databases, 461-17-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/80343; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.4 g of 2- (2, 2,3, 3,4, 4,5, 5- octafluoropentyl) malononitrile and 1.2 g of 1-iodo-4, 4,4- trifluorobutane were dissolved in 5 ml of dimethyl sulfoxide, 0.83 g of potassium carbonate was added, and the mixture was stirred at room temperature for 5 hours. Thereafter, dilute hydrochloric acid was added to the reaction mixture, followed by extraction with methyl tert- butyl ether. The organic layer was washed successively with water, aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.35 g of 2- (2, 2,3, 3,4, 4,5, 5- octafluoropentyl)-2- (4, 4,4-trifluorobutyl) malononitrile (hereinafter, referred to as the present compound (66)). The present compound (66): lH-NMR (CDCl3, TMS) b (ppm): 2.01-2. 13 (2H, m), 2. 16-2. 32 (4H, m), 2.78 (2H, t), 6.02 (1H, tt).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, A new synthetic method of this compound is introduced below., name: 1,1,1-Trifluoro-4-iodobutane

2-(2,4-Dichlorophenyl)-5-methyl-1-[4-(4,4,4-trifluorobutoxy)-phenyl]-1H-imidazole-4-carboxylic acid piperidin-1-ylamide l-Iodo-4, 4,4-trifluorobutane (376 mg, 1.58 mmol) was added dropwise to a suspension of 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-1H-imidazole-4-carboxylic acid piperidin-1-ylamide, from Ex 2, Step 1 (351 mg, 0.79 mmol) and K2CO3 (218 mg, 1.58 mmol) in 50 ml acetone. The reaction mixture was refluxed overnight, cooled, filtered and concentrated. Flash chromatography (silica, hexane: EtOAc 1: 2) afforded 200 mg (46%) of the title compound as a white solid. ‘H NMR (CDC13) : 8 8. 0 (1H, broad s), 7.4-7. 2 (3H, m), 7.1-7. 0 (2H, m), 6.9-6. 8 (2H, m), 4.1-4. 0 (2H, m), 3.0-2. 9 (4H, m), 2.5-2. 2 (5H, m), 2.2-2. 0 (2H, m), 1.9-1. 7 (4H, m), 1.6-1. 4 (2H, m). MS m/z 578 (M+Na). HPLC: 99.4%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

l-(2,4-Dichlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-lH-pyrazole-3-carboxylic acid piperidin-l-yl amide from 1, Step F (250 mg, 0.56 mmol) was dissolved in acetone (10 ml) and potassium carbonate (77 mg, 0.56 mmol) was added followed by l-iodo-4,4,4- trifluorobutane (140 mg, 0.56 mmol). The reaction mixture was boiled under reflux overnight, concentrated and purified by flash chromatography (hexane : EtOAc 70 : 30 – 60 : 40) afforded 130 mg (42%) of a white solid that was triturated with hexane : EtOAc 95 : 5 and filtered.1H NMR(CDCl3): 5 7.63 (IH, broad s), 7.43 (IH, m), 7.30 (2H, m), 7.10-7.00 (2H, m), 6.85-6.78 (2H, m), 4.05 (2H, t), 2.90 (4H, m), 2.40-2.19 (5H, s and m), 2.15-1.97 (2H, m), 1.78 (4H, m), 1.45 (2 H, m). MS m/z 577 (M+Na). HPLC: 98.4%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.