Category: 460-37-7

Chemistry, like all the natural sciences, Formula: C3H4F3I, begins with the direct observation of nature¡ª in this case, of matter.460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, SMILES is ICCC(F)(F)F, belongs to iodides-buliding-blocks compound. In a document, author is Kogai, T, introduce the new discover.

Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells

The absence of TSH-stimulated radioiodide uptake in differentiated thyroid cancer is associated with a high recurrence rate and reduced survival. We studied regulation of the sodium/iodide symporter gene in human papillary thyroid cancer cell lines (BHP) and primary human thyroid cells. BHP cells expressed very low levels of sodium/iodide symporter mRNA and did not concentrate iodide, but iodide uptake was restored to levels seen in FRTL-5 rat thyroid cells by stable transfection of a sodium/iodide symporter cDNA. Sodium/iodide symporter gene expression, therefore, was necessary and sufficient for iodide uptake in BHP cells. We cloned the human sodium/iodide symporter gene 5′-flanking region and analyzed progressive 5′-deletions in transient transfections. We identified a region, -596 to -268, essential to confer full promoter activity in primary normal human thyroid cells. Sodium/iodide symporter promoter activity in four BHP cell lines, however, was markedly reduced, consistent with downregulation of the endogenous sodium/iodide symporter gene. Nuclear extracts from BHP 2-7 cells had reduced or absent binding to regions of the sodium/iodide symporter promoter shown to be critical for expression, compared with nuclear extracts from FRTL-5 cells. Competition studies indicated that these nuclear proteins were not known thyroid transcription factors. Modifications of the sodium/iodide symporter promoter with demethylation or histone acetylation did not increase sodium/iodide symporter expression, and no deletions of the critical regulatory region were identified in the endogenous gene in BHP cells. Regulation of the sodium/iodide symporter 5′-flanking region in transient transfection paralleled endogenous sodium/iodide symporter expression. Reduced expression of potential novel nuclear factor(s) in these cell lines may contribute to reduced sodium/iodide symporter expression resulting in absence of iodide uptake in some papillary thyroid cancers.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 460-37-7. Formula: C3H4F3I.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Sase, Shohei, once mentioned the application of 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, molecular weight is 223.9635, MDL number is MFCD00038531, category is iodides-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of 1,1,1-Trifluoro-3-iodopropane.

Iodide-promoted Deselenylation of beta-Chloro- and beta-Oxyselenides to Form Alkenes and Selenenyl Iodides

Deselenylation reaction of beta-chloro- and beta-oxyselenides proceeded efficiently by treatment with tetrabutylammonium iodide (TBAI) to afford alkenes in good yields. It was established that selenenyl iodides were formed in these reactions. Catalytic transformation of beta-chloro- and beta-oxyselenides to alkenes was also developed.

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Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, SMILES is ICCC(F)(F)F, in an article , author is Rayburn, William F., once mentioned of 460-37-7, Recommanded Product: 460-37-7.

Iodide concentrations in matched maternal serum, cord serum, and amniotic fluid from preterm and term human pregnancies

Objectives: To characterize the matched maternal and cord plasma and the amniotic fluid concentrations of iodide in preterm and term human pregnancies. Methods: Specimens were collected at the delivery of 121 singleton pregnancies (92 at term, 29 preterm) with no pre-existing medical complications. Plasma unbound iodide concentrations were measured by the difference between the protein bound iodine and the total iodine measured spectrophotometrically. Total iodide was measured in amniotic fluid. Results: Maternal plasma iodide concentrations were 1.6 +/- 0.4 mcg/dL (mean +/- S.D.) for preterm deliveries and 1.5 +/- 0.5 mcg/dL for term deliveries. Cord plasma iodide concentrations were 1.4 +/- 0.5 mcg/dL for preterm deliveries and 1.7 +/- 0.7 mcg/dL for term deliveries. Cord plasma iodide concentrations at birth correlated highly with maternal levels (p < 0.001). The cord:maternal plasma iodide ratio for all pairs was 1.2 +/- 0.7. The average cord:maternal plasma iodide ratio was not significantly different between the preterm (0.9 +/- 0.4) and term (1.3 +/- 0.8) deliveries. Amniotic fluid iodide concentrations did not correlate significantly with cord plasma concentrations. Conclusion: Cord plasma concentrations of iodide correlate with paired maternal levels, indicating that, unlike the rabbit and other species, the human conceptus does not highly concentrate iodide. (C) 2007 Published by Elsevier Inc. Interested yet? Read on for other articles about 460-37-7, you can contact me at any time and look forward to more communication. Recommanded Product: 460-37-7.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Handley, C. M., once mentioned the application of 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, molecular weight is 223.9635, MDL number is MFCD00038531, category is iodides-buliding-blocks. Now introduce a scientific discovery about this category, Product Details of 460-37-7.

A new potential for methylammonium lead iodide

We present a new set of interatomic potentials for modelling methylammonium lead iodide. The potential model uses existing potentials for lead iodide and methylammonium, and new functions are fitted to enable these pre-existing potentials to be used together, while still being capable of modelling lead iodide and methylammonium iodide as separate materials. Fitting was performed using a combination of ab initio and experimental reference data. Our simulations are in agreement with experiment and reveal the short and long range ordering of the molecular cations and lead iodide octahedra.

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Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, SMILES is ICCC(F)(F)F, belongs to iodides-buliding-blocks compound. In a document, author is HERMON, H, introduce the new discover, Product Details of 460-37-7.

SPECTROPHOTOMETRIC MICRODETERMINATION OF EXCESS OF IODINE IN MERCURY(II) IODIDE-CRYSTALS

The excess of iodine in mercury(II) iodide crystals was determined by spectrophotometry. Dynamic dissolution of mercury(II) iodide samples in carbon tetrachloride allows the detection of minute amounts (< 1-mu-mol mol-1) of free iodine in the crystal. This method has a detection limit that is at least two orders of magnitude lower than for other methods for the determination of excess iodine. Many crystals grown under various iodine overpressure conditions were studied. The solubility limit of free iodine in mercury(II) iodide was found to be about 130-mu-mol mol-1 in the range 95-120-degrees-C. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 460-37-7 is helpful to your research. Product Details of 460-37-7.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Bernard, L, once mentioned the new application about 460-37-7, Computed Properties of C3H4F3I.

Gaseous species in mercuric iodide crystal growth ampoules

A thorough knowledge of vapor phase composition is necessary to control mercuric iodide crystal growth in closed ampoules. This phase involves mercuric iodide vapor and residual gases evolved from the starting material and from the wall of the ampoule. The mercuric iodide vapor pressure was measured from 333 to 453 K and the gaseous species were studied by mass spectrometry. Residual gases pressure versus material purity were measured by using a thermistor device.

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Chemistry is an experimental science, HPLC of Formula: C3H4F3I, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, belongs to iodides-buliding-blocks compound. In a document, author is Deng, Weili.

Iron-Catalyzed Carboiodination of Alkynes

An iron-catalyzed carboiodination of alkynes with alkyl iodides at room temperature was developed. This method could provide synthetically useful vinyl iodides with general alkyl chains, fluoroalkyl group, ester, and cyano group. Conjugated alkynes or unconjugated alkynes were both suitable for this transformation. A radical pathway was proposed for the mechanism and acetyl tert -butyl peroxide was selected as the radical initiator. Alkenes could also be applied to this chemistry and produce more complex alkyl iodides.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 460-37-7, in my other articles. HPLC of Formula: C3H4F3I.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, formurla is C3H4F3I. In a document, author is Lee, JC, introducing its new discovery. Product Details of 460-37-7.

Efficient method for alpha-iodination of ketones

alpha-Iodoketones are prepared in high yields from the initial reaction of various ketones with HNIB in CH3CN and subsequent treatment of potassium iodide or samarium(II) iodide.

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, SMILES is ICCC(F)(F)F, in an article , author is Yu, ZS, once mentioned of 460-37-7, Name: 1,1,1-Trifluoro-3-iodopropane.

Reactivity of iodide in volcanic soils and noncrystalline soil constituents

Reaction of iodide [I-(aq)] with a series of volcanic-ash soils was compared with reaction onto noncrystalline materials that constitute much of the inorganic fraction of these soils. Our hypothesis is that these high-surface-area materials account for iodide retention by providing sites for anion exchange. Iodide sorption onto imogolite and ferrihydrite is rapid (<30 min) but not particularly extensive; imogolite has a threefold to fourfold greater affinity for iodide compared to ferrihydrite on a mass basis. In contrast, rates of iodide retention by volcanic-ash soils were slow and did not attain a steady-state after 300 h. The extent of this largely irreversible reaction can be attenuated by sterilization, but it cannot be suppressed. The iodide retained by the soils can only be completely recovered by treatment with boiling 2 M sodium hydroxide. The amount of iodide retention by soils was inversely correlated with pH, but showed no relationship with organic matter concentration, surface area, or imogolite and ferrihydrite concentrations. The reaction of iodide with the volcanic-ash soils is consistent with a rapid initial uptake by soil mineral surfaces, followed by a slower reaction of soil organic matter with oxidized forms of iodide. Under our experimental conditions, iodide is likely slowly oxidized by dissolved oxygen to molecular iodine. Solutions of molecular iodine [I-2(aq)] react relatively quickly with laboratory-grade humic acid solutions and the rate increases with increasing pH. The slow rate of iodination is consistent with the continual formation and reaction of I-2(aq) or HOI(aq) by titration with soil organic matter. Interested yet? Read on for other articles about 460-37-7, you can contact me at any time and look forward to more communication. Name: 1,1,1-Trifluoro-3-iodopropane.

Related Products of 460-37-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 460-37-7, Name is 1,1,1-Trifluoro-3-iodopropane, SMILES is ICCC(F)(F)F, belongs to iodides-buliding-blocks compound. In a article, author is Rhoden, Kerry J., introduce new discover of the category.

A YELLOW FLUORESCENT PROTEIN VARIANT AS AN INTRACELLULAR IODIDE BIOSENSOR IN THYROID CELLS

Iodide is an essential trace element playing a vital role in the synthesis of thyroid hormones. Circulating iodide is accumulated in the thyroid gland thanks to a specific transporter, the Sodium Iodide Symporter (NIS). NIS-transported radioisotopes are clinically used to diagnose and treat thyroid cancer, and are being evaluated for radiotargeted cancer therapy and nuclear imaging following NIS gene transfer. Current techniques to measure the cellular accumulation of iodide via NIS in vitro include radiotracers and electrophysiological techniques. Fluorescent proteins are gaining popularity as genetically-encoded biosensors of intracellular events. Yellow Fluorescent Proteins (YFPs) are halide-sensitive, and have been used to monitor intracellular chloride concentration and chloride channel activity. In our laboratory, we have evaluated YFP-H148Q/I152L, a YFP variant with a high affinity and selectivity for iodide, as a potential biosensor of intracellular iodide concentration and NIS-mediated transport. YFP-H148Q/I152L can be transiently or stably expressed in cells by transfection with a cDNA-containing plasmid, resulting in a uniform cytoplasmic and nuclear distribution. Live cell imaging techniques permit dynamic changes in YFP-H148Q/I152L fluorescence to be monitored in small groups of cells or single cells. Iodide uptake can be quantified through calibration in a cell-free solution, or in intact cells permeabilized with ion-selective ionophores. Exposure of FRTL-5 thyroid cells to extracellular iodide produces a rapid and reversible decrease in YFP-H148Q/I152L fluorescence consistent with iodide uptake. Iodide is concentrated up to 60-fold with respect to its extracellular concentration. Fluorescence changes are characterized by a (i) high affinity for extracellular iodide in the micromolar range, (ii) inhibition by the NIS inhibitor perchlorate, (iii) dependence on extracellular Na+, and (iv) regulation by thyroid stimulating hormone (TSH), suggesting that they are mediated by NIS. Iodide also induces a perchlorate-sensitive decrease in YFP-H148Q/I152L fluorescence in COS-7 cells expressing ectopic NIS, but has no effect in cells lacking NIS. These results demonstrate that YFP-H148Q/I152L is a sensitive biosensor of iodide uptake in cells expressing endogenous and ectopic NIS. Intracellular iodide detection with YFP-H148Q/I152L may be a promising tool to study NIS function in thyroidal and nonthyroidal cells, to investigate the mechanisms underlying defective iodide transport in thyroid disease, and to identify compounds that augment the therapeutic and imaging potential of NIS-transported radioisotopes.

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