Category: 459424-72-7

Related Products of 459424-72-7,Some common heterocyclic compound, 459424-72-7, name is 1,2,3-Trifluoro-4-iodobenzene, molecular formula is C6H2F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 25 mL reaction tube, Mn(OAc)3.2H2O(10 mol%), DABCO (2.5 equiv.) and a stirring bar were added. Then iodobenzene(1 mmol), phenyl acetylene (1 mmol) and PEG-400 were injected by syringe. The reaction tube was closed and transferred to a 70 C oil bath for 19-24 hours. After the reaction completed, cool down the reaction mixture to room temperature. Water (2 mL) was added and the reaction mixture was extracted with ethyl acetate and then concentrated and purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2,3-Trifluoro-4-iodobenzene, its application will become more common.

Reference:
Article; Qi, Xinxin; Jiang, Li-Bing; Wu, Xiao-Feng; Tetrahedron Letters; vol. 57; 15; (2016); p. 1706 – 1710;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 459424-72-7, name is 1,2,3-Trifluoro-4-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 459424-72-7

To a solution of 1, 2, 3-trifluoro-4-iodobenzene (3.3 g, 18.8 mmoL) in 1, 4-dioxane (100 mL) was added 4, 4, 5, 5-tetramethyl-2- (1, 4-dioxaspiro [4.5] dec-7-en-8-yl) -1, 3, 2-dioxaborolane (5 g, 18.8 mmol) , Pd (dppf) Cl2(1.3 g, 1.88 mmol) and Cs2CO3(9.2 g, 28.2 mmol) and the mixture was heated at 70 for 5 hours. Then evaporated the solvent under reduced pressure and the residue was purified by column chromatography (PE: EA=5: 1) to give product as an oil (4.5 g in 88.6%yield) .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BEIGENE, LTD.; WANG, Hexiang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHANG, Guoliang; ZHOU, Changyou; (353 pag.)WO2018/54365; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 459424-72-7, name is 1,2,3-Trifluoro-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 459424-72-7, category: iodides-buliding-blocks

To a solution of diisopropylamine (4.3 g, 42.6 mmol) in THF (50 ml) was added n-butyl lithium (21.3 ml, 2 N in hexane) dropwise at -10 0C, and the solution was stirred for 30 minutes at -10 0C. The reaction mixture was cooled to -78 0C and to this was added l,2,3-trifluoro-4- iodobenzene (5 g, 19.38 mmol) in THF (50 ml), stirred at -78 0C under a nitrogen atmosphere. After stirring for 5 hours at this temperature, DMF (7 ml, 89 mmol) was added dropwise such that the temperature was maintained below -60 0C. The reaction mixture was slowly allowed to warm to room temperature and stirred overnight. The reaction mixture was treated with saturated aqueous NH4Cl solution and the aqueous layer extracted with ethyl acetate (2 X 100 ml). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified over silica gel flash column using a gradient of ethyl acetate in petroleum ether to give the title product as a yellow solid. Yield: 2.4 g (45%).MS (MH+): 287.2 for C7H2F3IO1H NMR (300MHz, CDCl3) delta: 8.1 (m, IH), 10.2 (s, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2,3-Trifluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/4382; (2009); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com